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NZ754689B2 - Novel compound and pharmaceutically-acceptable salt thereof - Google Patents

Novel compound and pharmaceutically-acceptable salt thereof

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Publication number
NZ754689B2
NZ754689B2 NZ754689A NZ75468917A NZ754689B2 NZ 754689 B2 NZ754689 B2 NZ 754689B2 NZ 754689 A NZ754689 A NZ 754689A NZ 75468917 A NZ75468917 A NZ 75468917A NZ 754689 B2 NZ754689 B2 NZ 754689B2
Authority
NZ
New Zealand
Prior art keywords
benzo
diazabicyclo
thiazol
oxazole
group
Prior art date
Application number
NZ754689A
Other versions
NZ754689A (en
Inventor
Natsuki Ishida
Satoshi ISSHIKI
Takashi MATSUHIRA
Shohei Ouchi
Yuji Tabata
Keiji Tamura
Yoshinari Wakiyama
Takeru Yamakawa
Original Assignee
Meiji Seika Pharma Co Ltd
Filing date
Publication date
Application filed by Meiji Seika Pharma Co Ltd filed Critical Meiji Seika Pharma Co Ltd
Priority claimed from PCT/JP2017/046610 external-priority patent/WO2018124060A1/en
Publication of NZ754689A publication Critical patent/NZ754689A/en
Publication of NZ754689B2 publication Critical patent/NZ754689B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Abstract

Provided is a compound represented by general formula (1) or a pharmaceutically-acceptable salt thereof. [In formula (1), R1and R2may be the same or different from each other, and each represents a hydrogen atom, a halogen atom, a hydroxy group, a carboxy group, a cyano group, or an optionally-substituted C1-6alkyl group or the like; R3represents a hydrogen atom; R4represents an optionally-substituted 4- to 10-membered monocyclic heterocyclic group containing 1-4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by -CH2-, -CH2-CH2-, -CH2-CH2-CH2-, or -CH2-O-CH2-; and Z represents a hydrogen atom or a hydroxy group.]

Claims (8)

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS: ]
1.[Claim 1] [Claim 1] A A compound represented by the general formula (1) below compound represented by the general formula (1) below or or a pharmacologically acceptable salt thereof: a pharmacologically acceptable salt thereof: N / /\ NZ (1) [In the formula (1), [In the formula (1), R RI- and and RR2 may may be the same or different and each be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally group, a carboxy group, a cyano group, an optionally 10 10 substituted C substituted C1-6 alkyl alkyl group, an optionally substituted C group, an optionally substituted 1-6 C3-7 3-7 cycloalkyl group, an optionally substituted C cycloalkyl group, an optionally substituted C6-10 monocyclic monocyclic or or polycyclic aryl group, an optionally substituted C polycyclic aryl group, an optionally substituted C7-11 7-11 monocyclic or polycyclic aralkyl group, a group, an n optionally optionally monocyclic or polycyclic aralkyl substituted 4- to 10-membered monocyclic or bicyclic bicyclic substituted 4- to 10-membered monocyclic or 15 15 aromatic aromatic heterocyclic group containing 1 to 4 heteroatoms heterocyclic group containing 1 to 4 heteroatoms selected from an oxy selected from an oxygen gen atom, atom, a a nitrogen atom, and nitrogen atom, and a a sulfur sulfur atom, atom, an optionally substituted 4 an optionally substituted 4- - to to 10 10-membered -membered monocyclic monocyclic or or bicyclic nonaromatic heterocyclic group containing 1 to 4 bicyclic nonaromatic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, heteroatoms selected from an oxygen atom, a nitrogen atom, 20 20 and and a sulfur atom, an optionally a sulfur atom, an optionally substituted substituted di di-C1-6 -C alkyl alkyl 777 777 amino amino group, an optionally substituted C group, an optionally substituted C3-7 3-7 cycloalkyl amino cycloalkyl amino group, an optionally substituted C group, an optionally substituted C1-6 acylamino acylamino group, an group, an optionally optionally substituted C substituted C1-6 alkyloxy alkyloxy group, an optionally group, an optionally substituted C substituted C2-6 alkenyloxy alkenyloxy group, an optionally subs group, an optionally substituted tituted 5 5 C alkyloxy-C alkyl alkyl group, an optionally substituted C group, an optionally substituted C1-6 1-6 alkyloxy-C1-6 1-6 C3-7 3-7 cycloalkyloxy group, an optionally substituted C cycloalkyloxy group, an optionally substituted 6-10 C6-10 monocyclic monocyclic or polycyclic aryloxy group, an optionally or polycyclic aryloxy group, an optionally substituted C substituted C7-11 monocyclic monocyclic or polycyclic aralkyloxy group, or polycyclic aralkyloxy group, an an optionally optionally sub substituted stituted 44- - to to 10 10-membered -membered monocyclic or monocyclic or 10 bicyclic aromatic heterocyclyloxy group containing 1 to 4 containing 1 to 4 10 bicyclic aromatic heterocyclyloxy group heteroatoms selected from an oxygen atom, a nitrogen atom, heteroatoms selected from an oxygen atom, a nitrogen atom, and and a sulfur atom, a a sulfur atom, an n optionally optionally substituted 4 substituted 4- - to to 10 10- - membered membered monocyclic or bicyclic nonaromatic monocyclic or bicyclic nonaromatic heterocyclyloxy heterocyclyloxy group containing 1 to 4 heteroatoms selected from an oxygen group containing 1 to 4 heteroatoms selected from an oxygen 15 15 atom, atom, a nitrogen atom, and a sulfur atom, an optionally a nitrogen atom, and a sulfur atom, an optionally substituted C alkylthio group, an optionally substituted substituted C1-6 1-6 alkylthio group, an optionally substituted C C1-6 alkylsulfonyl alkylsulfonyl group, an optionally substituted C group, an optionally substituted C1-6 1-6 1-6 alkylsulfinyl alkylsulfinyl group, an optionally substituted mono group, an optionally substituted mono- -C C1-6 1-6 alkylsulfamoyl alkylsulfamoyl group, an optionally substituted di group, an optionally substituted di-C -C1-6 1-6 20 20 alkylsulfamoyl alkylsulfamoyl group [two C group [two C1-6 alkyl alkyl groups in the di groups in the di-C 1-6 -C1-6 1-6 alkylsulfamoyl alkylsulfamoyl group may form a pyrrolidin group may form a pyrrolidin-l-yl yl group or a group or a morpholino group morpholino group with an adjacen with an adjacent t nitrogen atom], a nitrogen atom], a sulfamoyl group, an optionally substituted C sulfamoyl group, an optionally substituted C1-6 alkylcarbonyl alkylcarbonyl 778 778 group, an substituted group, an optionally substituted 1 optionally 1-(C1-6 -(C1-6 alkyloxy)imino-C1-6 alkyloxy)imino-C1-6 alkyl alkyl group, an aminocarbonyl group, an optionally group, an aminocarbonyl group, an optionally substituted mono substituted mono-C1-6 -C alkylaminocarbonyl alkylaminocarbonyl group, an optionally group, an optionally substituted di substituted di-C1-6 -C alkylaminocarbonyl alkylaminocarbonyl group, an optionally group, an optionally 5 5 substituted C substituted C3-7 cycloalkylaminocarbonyl group, an optionally cycloalkylaminocarbonyl group, an optionally substituted C substituted C7-11 7-11 monocyclic monocyclic or polycyclic or polycyclic aralkylaminocarbonyl aralkylaminocarbonyl group, an optionally substituted C group, an optionally substituted C1-6 1-6 alkyloxycarbonyl alkyloxycarbonyl group, or an op group, or an optionally tionally substituted substituted hydroxyaminocarbonyl group, hydroxyaminocarbonyl group, 10 R R represents a hydrogen atom, 10 3 represents a hydrogen atom, R represents an optionally substituted 4- to 10- R4 represents an optionally substituted 4- to 10- membered membered monocyclic heterocyclic group containing 1 to 4 monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, heteroatoms selected from an oxygen atom, a nitrogen atom, and and a a sulfur atom, sulfur atom, 15 15 X X represents a group represented by the represents a group represented by the following following formula: -CH -, -CH -CH -, -CH -CH -CH -, or -CH -O-CH -, and formula: -CH2-, 2 -CH2-CH2-, 2 2 -CH2-CH2-CH2-, 2 2 2 or -CH2CH2-, 2 2 and Z represents a hydrogen atom or a hydroxyl group Z represents a hydrogen atom or a hydroxyl group; ; and and wherein the optionally substituted group is wherein the optionally substituted group is one one or more or more selected from selected from a a halogen atom halogen atom; ; a a carboxy group carboxy group; ; a a cyano cyano 20 20 group group; ; a a hydroxyl group hydroxyl group; ; a a C C1-6 alkyl alkyl group group optionally optionally substituted with one or more halogen atom; a C alkenyl substituted with one or more halogen atom; a C2-6 2-6 alkenyl group group optionally optionally substituted substituted with with 44- - to to 10 10-membered -membered monocyclic monocyclic aromatic heterocyclic group containing 1 aromatic heterocyclic group containing 1 to to 4 4 779 779 heteroatoms selected from an oxygen atom, a nitrogen atom, heteroatoms selected from an oxygen atom, a nitrogen atom, and and a sulfur atom a sulfur atom; ; a a C C3-6 cycloalkyl group cycloalkyl group; ; a a hydroxy hydroxy-C 3-6 -C1-6 1-6 alkyl alkyl group group; ; a a C C1-6 alkyloxy alkyloxy group group optionally optionally substituted substituted with one or more halogen atom with one or more halogen atom; ; a a carbamoyl group carbamoyl group; ; an an 5 5 aminocarbonyl aminocarbonyl group group; ; a a C C1-6 alkylcarbonyl alkylcarbonyl group, an oxo group, an oxo group, a nitro group, a mono group, a nitro group, a mono-C1-6 -C1-6 alkyl alkyl amino group amino group optionally optionally substituted with one or more substituted with one or more hydroxyl hydroxyl group; group; a a di di-C1-6 -C alkyl alkyl amino group amino group optionally optionally substituted with one or substituted with one or more more hydroxyl group hydroxyl group; ; a a C alkylthio alkylthio group group; ; a a C C1-6 1-6 C1-6 1-6 10 alkylsulfonyl group; a C aryl group (monocyclic or 10 alkylsulfonyl group; a C6-10 6-10 aryl group (monocyclic or polycyclic); or a 4- to 10-membered monocyclic or bicyclic polycyclic); or a 4- to 10-membered monocyclic or bicyclic heterocyclic group (aromatic or nonaromatic, optionally heterocyclic group (aromatic or nonaromatic, optionally substituted with a C substituted with a C1-6 alkyl alkyl group group or or hydroxyl group hydroxyl group) ) containing 1 to 4 heteroatoms containing 1 to 4 heteroatoms selected selected from an oxygen atom, from an oxygen atom, 15 15 a a ni nitrogen trogen atom, and a sulfur atom atom, and a sulfur atom.] .]
2.[Claim 2] [Claim 2] The compound or the pharmacologically acceptable salt The compound or the pharmacologically acceptable salt thereof thereof according to Claim 1 according to Claim 1 wherein wherein, , in the general formula in the general formula (1), (1), 20 20 Rl R represents a hydrogen atom, a halogen atom, a represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an hydroxyl group, a carboxy group, a cyano group, an alkyl group, an optionally optionally optionally substituted C substituted C1-6 alkyl group, an optionally substituted C substituted C3-7 cycloalkyl group, a cycloalkyl group, an n optionally optionally substituted substituted 780 780 44- - to to 10 10-membered -membered monocyclic aromatic heterocyclic group monocyclic aromatic heterocyclic group containing 1 to 4 heteroatoms selected containing 1 to 4 heteroatoms selected from from an oxygen atom, an oxygen atom, a a nitrogen atom, and a sulfur atom, a nitrogen atom, and a sulfur atom, an n optionally optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic nonaromatic monocyclic nonaromatic 5 5 heterocyclic group containing 1 to 4 heteroatoms selected heterocyclic group containing 1 to 4 heteroatoms selected from from an oxygen atom, a nitrogen atom, and a sulfur atom, an an oxygen atom, a nitrogen atom, and a sulfur atom, an optionally optionally sub substituted stituted C C1-6 acylamino acylamino group, an optionally group, an optionally substituted C substituted C1-6 alkyloxy alkyloxy group, an optionally substituted C group, an optionally substituted Cl- 1-6 1- alkyloxy-C alkyl alkyl group, an optionally substituted C group, an optionally substituted 6 6 alkyloxy-C1-6 1-6 C3-7 3-7 10 10 cycloalkyloxy group, an optionally substituted 4- to 10- cycloalkyloxy group, an optionally substituted 4- to 10- membered monocyclic aromatic heterocyclyloxy group membered monocyclic aromatic heterocyclyloxy group containing 1 to 4 heteroatoms selected from an oxygen atom, containing 1 to 4 heteroatoms selected from an oxygen atom, a a nitrogen atom, and a sulfur atom, a nitrogen atom, and a sulfur atom, an n optionally optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic nonaromatic monocyclic nonaromatic 15 15 heterocyclyloxy group containing 1 to 4 heteroatoms selected heterocyclyloxy group containing 1 to 4 heteroatoms selected from from an oxygen an atom, a nitrogen atom, and a sulfur atom, an oxygen atom, a nitrogen atom, and a sulfur atom, an optionally optionally substituted C substituted C1-6 alkylthio alkylthio group, an optionally group, an optionally substituted C substituted C1-6 alkylsulfonyl alkylsulfonyl group, an optionally group, an optionally substituted C substituted C1-6 alkylsulfinyl alkylsulfinyl group, an optionally group, an optionally 20 20 substituted mono substituted mono-C1-6 -C alkylsulfamoyl alkylsulfamoyl group, an group, an optionally optionally substituted di-C alkylsulfamoyl group [two C alkyl substituted di-C1-6 1-6 alkylsulfamoyl group [two C1-6 1-6 alkyl groups in the di groups in the di-C1-6 -C alkylsulfamoyl alkylsulfamoyl group may form a group may form pyrrolidin pyrrolidin-l-yl yl group or a morpholino group with an adjacent group or a morpholino group with an adjacent 781 781 nitrogen atom], a sulfamoyl group, an optionally substituted nitrogen atom], a sulfamoyl group, an optionally substituted C C1-6 alkylcarbonyl alkylcarbonyl group, an optionally substituted 1 group, an optionally substituted 1-(C1-6 -(C 1-6 1-6 alkyloxy)imino alkyloxy)imino-C1-6 -C alkyl alkyl group, an aminocarbonyl group, an group, an aminocarbonyl group, an optionally optionally substituted mono substituted mono-C1-6 -C alkylaminocarbonyl alkylaminocarbonyl group, an group, an 5 5 optionally optionally substituted di substituted di-C1-6 -C alkylaminocarbonyl alkylaminocarbonyl group, an group, an optionally optionally substituted C substituted C3-7 3-7 cycloalkylaminocarbonyl group, an cycloalkylaminocarbonyl group, an optionally optionally substituted C substituted C7-11 monocyclic monocyclic aralkylaminocarbonyl aralkylaminocarbonyl group, an optionally substituted C group, an optionally substituted C1-6 alkyloxycarbonyl alkyloxycarbonyl group, group, or or an optionally substituted hydroxyaminocarbonyl group, and an optionally substituted hydroxyaminocarbonyl group, and 10 10 R represents a hydrogen atom, a halogen atom, a R2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an hydroxyl group, a carboxy group, a cyano group, an optionally optionally substituted C substituted C1-6 alkyl alkyl group, a group, an n optionally optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic aromatic monocyclic aromatic heterocyclic group containing 1 to 4 heteroatoms selected heterocyclic group containing 1 to 4 heteroatoms selected 15 15 from from an oxygen atom, a nitrogen atom, and a sulfur atom, a an oxygen atom, a nitrogen atom, and a sulfur atom, an n optionally substituted 4- to 10-membered monocyclic optionally substituted 4- to 10-membered monocyclic nonaromatic heterocyclic nonaromatic heterocyclic group containing 1 to 4 heteroatoms group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur selected from an oxygen atom, a nitrogen atom, and a sulfur atom, atom, an optionally substituted C an optionally substituted C1-6 acylamino acylamino group, an group, an 20 20 optionally optionally substituted C substituted C1-6 alkyloxy alkyloxy group, an optionally group, an optionally substituted C alkenyloxy group, an optionally substituted substituted C2-6 2-6 alkenyloxy group, an optionally substituted alkyl group, an C C1-6 alkyloxy alkyloxy-C1-6 -C alkyl group, an optionally substituted C optionally substituted 1-6 1-6 C3-7 3-7 cycloalkyloxy group, a cycloalkyloxy group, an n optionally optionally substituted 4 substituted 4- - to to 10 10- - 782 782 membered membered monocyclic aromatic heterocyclyloxy group monocyclic aromatic heterocyclyloxy group containing 1 to 4 heteroatoms selected from an oxygen atom, containing 1 to 4 heteroatoms selected from an oxygen atom, a a nitroge nitrogen n atom, and a sulfur atom, a atom, and a sulfur atom, an n optionally optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic nonaromatic monocyclic nonaromatic 5 5 heterocyclyloxy group containing 1 to 4 heteroatoms selected heterocyclyloxy group containing 1 to 4 heteroatoms selected from from an oxygen atom, a nitrogen atom, and a sulfur atom, an an oxygen atom, a nitrogen atom, and a sulfur atom, an optionally optionally substituted C substituted C1-6 alkylthio alkylthio gro group, up, an optionally an optionally substituted C substituted C1-6 alkylsulfonyl alkylsulfonyl group, an optionally group, an optionally substituted C substituted alkylsulfinyl alkylsulfinyl group, an optionally group, an optionally C1-6 1-6 10 substituted mono-C alkylsulfamoyl group, an optionally optionally 10 substituted mono-C1-6 1-6 alkylsulfamoyl group, an substituted di-C alkylsulfamoyl group, a sulfamoyl group, substituted di-C1-6 1-6 alkylsulfamoyl group, a sulfamoyl group, an an optionally s optionally substituted ubstituted C C1-6 alkylcarbonyl alkylcarbonyl group, an group, an optionally optionally substituted 1 substituted 1-(C1-6 -(C alkyloxy)imino-C1-6 alkyloxy)imino-C alkyl alkyl 1-6 1-6 group, an aminocarbonyl group, an optionally substituted group, an aminocarbonyl group, an optionally substituted 15 15 mono mono-C -C1-6 alkylaminocarbonyl alkylaminocarbonyl group, an optionally substituted group, an optionally substituted di-C alkylaminocarbonyl group, an optionally substituted di-C1-6 1-6 alkylaminocarbonyl group, an optionally substituted C C3-7 cycloalkylaminocarbonyl group, an optionally substituted cycloalkylaminocarbonyl group, an optionally substituted C C7-11 monocyclic monocyclic or polycyclic aralkylaminocarbonyl group, or or polycyclic aralkylaminocarbonyl group, or an an optionally substituted C optionally substituted C1-6 alkyloxycarbonyl alkyloxycarbonyl group. group. 20 20 [Claim 3] [Claim 3] The compound or the pharmacologically acceptable salt The compound or the pharmacologically acceptable salt Claim 1 wherein, in the general formula thereof thereof according to Claim 1 according to wherein, in the general formula (1), (1), 783 783 R Rl represents a hydrogen atom, a halogen atom, a represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an hydroxyl group, a carboxy group, a cyano group, an optionally optionally substituted C substituted C1-6 alkyl alkyl group, an optionally group, an optionally substituted C substituted C3-7 cycloalkyl group, a cycloalkyl group, an n optionally optionally substituted substituted 5 5 44- - to to 10 10-membered -membered monocyclic aromatic heterocyclic group monocyclic aromatic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, containing 1 to 4 heteroatoms selected from an oxygen atom, a a nitrogen atom, and a sulfur atom, a nitrogen atom, and a sulfur atom, an n optionally optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic nona monocyclic nonaromatic romatic heterocyclic group containing 1 to 4 heteroatoms selected heterocyclic group containing 1 to 4 heteroatoms selected 10 10 from from an oxygen atom, a nitrogen atom, and a sulfur atom, an an oxygen atom, a nitrogen atom, and a sulfur atom, an optionally substituted C acylamino group, an optionally optionally substituted C1-6 1-6 acylamino group, an optionally substituted C substituted C1-6 alkyloxy alkyloxy group, an optionally substituted C group, an optionally substituted Cl- 1-6 1- alkyloxy-C alkyl alkyl group, an optionally substituted C group, an optionally substituted 6 6 alkyloxy-C1-6 1-6 C3-7 3-7 cycloalkyloxy group, a cycloalkyloxy group, an n optionally optionally substituted 4 substituted 4- - to to 10 10- - 15 15 membered membered monocyclic aromatic heterocyclyloxy group monocyclic aromatic heterocyclyloxy group containing 1 to 4 heteroatoms selected from an oxygen atom, containing 1 to 4 heteroatoms selected from an oxygen atom, a a nitrogen atom, and a sulfur atom, a nitrogen atom, and a sulfur atom, an n optionally optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic nonaromatic monocyclic nonaromatic heterocyclyloxy group containing 1 to 4 heteroatoms selected heterocyclyloxy group containing 1 to 4 heteroatoms selected 20 20 from from an oxygen atom, a nitrogen atom, and a sulfur atom, an an oxygen atom, a nitrogen atom, and a sulfur atom, an optionally substituted C alkylthio group, an optionally optionally substituted C1-6 1-6 alkylthio group, an optionally alkylsulfonyl group, an optionally substituted substituted C C1-6 alkylsulfonyl group, an optionally substituted C substituted C1-6 alkylsulfinyl alkylsulfinyl group, an optionally group, an optionally 784 784 optionally substituted mono substituted mono-C1-6 -C1-6 alkylsulfamoyl alkylsulfamoyl group, an optionally group, an substituted di substituted di-C1-6 -C alkylsulfamoyl alkylsulfamoyl group [two C group [two C1-6 alkyl alkyl 1-6 1-6 groups in the di groups in the di-C1-6 -C alkylsulfamoyl alkylsulfamoyl group may f group may form orm a a pyrrolidin pyrrolidin-l-yl yl group or a morpholino group with an adjacent group or a morpholino group with an adjacent 5 5 nitrogen atom], a sulfamoyl group, an optionally substituted nitrogen atom], a sulfamoyl group, an optionally substituted C C1-6 1-6 alkylcarbonyl alkylcarbonyl group, an optionally substituted 1 group, an optionally substituted 1-(C1-6 -(C1-6 alkyloxy)imino alkyloxy)imino-C1-6 -C alkyl alkyl group, an aminocarbonyl group, an group, an aminocarbonyl group, an optionally optionally substituted mono substituted mono-C1-6 -C alkylaminocarbonyl alkylaminocarbonyl group, an group, an optionally optionally