AP619A - Use of hyaluronic acid or salt for the treatment of a human having a stroke or myocardial infarction. - Google Patents

Use of hyaluronic acid or salt for the treatment of a human having a stroke or myocardial infarction. Download PDF

Info

Publication number: AP619A
Authority: AP; ARIPO
Prior art keywords: hyaluronic acid; human; administration; pharmaceutically acceptable; effective amount
Prior art date: 1994-08-24

Application number

APAP/P/1995/000757A

Other languages

English (en)

Other versions

AP9500757A0 (en

Inventor

Eva Anne Turley

Samuel Simon Asculai

Original Assignee

Hyal Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-24

Filing date

1995-08-14

Publication date

1997-10-10

1995-08-14 Application filed by Hyal Pharma Corp filed Critical Hyal Pharma Corp

1995-10-31 Publication of AP9500757A0 publication Critical patent/AP9500757A0/xx

1997-10-10 Application granted granted Critical

1997-10-10 Publication of AP619A publication Critical patent/AP619A/en

Links

229920002674 hyaluronan Polymers 0.000 title claims abstract description 84
229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 83
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 82
150000003839 salts Chemical class 0.000 title claims abstract description 27
208000010125 myocardial infarction Diseases 0.000 title claims description 14
239000013543 active substance Substances 0.000 claims abstract 8
229920002385 Sodium hyaluronate Polymers 0.000 claims description 33
229940010747 sodium hyaluronate Drugs 0.000 claims description 33
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 33
230000037396 body weight Effects 0.000 claims description 22
239000003814 drug Substances 0.000 claims description 22
210000002540 macrophage Anatomy 0.000 claims description 21
210000000265 leukocyte Anatomy 0.000 claims description 19
229940079593 drug Drugs 0.000 claims description 18
238000000034 method Methods 0.000 claims description 17
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 14
230000008595 infiltration Effects 0.000 claims description 13
238000001764 infiltration Methods 0.000 claims description 13
210000004369 blood Anatomy 0.000 claims description 11
239000008280 blood Substances 0.000 claims description 11
201000010099 disease Diseases 0.000 claims description 11
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 10
238000010254 subcutaneous injection Methods 0.000 claims description 9
239000007929 subcutaneous injection Substances 0.000 claims description 9
238000001990 intravenous administration Methods 0.000 claims description 8
230000036765 blood level Effects 0.000 claims description 7
239000008194 pharmaceutical composition Substances 0.000 claims description 7
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 6
108010023197 Streptokinase Proteins 0.000 claims description 6
229940127218 antiplatelet drug Drugs 0.000 claims description 6
229960002897 heparin Drugs 0.000 claims description 6
229920000669 heparin Polymers 0.000 claims description 6
239000000106 platelet aggregation inhibitor Substances 0.000 claims description 6
229960005202 streptokinase Drugs 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 4
238000009472 formulation Methods 0.000 claims description 3
239000002876 beta blocker Substances 0.000 claims description 2
229940097320 beta blocking agent Drugs 0.000 claims description 2
BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims 5
239000012190 activator Substances 0.000 claims 5
230000000320 anti-stroke effect Effects 0.000 claims 5
238000004519 manufacturing process Methods 0.000 claims 3
238000001514 detection method Methods 0.000 claims 2
239000002552 dosage form Substances 0.000 claims 1
241001465754 Metazoa Species 0.000 description 14
241000700159 Rattus Species 0.000 description 13
230000006378 damage Effects 0.000 description 13
238000002474 experimental method Methods 0.000 description 12
208000006011 Stroke Diseases 0.000 description 10
210000004556 brain Anatomy 0.000 description 9
210000004027 cell Anatomy 0.000 description 9
206010061216 Infarction Diseases 0.000 description 8
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 8
230000007574 infarction Effects 0.000 description 8
210000000440 neutrophil Anatomy 0.000 description 8
210000001519 tissue Anatomy 0.000 description 8
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
230000028709 inflammatory response Effects 0.000 description 7
230000005012 migration Effects 0.000 description 7
238000013508 migration Methods 0.000 description 7
229910052760 oxygen Inorganic materials 0.000 description 7
239000001301 oxygen Substances 0.000 description 7
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
230000000694 effects Effects 0.000 description 5
239000008103 glucose Substances 0.000 description 5
210000004969 inflammatory cell Anatomy 0.000 description 5
238000002347 injection Methods 0.000 description 5
239000007924 injection Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
