AP2014007797A0 - Glucagon analogues - Google Patents

Glucagon analogues

Info

Publication number: AP2014007797A0
Authority: AP; ARIPO
Prior art keywords: glucagon analogues; glucagon; analogues
Prior art date: 2011-12-23

Application number

AP2014007797A

Other languages

English (en)

Inventor

Ditte Riber

Jakob Lind Tolborg

Dieter Wolfgang Hamprecht

Original Assignee

Boehringer Ingelheim Int

Zealand Pharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-23

Filing date

2012-12-19

Publication date

2014-07-31

2012-12-19 Application filed by Boehringer Ingelheim Int, Zealand Pharma As filed Critical Boehringer Ingelheim Int

2014-07-31 Publication of AP2014007797A0 publication Critical patent/AP2014007797A0/xx

Links

MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AP2014007797A 2011-12-23 2012-12-19 Glucagon analogues AP2014007797A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161579888P	2011-12-23	2011-12-23
PCT/EP2012/076137 WO2013092703A2 (en)	2011-12-23	2012-12-19	Glucagon analogues

Publications (1)

Publication Number	Publication Date
AP2014007797A0 true AP2014007797A0 (en)	2014-07-31

Family

ID=47594620

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AP2014007797A AP2014007797A0 (en)	2011-12-23	2012-12-19	Glucagon analogues
AP2014007774A AP2014007774A0 (en)	2011-12-23	2014-07-09	New pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AP2014007774A AP2014007774A0 (en)	2011-12-23	2014-07-09	New pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (20)

Country	Link
US (2)	US20130316941A1 (xx)
EP (1)	EP2793931A2 (xx)
JP (1)	JP2015502380A (xx)
KR (1)	KR20140114845A (xx)
CN (1)	CN104144696A (xx)
AP (2)	AP2014007797A0 (xx)
AU (1)	AU2012357739A1 (xx)
BR (1)	BR112014015681A2 (xx)
CA (1)	CA2858949A1 (xx)
EA (1)	EA201490982A1 (xx)
HK (1)	HK1200369A1 (xx)
IL (1)	IL232800A0 (xx)
IN (1)	IN2014CN04401A (xx)
MA (1)	MA35864B1 (xx)
MX (1)	MX2014007120A (xx)
PE (1)	PE20142113A1 (xx)
PH (1)	PH12014501336A1 (xx)
SG (1)	SG11201403377QA (xx)
TN (1)	TN2014000224A1 (xx)
WO (1)	WO2013092703A2 (xx)