substituted di substituted di-C1-6 -C alkylaminocarbonyl alkylaminocarbonyl group, an group, an 10 optionally substituted C cycloalkylaminocarbonyl group, an 10 optionally substituted C3-7 3-7 cycloalkylaminocarbonyl group, an optionally substituted C monocyclic aralkylaminocarbonyl optionally substituted C7-11 7-11 monocyclic aralkylaminocarbonyl group, an optionall group, an optionally y substituted C substituted C1-6 alkyloxycarbonyl alkyloxycarbonyl group, group, or or an optionally substituted hydroxyaminocarbonyl group, and an optionally substituted hydroxyaminocarbonyl group, and R R2 represents a hydrogen atom. represents a hydrogen atom. 15 15 [Claim 4] [Claim 4] The compound or the pharmacologically acceptable salt The compound or the pharmacologically acceptable salt thereof thereof according to Claim 1 according to Claim 1 wherein wherein, , in the general in the general formula formula (1), (1), Rl R represents a hydrogen atom, and represents a hydrogen atom, and 20 20 R R2 represents a hydrogen atom, a halogen atom, a represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an hydroxyl group, a carboxy group, a cyano group, an alkyl group, an optionally optionally optionally substituted C substituted C1-6 alkyl group, an optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic aromatic monocyclic aromatic 785 785 hheterocyclic eterocyclic group containing 1 to 4 heteroatoms selected group containing 1 to 4 heteroatoms selected from from an oxygen atom, a nitrogen atom, and a sulfur atom, an an oxygen atom, a nitrogen atom, and a sulfur atom, an optionally optionally substituted C substituted C1-6 acylamino acylamino group, an optionally group, an optionally substituted C substituted C1-6 alkyloxy alkyloxy group, an optionally substituted C group, an optionally substituted C2- 1-6 2- 5 5 6 alkenyloxy alkenyloxy group group, , an optionally substituted C an optionally substituted C1-6 alkyloxy- alkyloxy- 6 1-6 C C1- 1-6 6 alkyl alkyl group, an optionally substituted C group, an optionally substituted C3-7 3-7 cycloalkyloxy cycloalkyloxy group, a group, an n optionally optionally substituted 4 substituted 4- - to to 10 10-membered -membered monocyclic monocyclic aromatic heterocyclyloxy group containing 1 to 4 aromatic heterocyclyloxy group containing 1 to 4 heteroatoms selected from an oxygen atom heteroatoms selected from an oxygen atom, , a nitrogen atom, a nitrogen atom, 10 and a sulfur atom, an optionally substituted 4- to 10- 10 and a sulfur atom, an optionally substituted 4- to 10- membered monocyclic nonaromatic heterocyclyloxy group membered monocyclic nonaromatic heterocyclyloxy group containing 1 to 4 heteroatoms selected from an oxygen atom, containing 1 to 4 heteroatoms selected from an oxygen atom, a a nitrogen atom, and a sulfur atom, an optionally nitrogen atom, and a sulfur atom, an optionally substituted C substituted C1-6 alkylthio alkylthio group, an optionally substituted group, an optionally substituted 15 15 C C1-6 alkylsulfonyl alkylsulfonyl group, an optionally substituted C group, an optionally substituted C1-6 1-6 1-6 alkylsulfinyl alkylsulfinyl group, an optionally substituted mono group, an -C optionally substituted mono- 1-6 alkylsulfamoyl alkylsulfamoyl group, an optionally substituted di group, an optionally substituted di- -C C1-6 1-6 alkylsulfamoyl alkylsulfamoyl group, a sulfamoyl group, an o group, a sulfamoyl group, an optionally ptionally substituted C substituted C1-6 alkylcarbonyl alkylcarbonyl group, an aminocarbonyl group, group, an aminocarbonyl group, 20 20 an an optionally substituted 1 optionally substituted -(C alkyloxy)imino-C alkyl alkyl 1-(C1-6 1-6 alkyloxy)imino-C1-6 1-6 group, an aminocarbonyl group, an optionally substituted group, an aminocarbonyl group, an optionally substituted mono-C1-6 alkylaminocarbonyl mono-C alkylaminocarbonyl group, an optionally substituted group, an optionally substituted di di-C1-6 -C alkylaminocarbonyl alkylaminocarbonyl group, an optionally substituted group, an optionally substituted 786 786 C3-7 cycloalkylaminocarbonyl group, an optionally substituted cycloalkylaminocarbonyl group, an optionally substituted C C7-11 monocyclic monocyclic or polycyclic aralkylaminocarbonyl group, or or polycyclic aralkylaminocarbonyl group, or an an optionally substituted C optionally substituted C1-6 alkyloxycarbonyl alkyloxycarbonyl group. group. [[Claim Claim 55] ] 5 5 The The compound compound or or the pharmaceuticaly acceptable salt the pharmaceuticaly acceptable salt thereof thereof according to Claim 1 wherein, the compound according to Claim 1 wherein, the compound represented by the formula (1) is represented by the formula (1) is 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)chloro(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 10 2-(3,9-diazabicyclo[3.3.1]nonanyl)chloro(thiazol 10 2-(3,9-diazabicyclo[3.3.1]nonany1)chloro(thiazol yl)(trifluoromethoxy)benzo[d]oxazole, y1)(trifluoromethoxy)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)chloro(thiazol- -(3,6-diazabicyclo[3.1.1]heptanyl)chloro(thiazol- 22-y1)(trifluoromethoxy)benzo[d]oxazole, -yl)(trifluoromethoxy)benzo[d]oxazole, 77-(5-chloro(thiazoly1) -(5-chloro(thiazolyl) 15 15 (trifluoromethoxy)benzo[d]ox (trifluoromethoxy)benzo[d]oxazoly1)oxa-7,9- azolyl)oxa-7,9- diazabicyclo[3.3.1]nonane, diazabicyclo[3.3.1]nonane, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(1H- -(3,8-diazabicyclo[3.2.1]octanyl)chloro(1H- pyrazol pyrazoly1)(trifluoromethoxy)benzo[d]oxazole, yl)(trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(furan -(3,8-diazabicyclo[3.2.1]octanyl)chloro(furan 20 20 yl) yl)(trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(pyridin -(3,8-diazabicyclo[3.2.1]octanyl)chloro(pyridin yl) y1)(trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)chloro(thiazol 787 787 yl) y1)(trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(oxazol -(3,8-diazabicyclo[3.2.1]octanyl)chloro(oxazol yl) y1)(trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(5- -(3,8-diazabicyclo[3.2.1]octanyl)chloro(5- 5 5 fluoropyridinyl)(trifluoromethoxy)benzo[d]oxazole, fluoropyridinyl)(trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(pyridin -(3,8-diazabicyclo[3.2.1]octanyl)chloro(pyridin yl) y1)(trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)chloro(pyridin -(3,9-diazabicyclo[3.3.1]nonanyl)chloro(pyridin yl) y1)(trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 10 2-(3,6-diazabicyclo[3.1.1]heptanyl)chloro(pyridin- 10 2-(3,6-diazabicyclo[3.1.1]heptany1)chloro(pyridin- 2-yl)(trifluoromethyl)benzo[d]oxazole, 2-y1)(trifluoromethyl)benzo[d]oxazole, 77-(5-chloro(pyridiny1) -(5-chloro(pyridinyl) (trifluoromethyl)benzo[d]oxazo (trifluoromethyl)benzo[d]oxazoly1)oxa-7,9- lyl)oxa-7,9- diazabicyclo[3.3.1]nonane, diazabicyclo[3.3.1]nonane, 15 15 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(1H- -(3,8-diazabicyclo[3.2.1]octanyl)chloro(1H- pyrazolyl)(trifluoromethyl)benzo[d]oxazole, pyrazoly1)(trifluoromethyl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)chloro(1H- -(3,9-diazabicyclo[3.3.1]nonanyl)chloro(1H- pyrazol pyrazoly1)(trifluoromethyl)benzo[d]oxazole, yl)(trifluoromethyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)chloro(1H- -(3,6-diazabicyclo[3.1.1]heptanyl)chloro(1H- 20 20 pyrazol pyrazolyl)(trifluoromethyl)benzo[d]oxazole, yl)(trifluoromethyl)benzo[d]oxazole, 77-(5-chloro(1H-pyrazoly1) -(5-chloro(1H-pyrazolyl) (trifluoromethyl)benzo[d]oxazol (trifluoromethyl)benzo[d]oxazoly1)oxa-7,9- yl)oxa-7,9- diazabicyclo[3.3.1]nonane, diazabicyclo[3.3.1]nonane, 788 788 7-(5-chloro(thiazoly1) 7-(5-chloro(thiazolyl) (trifluoromethyl) (trifluoromethyl)benzo[d]oxazoly1)oxa-7,9- benzo[d]oxazolyl)oxa-7,9- diazabicyclo[3.3.1]nonane, diazabicyclo[3.3.1]nonane, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)chloro(thiazol 5 5 yl) yl)(trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)isopropy1 -(3,8-diazabicyclo[3.2.1]octanyl)isopropyl (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)isopropy1 -(3,6-diazabicyclo[3.1.1]heptanyl)isopropyl (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 10 77-(5-isopropy1(thiazoly1)benzo[d]oxazoly1)oxa- -(5-isopropyl(thiazolyl)benzo[d]oxazolyl)oxa- 7,9 7,9-diazabicyclo[3.3.1]nonane, -diazabicyclo[3.3.1]nonane, 22-(3,9-diazabicyclo[3.3.1]nonany1)isopropy1 -(3,9-diazabicyclo[3.3.1]nonanyl)isopropyl (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)methy1(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)methyl(thiazol 15 15 yl)benzo[d]oxazole, yl) benzo [d] oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)methy1(thiazol- -(3,6-diazabicyclo[3.1.1]heptanyl)methyl(thiazol- 22-yl)benzo[d]oxazole, -yl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)methy1(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)methyl(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 20 20 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) 2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 789 789 2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) 2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) (trifluoromethoxy)be (trifluoromethoxy)benzo[d]oxazole, nzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 5 5 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) ((trifluoromethyl)benzo[d]oxazole, trifluoromethyl)benzo[d]oxazole, NN-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol 10 10 yl)benzo[d]oxazol yl) oxazolyl) yl)acetamide, benzo [d] acetamide, N-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol N-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)acetamide, yl)acetamide, 22-(3,8-diazabicyclo[3.2.1]octany1)chloro(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)chloro(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 15 15 22-(3,6-diazabicyclo[3.1.1]heptany1)chloro(thiazol- -(3,6-diazabicyclo[3.1.1]heptanyl)chloro(thiazol- 2-yl)benzo[d]oxazole, 2-yl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)chloro(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)chloro(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(methylthio) -(3,8-diazabicyclo[3.2.1]octanyl)(methylthio) 20 20 (thiaz (thiazolyl)benzo[d]oxazole, olyl)benzo[d]oxazole, 2-(3,6-diazabicyclo[3.1.1]heptanyl)(methylthio) 2-(3,6-diazabicyclo[3.1.1]heptany1)(methylthio) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)(methylthio) -(3,9-diazabicyclo[3.3.1]nonanyl)(methylthio) 790 790 (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(methylsulfony1) -(3,8-diazabicyclo[3.2.1]octanyl)(methylsulfonyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(methylsulfony1) -(3,6-diazabicyclo[3.1.1]heptanyl)(methylsulfonyl) 5 5 (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)(methylsulfony1) -(3,9-diazabicyclo[3.3.1]nonanyl)(methylsulfonyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(methylsulfiny1) -(3,8-diazabicyclo[3.2.1]octanyl)(methylsulfinyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 10 22-(3,6-diazabicyclo[3.1.1]heptany1)(methylsulfiny1) -(3,6-diazabicyclo[3.1.1]heptanyl)(methylsulfinyl) (thiazolyl)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)(methylsulfiny1) -(3,9-diazabicyclo[3.3.1]nonanyl)(methylsulfinyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, NN-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol 15 15 yl)benzo[d]oxazol yl) benzo [d] oxazolyl) yl)acetamide, acetamide, N-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol N-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)acetamide, yl)acetamide, NN-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)acetamide, yl)acetamide, 20 20 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) 2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 791 791 2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) 2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazole, (trifluoromethyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 5 5 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 yl)benzo[d]oxazolesulfonamide, 10 yl)benzo[d]oxazolesulfonamide, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolesulfonamide, sulfonamide, 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolesulfonamide, sulfonamide, 15 15 22-(3,8-diazabicyclo[3.2.1]octany1)methoxy(thiazol- -(3,8-diazabicyclo[3.2.1]octanyl)methoxy(thiazol- 2-yl)benzo[d]oxazole, 2-yl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)methoxy(thiazol- -(3,6-diazabicyclo[3.1.1]heptanyl)methoxy(thiazol- 22-yl)benzo[d]oxazole, -yl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)methoxy(thiazol- -(3,9-diazabicyclo[3.3.1]nonanyl)methoxy(thiazol- 20 20 2 2-yl) -yl)benzo[d]oxazole, benzo [d] oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolol, ol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 792 792 yl)benzo[d]oxazol yl)benzo[d]oxazolol, ol, 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolol, ol, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 5 5 (2,2,2 (2,2,2-trifluoroethoxy)benzo[d]oxazole, -trifluoroethoxy)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoroethoxy)benzo[d]oxazole, -trifluoroethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)isopropoxy -(3,8-diazabicyclo[3.2.1]octanyl)isopropoxy (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 10 2-(3,8-diazabicyclo[3.2.1]octanyl)(2-methoxyethoxy) 10 2-(3,8-diazabicyclo[3.2.1]octany1)(2-methoxyethoxy) (thiazolyl)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(oxetan -(3,8-diazabicyclo[3.2.1]octanyl)(oxetan ylmethoxy) ylmethoxy)(thiazolyl)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, 2-( 2-(((2 ((2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)methyl)propane-1,3-diol, yl)oxy)methyl)propane-1,3-diol, 5-(allyloxy)(3,8-diazabicyclo[3.2.1]octanyl) 5-(allyloxy)(3,8-diazabicyclo[3.2.1]octany1) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 2-( 2-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[ yl)benzo[d]oxazolyl)oxy)acetonitrile, d]oxazolyl)oxy)acetonitrile, 20 20 2-( 2-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazolyl)oxy)acetic acid, yl)benzo[d]oxazolyl)oxy)acetic acid, 22-(3,8-diazabicyclo[3.2.1]octany1)methoxy(thiazol- -(3,8-diazabicyclo[3.2.1]octanyl)methoxy(thiazol- 22-yl)benzo[d]oxazole, -yl)benzo[d]oxazole, 793 793 22-(3,6-diazabicyclo[3.1.1]heptany1)methoxy(thiazol- -(3,6-diazabicyclo[3.1.1]heptanyl)methoxy(thiazol- 22-yl)benzo[d]oxazole, -yl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)methoxy(thiazol- -(3,9-diazabicyclo[3.3.1]nonanyl)methoxy(thiazol- 22-yl)benzo[d]oxazole, -yl)benzo[d]oxazole, 5 5 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolol, ol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxa yl)benzo[d]oxazolol, zolol, 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol 10 yl)benzo[d]oxazol yl)benzo[d]oxazolol, ol, 2-(3,8-diazabicyclo[3.2.1]octanyl)cyclobutoxy 2-(3,8-diazabicyclo[3.2.1]octany1)cyclobutoxy (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 2-( 2-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)acetonitrile, yl)oxy)acetonitrile, 15 15 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)methoxypropanol, yl)oxy)methoxypropanol, 22-(3,8-diazabicyclo[3.2.1]octany1)( -(3,8-diazabicyclo[3.2.1]octanyl)((tetrahydrofuran (tetrahydrofuran yl)ox yl)oxy)(thiazolyl)benzo[d]oxazole, y)(thiazolyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)-4,7-di(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)-4,7-di(thiazol 20 20 yl)benzo[d]oxazole, yl) benzo [d] oxazole, ethyl 2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol ethyl 2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, ethyl ethyl 22-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 794 794 yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, ethyl ethyl 22-(3-oxa-7,9-diazabicyclo[3.3.1]nonany1) -(3-oxa-7,9-diazabicyclo[3.3.1]nonanyl) (thiazol (thiazolyl)benzo[d]oxazolecarboxylate, yl)benzo[d]oxazolecarboxylate, ethyl ethyl 22-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol 5 5 yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, ethyl ethyl 22-(3,8-diazabicyclo[3.2.1]octany1)(1H-pyrazol -(3,8-diazabicyclo[3.2.1]octanyl)(1H-pyrazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, ethyl ethyl 22-(3,6-diazabicyclo[3.1.1]heptany1)(1H-pyrazol- -(3,6-diazabicyclo[3.1.1]heptanyl)(1H-pyrazol- 1-yl)benzo[d]oxazolecarboxylate, 1-yl)benzo[d]oxazolecarboxylate, 10 ethyl 2-(3-oxa-7,9-diazabicyclo[3.3.1]nonanyl)(1H- 10 ethyl 2-(3-oxa-7,9-diazabicyclo[3.3.1]nonany1)(1H- pyrazolyl)benzo[d]oxazolecarboxylate, pyrazolyl)benzo[d]oxazolecarboxylate, ethyl ethyl 22-(3,9-diazabicyclo[3.3.1]nonany1)(1H-pyrazol -(3,9-diazabicyclo[3.3.1]nonanyl)(1H-pyrazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, 22-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)propanol, yl)propanol, 2-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 2-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxa yl)benzo[d]oxazolyl)propanol, zolyl)propanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(2-methoxypropan -(3,6-diazabicyclo[3.1.1]heptanyl)(2-methoxypropan yl) y1)(thiazoly1)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, 20 20 22-(3,8-diazabicyclo[3.2.1]octany1)(2-methoxypropan -(3,8-diazabicyclo[3.2.1]octanyl)(2-methoxypropan yl)(thiazolyl)benzo[d]oxazole, y1)(thiazolyl)benzo[d]oxazole, 2-(3,8-diazabicyclo[3.2.1]octany1)-N,N-dimethy1 2-(3,8-diazabicyclo[3.2.1]octanyl)-N,N-dimethyl (thiazol (thiazolyl)benzo[d]oxazolecarboxamide, yl)benzo[d]oxazolecarboxamide, 795 795 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1) yl)(morpholino)methanone, (morpholino)methanone, (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1) yl)(piperidin (piperidin-l-y1)methanone, yl)methanone, 5 5 (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1) yl)(azetidin (azetidiny1)methanone, yl)methanone, NN-benzy1(3,8-diazabicyclo[3.2.1]octany1)(thiazol -benzyl(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxamide, carboxamide, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 yl)benzo[d]oxazolecarboxamide, 10 yl)benzo[d]oxazolecarboxamide, 22-(3,8-diazabicyclo[3.2.1]octany1)-N-methy1(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)-N-methyl(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxamide, carboxamide, NN-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-N-methylacetamide, yl)-N-methylacetamide, 15 15 22-(3,8-diazabicyclo[3.2.1]octany1)(morpholinomethyl)- -(3,8-diazabicyclo[3.2.1]octanyl)(morpholinomethyl)- 7-(thiazolyl)benzo[d]oxazole, 7-(thiazolyl)benzo[d]oxazole, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-N,N-dimethylmethanamine, yl)-N,N-dimethylmethanamine, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 20 20 (1,1,1 (1,1,1-trifluoromethoxypropanyl)benzo[d]oxazole, -trifluoromethoxypropanyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (1,1,1 (1,1,1-trifluoromethoxypropanyl)benzo[d]oxazole, -trifluoromethoxypropanyl)benzo[d]oxazole, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 796 796 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)ethanone, yl)ethanone, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)ethanone, yl)ethanone, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 5 5 yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2-difluoroethan-l-ol, yl)-2,2-difluoroethanol, 22-(3,8-diazabicyclo[3.2.1]octany1)(2,2-difluoro -(3,8-diazabicyclo[3.2.1]octanyl)(2,2-difluoro methoxyethyl)(thiazoly1)benzo[d]oxazole, methoxyethyl)(thiazolyl)benzo[d]oxazole, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)ethanol, yl)ethanol, 10 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)ethanol, yl)ethanol, 22-(3,8-diazabicyclo[3.2.1]octany1)(1-methoxyethyl) -(3,8-diazabicyclo[3.2.1]octanyl)(1-methoxyethyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(1-methoxyethyl) -(3,6-diazabicyclo[3.1.1]heptanyl)(1-methoxyethyl) 15 15 (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, (2 (2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)methanol, yl)methanol, (2 (2-(3,6-diazabicyclo[3.1.1]hepany1)(thiazol -(3,6-diazabicyclo[3.1.1]hepanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)methanol, yl)methanol, 20 20 (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)methanol, yl)methanol, ethyl ethyl 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, 797 797 ethyl ethyl 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, ethyl ethyl 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylate, carboxylate, 5 5 22-(3,8-diazabicyclo[3.2.1]octany1)-N,N-dimethy1 -(3,8-diazabicyclo[3.2.1]octanyl)-N,N-dimethyl (thiazol (thiazolyl)benzo[d]oxazolecarboxamide, yl)benzo[d]oxazolecarboxamide, (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1) yl)(morpholino)methanone, (morpholino)methanone, (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 10 yl)benzo[d]oxazol yl)benzo[d]oxazoly1) yl)(piperidin (piperidin-l-y1)methanone, yl)methanone, 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl)benzo yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, [d]oxazolyl)-2,2,2-trifluoroethanol, (R) (R)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)-2,2,2-trifluoroethanol, 15 15 (S) (S)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethanol, yl)-2,2,2-trifluoroethanol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)-2,2,2-trifluoroethanol, (R) (R)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 20 20 yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)-2,2,2-trifluoroethanol, (S) (S)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)benzo[d]oxazolyl)-2,2,2-trifluoroethanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) 798 798 (2,2,2 (2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, -trifluoromethoxyethyl)benzo[d]oxazole, (R) (R)(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- (3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, -(2,2,2-trifluoromethoxyethyl)benzo[d]oxazole, (S) (S)(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- (3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 5 5 44-(2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, -(2,2,2-trifluoromethoxyethyl)benzo[d]oxazole, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2-difluoroethan-l-ol, yl)-2,2-difluoroethanol, 22-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-1,1-difluoropropanol, yl)-1,1-difluoropropanol, 10 (R)(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 (R)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-1,1-difluoropropanol, yl)-1,1-difluoropropanol, (S) (S)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-1,1-difluoropropanol, yl)-1,1-difluoropropanol, 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2-difluoroethoxy)methylpropan- yl)-2,2-difluoroethoxy)methylpropan- 22-ol, -ol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxaz yl)benzo[d]oxazoly1)-2,2-difluoroethan-l-ol, olyl)-2,2-difluoroethanol, 22-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 20 20 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)-1,1-difluoropropanol, yl)-1,1-difluoropropanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(2,2-difluoro -(3,6-diazabicyclo[3.1.1]heptanyl)(2,2-difluoro methoxyethyl)(thiazoly1)benzo[d]oxazole, methoxyethyl)(thiazolyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(2,2-difluoro -(3,8-diazabicyclo[3.2.1]octanyl)(2,2-difluoro 799 799 methoxyethyl)(thiazoly1)benzo[d]oxazole, methoxyethyl)(thiazolyl)benzo[d]oxazole, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)ethanol, yl)ethanol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 5 5 yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)-2,2,2-trifluoroethanol, 1-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol 1-(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)-2,2,2-trifluoroethanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)-2,2,2-trifluoroethanol, 10 (R)(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 (R)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethanol, yl)-2,2,2-trifluoroethanol, (S) (S)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, yl)-2,2,2-trifluoroethanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(1H-pyrazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(1H-pyrazol 15 15 yyl)benzo[d]oxazoly1)-2,2,2-trifluoroethan-l-ol, l)benzo[d]oxazolyl)-2,2,2-trifluoroethanol, 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethyl yl)-2,2,2-trifluoroethyl acetate, acetate, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, -trifluoromethoxyethyl)benzo[d]oxazole, 20 20 (R) (R)(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1)- (3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl)- 5-(2,2,2-trifluoromethoxyethyl)benzo[d]oxazole, 5-(2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, (S)(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1)- (S)(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl)- 5-(2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, 5-(2,2,2-trifluoromethoxyethyl)benzo[d]oxazole, 800 800 2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) 2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, -trifluoromethoxyethyl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, -trifluoromethoxyethyl)benzo[d]oxazole, 5 5 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro(2,2,2- -trifluoro(2,2,2- trifluoroethoxy)ethyl)benzo[d]oxazole, trifluoroethoxy)ethyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro(2-methoxyethoxy)ethyl)benzo[d]oxazole, -trifluoro(2-methoxyethoxy)ethyl)benzo[d]oxazole, 10 22-(3,8-diazabicyclo[3.2.1]octany1)(1-ethoxy-2,2,2- -(3,8-diazabicyclo[3.2.1]octanyl)(1-ethoxy-2,2,2- trifluoroethyl)(thiazolyl)benzo[d]oxazole, trifluoroethyl)(thiazolyl)benzo[d]oxazole, 22-(1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)ethan-l-ol, yl)-2,2,2-trifluoroethoxy)ethanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(1-ethoxy-2,2,2- -(3,6-diazabicyclo[3.1.1]heptanyl)(1-ethoxy-2,2,2- 15 15 trifluoroethyl)(thiazoly1)benzo[d]oxazole, trifluoroethyl)(thiazolyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro(2,2,2- -trifluoro(2,2,2- trifluoroethoxy)ethyl)benzo[d]oxazole, trifluoroethoxy)ethyl)benzo[d]oxazole, 22-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 20 20 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)-2,2,2-trifluoroethoxy)acetonitrile, yl)-2,2,2-trifluoroethoxy)acetonitrile, 2-(1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 2-(1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)acetonitrile, yl)-2,2,2-trifluoroethoxy)acetonitrile, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) 801 801 (2,2,2 (2,2,2-trifluoro(2-methoxyethoxy)ethyl)benzo[d]oxazole, -trifluoro(2-methoxyethoxy)ethyl)benzo[d]oxazole, 1-(1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)propanol, yl)-2,2,2-trifluoroethoxy)propanol, 1-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol 1-(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol 5 5 yl yl)benzo[d]oxazolyl)-2,2,2-trifluoroethane-1,1-diol, )benzo[d]oxazolyl)-2,2,2-trifluoroethane-1,1-diol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethane-1,1-diol, yl)-2,2,2-trifluoroethane-1,1-diol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethane-1,1-diol, yl)-2,2,2-trifluoroethane-1,1-diol, 10 2-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 2-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-1,1,1-trifluoropropanol, yl)-1,1,1-trifluoropropanol, 22-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-1,1,1-trifluoropropanol, yl)-1,1,1-trifluoropropanol, 22-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)-1,1,1-trifluoropropanol, yl)-1,1,1-trifluoropropanol, 2-(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) 2-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) (1,1,1 (1,1,1-trifluoromethoxypropanyl)benzo[d]oxazole, -trifluoromethoxypropanyl)benzo[d]oxazole, ethyl ethyl 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl y1)(trifluoromethyl)benzo[d]oxazolecarboxylate, )(trifluoromethyl)benzo[d]oxazolecarboxylate, 20 20 ethyl ethyl 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol yl)(trifluoromethyl)benzo[d]oxazolecarboxylate, y1)(trifluoromethyl)benzo[d]oxazolecarboxylate, ethyl ethyl 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl) y1)(trifluoromethyl)benzo[d]oxazolecarboxylate, (trifluoromethyl)benzo[d]oxazolecarboxylate, 802 802 2-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) 2-(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazol (trifluoromethyl)benzo[d]oxazolyl)propanol, yl)propanol, 22-(3,8-diazabicyclo[3.2.1]octany1)(methoxymethyl) -(3,8-diazabicyclo[3.2.1]octanyl)(methoxymethyl) (thiazol (thiazoly1)(trifluoromethyl)benzo[d]oxazole, yl)(trifluoromethyl)benzo[d]oxazole, 5 5 (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazol (trifluoromethyl)benzo[d]oxazolyl)methanol, yl)methanol, 22-(3,8-diazabicyclo[3.2.1]octany1)(2-methoxypropan -(3,8-diazabicyclo[3.2.1]octanyl)(2-methoxypropan yl) y1)(thiazoly1)(trifluoromethyl)benzo[d]oxazole, (thiazolyl)(trifluoromethyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(2-methoxypropan -(3,6-diazabicyclo[3.1.1]heptanyl)(2-methoxypropan 10 10 yl)(thiazolyl)(trifluoromethyl)benzo[d]oxazole, yl)(thiazolyl)(trifluoromethyl)benzo[d]oxazole, 22-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazol (trifluoromethyl)benzo[d]oxazolyl)propanol, yl)propanol, 22-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethyl)benzo[d]oxazolyl)propanol, -(trifluoromethyl)benzo[d]oxazolyl)propanol, 15 15 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazolyl)ethanone, (trifluoromethyl)benzo[d]oxazolyl)ethanone, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethyl)benzo[d]oxazolyl)ethanone, -(trifluoromethyl)benzo[d]oxazolyl)ethanone, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 20 20 (trifluoromethyl)benzo[d]oxazol (trifluoromethyl)benzo[d]oxazolyl)ethanol, yl)ethanol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethyl)benzo[d]oxazolyl)ethanol, -(trifluoromethyl)benzo[d]oxazolyl)ethanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 803 803 (trifluoromethyl)benzo[d]oxazoly1)-2,2-difluoroethan (trifluoromethyl)benzo[d]oxazolyl)-2,2-difluoroethan ol, ol, 22-(3,8-diazabicyclo[3.2.1]octany1)(1-methoxyethyl) -(3,8-diazabicyclo[3.2.1]octanyl)(1-methoxyethyl) (thiazol (thiazoly1)(trifluoromethyl)benzo[d]oxazole, yl)(trifluoromethyl)benzo[d]oxazole, 5 22-(3,6-diazabicyclo[3.1.1]heptany1)(1-methoxyethyl) -(3,6-diazabicyclo[3.1.1]heptanyl)(1-methoxyethyl) (thiazol (thiazoly1)(trifluoromethyl)benzo[d]oxazole, yl)(trifluoromethyl)benzo[d]oxazole, ethyl ethyl 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazolecarboxylate, (trifluoromethoxy)benzo[d]oxazolecarboxylate, ethyl ethyl 22-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 yl)(trifluoromethoxy)benzo[d]oxazolecarboxylate, 10 yl)(trifluoromethoxy)benzo[d]oxazolecarboxylate, ethyl 2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol ethyl 2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazolecarboxylate, (trifluoromethoxy)benzo[d]oxazolecarboxylate, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole (trifluoromethoxy)benzo[d]oxazolecarboxylic carboxylic acid, acid, 15 15 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazolecarboxylic acid, (trifluoromethoxy)benzo[d]oxazolecarboxylic acid, 22-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) -(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole (trifluoromethoxy)benzo[d]oxazolecarboxylic carboxylic acid, acid, 22-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 20 20 (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazolyl)propanol, yl)propanol, 22-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethoxy)benzo[d]oxazolyl)propanol, -(trifluoromethoxy)benzo[d]oxazolyl)propanol, 22-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazoly1) -(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazolyl) 804 804 (trifluoromethoxy)benzo[d]oxazolyl)propanol, (trifluoromethoxy)benzo[d]oxazolyl)propanol, 22-(3,8-diazabicyclo[3.2.1]octany1)(2-methoxypropan -(3,8-diazabicyclo[3.2.1]octanyl)(2-methoxypropan yl) y1)(thiazoly1)(trifluoromethoxy)benzo[d]oxazole, (thiazolyl)(trifluoromethoxy)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(2-methoxypropan -(3,6-diazabicyclo[3.1.1]heptanyl)(2-methoxypropan 5 5 yl) yl)(thiazolyl)(trifluoromethoxy)benzo[d]oxazole, (thiazolyl)(trifluoromethoxy)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)(2-methoxypropan -(3,9-diazabicyclo[3.3.1]nonanyl)(2-methoxypropan yl) y1)(thiazoly1)(trifluoromethoxy)benzo[d]oxazole, (thiazolyl)(trifluoromethoxy)benzo[d]oxazole, (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1) yl)(azetidin (azetidin 10 10 yl)methanone, yl)methanone, 22-(3,8-diazabicyclo[3.2.1]octany1)-N-(2-hydroxyethyl)-N- -(3,8-diazabicyclo[3.2.1]octanyl)-N-(2-hydroxyethyl)-N- methy1(thiazoly1)(trifluoromethoxy)benzo[d]oxazole- methyl(thiazolyl)(trifluoromethoxy)benzo[d]oxazole- 5-carboxamide, 5-carboxamide, (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 15 15 (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1) yl)(3 (3-hydroxy -hydroxy (trifluoromethyl)azetidin (trifluoromethyl)azetidin-l-y1)methanone, yl)methanone, (2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazolyl)methanol, yl)methanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 20 20 (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazolyl)ethanol, yl)ethanol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethoxy)benzo[d]oxazolyl)ethanol, -(trifluoromethoxy)benzo[d]oxazolyl)ethanol, (R) (R)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 805 805 yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)ethanol, (trifluoromethoxy)benzo[d]oxazolyl)ethanol, (S) (S)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)ethanol, (trifluoromethoxy)benzo[d]oxazolyl)ethanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 5 5 (trifluoromet (trifluoromethoxy)benzo[d]oxazolyl)propanol, hoxy)benzo[d]oxazolyl)propanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1)methylpropanol, yl)methylpropanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1)-2,2-difluoroethan yl)-2,2-difluoroethan 10 10 ol, ol, (R)(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol (R)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- (trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan difluoroethan-l-ol, ol, (S) (S)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 15 15 yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- (trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan difluoroethanol, ol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethoxy)benzo[d]oxazoly1)-2,2-difluoroethan- -(trifluoromethoxy)benzo[d]oxazolyl)-2,2-difluoroethan- 1-ol, 1-ol, 20 20 (R) (R)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- (trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan-l-ol, difluoroethanol, (S) (S)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 806 806 y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- yl)(trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan difluoroethan-l-ol, ol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(2,2-difluoro -(3,6-diazabicyclo[3.1.1]heptanyl)(2,2-difluoro methoxyethyl)(thiazoly1) methoxyethyl)(thiazolyl) 5 5 (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(2,2-difluoro -(3,8-diazabicyclo[3.2.1]octanyl)(2,2-difluoro methoxyethyl)(thiazoly1) methoxyethyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(1-methoxyethyl) -(3,8-diazabicyclo[3.2.1]octanyl)(1-methoxyethyl) 10 10 (thiazolyl)(trifluoromethoxy)benzo[d]oxazole, (thiazolyl)(trifluoromethoxy)benzo[d]oxazole, 2-(3,6-diazabicyclo[3.1.1]heptanyl)(1-methoxyethyl) 2-(3,6-diazabicyclo[3.1.1]heptany1)(1-methoxyethyl) (thiazol (thiazoly1)(trifluoromethoxy)benzo[d]oxazole, yl)(trifluoromethoxy)benzo[d]oxazole, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethoxy)benzo[d]oxazolyl)ethanone, -(trifluoromethoxy)benzo[d]oxazolyl)ethanone, 15 15 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazolyl)ethanone, (trifluoromethoxy)benzo[d]oxazolyl)ethanone, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (1,1,1 (1,1,1-trifluoromethoxypropany1) -trifluoromethoxypropanyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 20 20 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (1,1,1 (1,1,1-trifluoromethoxypropany1) -trifluoromethoxypropanyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 22-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 807 807 4-(trifluoromethoxy)benzo[d]oxazoly1)-1,1,1- 4-(trifluoromethoxy)benzo[d]oxazolyl)-1,1,1- trifluoropropanol, trifluoropropanol, 22-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1)-1,1,1- yl)-1,1,1- 5 5 trifluoropropanol, trifluoropropanol, (E) (E)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)ethanone (trifluoromethoxy)benzo[d]oxazolyl)ethanone O 0- - methyloxime, methyloxime, (Z) (Z)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 10 yl)(trifluoromethoxy)benzo[d]oxazolyl)ethanone O- yl)(trifluoromethoxy)benzo[d]oxazolyl)ethanone 0- methyloxime, methyloxime, (E) (E)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)ethanone (trifluoromethoxy)benzo[d]oxazolyl)ethanone O 0- - methyloxime, methyloxime, 15 15 (Z) (Z)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)(trifluoromethoxy)benzo[d]oxazolyl)ethanone O- y1)(trifluoromethoxy)benzo[d]oxazolyl)ethanone 0- methyloxime, methyloxime, 22-(3,8-diazabicyclo[3.2.1]octany1)(1-ethoxy-2,2,2- -(3,8-diazabicyclo[3.2.1]octanyl)(1-ethoxy-2,2,2- trifluoroethyl)(thiazoly1)benzo[d]oxazole, trifluoroethyl)(thiazolyl)benzo[d]oxazole, 20 20 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro(2,2,2- -trifluoro(2,2,2- trifluoroethoxy)ethyl)benzo[d]oxazole, trifluoroethoxy)ethyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) 808 808 (2,2,2 (2,2,2-trifluoro-l-methoxyethyl)benzo[d]oxazole, -trifluoromethoxyethyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro(2,2,2- -trifluoro(2,2,2- trifluoroethoxy)ethyl)benzo[d]oxazole, trifluoroethoxy)ethyl)benzo[d]oxazole, 5 5 22-(3,6-diazabicyclo[3.1.1]heptany1)(1-ethoxy-2,2,2- -(3,6-diazabicyclo[3.1.1]heptanyl)(1-ethoxy-2,2,2- trifluoroethyl)(thiazolyl)benzo[d]oxazole, trifluoroethyl)(thiazolyl)benzo[d]oxazole, 22-(1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)ethan-l-ol, yl)-2,2,2-trifluoroethoxy)ethanol, 22-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 10 yl)benzo[d]oxazolyl)-2,2,2-trifluoroethoxy)acetonitrile, yl)benzo[d]oxazolyl)-2,2,2-trifluoroethoxy)acetonitrile, 2-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 2-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)ethan-l-ol, yl)-2,2,2-trifluoroethoxy)ethanol, 22-(1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)acetonitrile, yl)-2,2,2-trifluoroethoxy)acetonitrile, 15 15 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (2,2,2-trifluoro(2-methoxyethoxy)ethyl)benzo[d]oxazole, (2,2,2-trifluoro(2-methoxyethoxy)ethyl)benzo[d]oxazole, 44-(1-( -(1-((1H (1H-tetrazolyl)methoxy)-2,2,2-trifluoroethyl) -tetrazolyl)methoxy)-2,2,2-trifluoroethyl) (3,8 (3,8-diazabicyclo[3.2.1]octany1)(thiazol -diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 20 20 44-(1-( -(1-((1H (1H-tetrazolyl)methoxy)-2,2,2-trifluoroethyl) -tetrazolyl)methoxy)-2,2,2-trifluoroethyl) (3,6 (3,6-diazabicyclo[3.1.1]heptany1)(thiazol -diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 1-( 1-((1 (1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 809 809 yl)benzo[d]oxazoly1)-2,2,2- yl)benzo[d]oxazolyl)-2,2,2- trifluoroethoxy)methyl)cyclopropan-l-ol, trifluoroethoxy)methyl)cyclopropanol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethane-1,1-diol, yl)-2,2,2-trifluoroethane-1,1-diol, 5 5 22-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-1,1,1-trifluoropropanol, yl)-1,1,1-trifluoropropanol, (R) (R)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d yl)benzo[d]oxazoly1)-1,1,1-trifluoropropanol, ]oxazolyl)-1,1,1-trifluoropropanol, (S) (S)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 10 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)-1,1,1-trifluoropropanol, yl)-1,1,1-trifluoropropanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (1,1,1 (1,1,1-trifluoromethoxypropanyl)benzo[d]oxazole, -trifluoromethoxypropanyl)benzo[d]oxazole, 22-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-1,1,1-trifluoropropanol, yl)-1,1,1-trifluoropropanol, 15 15 methyl methyl 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazolecarboxylate, yl)benzo[d]oxazolecarboxylate, 22-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylic carboxylic acid, acid, 22-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 20 20 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)propanol, yl)propanol, 2-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 2-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol yl)benzo[d]oxazolyl)propanol, yl)benzo[d]oxazolyl)propanol, 1-(2-(3,9-diazabicyclo[3.3.1]nonany1)(thiazol 1-(2-(3,9-diazabicyclo[3.3.1]nonanyl)(thiazol 810 810 yl)benzo[d]oxazolyl)ethanol, yl)benzo[d]oxazolyl)ethanol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)ethanol, yl)ethanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(1-methoxyethyl) -(3,6-diazabicyclo[3.1.1]heptanyl)(1-methoxyethyl) 5 5 (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(1-methoxyethyl) -(3,8-diazabicyclo[3.2.1]octanyl)(1-methoxyethyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,9-diazabicyclo[3.3.1]nonany1)(1-methoxyethyl) -(3,9-diazabicyclo[3.3.1]nonanyl)(1-methoxyethyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 10 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)ethanone, yl)ethanone, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)ethanone, yl)ethanone, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan ol, ol, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoroethanol, yl)oxy)-2,2-difluoroethanol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 20 20 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropanol, yl)oxy)-1,1-difluoropropanol, (R) (R) ((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropanol, yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropanol, (S) (S)( ((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 811 811 yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropanol, yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropanol, 22-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)acetic yl)-2,2,2-trifluoroethoxy)acetic acid, acid, 22-(3,8-diazabicyclo[3.2.1]octanyl)( -(3,8-diazabicyclo[3.2.1]octanyl)((tetrahydro (tetrahydro-2H- -2H- 5 5 pyran pyranyl)oxy)(thiazolyl)benzo[d]oxazole, yl)oxy)(thiazolyl)benzo[d]oxazole, 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy) yl)-2,2,2-trifluoroethoxy) methylpropanol, methylpropanol, 22-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 10 yl)benzo[d]oxazolyl)-2,2,2-trifluoroethoxy)acetamide, yl)benzo[d]oxazolyl)-2,2,2-trifluoroethoxy)acetamide, 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)-1,1-difluoro- yl)-2,2,2-trifluoroethoxy)-1,1-difluoro- 22-methylpropanol, -methylpropanol, 22-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)-2,2- yl)-2,2,2-trifluoroethoxy)-2,2- difluoroethan difluoroethan-l-ol, ol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)propanol, yl)oxy)propanol, 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 20 20 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)-2,2,2-trifluoroethoxy)propanol, yl)-2,2,2-trifluoroethoxy)propanol, 2-(3,8-diazabicyclo[3.2.1]octanyl)((tetrahydro-2H- 2-(3,8-diazabicyclo[3.2.1]octany1)((tetrahydro-2H- pyran pyranyl)oxy)(thiazoly1)benzo[d]oxazole, yl)oxy)(thiazolyl)benzo[d]oxazole, 22-(3,8-diazabicyclo[3.2.1]octany1)(difluoromethoxy) -(3,8-diazabicyclo[3.2.1]octanyl)(difluoromethoxy) 812 812 (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)methylpropanol, yl)oxy)methylpropanol, 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 5 5 yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)-1,1- yl)-2,2,2-trifluoroethoxy)-1,1- difluoropropan difluoropropanol, ol, 3-( 3-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)cyclobutanecarbonitrile, yl)oxy)cyclobutanecarbonitrile, 22-(3-( -(3-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 yl)benzo[d]oxazolyl)oxy)cyclobutyl)propanol, 10 yl)benzo[d]oxazolyl)oxy)cyclobutyl)propanol, 2-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 2-((2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)methylpropanol, yl)oxy)methylpropanol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethoxy)benzo[d]oxazolyl)cyclopropanol, -(trifluoromethoxy)benzo[d]oxazolyl)cyclopropanol, 15 15 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazolyl)cyclopropanol, (trifluoromethoxy)benzo[d]oxazolyl)cyclopropan-l-ol, 3-( 3-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1,1-trifluoropropanol, yl)oxy)-1,1,1-trifluoropropanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(difluoromethoxy)- -(3,6-diazabicyclo[3.1.1]heptanyl)(difluoromethoxy)- 20 20 77-(thiazolyl)benzo[d]oxazole, -(thiazolyl)benzo[d]oxazole, 1-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 1-((2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazolyl)oxy)methylpropanol, yl)benzo[d]oxazolyl)oxy)methylpropanol,
3.-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 3-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 813 813 yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy)-2,3- yl)benzo[d]oxazolyl)-2,2,2-trifluoroethoxy)-2,3- dimethylbutan dimethylbutanol, ol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro(2-methoxy -trifluoro(2-methoxy 5 5 methylpropoxy)ethyl)benzo[d]oxazole, methylpropoxy)ethyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) (2,2,2 (2,2,2-trifluoro( -trifluoro((1 (1- - methoxycyclopropyl)methoxy)ethyl)benzo[d]oxazole, methoxycyclopropyl)methoxy)ethyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(1- -(3,6-diazabicyclo[3.1.1]heptanyl)(1- 10 methoxycyclopropy1)(thiazoly1) methoxycyclopropyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazole, (trifluoromethoxy)benzo[d]oxazole, 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2-trifluoroethoxy) yl)-2,2,2-trifluoroethoxy) methylpropanol, methylpropanol, 15 15 3-( 3-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazolyl)oxy)cyclobutanol, yl)benzo[d]oxazolyl)oxy)cyclobutan-l-ol, 1-( 1-((1 (1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-2,2,2- yl)-2,2,2- trifluoroethoxy)methyl)cyclopropan-l-ol, trifluoroethoxy)methyl)cyclopropanol, 20 20 22-(3,6-diazabicyclo[3.1.1]heptany1)(2-methoxypropan -(3,6-diazabicyclo[3.1.1]heptanyl)(2-methoxypropan yl)(thiazolyl)(trifluoromethoxy)benzo[d]oxazole, y1)(thiazoly1)(trifluoromethoxy)benzo[d]oxazole, 2-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 2-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethoxy)benzo[d]oxazolyl)propanol, -(trifluoromethoxy)benzo[d]oxazolyl)propanol, 814 814 1-((2-(3,6-diazabicyclo[3.1.1]heptany1)(pyridin 1-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(pyridin yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan ol, ol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(oxazol -(3,6-diazabicyclo[3.1.1]heptanyl)(oxazol 5 5 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan ol, ol, 22-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) -(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazolyl)propanol, yl)propanol, 22-(3,6-diazabicyclo[3.1.1]heptanyl)( -(3,6-diazabicyclo[3.1.1]heptanyl)((tetrahydro (tetrahydro-2H- -2H- 10 pyranyl)oxy)(thiazolyl)benzo[d]oxazole, 10 pyranyl)oxy)(thiazoly1)benzo[d]oxazole, 4-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 4-((2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-4,4-difluoromethylbutanol, yl)oxy)-4,4-difluoromethylbutanol, 22-(3,8-diazabicyclo[3.2.1]octany1)(2-methoxypropan -(3,8-diazabicyclo[3.2.1]octanyl)(2-methoxypropan yl) y1)(thiazoly1)(trifluoromethoxy)benzo[d]oxazole, (thiazolyl)(trifluoromethoxy)benzo[d]oxazole, 15 15 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 4-(trifluoromethoxy)benzo[d]oxazolyl)cyclopropanol,
