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NO994110L - Fremgangsmaate ved fremstilling av stabile, ikke-hygroskopiske salter av L(-)-carnitin - Google Patents

Fremgangsmaate ved fremstilling av stabile, ikke-hygroskopiske salter av L(-)-carnitin

Info

Publication number
NO994110L
NO994110L NO994110A NO994110A NO994110L NO 994110 L NO994110 L NO 994110L NO 994110 A NO994110 A NO 994110A NO 994110 A NO994110 A NO 994110A NO 994110 L NO994110 L NO 994110L
Authority
NO
Norway
Prior art keywords
carnitine
stable
preparation
hygroscopic salts
salts
Prior art date
Application number
NO994110A
Other languages
English (en)
Other versions
NO994110D0 (no
Inventor
Aldo Fassi
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of NO994110L publication Critical patent/NO994110L/no
Publication of NO994110D0 publication Critical patent/NO994110D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

En forbedret fremgangsmåte ved fremstilling av stabile, ikke-hygroskopiske salter av L(-)-carnitin presenteres, hvilken omfatter å fremstille en pastaaktig/semiflytende slurry av L(-)-carnitin indre salt og vann ved romtempe- ratur, og å tilsette en organisk dikarboksylsyre, egnet ved dannelse av slike salter, til slurryen.
NO994110A 1997-02-25 1999-08-25 FremgangsmÕte ved fremstilling av stabile, ikke-hygroskopiske salter av L(-)-carnitin NO994110D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000409A IT1289974B1 (it) 1997-02-25 1997-02-25 Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
PCT/EP1998/001039 WO1998038157A1 (en) 1997-02-25 1998-02-24 Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines

Publications (2)

Publication Number Publication Date
NO994110L true NO994110L (no) 1999-08-25
NO994110D0 NO994110D0 (no) 1999-08-25

Family

ID=11376175

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994110A NO994110D0 (no) 1997-02-25 1999-08-25 FremgangsmÕte ved fremstilling av stabile, ikke-hygroskopiske salter av L(-)-carnitin

Country Status (25)

