AR006202A1 - USES OF IGE ANTAGONIST TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF ALLERGIC DISEASES AND COMPOSITIONS CONTAINING THEM - Google Patents
USES OF IGE ANTAGONIST TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF ALLERGIC DISEASES AND COMPOSITIONS CONTAINING THEMInfo
- Publication number
- AR006202A1 AR006202A1 ARP970100986A ARP970100986A AR006202A1 AR 006202 A1 AR006202 A1 AR 006202A1 AR P970100986 A ARP970100986 A AR P970100986A AR P970100986 A ARP970100986 A AR P970100986A AR 006202 A1 AR006202 A1 AR 006202A1
- Authority
- AR
- Argentina
- Prior art keywords
- prepare
- treatment
- ige
- ige antagonist
- compositions containing
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000172 allergic effect Effects 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 210000002966 serum Anatomy 0.000 abstract 2
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Usos y composiciones de antagonista IgE para preparar un medicamento útil para el tratamiento de una enfermedad alérgica caracterizado por una cantidadefectiva de dicho antagonista IgE, que es administrado como: (a) una dosis de carga durante unperíodo de al menos alrededor de 14 días suficientes parareducir el nivel promedio de IgE libre en suero del paciente hasta un nivel no mayor de alrededor de 50ng/ml al final del período de carga; seguido por (b)una dosis de mantenimiento entrealre dedor de 8x10(5) hasta 2.4x10(3) mg/kg/semana del antagonista IgE para cada IU/ml línea de base IgE libre en elsuero del paciente.Uses and compositions of IgE antagonist to prepare a medicament useful for the treatment of an allergic disease characterized by a defective amount of said IgE antagonist, which is administered as: (a) a loading dose over a period of at least about 14 days sufficient to reduce the average level of free IgE in the patient's serum to a level no greater than about 50ng / ml at the end of the loading period; followed by (b) an interval maintenance dose of 8x10 (5) to 2.4x10 (3) mg / kg / week of the IgE antagonist for each IU / ml baseline free IgE in the patient's serum.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61422096A | 1996-03-12 | 1996-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006202A1 true AR006202A1 (en) | 1999-08-11 |
Family
ID=24460327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100986A AR006202A1 (en) | 1996-03-12 | 1997-03-12 | USES OF IGE ANTAGONIST TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF ALLERGIC DISEASES AND COMPOSITIONS CONTAINING THEM |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0904108A1 (en) |
| JP (1) | JP2001505181A (en) |
| AR (1) | AR006202A1 (en) |
| AU (1) | AU726143B2 (en) |
| CA (1) | CA2246427A1 (en) |
| IL (1) | IL126113A0 (en) |
| WO (1) | WO1997033616A1 (en) |
| ZA (1) | ZA971607B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US7393529B2 (en) | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
| AU2065801A (en) * | 1999-12-06 | 2001-06-12 | Panacea Pharmaceuticals, Llc | Passive desensitization |
| GB0016441D0 (en) | 2000-07-04 | 2000-08-23 | Pharmagene Lab Limited | Therapeutic method |
| US6787524B2 (en) | 2000-09-22 | 2004-09-07 | Tanox, Inc. | CpG oligonucleotides and related compounds for enhancing ADCC induced by anti-IgE antibodies |
| JP2004524375A (en) * | 2001-05-03 | 2004-08-12 | ノバルティス アクチエンゲゼルシャフト | Use of organic compounds |
| GB201610198D0 (en) * | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
| CN114028569B (en) * | 2021-12-20 | 2023-04-28 | 中国医学科学院基础医学研究所 | Use of immunoglobulin IgE for diagnosis and/or treatment of hypertension |
| CN114504644B (en) * | 2021-12-24 | 2024-02-13 | 北京大学第一医院 | Use of anti-IgE antibodies for the treatment of adenoid hypertrophy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449760A (en) * | 1987-12-31 | 1995-09-12 | Tanox Biosystems, Inc. | Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils |
| US4940715A (en) * | 1988-05-17 | 1990-07-10 | Kissei Pharmaceutical Co., Ltd. | 5H-pyrazolo[4,3-A] quinolizin-5-one compounds exhibiting therapeutic activities |
| JP3156237B2 (en) * | 1991-12-24 | 2001-04-16 | 雪印乳業株式会社 | Anti-human IgE monoclonal antibody |
-
1997
- 1997-02-25 ZA ZA971607A patent/ZA971607B/en unknown
- 1997-03-06 IL IL12611397A patent/IL126113A0/en unknown
- 1997-03-06 CA CA002246427A patent/CA2246427A1/en not_active Abandoned
- 1997-03-06 EP EP97908025A patent/EP0904108A1/en not_active Withdrawn
- 1997-03-06 WO PCT/US1997/003443 patent/WO1997033616A1/en not_active Ceased
- 1997-03-06 AU AU19875/97A patent/AU726143B2/en not_active Ceased
- 1997-03-06 JP JP53267597A patent/JP2001505181A/en active Pending
- 1997-03-12 AR ARP970100986A patent/AR006202A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997033616A1 (en) | 1997-09-18 |
| JP2001505181A (en) | 2001-04-17 |
| CA2246427A1 (en) | 1997-09-18 |
| AU726143B2 (en) | 2000-11-02 |
| ZA971607B (en) | 1998-08-25 |
| IL126113A0 (en) | 1999-05-09 |
| AU1987597A (en) | 1997-10-01 |
| EP0904108A1 (en) | 1999-03-31 |
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