AP2015008628A0 - Crenolanib for treating FLT3 mutated proliferativedisorders - Google Patents

Crenolanib for treating FLT3 mutated proliferativedisorders

Info

Publication number: AP2015008628A0
Authority: AP; ARIPO
Prior art keywords: proliferativedisorders; crenolanib; flt3 mutated; treating flt3; treating
Prior art date: 2013-01-07

Application number

AP2015008628A

Other languages

English (en)

Inventor

Vinay K Jain

Original Assignee

Arog Pharmaceuticals Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-01-07

Filing date

2013-10-14

Publication date

2015-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51061430&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2015008628(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-10-14 Application filed by Arog Pharmaceuticals Llc filed Critical Arog Pharmaceuticals Llc

2015-08-31 Publication of AP2015008628A0 publication Critical patent/AP2015008628A0/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Hematology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Oncology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Food Science & Technology (AREA)
Nutrition Science (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Hospice & Palliative Care (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Physiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2015008628A 2013-01-07 2013-10-14 Crenolanib for treating FLT3 mutated proliferativedisorders AP2015008628A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361749695P	2013-01-07	2013-01-07
PCT/US2013/064821 WO2014107209A2 (en)	2013-01-07	2013-10-14	Crenolanib for treating flt3 mutated proliferative disorders

Publications (1)

Publication Number	Publication Date
AP2015008628A0 true AP2015008628A0 (en)	2015-08-31

Family

ID=51061430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2015008628A AP2015008628A0 (en)	2013-01-07	2013-10-14	Crenolanib for treating FLT3 mutated proliferativedisorders

Country Status (32)

Country	Link
US (8)	US9101624B2 (es)
EP (1)	EP2941251B1 (es)
JP (1)	JP6288726B2 (es)
KR (1)	KR101885952B1 (es)
CN (4)	CN109966292A (es)
AP (1)	AP2015008628A0 (es)
AU (1)	AU2013371624B2 (es)
BR (1)	BR112015016282A2 (es)
CA (1)	CA2897445C (es)
CL (1)	CL2015001923A1 (es)
CY (1)	CY1120026T1 (es)
DK (1)	DK2941251T3 (es)
EA (1)	EA033910B1 (es)
ES (1)	ES2667958T3 (es)
HK (1)	HK1224211A1 (es)
HR (1)	HRP20180478T1 (es)
HU (1)	HUE038594T2 (es)
IL (1)	IL239802B (es)
LT (1)	LT2941251T (es)
MX (1)	MX369137B (es)
NO (1)	NO3019692T3 (es)
NZ (1)	NZ710720A (es)
PE (1)	PE20151525A1 (es)
PH (1)	PH12015501531A1 (es)
PL (1)	PL2941251T3 (es)
PT (1)	PT2941251T (es)
RS (1)	RS57076B1 (es)
SG (2)	SG11201505327SA (es)
SI (1)	SI2941251T1 (es)
SM (1)	SMT201800185T1 (es)
WO (1)	WO2014107209A2 (es)
ZA (1)	ZA201505545B (es)

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KR101738063B1 (ko)	2012-09-21	2017-05-19	아로그 파마슈티칼스, 인코퍼레이티드	구조적으로 활성인 인산화된 ｆｌｔ３ 키나제의 억제 방법
BR112015016282A2 (pt)	2013-01-07	2017-07-11	Arog Pharmaceuticals Inc	crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado
GB201311891D0 (en)	2013-07-03	2013-08-14	Glaxosmithkline Ip Dev Ltd	Novel compound
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US20180228907A1 (en)	2014-04-14	2018-08-16	Arvinas, Inc.	Cereblon ligands and bifunctional compounds comprising the same
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JP7466308B2 (ja)	2016-09-20	2024-04-12	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法
CN108778276A (zh) *	2016-11-02	2018-11-09	安罗格制药有限责任公司	用于治疗flt3突变型增殖性疾患相关突变的克莱拉尼
WO2018118598A1 (en)	2016-12-23	2018-06-28	Arvinas, Inc.	Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
AU2020370110A1 (en) *	2019-10-21	2022-05-26	Rhizen Pharmaceuticals Ag	Compositions comprising a DHODH inhibitor for the treatment of acute myeloid leukemia
CN118767143A (zh)	2019-12-12	2024-10-15	听治疗有限责任公司	用于预防和治疗听力损失的组合物和方法
CA3186319A1 (en) *	2020-07-20	2022-01-27	Arog Pharmaceuticals, Inc.	Crystal forms of crenolanib and methods of use thereof
US11713310B2 (en)	2020-07-20	2023-08-01	Arog Pharmaceuticals, Inc.	Crystal forms of crenolanib and methods of use thereof
US20220047574A1 (en) *	2020-08-15	2022-02-17	Arog Pharmaceuticals, Inc.	Crenolanib for treating pdgfr alpha mutated proliferative disorders
WO2022051429A1 (en)	2020-09-02	2022-03-10	Daniel Choi	Systems and methods for augmented reality environments and tokens
US11969420B2 (en)	2020-10-30	2024-04-30	Arog Pharmaceuticals, Inc.	Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders
WO2022090547A1 (en)	2020-10-30	2022-05-05	Dsm Ip Assets B.V.	Production of carotenoids by fermentation
JP2023063189A (ja) *	2021-10-22	2023-05-09	アログ・ファーマシューティカルズ・インコーポレイテッド	以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ

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KR101738063B1 (ko) *	2012-09-21	2017-05-19	아로그 파마슈티칼스, 인코퍼레이티드	구조적으로 활성인 인산화된 ｆｌｔ３ 키나제의 억제 방법
TWI599356B (zh)	2012-09-26	2017-09-21	安羅格製藥有限責任公司	抑制突變型ｃ－ｋｉｔ的方法
BR112015016282A2 (pt)	2013-01-07	2017-07-11	Arog Pharmaceuticals Inc	crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado

2013
- 2013-07-10 BR BR112015016282A patent/BR112015016282A2/pt not_active Application Discontinuation
- 2013-10-14 EP EP13869984.8A patent/EP2941251B1/en active Active
- 2013-10-14 CN CN201910222133.6A patent/CN109966292A/zh active Pending
- 2013-10-14 HU HUE13869984A patent/HUE038594T2/hu unknown
- 2013-10-14 WO PCT/US2013/064821 patent/WO2014107209A2/en not_active Ceased
- 2013-10-14 US US14/053,011 patent/US9101624B2/en active Active
- 2013-10-14 SG SG11201505327SA patent/SG11201505327SA/en unknown
- 2013-10-14 KR KR1020157021078A patent/KR101885952B1/ko active Active
- 2013-10-14 SM SM20180185T patent/SMT201800185T1/it unknown
- 2013-10-14 RS RS20180287A patent/RS57076B1/sr unknown
- 2013-10-14 CN CN201380069700.XA patent/CN105555272A/zh active Pending
- 2013-10-14 NZ NZ710720A patent/NZ710720A/en unknown
- 2013-10-14 LT LTEP13869984.8T patent/LT2941251T/lt unknown
- 2013-10-14 MX MX2015008777A patent/MX369137B/es active IP Right Grant
- 2013-10-14 ES ES13869984.8T patent/ES2667958T3/es active Active
- 2013-10-14 CA CA2897445A patent/CA2897445C/en active Active
- 2013-10-14 DK DK13869984.8T patent/DK2941251T3/en active
- 2013-10-14 SG SG10201705611PA patent/SG10201705611PA/en unknown
- 2013-10-14 EA EA201591290A patent/EA033910B1/ru unknown
- 2013-10-14 HR HRP20180478TT patent/HRP20180478T1/hr unknown
- 2013-10-14 CN CN202011110066.8A patent/CN112138010A/zh active Pending
- 2013-10-14 HK HK16112610.7A patent/HK1224211A1/zh unknown
- 2013-10-14 PL PL13869984T patent/PL2941251T3/pl unknown
- 2013-10-14 PE PE2015001247A patent/PE20151525A1/es not_active Application Discontinuation
- 2013-10-14 PT PT138699848T patent/PT2941251T/pt unknown
- 2013-10-14 JP JP2015551670A patent/JP6288726B2/ja active Active
- 2013-10-14 AP AP2015008628A patent/AP2015008628A0/xx unknown
- 2013-10-14 SI SI201330974T patent/SI2941251T1/en unknown
- 2013-10-14 AU AU2013371624A patent/AU2013371624B2/en active Active
- 2013-10-14 CN CN201910222143.XA patent/CN110200970A/zh active Pending
2014
- 2014-07-03 NO NO14742440A patent/NO3019692T3/no unknown
2015
- 2015-05-04 US US14/703,500 patent/US9393240B2/en active Active
- 2015-07-06 IL IL239802A patent/IL239802B/en active IP Right Grant
- 2015-07-07 PH PH12015501531A patent/PH12015501531A1/en unknown
- 2015-07-07 CL CL2015001923A patent/CL2015001923A1/es unknown
- 2015-07-31 ZA ZA2015/05545A patent/ZA201505545B/en unknown
2016
- 2016-06-28 US US15/195,297 patent/US9801870B2/en active Active
2017
- 2017-09-26 US US15/715,274 patent/US10213423B2/en active Active
2018
- 2018-03-12 CY CY20181100293T patent/CY1120026T1/el unknown
2019
- 2019-02-22 US US16/282,716 patent/US11007188B2/en active Active
2020
- 2020-08-18 US US16/996,400 patent/US11458131B2/en active Active
2022
- 2022-08-30 US US17/898,632 patent/US12171757B2/en active Active
2024
- 2024-10-09 US US18/910,067 patent/US20250032475A1/en active Pending

Also Published As

Publication number	Publication date
CA2897445C (en)	2019-04-30
BR112015016282A2 (pt)	2017-07-11
ZA201505545B (en)	2016-10-26
CN105555272A (zh)	2016-05-04
WO2014107209A2 (en)	2014-07-10
US20200390756A1 (en)	2020-12-17
ES2667958T3 (es)	2018-05-16
JP6288726B2 (ja)	2018-03-07
US20220409610A1 (en)	2022-12-29
US20150238479A1 (en)	2015-08-27
HRP20180478T1 (hr)	2018-06-15
IL239802B (en)	2020-06-30
AU2013371624A1 (en)	2015-08-20
IL239802A0 (en)	2015-08-31
US12171757B2 (en)	2024-12-24
HUE038594T2 (hu)	2018-10-29
RS57076B1 (sr)	2018-06-29
US10213423B2 (en)	2019-02-26
PE20151525A1 (es)	2015-10-23
SI2941251T1 (en)	2018-06-29
US9393240B2 (en)	2016-07-19
US20160303109A1 (en)	2016-10-20
PL2941251T3 (pl)	2018-07-31
CL2015001923A1 (es)	2016-01-15
PH12015501531B1 (en)	2015-09-21
PT2941251T (pt)	2018-03-23
LT2941251T (lt)	2018-04-10
EA201591290A2 (ru)	2016-03-31
MX369137B (es)	2019-10-30
CA2897445A1 (en)	2014-07-10
SG11201505327SA (en)	2015-08-28
AU2013371624B2 (en)	2018-02-08
NO3019692T3 (es)	2018-06-16
EA201591290A3 (ru)	2016-07-29
MX2015008777A (es)	2015-11-13
KR101885952B1 (ko)	2018-08-06
US11458131B2 (en)	2022-10-04
US20190183879A1 (en)	2019-06-20
DK2941251T3 (en)	2018-03-26
EP2941251A4 (en)	2016-08-24
US20140194464A1 (en)	2014-07-10
US20250032475A1 (en)	2025-01-30
HK1224211A1 (zh)	2017-08-18
SMT201800185T1 (it)	2018-05-02
KR20150141930A (ko)	2015-12-21
CY1120026T1 (el)	2018-12-12
US9801870B2 (en)	2017-10-31
CN109966292A (zh)	2019-07-05
PH12015501531A1 (en)	2015-09-21
NZ710720A (en)	2020-06-26
SG10201705611PA (en)	2017-08-30
JP2016508148A (ja)	2016-03-17
EP2941251B1 (en)	2018-03-07
CN112138010A (zh)	2020-12-29
US20180015081A1 (en)	2018-01-18
US9101624B2 (en)	2015-08-11
EP2941251A2 (en)	2015-11-11
US11007188B2 (en)	2021-05-18
CN110200970A (zh)	2019-09-06
EA033910B1 (ru)	2019-12-09

Publication	Publication Date	Title
AP2015008628A0 (en)	2015-08-31	Crenolanib for treating FLT3 mutated proliferativedisorders
GB201321440D0 (en)	2014-01-22	Process
GB201312991D0 (en)	2013-09-04	Process
GB201307334D0 (en)	2013-05-29	Process
GB201416005D0 (en)	2014-10-22	Process
GB201304872D0 (en)	2013-05-01	Treatment
GB201421428D0 (en)	2015-01-14	Process
GB201421426D0 (en)	2015-01-14	Process
PL2941584T3 (pl)	2019-09-30	Środki chwytające
GB201322454D0 (en)	2014-02-05	Process
GB201318888D0 (en)	2013-12-11	Process
GB201401963D0 (en)	2014-03-19	Process
GB201401922D0 (en)	2014-03-19	Process
GB201322273D0 (en)	2014-01-29	Process
GB201320869D0 (en)	2014-01-08	Process
GB201314334D0 (en)	2013-09-25	Process
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