Country Link
US (1) US6271258B1 (no)
EP (1) EP1019362B1 (no)
JP (1) JP2001513096A (no)
KR (1) KR100538788B1 (no)
CN (1) CN1248967A (no)
AT (1) ATE222233T1 (no)
AU (1) AU724276B2 (no)
BR (1) BR9807761A (no)
CA (1) CA2281630C (no)
CZ (1) CZ290893B6 (no)
DE (1) DE69807245T2 (no)
DK (1) DK1019362T3 (no)
EE (1) EE03561B1 (no)
ES (1) ES2182290T3 (no)
HU (1) HUP0001674A3 (no)
IL (1) IL131256A (no)
IS (1) IS5160A (no)
IT (1) IT1289974B1 (no)
NO (1) NO994110D0 (no)
NZ (1) NZ337188A (no)
PL (1) PL188762B1 (no)
PT (1) PT1019362E (no)
SK (1) SK115399A3 (no)
TR (1) TR199902043T2 (no)
WO (1) WO1998038157A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
KR100461572B1 (ko) * 1999-03-27 2004-12-14 삼성정밀화학 주식회사 Ｌ-카르니틴 칼슘 염과 이의 제조방법
ATE418978T1 (de) * 1999-09-03 2009-01-15 Sigma Tau Healthscience Spa Ultrafeines l-carnitin, verfahren zur dessen herstellung, dieses enthaltende zusammensetzungen,sowie verfahren zu dessen verwendung
IT1316988B1 (it) * 2000-02-10 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine.
IT1317013B1 (it) * 2000-04-12 2003-05-26 Biosalts Srl Sostanze dolcificanti, particolarmente per il caffe' ed il the'.
ITRM20020055A1 (it) * 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti
CN101212956A (zh) * 2005-07-05 2008-07-02 隆萨股份公司 生产干肉碱粉末或颗粒的喷雾干燥法
US7523176B2 (en) * 2005-08-02 2009-04-21 International Business Machines Corporation Method, apparatus, and computer program product for reconfiguring a storage area network to support the execution of an application automatically upon execution of the application
WO2007056376A2 (en) * 2005-11-07 2007-05-18 Perque, Llc. Compositions for regulating metabolic disorders and methods of use thereof
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
JP2011068563A (ja) * 2008-09-09 2011-04-07 Mitsubishi Rayon Co Ltd カルニチンフマル酸塩及びその製造方法
KR101291186B1 (ko) * 2010-07-23 2013-09-13 주식회사 셀트리온제약 Ｌ-카르니틴 1,5-나프탈렌다이설폰산염 및 이를 포함하는 약제학적 조성물
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
CN108383741A (zh) * 2018-03-16 2018-08-10 开原亨泰化工有限公司 一种制备左旋肉碱成盐的新方法
CN118638020B (zh) * 2024-08-08 2024-11-19 杭州海尔希畜牧科技有限公司 L-天门冬氨酸l(-)肉碱(1:1)的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU549565B2 (en) * 1983-11-02 1986-01-30 Pirrel S.p.A L (-) carnotine hydrochloride and l (-) carnotine inner salt
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
DE4111913A1 (de) * 1991-04-12 1992-10-15 Degussa Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen
CH682485A5 (de) 1991-08-13 1993-09-30 Lonza Ag Verfahren zur Herstellung optisch aktiver Carbonsäuren durch Racematspaltung.
TW397686B (en) * 1993-08-11 2000-07-11 Takeda Chemical Industries Ltd Antacid compositions and pharmaceutical compositions
IT1272290B (it) * 1994-06-20 1997-06-16 Avantgarde Spa Sale della l-carnitina e composizioni farmaceutiche che lo contengono per il trattamento di affezioni cutanee
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
BR9709627A (pt) 1996-05-31 1999-08-10 Sigma Tau Ind Farmaceuti Sais n o-higroscópicos estáveis de L(-)carnitina e alcanoílal(-)carnitinas um processo para sua preparação e composições sólidas oralmente administráveis contendo tais sais

Also Published As

Publication number Publication date
AU6822998A (en) 1998-09-18
IL131256A0 (en) 2001-01-28
ATE222233T1 (de) 2002-08-15
TR199902043T2 (xx) 1999-10-21
HUP0001674A3 (en) 2000-10-30
SK115399A3 (en) 2000-01-18
EP1019362B1 (en) 2002-08-14
CZ290893B6 (cs) 2002-11-13
KR100538788B1 (ko) 2005-12-23
US6271258B1 (en) 2001-08-07
ITMI970409A1 (it) 1998-08-25
WO1998038157A1 (en) 1998-09-03
IT1289974B1 (it) 1998-10-19
CA2281630A1 (en) 1998-09-03
PT1019362E (pt) 2002-11-29
EE9900361A (et) 2000-04-17
BR9807761A (pt) 2000-03-21
HUP0001674A1 (hu) 2000-09-28
EP1019362A1 (en) 2000-07-19
CN1248967A (zh) 2000-03-29
JP2001513096A (ja) 2001-08-28
DE69807245D1 (de) 2002-09-19
AU724276B2 (en) 2000-09-14
EE03561B1 (et) 2001-12-17
NZ337188A (en) 2000-05-26
IL131256A (en) 2003-07-31
PL335350A1 (en) 2000-04-25
ES2182290T3 (es) 2003-03-01
KR20000075710A (ko) 2000-12-26
IS5160A (is) 1999-08-20
NO994110D0 (no) 1999-08-25
PL188762B1 (pl) 2005-04-29
DE69807245T2 (de) 2002-12-05
CA2281630C (en) 2006-11-14
DK1019362T3 (da) 2002-12-02
CZ302899A3 (cs) 2000-02-16

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