AP2006003619A0 - Novel quinoline derivatives - Google Patents
Novel quinoline derivativesInfo
- Publication number
- AP2006003619A0 AP2006003619A0 AP2006003619A AP2006003619A AP2006003619A0 AP 2006003619 A0 AP2006003619 A0 AP 2006003619A0 AP 2006003619 A AP2006003619 A AP 2006003619A AP 2006003619 A AP2006003619 A AP 2006003619A AP 2006003619 A0 AP2006003619 A0 AP 2006003619A0
- Authority
- AP
- ARIPO
- Prior art keywords
- quinoline derivatives
- novel quinoline
- novel
- derivatives
- quinoline
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53272503P | 2003-12-23 | 2003-12-23 | |
| PCT/IB2004/004151 WO2005063739A1 (fr) | 2003-12-23 | 2004-12-13 | Derives nouveaux de quinoleine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2006003619A0 true AP2006003619A0 (en) | 2006-06-30 |
Family
ID=34738830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2006003619A AP2006003619A0 (en) | 2003-12-23 | 2004-12-13 | Novel quinoline derivatives |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US7381824B2 (fr) |
| EP (1) | EP1699780A1 (fr) |
| JP (1) | JP4503022B2 (fr) |
| KR (1) | KR100807920B1 (fr) |
| CN (1) | CN1890234A (fr) |
| AP (1) | AP2006003619A0 (fr) |
| AR (1) | AR048292A1 (fr) |
| AU (1) | AU2004309166B2 (fr) |
| BR (1) | BRPI0418102A (fr) |
| CA (1) | CA2551508C (fr) |
| CR (1) | CR8482A (fr) |
| EA (1) | EA009994B1 (fr) |
| EC (1) | ECSP066671A (fr) |
| GE (1) | GEP20084572B (fr) |
| GT (1) | GT200400274A (fr) |
| HN (1) | HN2004000544A (fr) |
| IL (1) | IL175947A (fr) |
| IS (1) | IS8439A (fr) |
| MA (1) | MA28396B1 (fr) |
| MX (1) | MXPA06007242A (fr) |
| MY (1) | MY139446A (fr) |
| NL (1) | NL1027847C2 (fr) |
| NO (1) | NO20063382L (fr) |
| NZ (1) | NZ547009A (fr) |
| OA (1) | OA13349A (fr) |
| PE (1) | PE20050757A1 (fr) |
| SG (1) | SG141459A1 (fr) |
| TN (1) | TNSN06200A1 (fr) |
| TW (1) | TWI331148B (fr) |
| UA (1) | UA82577C2 (fr) |
| UY (1) | UY28692A1 (fr) |
| WO (1) | WO2005063739A1 (fr) |
| ZA (1) | ZA200603657B (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06007242A (es) * | 2003-12-23 | 2006-08-18 | Pfizer | Nuevos derivados de quinolina. |
| WO2005073224A2 (fr) * | 2004-01-23 | 2005-08-11 | Amgen Inc | Composes et methodes d'utilisation de ces derniers |
| KR20080027923A (ko) | 2005-08-08 | 2008-03-28 | 화이자 인코포레이티드 | Vegf-r 억제제의 염 및 다형체 |
| JP2009518382A (ja) * | 2005-12-05 | 2009-05-07 | ファイザー・プロダクツ・インク | Vegf−r阻害剤を調製する方法 |
| GB0604937D0 (en) * | 2006-03-10 | 2006-04-19 | Novartis Ag | Organic compounds |
| WO2008020302A2 (fr) * | 2006-08-17 | 2008-02-21 | Pfizer Products Inc. | Composés hétéro-aromatiques à base de quinoline |
| US8148532B2 (en) * | 2007-03-14 | 2012-04-03 | Guoqing Paul Chen | Spiro substituted compounds as angiogenesis inhibitors |
| US8163923B2 (en) | 2007-03-14 | 2012-04-24 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| HRP20140377T2 (hr) | 2007-04-16 | 2015-01-16 | Hutchison Medipharma Enterprises Limited | Derivati pirimidina |
| US7829574B2 (en) * | 2008-05-09 | 2010-11-09 | Hutchison Medipharma Enterprises Limited | Substituted quinazoline compounds and their use in treating angiogenesis-related diseases |
| CN101584696A (zh) * | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
| US8426430B2 (en) | 2008-06-30 | 2013-04-23 | Hutchison Medipharma Enterprises Limited | Quinazoline derivatives |
| US8211911B2 (en) | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
| TW201008933A (en) | 2008-08-29 | 2010-03-01 | Hutchison Medipharma Entpr Ltd | Pyrimidine compounds |
| WO2010045095A1 (fr) * | 2008-10-14 | 2010-04-22 | Ning Xi | Composés et procédés d'utilisation |
| IT1393351B1 (it) * | 2009-03-16 | 2012-04-20 | Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa | Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi |
| CA2752421C (fr) * | 2009-03-21 | 2013-08-06 | Ning Xi | Derives d'ester d'amino, sels de ceux-ci et procedes d'utilisation |
| CN106866667B (zh) | 2009-11-05 | 2019-11-15 | 圣母大学 | 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 |
| WO2012042421A1 (fr) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Procédé de traitement de la croissance cellulaire anormale |
| SG192769A1 (en) | 2011-03-04 | 2013-09-30 | Glaxosmithkline Ip No 2 Ltd | Amino-quinolines as kinase inhibitors |
| FR2973703A1 (fr) * | 2011-04-08 | 2012-10-12 | Univ Provence Aix Marseille 1 | Derives de 4-arylcoumarine et de 4-arylquinoleine, leurs utilisations therapeutiques et leur procede de synthese |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
| AR092530A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| CN105189462B (zh) | 2013-02-20 | 2017-11-10 | 卡拉制药公司 | 治疗性化合物和其用途 |
| JP6301374B2 (ja) | 2013-02-21 | 2018-03-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | キナーゼ阻害剤としてのキナゾリン類 |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| CN103524409B (zh) * | 2013-09-26 | 2015-09-02 | 上海仁力医药科技有限公司 | 喹啉类化合物及其制备方法与应用 |
| CN105213394B (zh) * | 2014-06-06 | 2019-04-09 | 正大天晴药业集团股份有限公司 | 具有抗肿瘤活性的喹啉衍生物 |
| CN105311029A (zh) * | 2014-06-06 | 2016-02-10 | 正大天晴药业集团股份有限公司 | 抗肿瘤活性的喹啉衍生物 |
| EP2974729A1 (fr) * | 2014-07-17 | 2016-01-20 | Abivax | Dérivés de quinoléine utilisés dans le traitement de maladies inflammatoires |
| CN104628686A (zh) * | 2015-01-27 | 2015-05-20 | 南通恒盛精细化工有限公司 | 一种带酰胺侧链的苯并呋喃制备工艺 |
| CN112028825B (zh) * | 2015-04-07 | 2025-03-14 | 广东众生睿创生物科技有限公司 | 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物 |
| US9890187B2 (en) | 2015-06-26 | 2018-02-13 | Epos-Iasis Research And Development, Ltd. | Prototype systems of theranostic biomarkers for in vivo molecular management of cancer |
| KR20180053386A (ko) | 2015-09-17 | 2018-05-21 | 마빈 제이. 밀러 | 마이코박테리아 감염에 대해 유용한 벤질 아민-함유 헤테로사이클릭 화합물 및 조성물 |
| MX2018004109A (es) | 2015-10-05 | 2018-09-27 | Univ Columbia | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. |
| CN110023288B (zh) * | 2016-09-30 | 2022-10-28 | 广东众生睿创生物科技有限公司 | 酪氨酸激酶抑制剂的晶型、盐型以及制备方法 |
| CN107337634B (zh) * | 2017-08-28 | 2019-07-09 | 新发药业有限公司 | 一种阿贝西利中间体化合物的制备方法 |
| FR3080620B1 (fr) | 2018-04-27 | 2021-11-12 | Univ Paris Sud | Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices |
| JP7568641B2 (ja) * | 2019-04-12 | 2024-10-16 | ナショナル ヘルス リサーチ インスティトゥーツ | 治療的使用のためのキナーゼ阻害剤としての複素環式化合物 |
| CN116478130B (zh) * | 2022-01-21 | 2025-05-30 | 深圳默元生物科技有限公司 | N-羟基喹啉甲酰胺化合物及其用途 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE317376B (fr) * | 1961-07-10 | 1969-11-17 | Roussel Uclaf | |
| FR2077455A1 (en) | 1969-09-03 | 1971-10-29 | Aries Robert | 5-haloveratryl-4-aminoquinoles - antimalarials amoebicides anthelmintics anticoccidials |
| US3755332A (en) * | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
| US3936461A (en) * | 1973-09-24 | 1976-02-03 | Warner-Lambert Company | Substituted 4-benzylquinolines |
| FR2498187A1 (fr) * | 1981-01-16 | 1982-07-23 | Rhone Poulenc Sante | Procede de preparation d'amino-4 chloro-7 quinoleines |
| JPS62168137A (ja) * | 1985-12-20 | 1987-07-24 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料およびその処理方法 |
| IL89029A (en) | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them |
| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| JPH06503095A (ja) | 1991-05-29 | 1994-04-07 | ファイザー・インコーポレーテッド | 三環式ポリヒドロキシ系のチロシンキナーゼ阻害薬 |
| EP0597003A1 (fr) | 1991-08-02 | 1994-05-18 | Pfizer Inc. | Derives de quinoline utilises comme immunostimulants------------ |
| GB9127252D0 (en) | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| KR100225721B1 (ko) | 1994-02-23 | 1999-10-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 4-헤테로사이클릴-치환된 퀴나졸린 유도체, 이들의 제조 방법 및항암제로서의 용도 |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| TW321649B (fr) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| EP0817775B1 (fr) | 1995-03-30 | 2001-09-12 | Pfizer Inc. | Derives de quinazoline |
| SK72996A3 (en) | 1995-06-07 | 1997-04-09 | Pfizer | Heterocyclic ring-fused pyrimidine derivatives and pharmaceutical compositions on their base |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| EP0860433B1 (fr) | 1995-11-07 | 2002-07-03 | Kirin Beer Kabushiki Kaisha | Derives de quinoline et derives de quinazoline inhibant l'autophosphorylation d'un recepteur de facteur de croissance originaire de plaquettes, et compositions pharmaceutiques les contenant |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | 4―アニリノキナゾリン誘導体 |
| DE69734513T2 (de) | 1996-06-24 | 2006-07-27 | Pfizer Inc. | Phenylamino-substituierte tricyclische derivate zur behandlung hyperproliferativer krankheiten |
| JPH11512750A (ja) * | 1996-06-27 | 1999-11-02 | ファイザー インク. | 2―(2―オキソ―エチリデン)―イミダゾリジン―4―オンの誘導体およびファルネシル蛋白質トランスフェラーゼ阻害物質としてのそれらの使用法 |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| CA2260058A1 (fr) | 1996-07-13 | 1998-01-22 | Kathryn Jane Smith | Composes heteroaromatiques bicycliques en tant qu'inhibiteurs de la proteine tyrosine kinase |
| JP2001500890A (ja) | 1996-09-25 | 2001-01-23 | ゼネカ リミテッド | Vegfのような成長因子の作用を阻害するキノリン誘導体 |
| US6225318B1 (en) * | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| KR20000057228A (ko) | 1996-11-27 | 2000-09-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 축합된 비사이클릭 피리미딘 유도체 |
| PT968206E (pt) | 1997-02-19 | 2007-02-28 | Pharmacopeia Inc | Derivados n-heterocíclicos como inibidores de nos |
| CA2289102A1 (fr) | 1997-05-07 | 1998-11-12 | Sugen, Inc. | Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase |
| AU7345798A (en) | 1997-05-12 | 1998-12-08 | Kennedy Institute Of Rheumatology, The | Suppression of tumor necrosis factor alpha and vascular endothelial growth factor in therapy |
| EP0984692A4 (fr) | 1997-05-30 | 2001-02-21 | Merck & Co Inc | Nouveaux inhibiteurs d'angiogenese |
| US6294532B1 (en) | 1997-08-22 | 2001-09-25 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
| WO1999016755A1 (fr) | 1997-09-26 | 1999-04-08 | Merck & Co., Inc. | Nouveaux inhibiteurs de l'angiogenese |
| WO1999024440A1 (fr) | 1997-11-11 | 1999-05-20 | Pfizer Products Inc. | Derives de thienopyrimidine et thienopyridine utiles comme agents anticancereux |
| JP4194678B2 (ja) | 1997-11-28 | 2008-12-10 | キリンファーマ株式会社 | キノリン誘導体およびそれを含む医薬組成物 |
| EP1086705A4 (fr) | 1998-05-20 | 2002-02-06 | Kyowa Hakko Kogyo Kk | Inhibiteurs de l'activite du facteur de croissance endothelial vasculaire (vegf) |
| TR200003514T2 (tr) | 1998-05-29 | 2002-05-21 | Sugen Inc. | Pirol ikame edilmiş 2-indolinon protein kinaz inhibitörleri |
| EA004436B1 (ru) * | 1998-09-29 | 2004-04-29 | Уайт Холдингз Корпорейшн | Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ |
| GB9827882D0 (en) | 1998-12-17 | 1999-02-10 | Smithkline Beecham Plc | Novel compounds |
| JP2002533422A (ja) | 1998-12-23 | 2002-10-08 | ジー・ディー・サール・アンド・カンパニー | 新形成の治療における併用療法としてシクロオキシゲナーゼ−2阻害剤とインテグリン拮抗剤を使用する方法 |
| AU771504B2 (en) * | 1999-01-22 | 2004-03-25 | Kyowa Hakko Kirin Co., Ltd. | Quinoline derivatives and quinazoline derivatives |
| PL199802B1 (pl) | 1999-02-10 | 2008-10-31 | Astrazeneca Ab | Pochodne chinazoliny, sposoby ich wytwarzania, ich kompozycje farmaceutyczne i ich zastosowania |
| GB9904103D0 (en) | 1999-02-24 | 1999-04-14 | Zeneca Ltd | Quinoline derivatives |
| ES2238335T3 (es) | 1999-12-24 | 2005-09-01 | Kyowa Hakko Kogyo Co., Ltd. | Derivados de purina condensados. |
| WO2001047890A1 (fr) | 1999-12-24 | 2001-07-05 | Kirin Beer Kabushiki Kaisha | Quinoline, derives de la quinazoline et medicaments contenant ces substances |
| WO2001070268A1 (fr) | 2000-03-22 | 2001-09-27 | Glaxo Group Limited | Produit pharmaceutique comprenant un agent bloquant le cycle cellulaire et anticorps |
| EP1436000A2 (fr) | 2000-03-31 | 2004-07-14 | Imclone Systems, Inc. | Traitement de tumeurs non solides chez des mammiferes au moyen d'antagonistes de recepteur de facteur de croissance endothelial vasculaire |
| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| AU2001265953B2 (en) | 2000-05-12 | 2005-09-29 | D. Collen Research Foundation Vzw | Use of inhibitors of placental growth factor for the treatment of pathological angiogenesis, pathological arteriogenesis, inflammation, tumour formation and/or vascular leakage |
| BR0113056A (pt) * | 2000-08-09 | 2003-07-08 | Astrazeneca Ab | Composto, processo papa a preparação do mesmo, composição farmacêutica, e, método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente, e, uso de um composto |
| KR100389127B1 (ko) | 2000-10-09 | 2003-06-25 | 동부한농화학 주식회사 | 벤조피라닐 헤테로고리 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물 |
| WO2002030453A1 (fr) | 2000-10-12 | 2002-04-18 | Beth Israel Deaconess Medical Center, Inc. | Procedes d'inhibition de l'angiogenese utilisant des inhibiteurs de la nadph-oxydase |
| HU230302B1 (hu) * | 2000-10-20 | 2015-12-28 | Eisai R&D Management Co., Ltd. | Nitrogéntartalmú aromás származékok és ezeket tartalmazó gyógyászati készítmények |
| EP1339458B1 (fr) | 2000-11-22 | 2007-08-15 | Novartis AG | Combinaison comprenant un agent diminuant l'activite du facteur de croissance endotelial vasculaire et un agent diminuant l'activite du facteur de croissance de l'epiderme |
| WO2002064170A1 (fr) | 2001-02-09 | 2002-08-22 | Children's Medical Center Corporation | Methode pour traiter le cancer et augmenter le taux d'hematocrite |
| WO2003006059A1 (fr) | 2001-07-13 | 2003-01-23 | Imclone Systems Incorporated | Anticorps diriges contre vegfr-1 pour traiter le cancer du sein |
| WO2003033472A1 (fr) | 2001-10-17 | 2003-04-24 | Kirin Beer Kabushiki Kaisha | Derives de quinoline ou de quinazoline inhibant l'autophosphorylation de recepteurs du facteur de croissance des fibroblastes |
| BR0213486A (pt) | 2001-10-25 | 2005-05-10 | Novartis Ag | Combinações que compreendem um inibidor seletivo de ciclooxigenase-2 |
| JP2005527511A (ja) * | 2002-03-01 | 2005-09-15 | ファイザー インコーポレイテッド | 抗血管形成剤として有用なチエノピリジンのインドリル−尿素誘導体およびその使用法 |
| EP1548008A4 (fr) | 2002-08-23 | 2008-08-06 | Kirin Pharma Kk | Compose presentant une activite inhibitrice du facteur de croissance transformant beta et composition medicamenteuse en contenant |
| KR100732440B1 (ko) | 2002-08-30 | 2007-06-27 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 질소 함유 방향환 유도체 |
| MXPA06007242A (es) * | 2003-12-23 | 2006-08-18 | Pfizer | Nuevos derivados de quinolina. |
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- 2004-12-13 BR BRPI0418102-6A patent/BRPI0418102A/pt not_active IP Right Cessation
- 2004-12-13 EP EP04801393A patent/EP1699780A1/fr not_active Withdrawn
- 2004-12-13 OA OA1200600212A patent/OA13349A/en unknown
- 2004-12-13 AU AU2004309166A patent/AU2004309166B2/en not_active Ceased
- 2004-12-13 WO PCT/IB2004/004151 patent/WO2005063739A1/fr not_active Ceased
- 2004-12-13 JP JP2006546363A patent/JP4503022B2/ja not_active Expired - Fee Related
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- 2004-12-13 CA CA2551508A patent/CA2551508C/fr not_active Expired - Fee Related
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