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AP2005003196A0 - Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor. - Google Patents

Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor.

Info

Publication number
AP2005003196A0
AP2005003196A0 AP2005003196A AP2005003196A AP2005003196A0 AP 2005003196 A0 AP2005003196 A0 AP 2005003196A0 AP 2005003196 A AP2005003196 A AP 2005003196A AP 2005003196 A AP2005003196 A AP 2005003196A AP 2005003196 A0 AP2005003196 A0 AP 2005003196A0
Authority
AP
ARIPO
Prior art keywords
antagonists
chemokine receptor
piperidine derivatives
ccr1 chemokine
bicyclic piperidine
Prior art date
Application number
AP2005003196A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Matthew Frank Brown
Matthew Me Hayward
Christopher Stanley Poss
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2005003196A0 publication Critical patent/AP2005003196A0/xx

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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AP2005003196A 2002-07-18 2003-07-07 Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor. AP2005003196A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39726302P 2002-07-18 2002-07-18
PCT/IB2003/003155 WO2004009588A1 (en) 2002-07-18 2003-07-07 Bicyclic piperidine derivatives as antagonists of the ccr1 chemokine receptor

Publications (1)

Publication Number Publication Date
AP2005003196A0 true AP2005003196A0 (en) 2005-03-31

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AP2005003196A AP2005003196A0 (en) 2002-07-18 2003-07-07 Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor.

Country Status (24)

Country Link
US (1) US20040063688A1 (es)
EP (1) EP1525201A1 (es)
JP (1) JP2005533845A (es)
KR (1) KR20050028036A (es)
CN (1) CN1668614A (es)
AP (1) AP2005003196A0 (es)
AR (1) AR040586A1 (es)
AU (1) AU2003281527A1 (es)
BR (1) BR0312699A (es)
CA (1) CA2492110A1 (es)
EA (1) EA200500033A1 (es)
EC (1) ECSP055548A (es)
GT (1) GT200300147A (es)
IL (1) IL166075A0 (es)
IS (1) IS7615A (es)
MA (1) MA27327A1 (es)
MX (1) MXPA05000757A (es)
OA (1) OA12886A (es)
PA (1) PA8577401A1 (es)
PE (1) PE20040668A1 (es)
TN (1) TNSN05013A1 (es)
TW (1) TW200401639A (es)
UY (1) UY27896A1 (es)
WO (1) WO2004009588A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2530023A1 (en) * 2003-06-24 2004-12-29 Neurosearch A/S Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
GB0409236D0 (en) * 2004-04-26 2004-05-26 Novartis Ag Organic compounds
US7713990B2 (en) 2005-01-13 2010-05-11 Neurosearch A/S 3,8-substituted 8-AZA-bicyclo[3.2.1]octane derivatives and their use as monomine neurotransmitter re-uptake inhibitors
ES2277745B1 (es) * 2005-06-14 2008-06-01 Laboratorios Almirall S.A. Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1.
US20070105874A1 (en) * 2005-09-23 2007-05-10 Conforma Therapeutics Corporation Anti-Tumor Methods Using Multi Drug Resistance Independent Synthetic HSP90 Inhibitors
ITFI20120062A1 (it) * 2012-03-21 2013-09-22 Minerva Patents S A Componenti per il trattamento di malattie correlate a ischemia-riperfusione.
KR20160033726A (ko) 2013-07-18 2016-03-28 노파르티스 아게 헤테로방향족 고리-벤질-아미드-사이클 코어를 포함하는 오토탁신 억제제
CN104122392B (zh) * 2014-06-24 2016-05-25 上海交通大学医学院附属瑞金医院 检测ccl15趋化因子的试剂在制备筛选甲状腺滤泡癌试剂中的应用

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AR028947A1 (es) * 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
PA8575901A1 (es) * 2002-07-18 2004-07-20 Pfizer Prod Inc Derivados de piperidina novedosos

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