241000282412 Homo Species 0.000 description 4
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
230000008033 biological extinction Effects 0.000 description 4
229960000905 indomethacin Drugs 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
230000004044 response Effects 0.000 description 4
238000007920 subcutaneous administration Methods 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 3
159000000000 sodium salts Chemical class 0.000 description 3
238000010186 staining Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 2
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
229920002683 Glycosaminoglycan Polymers 0.000 description 2
102000018866 Hyaluronan Receptors Human genes 0.000 description 2
108010013214 Hyaluronan Receptors Proteins 0.000 description 2
OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
230000006931 brain damage Effects 0.000 description 2
231100000874 brain damage Toxicity 0.000 description 2
208000029028 brain injury Diseases 0.000 description 2
210000001715 carotid artery Anatomy 0.000 description 2
230000003292 diminished effect Effects 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
239000012634 fragment Substances 0.000 description 2
229960002442 glucosamine Drugs 0.000 description 2
210000005003 heart tissue Anatomy 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
229910052742 iron Inorganic materials 0.000 description 2
229950006780 n-acetylglucosamine Drugs 0.000 description 2
230000004770 neurodegeneration Effects 0.000 description 2
150000003180 prostaglandins Chemical class 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
102100032912 CD44 antigen Human genes 0.000 description 1
102000001045 Connexin 43 Human genes 0.000 description 1
108010069241 Connexin 43 Proteins 0.000 description 1
AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
102100039289 Glial fibrillary acidic protein Human genes 0.000 description 1
101710193519 Glial fibrillary acidic protein Proteins 0.000 description 1
206010018341 Gliosis Diseases 0.000 description 1
101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
102100027735 Hyaluronan mediated motility receptor Human genes 0.000 description 1
108010003272 Hyaluronate lyase Proteins 0.000 description 1
102000001974 Hyaluronidases Human genes 0.000 description 1
MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
206010028851 Necrosis Diseases 0.000 description 1
238000010826 Nissl staining Methods 0.000 description 1
206010061137 Ocular toxicity Diseases 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
108010001014 Plasminogen Activators Proteins 0.000 description 1
102000001938 Plasminogen Activators Human genes 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
206010044245 Toxic optic neuropathy Diseases 0.000 description 1
108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000000061 acid fraction Substances 0.000 description 1
210000001130 astrocyte Anatomy 0.000 description 1
230000036770 blood supply Effects 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
239000005388 borosilicate glass Substances 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000009429 distress Effects 0.000 description 1
239000002158 endotoxin Substances 0.000 description 1
238000011990 functional testing Methods 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000005046 glial fibrillary acidic protein Anatomy 0.000 description 1
230000007387 gliosis Effects 0.000 description 1
229940097043 glucuronic acid Drugs 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
229940099552 hyaluronan Drugs 0.000 description 1
108010003425 hyaluronan-mediated motility receptor Proteins 0.000 description 1
229960002773 hyaluronidase Drugs 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000004941 influx Effects 0.000 description 1
208000014674 injury Diseases 0.000 description 1
239000000463 material Substances 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
230000004660 morphological change Effects 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
230000001338 necrotic effect Effects 0.000 description 1
230000031990 negative regulation of inflammatory response Effects 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
230000000926 neurological effect Effects 0.000 description 1
210000002569 neuron Anatomy 0.000 description 1
231100000327 ocular toxicity Toxicity 0.000 description 1
239000002245 particle Substances 0.000 description 1
229940127126 plasminogen activator Drugs 0.000 description 1
230000002028 premature Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
238000009781 safety test method Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940049529 sodium hyaluronate 20 mg/ml Drugs 0.000 description 1
239000013589 supplement Substances 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
231100000041 toxicology testing Toxicity 0.000 description 1
230000008733 trauma Effects 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

