NZ619257A - Ketamine derivatives - Google Patents
Ketamine derivativesInfo
- Publication number
- NZ619257A NZ619257A NZ619257A NZ61925712A NZ619257A NZ 619257 A NZ619257 A NZ 619257A NZ 619257 A NZ619257 A NZ 619257A NZ 61925712 A NZ61925712 A NZ 61925712A NZ 619257 A NZ619257 A NZ 619257A
- Authority
- NZ
- New Zealand
- Prior art keywords
- oxocyclohexyl
- chlorophenyl
- amino
- compounds
- butanoate
- Prior art date
Links
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical class C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- BEMFAESGNZMDAI-UHFFFAOYSA-N 3-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]propyl acetate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCCOC(=O)C)CCCCC1=O BEMFAESGNZMDAI-UHFFFAOYSA-N 0.000 abstract 1
- 206010039897 Sedation Diseases 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- MLQTZSYHBXPNKI-UHFFFAOYSA-N ethyl 4-[[1-(2-chlorophenyl)-2-oxocyclohexyl]-methylamino]butanoate Chemical compound C=1C=CC=C(Cl)C=1C1(N(C)CCCC(=O)OCC)CCCCC1=O MLQTZSYHBXPNKI-UHFFFAOYSA-N 0.000 abstract 1
- FZIHUEMGZWQMJF-UHFFFAOYSA-N ethyl 4-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]butanoate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCCC(=O)OCC)CCCCC1=O FZIHUEMGZWQMJF-UHFFFAOYSA-N 0.000 abstract 1
- 238000002695 general anesthesia Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- VELFQRXGQQEDQS-UHFFFAOYSA-N propan-2-yl 5-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]pentanoate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCCCC(=O)OC(C)C)CCCCC1=O VELFQRXGQQEDQS-UHFFFAOYSA-N 0.000 abstract 1
- GSLQTNIISBAJKM-UHFFFAOYSA-N propyl 3-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]propanoate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCC(=O)OCCC)CCCCC1=O GSLQTNIISBAJKM-UHFFFAOYSA-N 0.000 abstract 1
- 230000036280 sedation Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
This disclosure relates to a family of compounds of formula (I). These are ketamine derivatives wherein Y1, Y2, X1 and X2 are as defined in the specification. The disclosure also related to pharmaceutical compositions comprising these compounds and methods of providing provide pain relief or analgesia and inducing and maintaining general anesthesia or sedation using these compounds. Examples of the compounds include: 3-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)propyl acetate, n-propyl 3-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)propanoate, ethyl4-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)butanoate, isopropyl 5-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)pentanoate and ethyl 4-((1-(2-chlorophenyl)-2-oxocyclohexyl)(methyl)amino)butanoate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ619257A NZ619257A (en) | 2012-10-08 | 2012-10-08 | Ketamine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ619257A NZ619257A (en) | 2012-10-08 | 2012-10-08 | Ketamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ619257A true NZ619257A (en) | 2015-07-31 |
Family
ID=53773589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ619257A NZ619257A (en) | 2012-10-08 | 2012-10-08 | Ketamine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| NZ (1) | NZ619257A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10869844B2 (en) | 2014-09-15 | 2020-12-22 | Janssen Pharmaceutica Nv | Methods for the treatment of depression |
| US11446260B2 (en) | 2013-03-15 | 2022-09-20 | Janssen Pharmaceutica Nv | Pharmaceutical composition of S-ketamine hydrochloride |
| US11707440B2 (en) | 2017-12-22 | 2023-07-25 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| US11883526B2 (en) | 2019-03-05 | 2024-01-30 | Janssen Pharmaceutica Nv | Esketamine for the treatment of depression |
| US11980596B2 (en) | 2017-09-13 | 2024-05-14 | Janssen Pharmaceutica Nv | Delivery of esketamine for the treatment of depression |
-
2012
- 2012-10-08 NZ NZ619257A patent/NZ619257A/en not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11446260B2 (en) | 2013-03-15 | 2022-09-20 | Janssen Pharmaceutica Nv | Pharmaceutical composition of S-ketamine hydrochloride |
| US10869844B2 (en) | 2014-09-15 | 2020-12-22 | Janssen Pharmaceutica Nv | Methods for the treatment of depression |
| US11173134B2 (en) | 2014-09-15 | 2021-11-16 | Janssen Pharmaceutica Nv | Methods for the treatment of depression |
| US11311500B2 (en) | 2014-09-15 | 2022-04-26 | Janssen Pharmaceutica Nv | Methods for the treatment of depression |
| US11980596B2 (en) | 2017-09-13 | 2024-05-14 | Janssen Pharmaceutica Nv | Delivery of esketamine for the treatment of depression |
| US11707440B2 (en) | 2017-12-22 | 2023-07-25 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| US11883526B2 (en) | 2019-03-05 | 2024-01-30 | Janssen Pharmaceutica Nv | Esketamine for the treatment of depression |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TN2012000371A1 (en) | Pyrazole compounds as crth2 antagonists | |
| IL238327A0 (en) | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof and methods of use | |
| MD20140136A2 (en) | Inhibitors of hepatitis C virus | |
| GEP20176631B (en) | Alkoxy pyrazoles as soluble guanylate cyclase activators | |
| EA201490228A1 (en) | NEW DERIVATIVES OF TRIFTOROMETHYLOROXIAZOLE AND THEIR APPLICATION FOR THE TREATMENT OF DISEASE | |
| IN2015DN01119A (en) | ||
| MX2011012344A (en) | Disaccharin, difumaric acid, di-l-hydroxy-2-naphthoic acid and mono-benzoic acid salts of 4- (dimethylamin0)butyl 2- (4- ( (2-amino-4-methyl-6- (pentylamino) pyrimidin- 5 -yl) methyl) phenyl)acetate. | |
| MX392150B (en) | CANABINOID RECEPTOR MODULATORS. | |
| IN2014CN04530A (en) | ||
| IN2012DN03182A (en) | ||
| TN2015000574A1 (en) | Compounds and compositions as inhibitors of mek | |
| GEP20186880B (en) | 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease | |
| WO2013061004A8 (en) | Novel disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases | |
| MX2014004858A (en) | Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies. | |
| MY172729A (en) | Pharmaceutical formulations | |
| HU0700473D0 (en) | Pharmaceutical compositions containing silicones of high volatility | |
| MX360330B (en) | Administration regime for nitrocatechols. | |
| NZ619257A (en) | Ketamine derivatives | |
| IN2014DN02926A (en) | ||
| GEP201606566B (en) | Isoxazolidine derivatives | |
| GB201305247D0 (en) | Amide Compounds | |
| MX2009010483A (en) | 5-oxo-isoxazoles as inhibitors of lipases and phospholipases. | |
| UA103290C2 (en) | Pharmaceutical composition of ibuprofen for injection | |
| WO2014166836A8 (en) | Growth hormone compound formulation | |
| EA201291401A1 (en) | NEW ANTI-FIRING DERIVATIVES 5,6-DIHYDRO-4 - [(DIFTOROTHYL) PHENYL] -4H-PIRROLO [1,2-a] [1,4] BENZODIAZEPINA and 4- (DIFTORETHYL) PHENYL-6H-PIERR-RIR-6H-PIERR a] [1,4] BENZODIAZEPINA |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 DEC 2018 BY PATRIX IP SERVICES Effective date: 20171025 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 DEC 2019 BY AJ PARK Effective date: 20181112 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 19 DEC 2020 BY AJ PARK Effective date: 20191112 |
|
| LAPS | Patent lapsed |