NZ525368A - Novel aggrecanase molecules - Google Patents
Novel aggrecanase moleculesInfo
- Publication number
- NZ525368A NZ525368A NZ525368A NZ52536801A NZ525368A NZ 525368 A NZ525368 A NZ 525368A NZ 525368 A NZ525368 A NZ 525368A NZ 52536801 A NZ52536801 A NZ 52536801A NZ 525368 A NZ525368 A NZ 525368A
- Authority
- NZ
- New Zealand
- Prior art keywords
- aggrecanase
- antibodies
- enzymes
- inhibitors
- novel aggrecanase
- Prior art date
Links
- 108010003059 aggrecanase Proteins 0.000 title abstract 7
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 210000001188 articular cartilage Anatomy 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The identification of aggrecanase protein molecules capable of cleaving aggrecanase, the nucleotide sequences which encode aggrecanase enzymes and the processes for the production of aggrecanases are disclosed. The composition comprises the aggrecanase enzymes, the antibodies and methods for developing inhibitors of the aggrecanase. The inhibitors and antibodies may be used in the treatment of conditions characterised by degradation of articular cartilage.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24231700P | 2000-10-20 | 2000-10-20 | |
| PCT/US2001/032596 WO2002034895A2 (en) | 2000-10-20 | 2001-10-17 | Novel aggrecanase molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ525368A true NZ525368A (en) | 2006-03-31 |
Family
ID=22914296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ525368A NZ525368A (en) | 2000-10-20 | 2001-10-17 | Novel aggrecanase molecules |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1326967A2 (en) |
| JP (2) | JP2004512043A (en) |
| AU (1) | AU2002245758A1 (en) |
| BR (1) | BR0114719A (en) |
| CA (1) | CA2426463A1 (en) |
| CZ (1) | CZ2003996A3 (en) |
| MX (1) | MXPA03003425A (en) |
| NO (1) | NO20031649L (en) |
| NZ (1) | NZ525368A (en) |
| PL (1) | PL362008A1 (en) |
| SK (1) | SK4632003A3 (en) |
| WO (1) | WO2002034895A2 (en) |
| ZA (1) | ZA200303865B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20241562T1 (en) | 2017-06-02 | 2025-01-31 | Merck Patent Gmbh | Adamts binding immunoglobulins |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391610B1 (en) * | 1999-08-06 | 2002-05-21 | The Cleveland Clinic Foundation | Nucleic acids encoding zinc metalloproteases |
| AU7717800A (en) * | 1999-09-27 | 2001-04-30 | Curagen Corporation | Novel polynucleotides encoding proteins containing thrombospondin type 1 repeats |
-
2001
- 2001-10-17 JP JP2002537866A patent/JP2004512043A/en not_active Withdrawn
- 2001-10-17 PL PL36200801A patent/PL362008A1/en unknown
- 2001-10-17 BR BR0114719-6A patent/BR0114719A/en not_active IP Right Cessation
- 2001-10-17 CA CA002426463A patent/CA2426463A1/en not_active Abandoned
- 2001-10-17 EP EP01988767A patent/EP1326967A2/en not_active Ceased
- 2001-10-17 WO PCT/US2001/032596 patent/WO2002034895A2/en not_active Ceased
- 2001-10-17 NZ NZ525368A patent/NZ525368A/en unknown
- 2001-10-17 MX MXPA03003425A patent/MXPA03003425A/en active IP Right Grant
- 2001-10-17 AU AU2002245758A patent/AU2002245758A1/en not_active Abandoned
- 2001-10-17 CZ CZ2003996A patent/CZ2003996A3/en unknown
- 2001-10-17 SK SK463-2003A patent/SK4632003A3/en not_active Application Discontinuation
-
2003
- 2003-04-10 NO NO20031649A patent/NO20031649L/en not_active Application Discontinuation
- 2003-05-19 ZA ZA200303865A patent/ZA200303865B/en unknown
-
2008
- 2008-05-07 JP JP2008121344A patent/JP2008301813A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002034895A3 (en) | 2002-10-10 |
| SK4632003A3 (en) | 2004-05-04 |
| AU2002245758A1 (en) | 2002-05-06 |
| ZA200303865B (en) | 2004-08-19 |
| PL362008A1 (en) | 2004-10-18 |
| NO20031649L (en) | 2003-06-11 |
| MXPA03003425A (en) | 2004-05-04 |
| JP2004512043A (en) | 2004-04-22 |
| WO2002034895A2 (en) | 2002-05-02 |
| JP2008301813A (en) | 2008-12-18 |
| BR0114719A (en) | 2004-01-27 |
| CZ2003996A3 (en) | 2004-04-14 |
| NO20031649D0 (en) | 2003-04-10 |
| CA2426463A1 (en) | 2002-05-02 |
| EP1326967A2 (en) | 2003-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |