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NZ502862A - Optically pure camptothecin analogues, optically pure synthesis intermediate and method for preparing same - Google Patents

Optically pure camptothecin analogues, optically pure synthesis intermediate and method for preparing same

Info

Publication number
NZ502862A
NZ502862A NZ502862A NZ50286298A NZ502862A NZ 502862 A NZ502862 A NZ 502862A NZ 502862 A NZ502862 A NZ 502862A NZ 50286298 A NZ50286298 A NZ 50286298A NZ 502862 A NZ502862 A NZ 502862A
Authority
NZ
New Zealand
Prior art keywords
optically pure
preparing same
synthesis intermediate
camptothecin analogues
camptothecin
Prior art date
Application number
NZ502862A
Inventor
Jean-Bernard Cazaux
Olivier Lavergne
Breton Christine Le
Eric Manginot
Dennis Bigg
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of NZ502862A publication Critical patent/NZ502862A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)

Abstract

An analogue of camptothecin characterized in that it possesses one of the general formulae (I) or (II). These analogues of camptothecin can be used for producing antitumoral, antiviral or antiparasitic medicines.
NZ502862A 1997-08-29 1998-08-07 Optically pure camptothecin analogues, optically pure synthesis intermediate and method for preparing same NZ502862A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710785A FR2768431B1 (en) 1997-08-29 1997-08-29 NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS, A NEW OPTICALLY PURE SYNTHESIS INTERMEDIATE AND PROCESS FOR PREPARING THE SAME
PCT/FR1998/001768 WO1999011646A1 (en) 1997-08-29 1998-08-07 Optically pure camptothecin analogues, optically pure synthesis intermediate and method for preparing same

Publications (1)

Publication Number Publication Date
NZ502862A true NZ502862A (en) 2002-10-25

Family

ID=9510590

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ502862A NZ502862A (en) 1997-08-29 1998-08-07 Optically pure camptothecin analogues, optically pure synthesis intermediate and method for preparing same

Country Status (25)

Country Link
EP (2) EP1378512A1 (en)
JP (1) JP2001514261A (en)
KR (1) KR100570254B1 (en)
CN (3) CN1104434C (en)
AR (1) AR016856A1 (en)
AT (1) ATE253069T1 (en)
AU (1) AU760863B2 (en)
BR (1) BR9811405A (en)
CA (1) CA2301739C (en)
CZ (1) CZ297896B6 (en)
DE (1) DE69819340T2 (en)
DK (1) DK1007527T3 (en)
ES (1) ES2209196T3 (en)
FR (1) FR2768431B1 (en)
HR (1) HRP20000110A2 (en)
HU (1) HUP0003429A3 (en)
IL (2) IL134437A0 (en)
NO (1) NO324882B1 (en)
NZ (1) NZ502862A (en)
PL (1) PL195289B1 (en)
PT (1) PT1007527E (en)
RU (1) RU2233283C2 (en)
TW (1) TW419479B (en)
WO (1) WO1999011646A1 (en)
ZA (1) ZA987445B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (en) 1999-02-26 2004-09-10 Sod Conseils Rech Applic NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
CN100408582C (en) * 2004-02-12 2008-08-06 中国人民解放军第二军医大学 Homocamptothecin compound and its preparation method and use
CA2580747A1 (en) * 2004-09-21 2006-03-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R .A.S.) Novel processes for the production of useful intermediates
CN100465175C (en) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-position substituted homocamptothecin compound and its use as medicine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3008226B2 (en) * 1991-01-16 2000-02-14 第一製薬株式会社 Hexacyclic compounds
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
FR2757514B1 (en) * 1996-12-20 1999-02-12 Sod Conseils Rech Applic NOVEL CAMPTOTHECIN ANALOGS, PREPARATION METHODS, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP3576171B2 (en) * 1995-06-21 2004-10-13 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） Novel homolog of camptothecin, method for producing the same, use thereof as a medicament, and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
EP1378512A1 (en) 2004-01-07
CN1195758C (en) 2005-04-06
CN1440973A (en) 2003-09-10
KR100570254B1 (en) 2006-04-12
ATE253069T1 (en) 2003-11-15
CA2301739A1 (en) 1999-03-11
AU8989698A (en) 1999-03-22
NO324882B1 (en) 2007-12-27
DE69819340T2 (en) 2004-08-19
EP1007527B1 (en) 2003-10-29
RU2233283C2 (en) 2004-07-27
WO1999011646A1 (en) 1999-03-11
TW419479B (en) 2001-01-21
HK1058665A1 (en) 2004-05-28
CZ297896B6 (en) 2007-04-25
AU760863B2 (en) 2003-05-22
CZ2000711A3 (en) 2000-08-16
CN1104434C (en) 2003-04-02
CA2301739C (en) 2009-11-17
HK1031732A1 (en) 2001-06-22
NO20000995L (en) 2000-02-28
ZA987445B (en) 1999-02-17
HUP0003429A3 (en) 2002-11-28
PT1007527E (en) 2004-03-31
FR2768431B1 (en) 2000-03-24
FR2768431A1 (en) 1999-03-19
HUP0003429A1 (en) 2001-07-30
DK1007527T3 (en) 2004-03-08
BR9811405A (en) 2000-08-29
PL338835A1 (en) 2000-11-20
AR016856A1 (en) 2001-08-01
PL195289B1 (en) 2007-08-31
JP2001514261A (en) 2001-09-11
IL134437A (en) 2006-08-01
ES2209196T3 (en) 2004-06-16
HRP20000110A2 (en) 2001-02-28
EP1007527A1 (en) 2000-06-14
CN1440972A (en) 2003-09-10
CN1268948A (en) 2000-10-04
KR20010023394A (en) 2001-03-26
IL134437A0 (en) 2001-04-30
DE69819340D1 (en) 2003-12-04
NO20000995D0 (en) 2000-02-28

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