OA10880A - Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs - Google Patents

Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs Download PDF

Info

Publication number: OA10880A
Authority: OA; OAPI
Prior art keywords: tpgs; vitamin; compound; water soluble; hiv protease
Prior art date: 1996-03-22

Application number

OA9800171A

Other languages

English (en)

Inventor

Arup K Roy

Lioyd Gary Tillman

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-22

Filing date

1998-09-18

Publication date

2001-10-11

1996-03-26 Priority claimed from GBGB9606372.2A external-priority patent/GB9606372D0/en

1998-09-18 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2001-10-11 Publication of OA10880A publication Critical patent/OA10880A/en

Links

239000004030 hiv protease inhibitor Substances 0.000 title claims abstract description 27
239000000203 mixture Substances 0.000 title claims description 49
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 28
AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 title claims description 27
229940122440 HIV protease inhibitor Drugs 0.000 title claims description 18
150000001875 compounds Chemical class 0.000 title description 48
229940088594 vitamin Drugs 0.000 title description 4
229930003231 vitamin Natural products 0.000 title description 4
239000011782 vitamin Substances 0.000 title description 4
235000013343 vitamin Nutrition 0.000 title description 4
150000003722 vitamin derivatives Chemical class 0.000 title description 4
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 23
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 23
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UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims abstract description 5
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 5
KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims abstract description 5
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229960000311 ritonavir Drugs 0.000 description 2
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

OA9800171A 1996-03-22 1998-09-18 Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs OA10880A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1389396P	1996-03-22	1996-03-22
GBGB9606372.2A GB9606372D0 (en)	1996-03-26	1996-03-26	Pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
OA10880A true OA10880A (en)	2001-10-11

Family

ID=26308992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9800171A OA10880A (en)	1996-03-22	1998-09-18	Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs

Country Status (12)

Country	Link
JP (1)	JP3117726B2 (fr)
AR (1)	AR006345A1 (fr)
BG (1)	BG64457B1 (fr)
CO (1)	CO4790151A1 (fr)
HU (1)	HU228026B1 (fr)
ID (1)	ID16781A (fr)
IL (1)	IL126185A (fr)
MY (1)	MY126358A (fr)
OA (1)	OA10880A (fr)
PL (1)	PL187919B1 (fr)
TW (1)	TW455491B (fr)
WO (1)	WO1997035587A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1017366A4 (fr) *	1996-09-01	2006-03-22	Pharmos Corp	Coprecipites solides augmentant la biodisponibilite de substances lipophiles
WO1998057648A1 (fr) *	1997-06-16	1998-12-23	Vertex Pharmaceuticals Incorporated	Procede d'amelioration de la biodisponibilite des polymorphes cristallins stables d'un compose
US5891845A (en) *	1997-11-21	1999-04-06	Fuisz Technologies Ltd.	Drug delivery systems utilizing liquid crystal structures
ES2140329B1 (es) *	1997-12-04	2000-10-16	Univ Granada	Utilizacion de acido maslinico como inhibidor de proteasas para el tratamiento de la enfermedad causada por los virus de la inmunodeficiencia adquirida.
GB9812189D0 (en) *	1998-06-05	1998-08-05	Glaxo Group Ltd	Methods and compositions for increasing penetration of HIV protease inhibitors
CA2432527A1 (fr) *	2000-12-22	2002-07-04	Takeda Chemical Industries, Ltd.	Compositions medicinales s'administrant par voie orale
AU2002350719A1 (en)	2002-11-29	2004-06-23	Janssen Pharmaceutica N.V.	Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
US7423004B2 (en)	2003-01-31	2008-09-09	Smithkline Beecham Corporation	Solid dispersion compositions
ATE533473T1 (de) *	2004-09-24	2011-12-15	Boehringer Ingelheim Pharma	Neue klasse von surfuctantähnlichen materialien mit vitamin-e-tpgs und wasserlöslichem polymer
JP2008514714A (ja) *	2004-09-30	2008-05-08	イーストマンケミカルカンパニー	有意な流出阻害を示さない、親油性薬物を可溶化するビタミンｅｔｐｇｓ分子を含む医薬製剤及びこのような医薬製剤の使用
EP1880715A1 (fr) *	2006-07-19	2008-01-23	Abbott GmbH & Co. KG	Composition de solubilisation acceptable sur le plan pharmaceutique et forme posologique contenant celle-ci
SA109300195B1 (ar)	2008-03-28	2013-04-20	Astrazeneca Ab	تركيبة صيدلانية جديدة مضادة للسرطان
ITRM20120331A1 (it)	2012-07-12	2014-01-13	Guidotti & C Spa Labor	Composizioni pediatriche orali liquide contenenti nepadutant.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992016501A1 (fr) *	1991-03-20	1992-10-01	Vertex Pharmaceuticals Incorporated	Derives de tetrahydroxyalcane utiles comme inhibiteurs de la protease d'aspartyle du vih
CA2195027C (fr) *	1991-11-08	2000-01-11	Joseph P. Vacca	Inhibiteurs de la protease du vih utiles pour le traitement du sida
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
WO1994013629A1 (fr) *	1992-12-11	1994-06-23	Vertex Pharmaceuticals Incorporated	Derives de mannitol et leur utilisation comme inhibiteurs de l'aspartyle-protease
US5484926A (en) *	1993-10-07	1996-01-16	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
KR100187613B1 (ko) *	1992-12-29	1999-06-01	스티븐 에프. 웨인스톡	레트로바이러스성 프로테이제 억제 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물
DE69418035T2 (de) *	1993-01-15	1999-08-12	Agouron Pharmaceuticals , Inc., San Diego, Calif.	Hiv-proteaseinhibitoren
AU1046895A (en) *	1993-11-05	1995-05-23	Merck & Co., Inc.	New quinazolines as inhibitors of hiv reverse transcriptase
IL111584A0 (en) *	1993-11-18	1995-01-24	Merck & Co Inc	Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
BR9408305A (pt) *	1993-12-15	1997-08-26	Merck & Co Inc	Composto composição farmacêutica processos para tratamento de aids e da infecção por hiv para preparação da infecção por hiv e para inibição de protease de hiv e combinação de compostos
DE69512220T2 (de) *	1994-03-07	2000-03-16	Vertex Pharmaceuticals Inc.	Sulfonamidderivate als aspartylprotease-inhibitoren
GB9409778D0 (en) *	1994-05-16	1994-07-06	Dumex Ltd As	Compositions
US5527829A (en) *	1994-05-23	1996-06-18	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
JPH11505257A (ja) *	1995-05-19	1999-05-18	アボツト・ラボラトリーズ	親油性薬物の自己乳化性製剤