4.-(trifluoromethoxy)benzo[d]oxazolyl)cyclopropanol, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1)- 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl)- 44-(trifluoromethoxy)benzo[d]oxazoly1)-2,2-difluoroethan- -(trifluoromethoxy)benzo[d]oxazolyl)-2,2-difluoroethan- 1-ol, 1-ol, 20 20 (R) (R)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- (trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan-l-ol, difluoroethanol, (S) (S)(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 815 815 y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- yl)(trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan difluoroethan-l-ol, ol, 1-(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazoly1) 1-(2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1)-2,2-difluoroethan yl)-2,2-difluoroethan 5 5 ol, ol, (R) (R)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- (trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan difluoroethan-l-ol, ol, (S) (S)(2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 10 yl) y1)(trifluoromethoxy)benzo[d]oxazoly1)-2,2- (trifluoromethoxy)benzo[d]oxazolyl)-2,2- difluoroethan difluoroethanol, ol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(1H-pyrazol -(3,6-diazabicyclo[3.1.1]heptanyl)(1H-pyrazol yl)benzo[d]ox yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan azolyl)oxy)-1,1-difluoromethylpropan ol, ol, 15 15 44-( -((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)cyclohexan-l-ol, yl)oxy)cyclohexanol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(4- -(3,6-diazabicyclo[3.1.1]heptanyl)(4- methylthiazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro methylthiazolyl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 20 20 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 816 816 yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan ol, ol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropanol, yl)oxy)-1,1-difluoropropanol, 5 5 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropanol, yl)oxy)-1,1-difluoropropanol, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoroethanol, yl)oxy)-2,2-difluoroethanol, 2-( 2-((2 (2-(3,8-diazabicyclo[3.2.1]octanyl)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol 10 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoroethanol, yl)oxy)-2,2-difluoroethanol, 3-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-4,4,4-trifluoromethylbutan yl)oxy)-4,4,4-trifluoromethylbutan ol, ol, 44-( -((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)tetrahydro-2H-thiopyran yl)oxy)tetrahydro-2H-thiopyran 1,1 1,1- - dioxide, dioxide, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(pyridin -(3,6-diazabicyclo[3.1.1]heptanyl)(pyridin yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoroethanol, yl)oxy)-2,2-difluoroethanol, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(1H-pyrazol -(3,8-diazabicyclo[3.2.1]octanyl)(1H-pyrazol 20 20 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan ol, ol, 1-((2-(3,8-diazabicyclo[3.2.1]octany1)(pyridin 1-((2-(3,8-diazabicyclo[3.2.1]octanyl)(pyridin yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan 817 817 ol, ol, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(4- -(3,8-diazabicyclo[3.2.1]octanyl)(4- methylthiazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro methylthiazolyl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 5 5 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(5- -(3,6-diazabicyclo[3.1.1]heptanyl)(5- fluoropyridinyl)benzo[d]oxazolyl)oxy)-2,2- fluoropyridinyl)benzo[d]oxazolyl)oxy)-2,2- difluoroethan difluoroethan-l-ol, ol, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(1H-pyrazol -(3,6-diazabicyclo[3.1.1]heptanyl)(1H-pyrazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoroethanol, yl)oxy)-2,2-difluoroethanol, 10 1-((2-(3,8-diazabicyclo[3.2.1]octanyl)(oxazol 10 1-((2-(3,8-diazabicyclo[3.2.1]octany1)(oxazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan ol, ol, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(2H-1,2,3- -(3,8-diazabicyclo[3.2.1]octanyl)(2H-1,2,3- triazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro triazolyl)benzo[d]oxazolyl)oxy)-1,1-difluoro 15 15 methylpropanol, methylpropanol, 2-(3,6-diazabicyclo[3.1.1]heptanyl)(((S)- 2-(3,6-diazabicyclo[3.1.1]heptany1)(((S)- tetrahydrofuranyl)oxy)(thiazoly1)benzo[d]oxazole, tetrahydrofuranyl)oxy)(thiazolyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)( -(3,6-diazabicyclo[3.1.1]heptanyl)(((R) ((R)- - tetrahydrofuranyl)oxy)(thiazoly1)benzo[d]oxazole, tetrahydrofuranyl)oxy)(thiazolyl)benzo[d]oxazole, 20 20 22-(3,6-diazabicyclo[3.1.1]heptany1)(oxetanyloxy) -(3,6-diazabicyclo[3.1.1]heptanyl)(oxetanyloxy) (thiazolyl)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 3-( 3-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-3,3-difluoromethylpropane- yl)oxy)-3,3-difluoromethylpropane- 818 818 1,2-diol, 1,2-diol, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(1,2,4- -(3,8-diazabicyclo[3.2.1]octanyl)(1,2,4- thiadiazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro thiadiazolyl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 5 5 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(1-methy1-1H- -(3,8-diazabicyclo[3.2.1]octanyl)(1-methyl-1H- pyrazol pyrazoly1)benzo[d]oxazoly1)oxy)-1,1-difluoro yl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(5- -(3,6-diazabicyclo[3.1.1]heptanyl)(5- fluoropyridinyl)benzo[d]oxazoly1)oxy)-1,1-difluoro fluoropyridinyl)benzo[d]oxazolyl)oxy)-1,1-difluoro 10 10 methylpropanol, methylpropanol, 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(pyrimidin -(3,8-diazabicyclo[3.2.1]octanyl)(pyrimidin yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan ol, ol, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octanyl)(isothiazol -(3,8-diazabicyclo[3.2.1]octanyl)(isothiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan ol, ol, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(5- -(3,8-diazabicyclo[3.2.1]octanyl)(5- fluoropyridinyl)benzo[d]oxazoly1)oxy)-1,1-difluoro fluoropyridinyl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 20 20 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(3-methy1-1,2,4- -(3,8-diazabicyclo[3.2.1]octanyl)(3-methyl-1,2,4- thiadiazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro thiadiazolyl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) 819 819 ((trifluoromethyl)sulfonyl)benzo[d]oxazole, (trifluoromethyl)sulfonyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarbonitrile, carbonitrile, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) 5 5 ( ((5 (5-(trifluoromethyl)pyridinyl)oxy)benzo[d]oxazole, -(trifluoromethyl)pyridinyl)oxy)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(pyridinyloxy)- -(3,6-diazabicyclo[3.1.1]heptanyl)(pyridinyloxy)- 77-(thiazolyl)benzo[d]oxazole, -(thiazolyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(pyrimidin -(3,6-diazabicyclo[3.1.1]heptanyl)(pyrimidin yloxy) yloxy)(thiazolyl)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, 10 22-(3,6-diazabicyclo[3.1.1]heptany1)(pyrazinyloxy)- -(3,6-diazabicyclo[3.1.1]heptanyl)(pyrazinyloxy)- 7-(thiazolyl)benzo[d]oxazole, 7-(thiazolyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)( -(3,6-diazabicyclo[3.1.1]heptanyl)((6 (6-methy1 -methyl (trifluoromethyl)pyri (trifluoromethyl)pyridazinyl)oxy)(thiazol dazinyl)oxy)(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 15 15 (6-( (6-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)oxy)pyridiny1)methanol, yl)oxy)pyridinyl)methanol, (6-( (6-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)(trifluoromethyl)pyridin yl)oxy)(trifluoromethyl)pyridin yl)methanol, yl)methanol, 20 20 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) ( ((5-(trifluoromethoxy)pyridinyl)oxy)benzo[d]oxazole, (5-(trifluoromethoxy)pyridinyl)oxy)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)cyclopropy1 -(3,6-diazabicyclo[3.1.1]heptanyl)cyclopropyl (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 820 820 2-(3,6-diazabicyclo[3.1.1]heptany1)(methylthio) 2-(3,6-diazabicyclo[3.1.1]heptanyl)(methylthio) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(methylsulfiny1) -(3,6-diazabicyclo[3.1.1]heptanyl)(methylsulfinyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 5 5 22-(3,6-diazabicyclo[3.1.1]heptany1)(methylsulfony1) -(3,6-diazabicyclo[3.1.1]heptanyl)(methylsulfonyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)thio)ethanol, yl)thio)ethanol, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)sulfinyl)ethanol, yl)sulfinyl)ethanol, 2-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 2-((2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxa yl)benzo[d]oxazolyl)sulfonyl)ethanol, zolyl)sulfonyl)ethanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)( -(3,6-diazabicyclo[3.1.1]heptanyl)((1,1 (1,1- - difluoroallyl)oxy) difluoroallyl)oxy)(thiazoly1)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, 15 15 22-(3,6-diazabicyclo[3.1.1]heptany1)( -(3,6-diazabicyclo[3.1.1]heptanyl)((5 (5- - (methylsulfonyl)pyridin (methylsulfonyl)pyridinyl)oxy)(thiazol yl)oxy)(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-(2-methoxyethyl) -(3,6-diazabicyclo[3.1.1]heptanyl)-N-(2-methoxyethyl) (thiazol (thiazolyl)benzo[d]oxazolecarboxamide, yl)benzo[d]oxazolecarboxamide, 20 20 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazolecarboxamide, yl)benzo[d]oxazolecarboxamide, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-(2-hydroxyethyl) -(3,6-diazabicyclo[3.1.1]heptanyl)-N-(2-hydroxyethyl) (thiazol (thiazolyl)benzo[d]oxazolecarboxamide, yl)benzo[d]oxazolecarboxamide, 821 821 2-(3,6-diazabicyclo[3.1.1]heptany1)-N-(2-hydroxyethyl)-N- 2-(3,6-diazabicyclo[3.1.1]heptanyl)-N-(2-hydroxyethyl)-N- methy1(thiazoly1)benzo[d]oxazolecarboxamide, methyl(thiazolyl)benzo[d]oxazolecarboxamide, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-cyclopropy1 -(3,6-diazabicyclo[3.1.1]heptanyl)-N-cyclopropyl (thiazol (thiazolyl)benzo[d]oxazolecarboxamide, yl)benzo[d]oxazolecarboxamide, 5 5 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-ethy1(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)-N-ethyl(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxamide, carboxamide, (2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1) yl)(morpholino)methanone, (morpholino)methanone, (2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 10 yl)benzo[d]oxazol yl)benzo[d]oxazoly1) yl)(pyr (pyrrolidin-l-y1)methanone, rolidinyl)methanone, N-benzyl(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol- N-benzy1(3,6-diazabicyclo[3.1.1]heptany1)(thiazol- 22-yl)benzo[d]oxazolecarboxamide, -yl)benzo[d]oxazolecarboxamide, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylbutanol, yl)oxy)-1,1-difluoromethylbutanol, 