NO982754L - Phospholipid derivatives of phosphonocarboxylic acids, preparation of such derivatives and use of the derivatives as antiviral drugs - Google Patents

Phospholipid derivatives of phosphonocarboxylic acids, preparation of such derivatives and use of the derivatives as antiviral drugs

Info

Publication number: NO982754L
Authority: NO; Norway
Prior art keywords: derivatives; preparation; phospholipid; antiviral drugs; phosphonocarboxylic acids
Prior art date: 1995-12-15

Application number

NO982754A

Other languages

Norwegian (no)

Other versions

NO982754D0 (en

Inventor

Harald Zilch

Dieter Herrmann

Hans-Georg Opitz

Gerd Zimmermann

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1998-06-15

Publication date

1998-08-13

1995-12-15 Priority claimed from DE1995147023 external-priority patent/DE19547023A1/en

1996-10-22 Priority claimed from DE1996143416 external-priority patent/DE19643416A1/en

1998-06-15 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1998-06-15 Publication of NO982754D0 publication Critical patent/NO982754D0/en

1998-08-13 Publication of NO982754L publication Critical patent/NO982754L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
- C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Crystallography & Structural Chemistry (AREA)
Oncology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO982754A 1995-12-15 1998-06-15 Phospholipid derivatives of phosphonocarboxylic acids, preparation of such derivatives and use of the derivatives as antiviral drugs NO982754L (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE1995147023 DE19547023A1 (en)	1995-12-15	1995-12-15	New phosphatidyl alkanoic acid derivatives
DE1996143416 DE19643416A1 (en)	1996-10-22	1996-10-22	New phospho:lipid derived from phosphono-carboxylate and thio-glycerol
PCT/EP1996/005647 WO1997022613A1 (en)	1995-12-15	1996-12-16	Phospholipid derivatives of phosphono-carboxylic acids, the production of said derivatives and the use of said derivatives as antiviral medicaments

Publications (2)

Publication Number	Publication Date
NO982754D0 NO982754D0 (en)	1998-06-15
NO982754L true NO982754L (en)	1998-08-13

Family

ID=26021319

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO982754A NO982754L (en)	1995-12-15	1998-06-15	Phospholipid derivatives of phosphonocarboxylic acids, preparation of such derivatives and use of the derivatives as antiviral drugs

Country Status (23)

Country	Link
US (1)	US6136797A (en)
EP (1)	EP0868425B1 (en)
JP (1)	JP2000515113A (en)
KR (1)	KR20000064374A (en)
CN (1)	CN1085672C (en)
AR (1)	AR005089A1 (en)
AT (1)	ATE278698T1 (en)
AU (1)	AU714236B2 (en)
BR (1)	BR9612133A (en)
CA (1)	CA2240366A1 (en)
CZ (1)	CZ291823B6 (en)
DE (1)	DE59611111D1 (en)
ES (1)	ES2230574T3 (en)
HU (1)	HUP0001534A3 (en)
IL (1)	IL124790A (en)
NO (1)	NO982754L (en)
NZ (1)	NZ325259A (en)
PL (1)	PL186402B1 (en)
RU (1)	RU2166508C2 (en)
SK (1)	SK75698A3 (en)
TR (1)	TR199801082T2 (en)
TW (1)	TW343975B (en)
WO (1)	WO1997022613A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19547022A1 (en) *	1995-12-15	1997-06-19	Boehringer Mannheim Gmbh	Covalent lipid-phosphonocarboxylic acid conjugates, their preparation and their use as antiviral drugs
US7915238B2 (en) *	1999-02-01	2011-03-29	Eisai R & D Management Co., Ltd.	Immunomodulatory compounds and methods of use thereof
US20040006242A1 (en)	1999-02-01	2004-01-08	Hawkins Lynn D.	Immunomodulatory compounds and method of use thereof
US6835721B2 (en)	1999-02-01	2004-12-28	Eisai Co., Ltd.	Immunomodulatory compounds and methods of use thereof
US6551600B2 (en) *	1999-02-01	2003-04-22	Eisai Co., Ltd.	Immunological adjuvant compounds compositions and methods of use thereof
US6818057B2 (en)	1999-03-02	2004-11-16	Construction Research & Technology Gmbh	Retarder for calcium sulfoaluminate cements
RU2265439C2 (en) *	2000-01-04	2005-12-10	Де Риджентс Ов Де Юниверсити Ов Калифорния	Treatment of hiv infection at medicinal resistance
RU2240792C2 (en) *	2002-07-30	2004-11-27	Государственное учреждение Научно-исследовательский институт вирусологии им. Д.И. Ивановского РАМН	Combinations based on netropsin or its bis-derivative eliciting anti-herpetic activity
US20040172288A1 (en) *	2003-02-27	2004-09-02	Korn Lawrence D.	Method for disseminating medical alert information
WO2006116423A2 (en)	2005-04-26	2006-11-02	Eisai Co., Ltd	Compositions and methods for cancer immunotherapy
US20070292418A1 (en) *	2005-04-26	2007-12-20	Eisai Co., Ltd.	Compositions and methods for immunotherapy
JP5752599B2 (en) *	2008-11-06	2015-07-22	ヴァスキュラーバイオジェニックスリミテッド	Oxidized lipid compounds and uses thereof
EP2876094A1 (en)	2014-04-03	2015-05-27	Basf Se	Cement and calcium sulphate based binder composition
KR101658048B1 (en)	2014-06-25	2016-09-20	한국생명공학연구원	Anti-viral composition comprising compounds related to phosphatidylcholine synthetic pathway
EP3813839A4 (en) *	2018-06-26	2022-07-20	TSRL, Inc.	METABOLICLY STABLE PRODRUGS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3164332D1 (en) *	1980-10-21	1984-07-26	Boehringer Mannheim Gmbh	Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
US5194654A (en) *	1989-11-22	1993-03-16	Vical, Inc.	Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
DE3929217A1 (en) *	1989-09-02	1991-03-07	Boehringer Mannheim Gmbh	USE OF PHOSPHOLIPID DERIVATIVES AS ANTIVIRAL MEDICINAL PRODUCTS AND NEW PHOSPHOLIPIDES
DE4026265A1 (en) *	1990-08-20	1992-02-27	Boehringer Mannheim Gmbh	NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PRODUCTION AND THEIR USE AS ANTIVIRAL MEDICINAL PRODUCTS
US5696277A (en) *	1994-11-15	1997-12-09	Karl Y. Hostetler	Antiviral prodrugs
DE19547022A1 (en) *	1995-12-15	1997-06-19	Boehringer Mannheim Gmbh	Covalent lipid-phosphonocarboxylic acid conjugates, their preparation and their use as antiviral drugs