1997
- 1997-03-20 MY MYPI97001186A patent/MY126358A/en unknown
- 1997-03-21 TW TW086103607A patent/TW455491B/zh not_active IP Right Cessation
- 1997-03-21 AR ARP970101146A patent/AR006345A1/es active IP Right Grant
- 1997-03-21 WO PCT/EP1997/001438 patent/WO1997035587A1/fr not_active Ceased
- 1997-03-21 ID IDP970927A patent/ID16781A/id unknown
- 1997-03-21 IL IL12618597A patent/IL126185A/xx not_active IP Right Cessation
- 1997-03-21 PL PL32891697A patent/PL187919B1/pl unknown
- 1997-03-21 CO CO97015457A patent/CO4790151A1/es unknown
- 1997-03-21 HU HU9901887A patent/HU228026B1/hu unknown
- 1997-03-21 JP JP09534017A patent/JP3117726B2/ja not_active Expired - Lifetime
1998
- 1998-09-18 OA OA9800171A patent/OA10880A/en unknown
- 1998-10-12 BG BG102838A patent/BG64457B1/bg unknown

Also Published As

Publication number	Publication date
AR006345A1 (es)	1999-08-25
BG102838A (en)	1999-09-30
IL126185A0 (en)	1999-05-09
JP3117726B2 (ja)	2000-12-18
HUP9901887A2 (hu)	1999-12-28
PL328916A1 (en)	1999-03-01
IL126185A (en)	2003-05-29
JP2000500504A (ja)	2000-01-18
ID16781A (id)	1997-11-13
PL187919B1 (pl)	2004-11-30
MY126358A (en)	2006-09-29
CO4790151A1 (es)	1999-05-31
TW455491B (en)	2001-09-21
WO1997035587A1 (fr)	1997-10-02
HU228026B1 (en)	2012-08-28
HUP9901887A3 (en)	2000-02-28
BG64457B1 (bg)	2005-03-31

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AP1150A (en)	2003-03-14	Compositions comprising an HIV protease inhibitor such as Vx 478 and a water soluble vitamin E compound such as vitamin E-TPGS.
KR100472581B1 (ko)	2005-06-16	Vx478과같은hiv프로테아제억제제및비타민e-tpgs와같은수용성비타민e화합물을포함하는조성물
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AU2010338249A1 (en)	2012-08-09	Oral liquid pharmaceutical composition of nifedipine
US20060217320A1 (en)	2006-09-28	Soft gel formulations for saquinavir
TR201510144A2 (tr)	2017-03-21	Yeni̇ oral çözelti̇ formülasyonu