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NZ210022A - Heat sterilisable polymeric laminate - Google Patents

Heat sterilisable polymeric laminate

Info

Publication number
NZ210022A
NZ210022A NZ210022A NZ21002284A NZ210022A NZ 210022 A NZ210022 A NZ 210022A NZ 210022 A NZ210022 A NZ 210022A NZ 21002284 A NZ21002284 A NZ 21002284A NZ 210022 A NZ210022 A NZ 210022A
Authority
NZ
New Zealand
Prior art keywords
ethylene
layer
vinyl acetate
propylene
weight
Prior art date
Application number
NZ210022A
Inventor
F Martini
Original Assignee
Grace W R & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grace W R & Co filed Critical Grace W R & Co
Publication of NZ210022A publication Critical patent/NZ210022A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/306—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl acetate or vinyl alcohol (co)polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2305/00—Condition, form or state of the layers or laminate
    • B32B2305/72—Cured, e.g. vulcanised, cross-linked
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/30—Properties of the layers or laminate having particular thermal properties
    • B32B2307/308—Heat stability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1334—Nonself-supporting tubular film or bag [e.g., pouch, envelope, packet, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/28—Web or sheet containing structurally defined element or component and having an adhesive outermost layer
    • Y10T428/2813—Heat or solvent activated or sealable
    • Y10T428/2817—Heat sealable
    • Y10T428/2826—Synthetic resin or polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31909—Next to second addition polymer from unsaturated monomers
    • Y10T428/31928—Ester, halide or nitrile of addition polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31935—Ester, halide or nitrile of addition polymer

Landscapes

  • Laminated Bodies (AREA)
  • Packages (AREA)
  • Bag Frames (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A heat-sterilizable laminate film especially useful for making disposible pouches for sterile injectable compositions comprises an ethylene-vinyl acetate copolymer layer and on either side of the said layer a layer of a propylene-ethylene copolymer which may contain an impact modifier. The laminate may be cross-linked by irradiation.

Description

New Zealand Paient Spedficaiion for Paient Number £10022 2 10022 I>A; - • ' Priority Oste(s): *£.? Complate Specification Fil Class: 3 ?£$&/<?.?**.. 3&$Ati/rA ....
Publication Date: P.!??/., P.O. Journal, Mo: no nmnms NEW ZEALAND PATENTS ACT, 1953 No.: Date: COMPLETE SPECIFICATION HEAT STERILIZABLE LAMINATE FILMS o 'i-W I/We, W R GRACE & CC. , a corporation organized and existing under the laws of the State of Connecticut, U.S.A., of 1114 'Avenue of the Americas, New York, N.Y. 10036 U.S.A. hereby declare the invention for which I / we pray that a patent may, be granted to me /us, and the method by which it is to be performed, to be particularly described in and by the following statement: - 1 - (followed by page -la-) 210022 <D - Iq- ' HEAT STERILIZABLE LAMINATE FILMS This invention relates to heat sterilizable laminated films suitable inter alia for the packaging of liquids for parenteral administration.
It is convenient in current medical practice 5 for liquids for parenteral administration to be supplied in the form of disposable, flexible pouches. Such pouches must be collapsible, transparent, and of adequate mechanical strength. They must also be able to resist the relatively high temperatures required 10 for heat sterilization of their contents. At present, such flexible pouches are customarily made of highly plasticized polyvinyl chloride. While this material meets the requirements mentioned, it is not entirely satifactory because of the possibility of migration 15 of plasticizer from the polyvinyl chloride into the contents of the pouch so that the latter becomes contaminated by potentially toxic material. Until now, however, no satisfactory alternative to highly plasticized polyvinyl chloride has been available.
C, 20 The present invention provides a novel heat ' sterilizable laminate suitable for making flexible pouches for liquids for parenteral administration, which are made from substantially non-toxic materials which ||p possess satisfactory properties without the incorporation of any additives which might present a toxicity problem. o * 21002: - 2 - ■ (.
The heat sterilizable laminate films of the present invention coirprise a layer of an ethylene-vinyl acetate copolymer containing 18 to 40 percent by weight of vinyl acetate units and, on each side of the said 5 layer, a layer of 60 to 100 percent by weight of a propylene—ethylene copolymer containing 2 to 4.5 percent O by weight of ethylene units, and 40 to 0 percent by weight of an impact modifier containing 30 to 63 parts by weight of an ethylene-propylene elastomer or ethylene-10 propylene-diene elastomer having an ethylene content of 55 to 70 weight percent and 70 to 37 parts by weight of a thermoplastic ethylane -vinyl acetate copolymer containing 9 to 40 percent of vinyl acetate units.
These three layers may constitute the whole 15 of the laminate film, but it is within the scope, of the invention to provide additional layers, more especially for the purpose of improving the bonding between the specified ethylene-vinyl acetate and propylene-ethylene copolymer layers, and/or improving the barrier properties of.the ; 20 laminate by inclusion of an oxygen barrier layer such as a layer based on polyvinylidene dichloride. Normally, the ethylene-propylene copolymer layers are on the surface of the laminate, and the ethylene-vinyl acetate copolymer : layer or layers are internal layers of the film. 25 The ethylene-vinyl acetate copolymer used; in the novel laminates contains 18 to 40 percent and preferably 18 to 30 percent by weight of vinyl acetate units. Such copolymers are commercially available. ■••:.- ■:/:■• r--^-r '. .vV •,^v.:-;' >;/ '■„•'■. / - , - r .# J 2 10022 Typical such copolymers have a melt flow index of 3 0.7 to 7 g/10 mins. , a density of 0.930 to 0.970 g/cm , and a Vicat softening point of 40 to 80°C.
The propylene-ethylene copolymer used in the 5 new films contains 2 to 4.5, and preferably about 4 percent by weight of ethylene units. Such copolymers are commercially available and typical such polymers have a melt flow index of 3 to 7 g/10 mins., a density of 0.890 to 0.910 g/cm^, and a Vicat softening 10 point of 120 to 130°C.
Preferably, the properties, and in particular the mechanical resistance, of the propylene-ethylene copolymer layer are improved by incorporation therein of an impact modifier. Appropriate impact modifiers 15 contain 30 to 63 parts by weight of an ethylene-propylene or ethylene-propylene-diene elastomer having an ethylene content of 55 to 70 weight percent and 30 to 37 parts by weight (for each 100 parts by weight in all) of a thermoplastic ethylene-vinyl acetate copolymer containing 20 9 to 40 percent by weight of vinyl acetate units.Such impact modifiers are commercially- available and are described in particular in European Patent Publication No. 32804 (Exxon Research Engineering Co. ) . The liquid hydrocarbon process oils referred to in that publication are not 25 however included in the impact modifiers used herein The novel laminates may advantageously be cross-linked in. order to inprove their mechanical properties.