15 15 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(5- -(3,6-diazabicyclo[3.1.1]heptanyl)(5- chloropyridin chloropyridinyl)benzo[d]oxazolyl)oxy)-1,1-difluoro yl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, (R) (R)( ((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-3,3-difluoromethylpropane- yl)oxy)-3,3-difluoromethylpropane- 20 20 1,2-diol, 1,2-diol, (S)((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol (S)( yl)benzo[d]oxazolyl)oxy)-3,3-difluoromethylpropane- yl)benzo[d]oxazolyl)oxy)-3,3-difluoromethylpropane- 1,2-diol, 1,2-diol, 822 822 2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarboxylic carboxylic acid, acid, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-hydroxy(thiazol- -(3,6-diazabicyclo[3.1.1]heptanyl)-N-hydroxy(thiazol- 22-yl)benzo[d]oxazolecarboxamide, -yl)benzo[d]oxazolecarboxamide, 5 5 3-(5-(2-hydroxypropany1)(thiazoly1) 3-(5-(2-hydroxypropanyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1)-3,8- yl)-3,8- diazabicyclo[3.2.1]octan diazabicyclo[3.2.1]octanol, ol, 22-(3,6-diazabicyclo[3.1.1]heptany1)morpholino -(3,6-diazabicyclo[3.1.1]heptanyl)morpholino (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 10 3-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 3-( yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-3,3-difluoropropane-1,2-diol, yl)oxy)-3,3-difluoropropane-1,2-diol, 3-(4-(1,1-difluorohydroxymethylpropoxy)(thiazol 3-(4-(1,1-difluorohydroxymethylpropoxy)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-3,6-diazabicyclo[3.1.1]heptanol, yl)-3,6-diazabicyclo[3.1.1]heptanol, (R) (R)(4-(1,1-difluorohydroxypropoxy)(thiazol (4-(1,1-difluorohydroxypropoxy)(thiazol 15 15 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)-3,6-diazabicyclo[3.1.1]heptanol, yl)-3,6-diazabicyclo[3.1.1]heptanol, (S) (S)(4-(1,1-difluorohydroxypropoxy)(thiazol (4-(1,1-difluorohydroxypropoxy)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-3,6-diazabicyclo[3.1.1]heptanol, yl)-3,6-diazabicyclo[3.1.1]heptanol, 3-(4-(1,1-difluorohydroxyethoxy)(thiazol 3-(4-(1,1-difluorohydroxyethoxy)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)-3,6-diazabicyclo[3.1.1]heptanol, yl)-3,6-diazabicyclo[3.1.1]heptanol, 20 20 3-(5-chloro(thiazoly1) 3-(5-chloro(thiazolyl) (trifluoromethoxy)benzo[d]oxazolyl)-3,8- (trifluoromethoxy)benzo[d]oxazoly1)-3,8- diazabicyclo[3.2.1]octan diazabicyclo[3.2.1]octanol, ol, (2-( (2-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 823 823 yl)benzo[d]oxazolyl)oxy)pyridiny1)methanol, yl)benzo[d]oxazolyl)oxy)pyridinyl)methanol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoropropane-2,2-diol, yl)oxy)-1,1-difluoropropane-2,2-diol, (R) (R)(7-(thiazoly1)(2,2,2-trifluoro (7-(thiazolyl)(2,2,2-trifluoro 5 5 hydroxyethyl)benzo[d]oxazol hydroxyethyl)benzo[d]oxazoly1)-3,8- yl)-3,8- dia diazabicyclo[3.2.1]octanol, zabicyclo[3.2.1]octanol, (S) (S)(7-(thiazoly1)(2,2,2-trifluoro (7-(thiazolyl)(2,2,2-trifluoro hydroxyethyl)benzo[d]oxazol hydroxyethyl)benzo[d]oxazoly1)-3,8- yl)-3,8- diazabicyclo[3.2.1]octan diazabicyclo[3.2.1]octanol, ol, 10 10 3-(7-(thiazoly1)(trifluoromethoxy)benzo[d]oxazol 3-(7-(thiazolyl)(trifluoromethoxy)benzo[d]oxazol yl)-3,6-diazabicyclo[3.1.1]heptanol, y1)-3,6-diazabicyclo[3.1.1]heptanol, 3-(5-(2-hydroxypropany1)(thiazoly1) 3-(5-(2-hydroxypropanyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazol (trifluoromethyl)benzo[d]oxazoly1)-3,8- yl)-3,8- diazabicyclo[3.2.1]octan diazabicyclo[3.2.1]octanol, ol, 15 15 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 3-(5-(1-hydroxyethyl)(thiazoly1) 3-(5-(1-hydroxyethyl)(thiazolyl) (trifluoromethoxy)benzo[d]oxazol (trifluoromethoxy)benzo[d]oxazoly1)-3,8- yl)-3,8- diazabicyclo[3.2.1]octan diazabicyclo[3.2.1]octanol, ol, 20 20 3-(5-(1-hydroxyethyl)(thiazoly1) 3-(5-(1-hydroxyethyl)(thiazolyl) (trifluoromethyl)benzo[d]oxazolyl)-3,8- (trifluoromethyl)benzo[d]oxazoly1)-3,8- diazabicyclo[3.2.1]octan diazabicyclo[3.2.1]octanol, ol, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-(2-hydroxyethyl) -(3,6-diazabicyclo[3.1.1]heptanyl)-N-(2-hydroxyethyl) 824 824 (thiazol (thiazolyl)benzo[d]oxazolesulfonamide, yl)benzo[d]oxazolesulfonamide, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-methy1(thiazol- -(3,6-diazabicyclo[3.1.1]heptanyl)-N-methyl(thiazol- 22-yl)benzo[d]oxazolesulfonamide, -yl)benzo[d]oxazolesulfonamide, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-(2-methoxyethyl) -(3,6-diazabicyclo[3.1.1]heptanyl)-N-(2-methoxyethyl) 5 5 (thiazol (thiazolyl)benzo[d]oxazolesulfonamide, yl)benzo[d]oxazolesulfonamide, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N,N-dimethy1 -(3,6-diazabicyclo[3.1.1]heptanyl)-N,N-dimethyl (thia (thiazolyl)benzo[d]oxazolesulfonamide, zolyl)benzo[d]oxazolesulfonamide, 22-(3,6-diazabicyclo[3.1.1]heptany1)-N-(2-hydroxyethyl)-N- -(3,6-diazabicyclo[3.1.1]heptanyl)-N-(2-hydroxyethyl)-N- methy1(thiazoly1)benzo[d]oxazolesulfonamide, methyl(thiazolyl)benzo[d]oxazolesulfonamide, 10 22-(3,6-diazabicyclo[3.1.1]heptany1)(pyrrolidin-l- -(3,6-diazabicyclo[3.1.1]heptanyl)(pyrrolidin ylsulfonyl)(thiazolyl)benzo[d]oxazole, ylsulfony1)(thiazolyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1) -(3,6-diazabicyclo[3.1.1]heptanyl) (morpholinosulfonyl) (morpholinosulfony1)(thiazoly1)benzo[d]oxazole, (thiazolyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(1,1-difluoro -(3,6-diazabicyclo[3.1.1]heptanyl)(1,1-difluoro 15 15 methoxyethoxy)(thiazolyl)benzo[d]oxazole, methoxyethoxy)(thiazolyl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(1,1-difluoro -(3,6-diazabicyclo[3.1.1]heptanyl)(1,1-difluoro methoxymethylpropoxy)(thiazolyl)benzo[d]oxazole, methoxymethylpropoxy)(thiazolyl)benzo[d]oxazole, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(1-methy1-1H- -(3,6-diazabicyclo[3.1.1]heptanyl)(1-methyl-1H- pyrazol pyrazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro yl)benzo[d]oxazolyl)oxy)-1,1-difluoro 20 20 methylpropanol, methylpropanol, 1-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 1-((2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d] yl)benzo[d]oxazolyl)oxy)-1,1-difluorobutanol, oxazolyl)oxy)-1,1-difluorobutanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 825 825 yl)benzo[d]oxazole yl)benzo[d]oxazolesulfonamide, sulfonamide, 1-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol 1-(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)piperidinol, yl)piperidinol, 44-(2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 5 5 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)thiomorpholine yl)thiomorpholine 1,1 1,1-dioxide, -dioxide, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)bromo -(3,6-diazabicyclo[3.1.1]heptanyl)bromo (thiazol (thiazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro yl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 1-( 1-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)chloro -(3,6-diazabicyclo[3.1.1]heptanyl)chloro 10 (thiazol (thiazolyl)benzo[d]oxazoly1)oxy)-1,1-difluoro yl)benzo[d]oxazolyl)oxy)-1,1-difluoro methylpropanol, methylpropanol, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)chloro -(3,6-diazabicyclo[3.1.1]heptanyl)chloro (thiazol (thiazolyl)benzo[d]oxazoly1)oxy)-2,2-difluoroethan yl)benzo[d]oxazolyl)oxy)-2,2-difluoroethan ol, ol, 15 15 22-(3,6-diazabicyclo[3.1.1]heptany1)(1,1- -(3,6-diazabicyclo[3.1.1]heptanyl)(1,1- difluoropropoxy)(thiazolyl)benzo[d]oxazole, difluoropropoxy)(thiazolyl)benzo[d]oxazole, 44-(benzo[d]oxazolyldifluoromethoxy)(3,6- -(benzo[d]oxazolyldifluoromethoxy)(3,6- diazabicyclo[3.1.1]heptan diazabicyclo[3.1.1]heptany1)(thiazol yl)(thiazol yl)benzo[d]oxazole, yl)benzo[d]oxazole, 20 20 2-( 2-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazo yl)benzo[d]oxazolyl)oxy)-2,2-difluoroethan-l-ol, lyl)oxy)-2,2-difluoroethanol, 1-( 1-((2 (2-(3,8-diazabicyclo[3.2.1]octany1)(thiazol -(3,8-diazabicyclo[3.2.1]octanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-1,1-difluoromethylpropan yl)oxy)-1,1-difluoromethylpropan 826 826 22-(3,6-diazabicyclo[3.1.1]heptany1)( -(3,6-diazabicyclo[3.1.1]heptanyl)((1,1 (1,1-difluoro -difluoro (pyridin (pyridinyl)allyl)oxy)(thiazoly1)benzo[d]oxazole, yl)allyl)oxy)(thiazolyl)benzo[d]oxazole, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 5 5 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoro-N-(2-hydroxyethyl)- yl)oxy)-2,2-difluoro-N-(2-hydroxyethyl)- NN-methylacetamide, -methylacetamide, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoro-N,N- yl)oxy)-2,2-difluoro-N,N- dimethy dimethylacetamide, lacetamide, 10 2-((2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol 10 2-((2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazoly1)oxy)-2,2-difluoromorpholinoethan- yl)oxy)-2,2-difluoromorpholinoethan- 1-one, 1-one, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoroacetamide, yl)oxy)-2,2-difluoroacetamide, 15 15 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoro-N-(2- yl)oxy)-2,2-difluoro-N-(2- hydroxyethyl)acetamide, hydroxyethyl)acetamide, 2-( 2-((2 (2-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)-2,2-difluoro(3- yl)oxy)-2,2-difluoro(3- 20 20 hydroxyazetidin hydroxyazetidinyl)ethanone, yl)ethanone, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazoly1) -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazolyl) ((5 (5-(trifluoromethyl)pyridinyl)oxy)benzo[d]oxazole, -(trifluoromethyl)pyridinyl)oxy)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)cyclobuty1 -(3,6-diazabicyclo[3.1.1]heptanyl)cyclobutyl 827 827 (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, 22-(3,6-diazabicyclo[3.1.1]heptany1)(pyrrolidin-l-y1)- -(3,6-diazabicyclo[3.1.1]heptanyl)(pyrrolidinyl)- 77-(thiazolyl)benzo[d]oxazole, -(thiazolyl)benzo[d]oxazole, (6-( (6-((2 (2-(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol
5.5 yl)benzo[d]oxazol yl)benzo[d]oxazolyl)oxy)pyridinyl)methanol, yl)oxy)pyridinyl)methanol, 22-(3,6-diazabicyclo[3.1.1]heptany1)(thiazol -(3,6-diazabicyclo[3.1.1]heptanyl)(thiazol yl)benzo[d]oxazole yl)benzo[d]oxazolecarbonitrile, carbonitrile, 22-(3,6-diazabicyclo[3.1.1]heptany1)(pyridiny1) -(3,6-diazabicyclo[3.1.1]heptanyl)(pyridinyl) (thiazol (thiazolyl)benzo[d]oxazole, yl)benzo[d]oxazole, or or 10 2-(3,6-diazabicyclo[3.1.1]heptanyl)cyclobutoxy 10 2-(3,6-diazabicyclo[3.1.1]heptany1)cyclobutoxy (thiazolyl)benzo[d]oxazole. (thiazolyl)benzo[d]oxazole.
6.[Claim 6] [Claim 6] A A PDE4 inhibitor PDE4 inhibitor comprising comprising at at least one selected from least one selected from the the group consisting of the compound and the group consisting of the compound and the 15 15 phar pharmacologically macologically acceptable salt thereof according to any acceptable salt thereof according to any one of Claims 1 to 5 as an active ingredient. one of Claims 1 to 5 as an active ingredient.
7.[Claim 7] [Claim 7] A A pharmaceutical composition pharmaceutical composition comprising comprising at at least one least one selected from the group consisting of the compound and the selected from the group consisting of the compound and the 20 20 pharmacologically acceptable pharmacologically acceptable salt salt thereof according to any thereof according to any one of Claims 1 to 5 as an active ingredient. one of Claims 1 to 5 as an active ingredient.
8.[Claim 8 [Claim 8] ] Use of a compound according to anyone of claims 1 to 5 Use of a compound according to anyone of claims 1 to 5 828 828 in in the manufacture of the manufacture of a a medicament medicament for for the the treatment treatment of of a a inflammatory inflammatory disease, disease, fibrosis, fibrosis, central nervous system central nervous system disease, cancerous disease, and metabolic disease disease, cancerous disease, and metabolic disease. . 829 829
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