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AR006816A1 - A PREPARATION CONTAINING 1- [2- [4- [5-CHLORINE-1- (P-FLUOROPHENYL) INDOL-3-IL] PIPERIDINE] ETHYL] -2-IMIDAZOLIDINONE (SERTINDOL) AND A PROCESS TO PREPARE LAMISM - Google Patents

A PREPARATION CONTAINING 1- [2- [4- [5-CHLORINE-1- (P-FLUOROPHENYL) INDOL-3-IL] PIPERIDINE] ETHYL] -2-IMIDAZOLIDINONE (SERTINDOL) AND A PROCESS TO PREPARE LAMISM

Info

Publication number
AR006816A1
AR006816A1 ARP970101658A ARP970101658A AR006816A1 AR 006816 A1 AR006816 A1 AR 006816A1 AR P970101658 A ARP970101658 A AR P970101658A AR P970101658 A ARP970101658 A AR P970101658A AR 006816 A1 AR006816 A1 AR 006816A1
Authority
AR
Argentina
Prior art keywords
imidazolidinone
indol
fluorophenyl
ethyl
preparation
Prior art date
Application number
ARP970101658A
Other languages
Spanish (es)
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of AR006816A1 publication Critical patent/AR006816A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una preparación que contiene 1-[2-[4-[5-cloro-1-(p-fluorofenil)indol-3-il] piperidino]etil]-2-imidazolidinona (sertindor), que está cubierta con unrecubrimiento que comprende óxido de titanio. La preparación puede estar preferentemente en laforma de gránulos, gránulos finos, tabletas, o cápsulas.En una realización preferida, la preparación de la presente invención comprende de aproximadamente 2 a aproximadamente 200 partes en peso de óxido de titaniopor 100 partes de 1-[2-[4-[5-cloro-1-(p-fluorofenil)indol]-3-il]piperidino] etil]-2-imidazolidinona. En otra realización preferida, la preparacióncomprende de aproximadamente 0,5 a aproximadamente 50 partes en peso de óxido de titanio por 100 partes en peso de recubrimiento. El recubrimientopreferentemente comprende además lactosa y/o talco. También se refiere a un procedimiento para la preparación de la presente invención.A preparation containing 1- [2- [4- [5-chloro-1- (p-fluorophenyl) indol-3-yl] piperidino] ethyl] -2-imidazolidinone (sertindor), which is covered with a coating comprising oxide titanium. The preparation may preferably be in the form of granules, fine granules, tablets, or capsules. In a preferred embodiment, the preparation of the present invention comprises from about 2 to about 200 parts by weight of titanium oxide per 100 parts of 1- [2 - [4- [5-chloro-1- (p-fluorophenyl) indol] -3-yl] piperidino] ethyl] -2-imidazolidinone. In another preferred embodiment, the preparation comprises from about 0.5 to about 50 parts by weight of titanium oxide per 100 parts by weight of coating. The coating preferably further comprises lactose and / or talc. It also relates to a process for the preparation of the present invention.

ARP970101658A 1996-04-24 1997-04-24 A PREPARATION CONTAINING 1- [2- [4- [5-CHLORINE-1- (P-FLUOROPHENYL) INDOL-3-IL] PIPERIDINE] ETHYL] -2-IMIDAZOLIDINONE (SERTINDOL) AND A PROCESS TO PREPARE LAMISM AR006816A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10293596 1996-04-24

Publications (1)

Publication Number Publication Date
AR006816A1 true AR006816A1 (en) 1999-09-29

Family

ID=14340706

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101658A AR006816A1 (en) 1996-04-24 1997-04-24 A PREPARATION CONTAINING 1- [2- [4- [5-CHLORINE-1- (P-FLUOROPHENYL) INDOL-3-IL] PIPERIDINE] ETHYL] -2-IMIDAZOLIDINONE (SERTINDOL) AND A PROCESS TO PREPARE LAMISM

Country Status (4)

Country Link
AR (1) AR006816A1 (en)
AU (1) AU2405097A (en)
WO (1) WO1997039752A1 (en)
ZA (1) ZA973433B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001151671A (en) * 1999-09-06 2001-06-05 Teikoku Hormone Mfg Co Ltd Particle formulation with protrusion
GB9922271D0 (en) * 1999-09-21 1999-11-17 Zeneca Ltd Formulation
JP2005187339A (en) * 2003-12-24 2005-07-14 Iwaki Seiyaku Co Ltd Light-resistant terbinafine hydrochloride film-coated tablets
CN1942173B (en) * 2004-04-08 2012-05-09 协和发酵麒麟株式会社 Solid formulation with improved stability and method for producing the same
KR20060135853A (en) * 2004-04-08 2006-12-29 교와 핫꼬 고교 가부시끼가이샤 Solid Agents Containing Dibenzo [ｂ, ｅ] oxepin Derivatives
UA97349C2 (en) * 2005-09-08 2012-02-10 Х. Луннбэк А/С Stable solid formulation of sertindole
JP2009073774A (en) * 2007-09-21 2009-04-09 Takada Seiyaku Kk Method for producing granular formulation of levofloxacin and granular formulation obtained by the same method
AR090073A1 (en) * 2012-02-16 2014-10-15 Teva Pharma N-ETIL-N-PHENYL-1,2-DIHIDRO-4,5-DI-HYDROXI-1-METHYL-2-OXO-3-CHINOLINACARBOXAMIDE, ITS PREPARATION AND USES
WO2013161103A1 (en) * 2012-04-26 2013-10-31 持田製薬株式会社 Composition having titanium oxide prevented from colour change
JP6133073B2 (en) * 2013-02-08 2017-05-24 株式会社三和化学研究所 Pharmaceutical formulation containing loop diuretic as active ingredient
JP6366547B2 (en) * 2015-08-03 2018-08-01 大原薬品工業株式会社 Pramipexole formulation package with improved photostability

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8908085D0 (en) * 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
JPH04346929A (en) * 1991-05-22 1992-12-02 Takada Seiyaku Kk Bromocriptine mesylate preparation having stability to light
US5411746A (en) * 1993-02-24 1995-05-02 Warner-Jenkinson Company, Inc. Dye compositions and methods for film coating tablets and the like

Also Published As

Publication number Publication date
AU2405097A (en) 1997-11-12
ZA973433B (en) 1997-12-10
WO1997039752A1 (en) 1997-10-30

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