NZ508981A - Means and methods for monitoring nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS - Google Patents
Means and methods for monitoring nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDSInfo
- Publication number
- NZ508981A NZ508981A NZ508981A NZ50898199A NZ508981A NZ 508981 A NZ508981 A NZ 508981A NZ 508981 A NZ508981 A NZ 508981A NZ 50898199 A NZ50898199 A NZ 50898199A NZ 508981 A NZ508981 A NZ 508981A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hiv
- reverse transcriptase
- aids
- monitoring
- treatment
- Prior art date
Links
- 238000011225 antiretroviral therapy Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 title 1
- 229940122313 Nucleoside reverse transcriptase inhibitor Drugs 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000035772 mutation Effects 0.000 abstract 2
- 108020004705 Codon Proteins 0.000 abstract 1
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A method of assessing the effectiveness of nucleoside reverse transcriptase antiretroviral therapy of an HIV- infected patient comprising evaluating whether a plasma sample from said HIV-infected patient contains a nucleic acid encoding HIV reverse transcriptase having a mutation/insertion at codon 69, wherein the presence of the mutation is correlated with decreased susceptibility to d4T.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10429598A | 1998-06-24 | 1998-06-24 | |
| PCT/US1999/014486 WO1999067427A1 (en) | 1998-06-24 | 1999-06-24 | Means and methods for monitoring nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of hiv/aids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ508981A true NZ508981A (en) | 2004-02-27 |
Family
ID=22299700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ508981A NZ508981A (en) | 1998-06-24 | 1999-06-24 | Means and methods for monitoring nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1015642A4 (en) |
| JP (1) | JP2003503004A (en) |
| CN (1) | CN1154747C (en) |
| AU (1) | AU769927B2 (en) |
| BR (1) | BR9912209A (en) |
| CA (1) | CA2341679A1 (en) |
| MX (1) | MXPA00012843A (en) |
| NZ (1) | NZ508981A (en) |
| WO (1) | WO1999067427A1 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7037644B1 (en) | 1998-05-26 | 2006-05-02 | Virologic, Inc. | Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
| JP2003501051A (en) | 1999-05-28 | 2003-01-14 | ビルコ・エヌ・ブイ | Novel mutation profile in HIV-1 reverse transcriptase correlates with phenotypic drug resistance |
| US7186506B1 (en) | 2000-06-12 | 2007-03-06 | Monogram Biosciences, Inc. | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
| US7138231B2 (en) | 2000-09-15 | 2006-11-21 | Monogram Biosciences, Inc. | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
| US6869759B1 (en) | 1999-06-22 | 2005-03-22 | Virologic, Inc. | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
| AU2007203337B2 (en) * | 2000-04-18 | 2009-12-17 | Virco Bvba | Methods for measuring drug resistance |
| DE60135366D1 (en) | 2000-04-18 | 2008-09-25 | Virco Bvba | METHOD FOR DETERMINING RESISTANCE TO MEDICAMENTS |
| US20040073378A1 (en) | 2000-10-20 | 2004-04-15 | Dehertogh Pascale Alfons Rosa | Mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
| US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
| US7384734B2 (en) | 2002-02-15 | 2008-06-10 | Monogram Biosciences, Inc. | Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors |
| ATE397669T1 (en) | 2002-07-01 | 2008-06-15 | Tibotec Pharm Ltd | MUTATION PROFILES IN HIV-1 REVERSE TRANSCRIPTASE CORRELATED WITH PHENOTYPICAL DRUG RESISTANCE |
| CA2490862A1 (en) | 2002-07-01 | 2004-01-08 | Tibotec Pharmaceuticals Ltd. | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
| TW200413720A (en) | 2002-07-01 | 2004-08-01 | Virologic Inc | Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors |
| TW200411180A (en) | 2002-07-01 | 2004-07-01 | Virologic Inc | Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors |
| WO2006089045A2 (en) | 2005-02-18 | 2006-08-24 | Monogram Biosciences, Inc. | Methods and compositions for determining hypersusceptibility of hiv-1 to non-nucleoside reverse transcriptase inhibitors |
| EP1896618A4 (en) | 2005-05-27 | 2009-12-30 | Monogram Biosciences Inc | METHOD AND COMPOSITIONS FOR DETERMINING THE RESISTANCE OF HIV-1 AGAINST PROTEASE INHIBITORS |
| WO2006133267A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs |
| US10480037B2 (en) | 2011-09-23 | 2019-11-19 | Laboratory Corporation Of America Holdings | Methods and systems for predicting HIV-1 coreceptor tropism |
| CN103965302B (en) * | 2013-01-29 | 2019-05-28 | 军事科学院军事医学研究院微生物流行病研究所 | A kind of recombination super antigen SEB mutant, preparation method and application |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087093A (en) * | 1996-01-26 | 2000-07-11 | Innogenetics N.V. | Method for detection of drug-induced mutations in the reverse transcriptase gene |
| CA2216126C (en) * | 1996-01-29 | 2009-03-31 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
-
1999
- 1999-06-24 AU AU49611/99A patent/AU769927B2/en not_active Ceased
- 1999-06-24 WO PCT/US1999/014486 patent/WO1999067427A1/en not_active Ceased
- 1999-06-24 BR BR9912209-0A patent/BR9912209A/en not_active IP Right Cessation
- 1999-06-24 CN CNB998134791A patent/CN1154747C/en not_active Expired - Fee Related
- 1999-06-24 EP EP99933581A patent/EP1015642A4/en not_active Withdrawn
- 1999-06-24 MX MXPA00012843A patent/MXPA00012843A/en unknown
- 1999-06-24 CA CA002341679A patent/CA2341679A1/en not_active Abandoned
- 1999-06-24 JP JP2000556067A patent/JP2003503004A/en active Pending
- 1999-06-24 NZ NZ508981A patent/NZ508981A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1015642A4 (en) | 2005-03-23 |
| WO1999067427A9 (en) | 2000-03-30 |
| EP1015642A1 (en) | 2000-07-05 |
| CN1154747C (en) | 2004-06-23 |
| JP2003503004A (en) | 2003-01-28 |
| CA2341679A1 (en) | 1999-12-29 |
| MXPA00012843A (en) | 2002-04-24 |
| CN1332804A (en) | 2002-01-23 |
| AU769927B2 (en) | 2004-02-12 |
| BR9912209A (en) | 2002-11-05 |
| AU4961199A (en) | 2000-01-10 |
| WO1999067427A1 (en) | 1999-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |