AR009435A1 - DERIVATIVE OF GUANAIDINA N- [CARBONIL (HETEROARIL-SUBSTITUTED FOR 5 MEMBERS)], A NA + / H + INTERCHANGER INHIBITOR THAT INCLUDES SUCH A DERIVATIVE AND USES IN THE MANUFACTURE OF MEDICINES. - Google Patents
DERIVATIVE OF GUANAIDINA N- [CARBONIL (HETEROARIL-SUBSTITUTED FOR 5 MEMBERS)], A NA + / H + INTERCHANGER INHIBITOR THAT INCLUDES SUCH A DERIVATIVE AND USES IN THE MANUFACTURE OF MEDICINES.Info
- Publication number
- AR009435A1 AR009435A1 ARP970105802A AR009435A1 AR 009435 A1 AR009435 A1 AR 009435A1 AR P970105802 A ARP970105802 A AR P970105802A AR 009435 A1 AR009435 A1 AR 009435A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- derivative
- alkyl group
- inhibitor
- lower alkyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 102000050381 Na+/H+ exchanger Human genes 0.000 abstract 2
- 108091006672 Sodium–hydrogen antiporter Proteins 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002357 guanidines Chemical class 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un derivado de guanidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor representado por la formula general (I) o una salfarmacéuticamente aceptable del mismo, el cual es util como inhibidor del intercambiador de Na+/H+ en la prevencion, tratamiento o diagnostico deenfermedades tales como la hipertension, la arritmia, la angina de pecho, la infartacion miocárdica, la arteriosclerosis, las complicaciones diabéticas ysimilares en las cuales está relacionado elintercambiador de Na+/H+. El derivado posee la formula (1) donde (2):R1 es un grupo arilo substituido con unsubstituyente seleccionado del grupo que consiste de un dialquilamino inferior- alquileno inferior-O-, un dialquilamino inferior-alquileno inferior-CONH-, unhetero anillo saturado conteniendo nitrogeno-CONH- que puede ser substituido con un grupo alquilo inferior sobre el átomo de nitrogeno en el anillo y unhetero anillo saturado conteniendo un nitrogeno-alquileno inferior-O- que puede ser substituido con un grupo alquilo inferior sobre el átomo de nitrogeno en elanillo, y un grupo de alquilo inferior que puede ser subtituido con un átomo de halogeno. R2: es un grupo alquilo inferior que puede estar sustituido con unátomo de halogeno.A guanidine derivative n- [carbonyl (5-membered heteroaryl-substituted)], an inhibitor represented by the general formula (I), or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of the Na + / H + exchanger in prevention , treatment or diagnosis of diseases such as hypertension, arrhythmia, angina pectoris, myocardial infarction, arteriosclerosis, diabetic and similar complications in which the Na + / H + exchanger is related. The derivative has the formula (1) where (2): R1 is an aryl group substituted with a substituent selected from the group consisting of a dialkylamino-lower alkylene-O-, a dialkylamino-lower alkylene-CONH-, a saturated ring hetero containing nitrogen-CONH- which can be substituted with a lower alkyl group on the ring nitrogen atom and a saturated ring hetero containing a nitrogen-lower alkylene-O- which can be substituted with a lower alkyl group on the nitrogen atom in ring, and a lower alkyl group that can be subtitled with a halogen atom. R2: is a lower alkyl group that can be substituted with a halogen atom.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33563896 | 1996-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009435A1 true AR009435A1 (en) | 2000-04-12 |
Family
ID=18290844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105802 AR009435A1 (en) | 1996-12-16 | 1997-12-10 | DERIVATIVE OF GUANAIDINA N- [CARBONIL (HETEROARIL-SUBSTITUTED FOR 5 MEMBERS)], A NA + / H + INTERCHANGER INHIBITOR THAT INCLUDES SUCH A DERIVATIVE AND USES IN THE MANUFACTURE OF MEDICINES. |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR009435A1 (en) |
| AU (1) | AU5411998A (en) |
| WO (1) | WO1998027061A1 (en) |
| ZA (1) | ZA9711102B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1289326A (en) | 1998-02-27 | 2001-03-28 | 辉瑞产品公司 | N-[(substituted five-membered di-or thiaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia |
| US6852733B2 (en) | 2000-04-28 | 2005-02-08 | Pfizer Inc. | Sodium-hydrogen exchanger type 1 inhibitor |
| JP4716547B2 (en) * | 2000-08-10 | 2011-07-06 | 住友精化株式会社 | Method for producing 2-phenylthiazoles |
| FR2842524B1 (en) * | 2002-07-16 | 2005-04-22 | Aventis Pharma Sa | PHARMACEUTICAL COMPOSITIONS CONTAINING 3-GUANIDINOCARBONYL-1-HETEROARYL-PYRROLE DERIVATIVE, PROCESS FOR PREPARING THE SAME AS MEDICAMENTS |
| US7790720B2 (en) * | 2005-03-31 | 2010-09-07 | Ucb Pharma, S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
| EP1991528A2 (en) * | 2006-01-18 | 2008-11-19 | Siena Biotech S.p.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
| KR100863336B1 (en) * | 2006-09-29 | 2008-10-15 | 한국화학연구원 | Novel oxazole-4-carbonylguanidine derivatives, pharmaceutically acceptable salts thereof, preparation methods thereof, and pharmaceutical compositions for the prevention and treatment of ischemic heart disease containing the same as active ingredients |
| KR100820173B1 (en) * | 2007-03-12 | 2008-04-08 | 한국화학연구원 | 4-Methylimidazole-5-carbonylguanidine derivative, pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for the prevention and treatment of ischemic heart disease containing the same as an active ingredient |
| EP2532239A3 (en) * | 2007-04-03 | 2013-03-13 | E. I. du Pont de Nemours and Company | Substituted benzene fungicides |
| EP2844634B1 (en) * | 2012-05-03 | 2021-04-14 | DSM IP Assets B.V. | Process for the preparation of intermediate compounds for preparing vitamin b6 |
| BR112023021111A2 (en) | 2021-04-13 | 2023-12-19 | Nuvalent Inc | COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF CANCER, METHOD OF SELECTIVELY INHIBITING HER2, METHOD OF REGULATING A LEVEL OF HER2, METHOD OF INCREASING A LEVEL OF HER2, METHOD OF DECREASING THE PHOSPHORYLATION OF HER2 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795808A (en) * | 1972-02-24 | 1973-08-22 | Beecham Group Ltd | AMIDAZOLES POLYSUBSTITUES |
| JPS63192755A (en) * | 1987-02-06 | 1988-08-10 | Fujisawa Pharmaceut Co Ltd | 2-phenylazole derivative and salt thereof |
| JPH0692375B2 (en) * | 1987-12-16 | 1994-11-16 | 四国化成工業株式会社 | Method for synthesizing carbamoylimidazole |
| FR2665898B1 (en) * | 1990-08-20 | 1994-03-11 | Sanofi | DERIVATIVES OF AMIDO-3 PYRAZOLE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1997
- 1997-12-10 AR ARP970105802 patent/AR009435A1/en unknown
- 1997-12-10 ZA ZA9711102A patent/ZA9711102B/en unknown
- 1997-12-15 AU AU54119/98A patent/AU5411998A/en not_active Abandoned
- 1997-12-15 WO PCT/JP1997/004605 patent/WO1998027061A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU5411998A (en) | 1998-07-15 |
| WO1998027061A1 (en) | 1998-06-25 |
| ZA9711102B (en) | 1998-08-13 |
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