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US9156901B2 (en)	2009-07-13	2015-10-13	Ditte Riber	Acylated glucagon analogues
UY33462A (es)	2010-06-23	2012-01-31	Zealand Pharma As	Analogos de glucagon
AU2011269430A1 (en)	2010-06-24	2013-01-10	Zealand Pharma A/S	Glucagon analogues
IN2014MN02304A (xx)	2012-05-03	2015-08-07	Zealand Pharma As
EP2664374A1 (en) *	2012-05-15	2013-11-20	F. Hoffmann-La Roche AG	Lysin-glutamic acid dipeptide derivatives
CN109456400A (zh)	2012-07-23	2019-03-12	西兰制药公司	胰高血糖素类似物
TWI608013B (zh)	2012-09-17	2017-12-11	西蘭製藥公司	升糖素類似物
UA116217C2 (uk)	2012-10-09	2018-02-26	Санофі	Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
SG10201705097PA (en)	2012-12-21	2017-07-28	Sanofi Sa	Functionalized exendin-4 derivatives
GB201315335D0 (en) *	2013-08-29	2013-10-09	Of Singapore	Amino diacids containing peptide modifiers
RS57632B1 (sr) *	2013-10-17	2018-11-30	Zealand Pharma As	Acilovani analozi glukagona
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues
JP2017503474A (ja)	2013-11-06	2017-02-02	ジーランドファーマアクティーゼルスカブ	グルカゴン−ｇｌｐ−１−ｇｉｐトリプルアゴニスト化合物
CN105849122B (zh)	2013-11-06	2021-04-30	西兰制药公司	Gip-glp-1双重激动剂化合物及方法
TW201609797A (zh)	2013-12-13	2016-03-16	賽諾菲公司	雙重ｇｌｐ－１／升糖素受體促效劑
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WO2015086728A1 (en)	2013-12-13	2015-06-18	Sanofi	Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201625668A (zh) *	2014-04-07	2016-07-16	賽諾菲公司	作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) *	2014-04-07	2016-07-16	賽諾菲公司	衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625669A (zh)	2014-04-07	2016-07-16	賽諾菲公司	衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
US9932381B2 (en)	2014-06-18	2018-04-03	Sanofi	Exendin-4 derivatives as selective glucagon receptor agonists
TWI705973B (zh)	2014-10-29	2020-10-01	丹麥商西蘭製藥公司	Ｇｉｐ促效劑化合物及方法
JOP20200119A1 (ar) *	2015-01-09	2017-06-16	Lilly Co Eli	مركبات مساعد مشترك من gip وglp-1
MX376200B (es)	2015-02-17	2025-03-07	Amphastar Pharmaceuticals Inc	Formulacion en polvo nasal para el tratamiento de hipoglicemia.
PE20180497A1 (es)	2015-03-18	2018-03-09	Zealand Pharma As	Analogos de amilina
WO2016168388A2 (en)	2015-04-14	2016-10-20	Palatin Technologies, Inc.	Therapies for obesity, diabetes and related indications
PL3283507T3 (pl)	2015-04-16	2020-05-18	Zealand Pharma A/S	Acylowany analog glukagonu
AR105319A1 (es)	2015-06-05	2017-09-27	Sanofi Sa	Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
WO2016198628A1 (en)	2015-06-12	2016-12-15	Sanofi	Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
WO2016198624A1 (en)	2015-06-12	2016-12-15	Sanofi	Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
AR105284A1 (es)	2015-07-10	2017-09-20	Sanofi Sa	Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
TWI622596B (zh) *	2015-10-26	2018-05-01	美國禮來大藥廠	升糖素受體促效劑
US11179444B2 (en)	2016-06-09	2021-11-23	Amidebio, Llc	Glucagon analogs and methods of use thereof
MA45843B1 (fr)	2016-08-05	2021-06-30	Boehringer Ingelheim Int	Dérivés d'oxadiazolopyridine utilisés comme inhibiteurs de la ghréline o-acyl transférase (chèvre)
TWI784968B (zh)	2016-09-09	2022-12-01	丹麥商西蘭製藥公司	澱粉素類似物
EP3551651B1 (en) *	2016-12-09	2024-03-06	Zealand Pharma A/S	Acylated glp-1/glp-2 dual agonists
CN116854804A (zh) *	2017-08-16	2023-10-10	东亚St株式会社	酰化胃泌酸调节素肽类似物
JP7150032B2 (ja)	2018-02-02	2022-10-07	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害薬として使用するためのヘテロシクリル置換オキサジアゾロピリジン誘導体
EP3746449B1 (en)	2018-02-02	2022-03-30	Boehringer Ingelheim International GmbH	Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors
CN111655700B (zh)	2018-02-02	2023-07-18	勃林格殷格翰国际有限公司	作为饥饿素o-酰基转移酶(goat)抑制剂的噁二唑并吡啶衍生物
JP7083397B2 (ja)	2018-02-02	2022-06-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのトリアゾロピリミジン誘導体
CN111349155B (zh) *	2018-12-24	2022-04-05	浙江和泽医药科技股份有限公司	一种胰高血糖素类似物及其制备方法和用途
TWI771669B (zh)	2019-04-26	2022-07-21	美商美國禮來大藥廠	製備穩定胜肽調配物之方法
PH12022551101A1 (en)	2019-11-11	2023-11-13	Boehringer Ingelheim Int	Npy2 receptor agonists
ES2984466T3 (es)	2020-05-22	2024-10-29	Boehringer Ingelheim Int	Procedimiento de fabricación de 7-amino-5-metil-[1,2,5]oxadiazolo[3,4-b]piridín-carboxilato de alquilo
CN115916789B (zh)	2020-05-22	2025-06-27	勃林格殷格翰国际有限公司	制备烷基7-氨基-5-甲基-[1,2,5]噁二唑并[3,4-b]吡啶羧酸酯的连续方法
CN113278060B (zh) *	2020-05-29	2022-03-25	东莞云璟生物技术有限公司	Glp-1/胰高血糖素双重激动剂融合蛋白
WO2022029231A1 (en)	2020-08-07	2022-02-10	Boehringer Ingelheim International Gmbh	Soluble npy2 receptor agonists

