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AP2007004058A0 - Novel spirotropane compounds and methods for the modulation of chemokine receptor activity - Google Patents

Novel spirotropane compounds and methods for the modulation of chemokine receptor activity

Info

Publication number
AP2007004058A0
AP2007004058A0 AP2007004058A AP2007004058A AP2007004058A0 AP 2007004058 A0 AP2007004058 A0 AP 2007004058A0 AP 2007004058 A AP2007004058 A AP 2007004058A AP 2007004058 A AP2007004058 A AP 2007004058A AP 2007004058 A0 AP2007004058 A0 AP 2007004058A0
Authority
AP
ARIPO
Prior art keywords
modulation
methods
chemokine receptor
receptor activity
novel
Prior art date
Application number
AP2007004058A
Other languages
English (en)
Inventor
Chung Kong Laval Chan
Marc Courchesne
Louis Baillan-Court
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Publication of AP2007004058A0 publication Critical patent/AP2007004058A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AP2007004058A 2004-12-09 2005-12-09 Novel spirotropane compounds and methods for the modulation of chemokine receptor activity AP2007004058A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63426604P 2004-12-09 2004-12-09
US69305105P 2005-06-23 2005-06-23
PCT/CA2005/001878 WO2006060919A1 (fr) 2004-12-09 2005-12-09 Nouveaux dérivés de spirotropane et méthodes de modulation de l’activité des récepteurs de la chimiokine

Publications (1)

Publication Number Publication Date
AP2007004058A0 true AP2007004058A0 (en) 2007-08-31

Family

ID=36577643

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2007004058A AP2007004058A0 (en) 2004-12-09 2005-12-09 Novel spirotropane compounds and methods for the modulation of chemokine receptor activity

Country Status (13)

Country Link
US (1) US7960403B2 (fr)
EP (1) EP1831222A4 (fr)
JP (1) JP2008522986A (fr)
KR (1) KR20070095310A (fr)
AP (1) AP2007004058A0 (fr)
AU (1) AU2005313813B2 (fr)
BR (1) BRPI0518859A2 (fr)
CA (1) CA2587508A1 (fr)
EA (1) EA200701248A1 (fr)
MX (1) MX2007006776A (fr)
NZ (1) NZ555624A (fr)
SG (1) SG158111A1 (fr)
WO (1) WO2006060919A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709642B2 (en) 2004-06-25 2010-05-04 Virochem Pharma, Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
CA2587508A1 (fr) 2004-12-09 2006-06-15 Virochem Pharma Inc. Nouveaux derives de spirotropane et methodes de modulation de l'activite des recepteurs de la chimiokine
EP1824853A4 (fr) 2004-12-09 2010-06-09 Virochem Pharma Inc Nouveau derives de spirotropane et methodes de modulation de l'activite des recepteurs de la chimiokine
CA2655203A1 (fr) 2006-06-14 2007-12-21 Virochem Pharma Inc. Composes de spirotropane
RU2565766C1 (ru) * 2014-11-17 2015-10-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Л. Гольдберга" 4-(3,4-дибромтиофенкарбонил)-2,6,8,12-тетраацетил-2,4,6,8,10,12-гексаазатетрацикло[5,5,0,03,11,05,9]додекан в качестве анальгетического средства и способ его получения
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5534520A (en) 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
AU2001241056A1 (en) 2000-03-09 2001-09-17 Mitsubishi Pharma Corporation Spiro compounds, process for preparing the same and use thereof as drugs
CA2419194C (fr) 2000-08-17 2007-10-16 Lihu Yang Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine
JP2006511500A (ja) 2002-10-30 2006-04-06 メルク　エンド　カムパニー　インコーポレーテッド γ−アミノアミド系のケモカイン受容体活性調節剤
EP1776362A1 (fr) * 2003-07-18 2007-04-25 Virochem Pharma Inc. Composes spiro et procedes pour moduler une activite de recepteur de chimiokime
EP1786815B1 (fr) 2003-09-10 2011-08-24 Virochem Pharma Inc. Composes spiro et procedes pour la modulation de l'activite de recepteur de chimiokine
CA2579609A1 (fr) * 2003-09-10 2005-03-17 Virochem Pharma Inc. Composes de spirohydantoine et procedes de modulation de l'activite des recepteurs de chimiokine
US7709642B2 (en) 2004-06-25 2010-05-04 Virochem Pharma, Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
CA2587508A1 (fr) 2004-12-09 2006-06-15 Virochem Pharma Inc. Nouveaux derives de spirotropane et methodes de modulation de l'activite des recepteurs de la chimiokine
EP1824853A4 (fr) 2004-12-09 2010-06-09 Virochem Pharma Inc Nouveau derives de spirotropane et methodes de modulation de l'activite des recepteurs de la chimiokine
CA2655203A1 (fr) 2006-06-14 2007-12-21 Virochem Pharma Inc. Composes de spirotropane

Also Published As

Publication number Publication date
KR20070095310A (ko) 2007-09-28
US20080267906A1 (en) 2008-10-30
EA200701248A1 (ru) 2007-12-28
BRPI0518859A2 (pt) 2008-12-09
NZ555624A (en) 2009-09-25
EP1831222A1 (fr) 2007-09-12
SG158111A1 (en) 2010-01-29
MX2007006776A (es) 2007-07-09
JP2008522986A (ja) 2008-07-03
AU2005313813B2 (en) 2011-04-14
US7960403B2 (en) 2011-06-14
AU2005313813A1 (en) 2006-06-15
EP1831222A4 (fr) 2009-10-21
WO2006060919A1 (fr) 2006-06-15
CA2587508A1 (fr) 2006-06-15

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