NZ292991A - Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them - Google Patents

Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them

Info

Publication number: NZ292991A
Authority: NZ; New Zealand
Prior art keywords: tetrahydropyrazolopyridines; pde; phosphodiesterase; tnf; bicyclic
Prior art date: 1994-10-20

Application number

NZ292991A

Other languages

English (en)

Inventor

Allen J Duplantier

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-20

Filing date

1995-10-06

Publication date

1999-02-25

1995-10-06 Application filed by Pfizer filed Critical Pfizer

1999-02-25 Publication of NZ292991A publication Critical patent/NZ292991A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Virology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NZ292991A 1994-10-20 1995-10-06 Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them NZ292991A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32643494A	1994-10-20	1994-10-20
PCT/IB1995/000847 WO1996012720A1 (en)	1994-10-20	1995-10-06	Bicyclic tetrahydro pyrazolopyridines and their use as medicaments

Publications (1)

Publication Number	Publication Date
NZ292991A true NZ292991A (en)	1999-02-25

Family

ID=23272184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ292991A NZ292991A (en)	1994-10-20	1995-10-06	Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them

Country Status (16)

Country	Link
EP (1)	EP0787132A1 (xx)
JP (1)	JPH09511758A (xx)
KR (1)	KR970707124A (xx)
CN (1)	CN1050129C (xx)
AU (1)	AU702105B2 (xx)
BR (1)	BR9504491A (xx)
CZ (1)	CZ120097A3 (xx)
FI (1)	FI954991L (xx)
HU (1)	HUT77517A (xx)
IL (1)	IL115667A0 (xx)
MX (1)	MX9504422A (xx)
NO (1)	NO971811L (xx)
NZ (1)	NZ292991A (xx)
PL (1)	PL319758A1 (xx)
WO (1)	WO1996012720A1 (xx)
ZA (1)	ZA958839B (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP1147A (en) *	1996-05-03	2003-02-25	Pfizer	Substituted indazole derivatives and related compounds.
WO1997048697A1 (en) *	1996-06-19	1997-12-24	Rhone-Poulenc Rorer Limited	Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
HUP9903009A3 (en) *	1996-06-25	2002-01-28	Pfizer	Substituted indazole derivatives and their use as phosphodiesterase (pde) type iv and tumor necrosis factor (tnf) inhibitors
WO1998050367A1 (en)	1997-05-08	1998-11-12	Pfizer Products Inc.	Processes and intermediates for preparing substituted indazole derivatives
IL126745A (en) *	1997-11-04	2003-09-17	Pfizer Prod Inc	Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
WO2000039131A1 (en)	1998-12-23	2000-07-06	Du Pont Pharmaceuticals Company	Nitrogen containing heterobicycles as factor xa inhibitors
US6858616B2 (en)	1998-12-23	2005-02-22	Bristol-Myers Squibb Pharma Company	Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en)	1999-04-30	2001-12-04	Pfizer Inc.	Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
CZ302882B6 (cs)	1999-08-21	2012-01-04	Nycomed Gmbh	Farmaceutický prostredek
CA2416527C (en) *	2000-08-10	2009-12-22	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US6998408B2 (en)	2001-03-23	2006-02-14	Bristol-Myers Squibb Pharma Company	6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
EP1379244A4 (en)	2001-04-18	2006-03-15	Bristol Myers Squibb Co	1,4,5,6-TETRAHYDROPYRAZOLO-3,4-C] -PYRIDINE-7-ONE AS FACTOR XA HEMMER
CA2444571A1 (en)	2001-04-18	2002-10-31	Bristol-Myers Squibb Company	1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c\|-pyridin-7-ones as factor xa inhi bitors
JP4196678B2 (ja)	2001-04-26	2008-12-17	味の素株式会社	複素環化合物
TWI331526B (en)	2001-09-21	2010-10-11	Bristol Myers Squibb Pharma Co	Lactam-containing compounds and derivatives thereof as factor xa inhibitors
SI1427415T1 (sl)	2001-09-21	2009-12-31	Bristol Myers Squibb Co	Sestavine, ki vsebujejo laktame in njihovi derivati kot inhibitorji faktorja xa
CA2493625A1 (en) *	2002-07-25	2004-02-19	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
BRPI0409229A (pt)	2003-04-01	2006-03-28	Applied Research Systems	inibidores das fosfodiesterases na infertilidade
FR2857363B1 (fr) *	2003-07-10	2007-09-07	Aventis Pharma Sa	4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c] pyridines substituees compositions les contenant et utilisation
AR045037A1 (es) *	2003-07-10	2005-10-12	Aventis Pharma Sa	Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
KR20080073359A (ko) *	2005-12-01	2008-08-08	엘란 파마슈티칼스, 인크.	5(아릴설포닐)피라졸로피페리딘
JP2011519372A (ja) *	2008-04-30	2011-07-07	フレードリク・アルムクヴィスト	新規ペプチド摸倣化合物
US7741350B1 (en)	2009-01-28	2010-06-22	Cara Therapeutics, Inc.	Bicyclic pyrazolo-heterocycles
CA2749884C (en)	2009-01-28	2018-01-23	Cara Therapeutics, Inc.	Bicyclic pyrazolo-heterocycles
US10144732B2 (en)	2014-06-06	2018-12-04	Biogen Ma Inc.	ATX modulating agents
CN115043768A (zh) *	2022-06-20	2022-09-13	新乡市润宇新材料科技有限公司	一种酸促进环丙基开环合成n-芳基吡咯烷-2-酮的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3340269A (en) *	1964-09-08	1967-09-05	Ciba Geigy Corp	1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) *	1964-09-08	1968-01-23	Ciba Geigy Corp	Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
FR1463883A (fr) *	1964-09-08	1966-07-22	Ciba Geigy	Procédé de préparation de triaza-composés bicycliques
CA2166721C (en) *	1993-07-06	1999-07-27	Allen Jacob Duplantier	Bicyclic tetrahydro pyrazolopyridines

1995
- 1995-10-06 JP JP8513751A patent/JPH09511758A/ja active Pending
- 1995-10-06 CZ CZ971200A patent/CZ120097A3/cs unknown
- 1995-10-06 NZ NZ292991A patent/NZ292991A/xx unknown
- 1995-10-06 KR KR1019970702557A patent/KR970707124A/ko not_active Abandoned
- 1995-10-06 PL PL95319758A patent/PL319758A1/xx unknown
- 1995-10-06 EP EP95932148A patent/EP0787132A1/en not_active Withdrawn
- 1995-10-06 AU AU35317/95A patent/AU702105B2/en not_active Ceased
- 1995-10-06 WO PCT/IB1995/000847 patent/WO1996012720A1/en not_active Ceased
- 1995-10-06 HU HU9702289A patent/HUT77517A/hu unknown
- 1995-10-06 CN CN95195743A patent/CN1050129C/zh not_active Expired - Fee Related
- 1995-10-18 IL IL11566795A patent/IL115667A0/xx unknown
- 1995-10-19 FI FI954991A patent/FI954991L/fi unknown
- 1995-10-19 ZA ZA958839A patent/ZA958839B/xx unknown
- 1995-10-19 MX MX9504422A patent/MX9504422A/es unknown
- 1995-10-20 BR BR9504491A patent/BR9504491A/pt not_active Application Discontinuation
1997
- 1997-04-18 NO NO971811A patent/NO971811L/no unknown

Also Published As

Publication number	Publication date
AU3531795A (en)	1996-05-15
FI954991A7 (fi)	1996-04-21
HUT77517A (hu)	1998-05-28
CN1161040A (zh)	1997-10-01
NO971811L (no)	1997-06-18
AU702105B2 (en)	1999-02-11
FI954991A0 (fi)	1995-10-19
WO1996012720A1 (en)	1996-05-02
MX9504422A (es)	1997-04-30
FI954991L (fi)	1996-04-21
IL115667A0 (en)	1996-01-19
NO971811D0 (no)	1997-04-18
EP0787132A1 (en)	1997-08-06
KR970707124A (ko)	1997-12-01
CN1050129C (zh)	2000-03-08
PL319758A1 (en)	1997-08-18
JPH09511758A (ja)	1997-11-25
ZA958839B (en)	1997-04-21
CZ120097A3 (cs)	1998-01-14
BR9504491A (pt)	1997-05-20

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