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DK0929567T3 (da)	1996-09-09	2005-06-27	Zealand Pharma As	Forbedret fastfase-peptidsyntese og middel til anvendelse af en sådan syntese
CA2321026A1 (en)	1998-03-09	1999-09-16	Zealand Pharmaceuticals A/S	Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
EP1076066A1 (en)	1999-07-12	2001-02-14	Zealand Pharmaceuticals A/S	Peptides for lowering blood glucose levels
GB0121709D0 (en)	2001-09-07	2001-10-31	Imp College Innovations Ltd	Food inhibition agent
PL1891105T3 (pl)	2005-06-13	2012-09-28	Imperial Innovations Ltd	Analogi oksyntomoduliny i ich wpływ na zachowania żywieniowe
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ZA200900545B (en)	2006-07-18	2010-03-31	Sanofi Aventis	Antagonist antibody against EPHA2 for the treatment of cancer
JP6017754B2 (ja)	2007-02-15	2016-11-02	インディアナユニバーシティーリサーチアンドテクノロジーコーポレーションＩｎｄｉａｎａＵｎｉｖｅｒｓｉｔｙＲｅｓｅａｒｃｈＡｎｄＴｅｃｈｎｏｌｏｇｙＣｏｒｐｏｒａｔｉｏｎ	グルカゴン／ｇｌｐ−１受容体コアゴニスト
ATE520714T1 (de)	2007-06-15	2011-09-15	Zealand Pharma As	Glucagonanaloga
EP2307037A4 (en)	2008-06-17	2011-08-03	Univ Indiana Res & Tech Corp	GLUCAGON ANALOGUE WITH IMPROVED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS
CA2728284C (en)	2008-06-17	2019-09-10	Richard D. Dimarchi	Glucagon/glp-1 receptor co-agonists
PL2370462T3 (pl) *	2008-12-15	2015-01-30	Zealand Pharma As	Analogi glukagonu
US9156901B2 (en) *	2009-07-13	2015-10-13	Ditte Riber	Acylated glucagon analogues
NZ601167A (en) *	2010-01-20	2014-12-24	Zealand Pharma As	Treatment of cardiac conditions
UY33462A (es) *	2010-06-23	2012-01-31	Zealand Pharma As	Analogos de glucagon

2012
- 2012-12-19 EA EA201490982A patent/EA201490982A1/ru unknown
- 2012-12-19 WO PCT/EP2012/076137 patent/WO2013092703A2/en not_active Ceased
- 2012-12-19 PE PE2014000970A patent/PE20142113A1/es not_active Application Discontinuation
- 2012-12-19 SG SG11201403377QA patent/SG11201403377QA/en unknown
- 2012-12-19 US US13/720,041 patent/US20130316941A1/en not_active Abandoned
- 2012-12-19 AP AP2014007797A patent/AP2014007797A0/xx unknown
- 2012-12-19 AU AU2012357739A patent/AU2012357739A1/en not_active Abandoned
- 2012-12-19 EP EP12816470.4A patent/EP2793931A2/en not_active Withdrawn
- 2012-12-19 KR KR1020147020623A patent/KR20140114845A/ko not_active Withdrawn
- 2012-12-19 IN IN4401CHN2014 patent/IN2014CN04401A/en unknown
- 2012-12-19 CA CA2858949A patent/CA2858949A1/en not_active Abandoned
- 2012-12-19 HK HK15101109.9A patent/HK1200369A1/xx unknown
- 2012-12-19 JP JP2014547973A patent/JP2015502380A/ja active Pending
- 2012-12-19 MX MX2014007120A patent/MX2014007120A/es unknown
- 2012-12-19 BR BR112014015681A patent/BR112014015681A2/pt not_active IP Right Cessation
- 2012-12-19 CN CN201280063090.8A patent/CN104144696A/zh active Pending
2014
- 2014-05-21 TN TNP2014000224A patent/TN2014000224A1/en unknown
- 2014-05-26 IL IL232800A patent/IL232800A0/en unknown
- 2014-06-11 PH PH12014501336A patent/PH12014501336A1/en unknown
- 2014-07-09 AP AP2014007774A patent/AP2014007774A0/xx unknown
- 2014-07-11 MA MA37205A patent/MA35864B1/fr unknown
2016
- 2016-08-17 US US15/239,154 patent/US20160347813A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PH12014501336A1 (en)	2014-09-15
HK1200369A1 (en)	2015-10-09
WO2013092703A3 (en)	2013-11-14
BR112014015681A2 (pt)	2019-09-24
KR20140114845A (ko)	2014-09-29
WO2013092703A2 (en)	2013-06-27
SG11201403377QA (en)	2014-07-30
US20130316941A1 (en)	2013-11-28
IN2014CN04401A (xx)	2015-09-04
US20160347813A1 (en)	2016-12-01
IL232800A0 (en)	2014-07-31
JP2015502380A (ja)	2015-01-22
EP2793931A2 (en)	2014-10-29
TN2014000224A1 (en)	2015-09-30
MX2014007120A (es)	2015-03-05
AP2014007774A0 (en)	2014-07-31
EA201490982A1 (ru)	2015-01-30
MA35864B1 (fr)	2014-12-01
CN104144696A (zh)	2014-11-12
AU2012357739A1 (en)	2014-07-03
PE20142113A1 (es)	2014-12-03
CA2858949A1 (en)	2013-06-27

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