Such cross-linking is particularly advantageous when no impact modifier is included in the layers; based -- vi; on the propylene-ethylene copolymer, but may also give a valuable improvement in the properties of the laminate even when the impact modifier is included. In such cases, the adhesion of the ethylene-propylene copolymer layers to the 5 ethylene-vinyl acetate copolymer layers may be improved by effecting cross-linking by irradiation of the laminate after it has been formed. A dosage of 1 to 6 and preferably about 2 megarad is generally appropriate.
The laminates of the present invention are not 10 oriented, but are conveniently produced by hot blowing or water quench co-extrusion to produce film having the required thickness. The individual layers of the laminate may be co-extruded through a multi-layer circular die in accordance with techniques which are well known in the art. 15 The laminate films of the present invention have properties which make them particularly suitable for manufacture of flexible pouches designed to contain liquids for parenteral administration. The pouches are transparent and collapsible and have good mechanical resistance. Moreover, 20 they resist the temperatures required for heat sterilization of the contents (about 120°C). It is a further advantage of the new laminates that pouches made therefrom may be heat-sealed using a radio frequency sealer, provided that the frequency of the latter is 70 MHz. Conventional sealers 25 working at frequencies of 20 to 30 MHz are not suitable. ■ The thickness of the new laminates is chosen to be appropriate for the contemplated end use. Normally,/ the ethylene-vinyl acetate layer makes up the greater part of the thickness of the film.• For example, for 2 10022 an overall thickness of 150 to 300 microns, the ethylene- vinyl acetate copolymer layer may constitute 50 to 95 percent of the total thickness. The outer layers of propylene-ethylene copolymer (and optional other layers) may then make up the remainder of the thickness.
The inner layer of the propylene-ethylene copolymer (i.e. that which contacts the contents of the pouch) is preferably somewhat thicker than .the external layer, and may be for example of from 1 to 3 times the thickness of the latter.
The following are examples of heat sterilizable laminate films in accordance with the present invention.
In place of the hot blowing inventions.in these Examples, water quench co — extrusion can be used. 15 - Example 1 A three layer laminate film is produced by extrusion through a multi layer circular die followed by hot blowing, of the follpwing materials: The inside surface and outside surface layers were made of a composition comprising 80 percent by weight of a propylene-ethylene copolymer and 20 percent by weight of an impact modifier. The ethylene-propylene copolymer contained A percent by weight of ethylene units, and had a melt flow index of 5 g/10 rains., a density of 0.900 g/crn^, and a Vicat softening point of 122°c. The impact modifier was a commercially available blend of an ethylene-propylene elastomer and an ethylene-vinyl acetate copolymer containing 40 percent by weight of vinyl acetate units.
The modifier had a melt flow index of 0.7, an elongation 6 2 100 2 2 at least of 735 percent, and a tensile strength of 835N/cm .
The inner layer of ethylene-vinyl acetate copolymer was based on a copolymer containing 26 percent by weight of vinyl acetate units, and having a melt flow Vicat softening point of 50°C.
Example II A three layer laminate film was produced in the manner described in Example I using for the inside surface 10 and outside surface layers the same propylene-ethylene copolymer a.s in Example I, but without the addition of any impact modifier. The inner layer of ethylene-vinyl acetate copolymer was based on a copolymer containing 28 percent by weight of vinyl acetate units and having a melt flow 15 index of 6 g/10 mins., a density of 0.95 g/cm^, and a Vicat softening point of 46°C. 9 index of 2 g/10 mins., a density of 0.95 g/cm , and a As this laminate film did not contain any impact modifier or adh""4 *■—at 2 M Rad to . increase bonding between .the layers. jle III 2 film was produced using the same propylene-ethylene copolymer for the inside surface and outside surface layers as in Example II and the same inner layer of ethylene-vinyl acetate copolymer as in Example xI.
In addition, adhesive layers of CXA (DuPont) or Plexar (Chernplex) were provided between the ethylene-vinyl acetate , copolymer layer and the two outer layers. These adhesivesare ethylene copolymer hav a density of 0 .02 to 0 .96 g/cm , and a Vicat softening point of 30 30 to 90°C.

Claims (1)

  1. ~xy~-—'ii. i ■■■ ■ •' 210022 i O iO - 7 - In the foregoing Exanples I to III, the overall thickness of the laminate may be for example 200 microns with the inner layer of ethylene-vinyl acetate copolymer constituting about 170 microns. The 5 remainder of the overall thickness is made up by the propylene-ethylene copolymer layers and adhesive layers (if any). The inside surface propylene-ethylene copolymer layer is preferably about twice as thick as the outside surface propylene-ethylene copolymer layer. o * s£;2 10022;WHAT^/WE CLAIM IS: _ 8 _;CLAIMS;1. A heat sterilizable laminate comprising a layer of an ethylene-vinyl acetate copolymer containing 18 to 40 percent by weight of vinyl acetate units and, on each side of the said layer, a layer of 56O to 100 percent by weight of a -propylene-ethylene copolymer containing 2 to 4.5 percent by weight of ethylene units, and 40 to 0 percent by weight of an impact modifier containing 30 to 63 parts by weight of an ethylene-propylene elastomer or ethylenepropylene-diene 10 elastomer having an ethylene content of 55 to 70 weight percent and 70 to 37 parts by weight of a thermoplastic ethylene-vinyl acetate copolymer containing 9 to 40 percent of vinyl acetate units.;;2. A laminate according to claim 1 consisting 15 of the said layer of an ethylene-vinyl acetate copolymer;•having on each side a layer of the said propylene-ethylene copolymer containing 40 to 10% by weight of the said impact modifier.;3. A laminate according to claim 1 consisting 20 of the said layer of an ethylene-vinyl acetate copolymer having on each side■a layer,of the said propylene-ethylene copolymer containing no impact modifier, the polymers of the said laminate being cross-linked by irradiation.;210022;' - 9 - : \;4. A laminate according to claim 1 consisting of five layers, namely a core layer of the said ethylene-vinyl acetate copolymer, two outer layers of the said propylene-ethylene copolymer , and two layers 5 of adhesive between the said outer layers and the said core layer.';. 5. A laminate according to any one of claims 1 to 4 in which the said ethylene-vinyl acetate copolymer contains 18 to 30 percent by weight of vinyl acetate;10 units and has a melt flow index- cf 0.7 to 7 g/10 mins. , /;3 r. ■' , "■;a density of 0.930 to 0.970 g/cm /and a Vicat softening point of 40 to 80°C. . .'"--V;6. A laminate according to any one of claims 1 to 5 in which the propylene-ethylene copolymer has a;15 melt flow index of 3 to 7 g/10 mins., a density of 0.890 to 0.910 g/cm^, and a Vicat softening pcint of 120 to 13tPc.;7. A laminate according to claim 1 substantially as described in any one of the foregoing Examples.;8. A disposable pouch made of a laminate as;20 claimed in any one of claims 1 to 7 -containing a sing le . dosage unit of a sterile injectable composition.;DAlfcDTHiS 1*^ DAY OF Oec«rvA>0-eJ |f A. J. PARK & SON PER l^jyAorv^Q1^ AGENTS FOR THE APPLICANTS t
NZ210022A 1983-11-09 1984-10-29 Heat sterilisable polymeric laminate NZ210022A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8329850A GB2149345B (en) 1983-11-09 1983-11-09 Heat sterilizable laminate films

Publications (1)

Publication Number Publication Date
NZ210022A true NZ210022A (en) 1987-02-20

Family

ID=10551473

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ210022A NZ210022A (en) 1983-11-09 1984-10-29 Heat sterilisable polymeric laminate

Country Status (13)

Country Link
US (1) US4599276A (en)
EP (1) EP0142315B1 (en)
JP (1) JPS60124246A (en)
AT (1) ATE34702T1 (en)
AU (1) AU564076B2 (en)
BR (1) BR8405684A (en)
CA (1) CA1225580A (en)
DE (1) DE3471607D1 (en)
DK (1) DK162077C (en)
GB (1) GB2149345B (en)
IE (1) IE55790B1 (en)
NZ (1) NZ210022A (en)
ZA (1) ZA848476B (en)

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CA1225580A (en) 1987-08-18
DK162077C (en) 1992-02-17
ATE34702T1 (en) 1988-06-15
GB2149345A (en) 1985-06-12
JPH0456743B2 (en) 1992-09-09
DK162077B (en) 1991-09-16
BR8405684A (en) 1985-09-10
IE55790B1 (en) 1991-01-16
ZA848476B (en) 1985-07-31
EP0142315A2 (en) 1985-05-22
US4599276A (en) 1986-07-08
DK532684A (en) 1985-05-10
DE3471607D1 (en) 1988-07-07
GB2149345B (en) 1987-03-11
GB8329850D0 (en) 1983-12-14
IE842863L (en) 1985-05-09
EP0142315A3 (en) 1986-07-16
DK532684D0 (en) 1984-11-08
AU564076B2 (en) 1987-07-30
JPS60124246A (en) 1985-07-03
AU3492284A (en) 1985-05-16
EP0142315B1 (en) 1988-06-01

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