APAP/P/1995/000757A 1994-08-24 1995-08-14 Use of hyaluronic acid or salt for the treatment of a human having a stroke or myocardial infarction. AP619A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002130762A CA2130762C (fr)	1994-08-24	1994-08-24	Traitement des maladies et des troubles associes a l'infiltration par des macrophages

Publications (2)

Publication Number	Publication Date
AP9500757A0 AP9500757A0 (en)	1995-10-31
AP619A true AP619A (en)	1997-10-10

Family

ID=4154227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1995/000757A AP619A (en)	1994-08-24	1995-08-14	Use of hyaluronic acid or salt for the treatment of a human having a stroke or myocardial infarction.

Country Status (14)

Country	Link
EP (1)	EP0777487B1 (fr)
JP (1)	JP4111537B2 (fr)
KR (1)	KR970705402A (fr)
CN (1)	CN1131539A (fr)
AP (1)	AP619A (fr)
AT (1)	ATE212850T1 (fr)
AU (1)	AU701014B2 (fr)
CA (1)	CA2130762C (fr)
DE (1)	DE69525349T2 (fr)
ES (1)	ES2172589T3 (fr)
HU (1)	HUT76895A (fr)
IL (1)	IL114915A0 (fr)
WO (1)	WO1996005845A2 (fr)
ZA (1)	ZA957056B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5888984A (en) *	1994-05-12	1999-03-30	Dermal Research Laboratories, Inc.	Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
ES2202581T3 (es) *	1996-03-14	2004-04-01	The Governors Of The University Of Alberta	Uso de hialuronan (ha) para la movilizacion celular.
US6875753B1 (en)	1996-03-14	2005-04-05	The Governors Of The University Of Alberta	Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
EP0949931B1 (fr)	1996-12-06	2008-08-27	Amgen Inc.,	Therapie combinee utilisant un inhibiteur de l'il-1 pour traiter les maladies induites par l'il-1
US6294170B1 (en)	1997-08-08	2001-09-25	Amgen Inc.	Composition and method for treating inflammatory diseases
WO2000044367A2 (fr)	1999-02-01	2000-08-03	Dermal Research Laboratories, Inc.	Composition pharmaceutique d'hydrates de carbone complexes et d'huiles essentielles et methode d'utilisation de celle-ci
US6472379B1 (en)	1999-03-15	2002-10-29	Trustees Of Boston University	Angiogenesis inhibition
US7879824B2 (en)	2001-07-31	2011-02-01	Dermal Research Laboratories, Inc.	Methods of preventing or treating diseases and conditions using complex carbohydrates
TWI711630B (zh)	2014-11-21	2020-12-01	美商必治妥美雅史谷比公司	抗ｃｄ７３抗體及其用途
AU2018324111B2 (en) *	2017-09-01	2023-11-09	National Cheng Kung University	Viscous composition for treating ischemia
CN111194220B (zh) *	2017-09-05	2024-06-18	黄玲惠	用于治疗缺血的肝素组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0057118A2 (fr) *	1981-01-27	1982-08-04	Thomson-Csf	Dispositif électromécanique d'impression pour imprimante du type série-parallèle
AP175A (en) *	1989-09-21	1992-04-03	Norpharmco Inc	Combination and formulations and the administration thereof to a mammal for the treatment of conditions and disease.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1229075B (it) *	1985-04-05	1991-07-17	Fidia Farmaceutici	Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
US4725585A (en) *	1985-04-26	1988-02-16	Pharmacia Ab	Method of enhancing the host defense
CA2061703C (fr) *	1992-02-20	2002-07-02	Rudolf E. Falk	Compositions renfermant de l'acide hyaluronique
CA2061567C (fr) *	1992-02-20	1998-02-03	Rudolf E. Falk	Utilisation de l'acide hyaluronique pour reparer les dommages de reperfusion de l'ischemie
AU3721793A (en) *	1992-02-24	1993-09-13	Paul L. Simmons	Biodegradable germicide

1994
- 1994-08-24 CA CA002130762A patent/CA2130762C/fr not_active Expired - Lifetime
1995
- 1995-08-02 AU AU31070/95A patent/AU701014B2/en not_active Expired
- 1995-08-02 ES ES95926813T patent/ES2172589T3/es not_active Expired - Lifetime
- 1995-08-02 AT AT95926813T patent/ATE212850T1/de not_active IP Right Cessation
- 1995-08-02 EP EP95926813A patent/EP0777487B1/fr not_active Expired - Lifetime
- 1995-08-02 DE DE69525349T patent/DE69525349T2/de not_active Expired - Lifetime
- 1995-08-02 KR KR1019970701073A patent/KR970705402A/ko not_active Ceased
- 1995-08-02 JP JP50766996A patent/JP4111537B2/ja not_active Expired - Lifetime
- 1995-08-02 WO PCT/CA1995/000467 patent/WO1996005845A2/fr not_active Ceased
- 1995-08-02 HU HU9701518A patent/HUT76895A/hu unknown
- 1995-08-11 IL IL11491595A patent/IL114915A0/xx unknown
- 1995-08-14 AP APAP/P/1995/000757A patent/AP619A/en active
- 1995-08-23 CN CN95116616A patent/CN1131539A/zh active Pending
- 1995-08-23 ZA ZA957056A patent/ZA957056B/xx unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0057118A2 (fr) *	1981-01-27	1982-08-04	Thomson-Csf	Dispositif électromécanique d'impression pour imprimante du type série-parallèle
AP175A (en) *	1989-09-21	1992-04-03	Norpharmco Inc	Combination and formulations and the administration thereof to a mammal for the treatment of conditions and disease.

Also Published As

Publication number	Publication date
JPH10506884A (ja)	1998-07-07
EP0777487A1 (fr)	1997-06-11
HUT76895A (en)	1997-12-29
CA2130762A1 (fr)	1996-02-25
CA2130762C (fr)	1999-07-06
ES2172589T3 (es)	2002-10-01
WO1996005845A3 (fr)	1996-04-11
CN1131539A (zh)	1996-09-25
WO1996005845A2 (fr)	1996-02-29
IL114915A0 (en)	1995-12-08
DE69525349D1 (de)	2002-03-21
DE69525349T2 (de)	2002-10-31
AP9500757A0 (en)	1995-10-31
ZA957056B (en)	1996-03-26
JP4111537B2 (ja)	2008-07-02
EP0777487B1 (fr)	2002-02-06
AU701014B2 (en)	1999-01-21
AU3107095A (en)	1996-03-14
KR970705402A (ko)	1997-10-09
ATE212850T1 (de)	2002-02-15

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US20170056561A1 (en)	2017-03-02	Compositions for the treatment of joints
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