NZ795347B2 - Method of treating epilepsy - Google Patents
Method of treating epilepsyInfo
- Publication number
- NZ795347B2 NZ795347B2 NZ795347A NZ79534717A NZ795347B2 NZ 795347 B2 NZ795347 B2 NZ 795347B2 NZ 795347 A NZ795347 A NZ 795347A NZ 79534717 A NZ79534717 A NZ 79534717A NZ 795347 B2 NZ795347 B2 NZ 795347B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- use according
- subject
- medicament
- seizure
- focal
- Prior art date
Links
Abstract
Alprazolam formulated as an inhaled condensation aerosol and method for treating epilepsy and/or seizures.
Claims (8)
1. Use of alprazolam in the manufacture of a medicament for the acute treatment of an ongoing seizure in a subject, wherein the subject is selected from patients with partial (focal) or generalized seizures, wherein the seizure has not progressed to status epilepticus, wherein the treatment comprises oral administration of the medicament as an aerosol using an inhalation device which is breath-activated and delivers alprazolam while the patient takes a single inspiration through a mouthpiece without any other coordination needed, and wherein the device allows for self-administration.
2. The use according to claim 1, wherein the aerosol is to be delivered non-invasively to the deep lung, thereby producing reliable IV-like pharmacokinetics.
3. The use according to claim 1 or claim 2, wherein the treatment comprises stopping the seizure within two minutes of administration of the medicament.
4. The use according to any one of claims 1 to 3, wherein the device comprises a first element for heating the medicament to form a vapor, a second element allowing the vapor to cool, thereby forming a condensation aerosol, and a third element permitting inhalation of the aerosol.
5. The use according to any one of claims 1 to 4, wherein the subject is selected from patients with aura, focal seizures that secondarily generalize, or patients with juvenile myoclonic epilepsy whereby the seizure typically manifests over a period of minutes.
6. The use according to any one of claims 1 to 4, wherein the subject is a patient with cluster seizures, prolonged focal partial seizures, or juvenile myoclonic epilepsy.
7. The use according to any one of claims 1 to 6, wherein the medicament is to be administered when the subject experiences an aura.
8. The use according to any one of claims 1 to 7, wherein the subject is a patient with a focal seizure without impairment of consciousness/awareness. 26660232.1:DCC -
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62/432,353 | 2016-12-09 | ||
| US62/485,281 | 2017-04-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ795347A NZ795347A (en) | 2025-01-31 |
| NZ795347B2 true NZ795347B2 (en) | 2025-05-01 |
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