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NZ762060B2 - Use of 3-methylmethcathinone - Google Patents

Use of 3-methylmethcathinone Download PDF

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Publication number
NZ762060B2
NZ762060B2 NZ762060A NZ76206018A NZ762060B2 NZ 762060 B2 NZ762060 B2 NZ 762060B2 NZ 762060 A NZ762060 A NZ 762060A NZ 76206018 A NZ76206018 A NZ 76206018A NZ 762060 B2 NZ762060 B2 NZ 762060B2
Authority
NZ
New Zealand
Prior art keywords
approximately
subject
mmc
distress
reducing
Prior art date
Application number
NZ762060A
Other versions
NZ762060A (en
Inventor
Ezekiel Golan
Mark Haden
Wettum Rene Van
Original Assignee
Ezekiel Golan
Filing date
Publication date
Application filed by Ezekiel Golan filed Critical Ezekiel Golan
Priority claimed from PCT/IB2018/055812 external-priority patent/WO2019026019A1/en
Publication of NZ762060A publication Critical patent/NZ762060A/en
Publication of NZ762060B2 publication Critical patent/NZ762060B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine

Abstract

The present invention relates to methods of drug-assisted psychotherapy with cathinone, particularly methods employing 3-methyl methcathinone (3-MMC). The present invention also relates to kits comprising 3-MMC for use in the treatment of subjects undergoing psychotherapeutic intervention. In particular, methods and kits for drug-assisted psychotherapy with 3-MMC for a variety of disorders and/or conditions, including PTSD, GAD and relationship distress are provided.

Claims (19)

WHAT IS CLAIMED IS:
1. Use of 3-methylmethcathinone (3-MMC) in the manufacture of a medicament for treating a subject undergoing a psychotherapeutic intervention.
2. The use of claim 1, wherein said 3-MMC is to be administered prior to said therapeutic intervention.
3. The use of claim 1, wherein said 3-MMC is to be administered during said psychotherapeutic intervention.
4. The use of claim 3, wherein said 3-MMC is to be administered at least twice during said psychotherapeutic intervention.
5. The use of claim 1, wherein said 3-MMC is to be administered after said psychotherapeutic intervention.
6. The use of any one of claims 1-5, wherein said 3-MMC is to be administered to said subject in an amount of approximately 50 mg to approximately 500 mg per therapeutic intervention.
7. The use of claim 6, n said 3-MMC is to be administered to said subject in an amount of approximately 100 mg to approximately 400 mg per therapeutic intervention.
8. The use of claim 6, wherein said 3-MMC is to be stered to said subject in an amount of imately 100 mg to approximately 200 mg per therapeutic intervention.
9. The use of any one of claims 1-8, wherein said 3-MMC is to be administered to said subject in an amount of approximately 25 mg, approximately 50 g, approximately 75 mg, approximately 100 mg, approximately 125 mg, approximately 150 mg, approximately 175 mg or approximately 200 mg per therapeutic intervention.
10. The use of any one of claims 1-9, wherein said psychotherapeutic intervention is for distress of said subject.
11. The use of claim 10, wherein said treating is for ng said distress in said subject.
12. The use of claim 10 or 11, wherein said distress is selected from the group consisting of cognitive, nal, behavioral, relationship and spiritual distress.
13. The use of any one of claims 10-12, wherein said distress is a condition or er selected from the group consisting of personal history of psychological trauma, parentchild relational problem, personal history (past history) of neglect in childhood, personal history (past history) of physical abuse in childhood, personal history (past y) of psychological abuse in childhood, personal history (past history) of sexual abuse in childhood, personal history (past history) of spouse or partner neglect, personal history (past history) of spouse or partner psychological abuse, personal history (past history) of spouse or partner physical violence, personal history (past history) of spouse or partner sexual violence, phase of life problem, relationship distress with spouse or intimate partner, stimulant use disorder and aumatic stress disorder.
14. The use of any one of claims 10-12, n said subject is diagnosed with a stress-sensitive disorder ed from the group consisting of Post-traumatic Stress er (PTSD), Bipolar Disorder, Acute Stress Disorder, anxiety disorders such as lized y Disorder, Obsessive-Compulsive Disorder, social anxiety ers, Panic Disorders, s, obsessive compulsive disorders, and Trichotillomania.
15. The use of any one of claims 1-14, wherein said therapeutic intervention is selected from the group consisting of psychoanalytic and psychodynamic therapy, behavioral therapy, ive therapy, humanistic therapy and integrative or holistic therapy.
16. The use of claim 15, wherein said psychotherapeutic intervention is humanistic therapy or integrative/holistic therapy.
17. The use of claim 10, wherein reducing said distress comprises at least one of the following: improving stability in the work/home environment, improving behaviors, improving employment functioning, improving vocational functioning, ng cognitive stress, reducing emotional stress, improving the subject’s living situation, improving the subject’s family relationships, improving social relationships, ing the subject’s sense of meaning to life, improving the subject’s sense of purpose to life, reducing mental health symptoms, reducing ion behaviors and reducing chemical dependencies.
18. The use of claim 10, wherein reducing said distress comprises reducing the number and/or frequency of psychotherapeutic interventions, and/or reducing addiction ors and reducing chemical dependencies.
19. The use of claim 1, substantially as herein described with reference to any one of the Examples thereof.
NZ762060A 2018-08-02 Use of 3-methylmethcathinone NZ762060B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762540617P 2017-08-03 2017-08-03
PCT/IB2018/055812 WO2019026019A1 (en) 2017-08-03 2018-08-02 Use of 3-methylmethcathinone

Publications (2)

Publication Number Publication Date
NZ762060A NZ762060A (en) 2024-07-26
NZ762060B2 true NZ762060B2 (en) 2024-10-30

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