1996
- 1996-12-14 TW TW085115475A patent/TW343975B/en active
- 1996-12-16 AR ARP960105701A patent/AR005089A1/en not_active Application Discontinuation
- 1996-12-16 TR TR1998/01082T patent/TR199801082T2/en unknown
- 1996-12-16 WO PCT/EP1996/005647 patent/WO1997022613A1/en not_active Ceased
- 1996-12-16 BR BR9612133A patent/BR9612133A/en not_active IP Right Cessation
- 1996-12-16 US US09/077,891 patent/US6136797A/en not_active Expired - Fee Related
- 1996-12-16 CZ CZ19981810A patent/CZ291823B6/en not_active IP Right Cessation
- 1996-12-16 KR KR1019980704352A patent/KR20000064374A/en not_active Ceased
- 1996-12-16 EP EP96943972A patent/EP0868425B1/en not_active Expired - Lifetime
- 1996-12-16 IL IL12479096A patent/IL124790A/en not_active IP Right Cessation
- 1996-12-16 SK SK756-98A patent/SK75698A3/en unknown
- 1996-12-16 CN CN96180011A patent/CN1085672C/en not_active Expired - Fee Related
- 1996-12-16 ES ES96943972T patent/ES2230574T3/en not_active Expired - Lifetime
- 1996-12-16 DE DE59611111T patent/DE59611111D1/en not_active Expired - Fee Related
- 1996-12-16 CA CA002240366A patent/CA2240366A1/en not_active Abandoned
- 1996-12-16 NZ NZ325259A patent/NZ325259A/en unknown
- 1996-12-16 HU HU0001534A patent/HUP0001534A3/en unknown
- 1996-12-16 PL PL96327173A patent/PL186402B1/en not_active IP Right Cessation
- 1996-12-16 RU RU98113304/04A patent/RU2166508C2/en not_active IP Right Cessation
- 1996-12-16 AT AT96943972T patent/ATE278698T1/en not_active IP Right Cessation
- 1996-12-16 AU AU13730/97A patent/AU714236B2/en not_active Ceased
- 1996-12-16 JP JP09522501A patent/JP2000515113A/en not_active Ceased
1998
- 1998-06-15 NO NO982754A patent/NO982754L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2240366A1 (en)	1997-06-26
JP2000515113A (en)	2000-11-14
US6136797A (en)	2000-10-24
AU1373097A (en)	1997-07-14
PL327173A1 (en)	1998-11-23
CZ291823B6 (en)	2003-06-18
TR199801082T2 (en)	1998-09-21
AU714236B2 (en)	1999-12-23
HUP0001534A3 (en)	2002-08-28
CN1085672C (en)	2002-05-29
SK75698A3 (en)	1999-03-12
CN1209133A (en)	1999-02-24
ES2230574T3 (en)	2005-05-01
RU2166508C2 (en)	2001-05-10
PL186402B1 (en)	2004-01-30
ATE278698T1 (en)	2004-10-15
EP0868425B1 (en)	2004-10-06
IL124790A0 (en)	1999-01-26
IL124790A (en)	2002-04-21
NZ325259A (en)	2000-01-28
NO982754D0 (en)	1998-06-15
AR005089A1 (en)	1999-04-14
BR9612133A (en)	1999-07-13
HUP0001534A2 (en)	2001-05-28
WO1997022613A1 (en)	1997-06-26
DE59611111D1 (en)	2004-11-11
EP0868425A1 (en)	1998-10-07
CZ181098A3 (en)	1998-10-14
TW343975B (en)	1998-11-01
KR20000064374A (en)	2000-11-06

Publication	Publication Date	Title
NO961006L (en)	1996-09-16	Phosphonomononucleic acids, processes for their preparation and use of the compounds
EP0948341A4 (en)	2003-05-21	DERIVATIVES OF PHOSPHOLIPIDIC DRUGS
AR027162A1 (en)	2003-03-19	COMPOUNDS OF 2-PHENYL-3-PHENOXYL-PHENYLTIO-BENZOTIOFEN, PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO20021111D0 (en)	2002-03-06	Use of 5-O-deoaminyl-6-O-methyl erythronolide A derivatives for the preparation of biologically active products
FI925633L (en)	1993-06-13	Foerfarande Foer framstaellning av en pharmaceutical sammanettning som seklitt saenker lipidnivaon i blood
BR9610396A (en)	1999-07-06	Pharmaceutical formulation
NO892936L (en)	1990-01-19	PROCEDURE FOR THE PREPARATION OF FURAND DERIVATIVES.
NO953367D0 (en)	1995-08-28	Use of substituted 4-phenyl-6-amino-nicotinic acid derivatives as drugs
NO984878D0 (en)	1998-10-19	Preparation and Use as Medicines of 3-Alkoxypyridine-2-Carboxylic Acid Amesters
NO982754D0 (en)	1998-06-15	Phospholipid derivatives of phosphonocarboxylic acids, preparation of such derivatives and use of the derivatives as antiviral drugs
EE9600172A (en)	1997-06-16	Purin-6-one derivatives, their preparation method, use in the preparation of medicaments and medicaments
NO982237L (en)	1998-07-10	Process for the preparation of phenylimidazolidine derivatives
NO891588D0 (en)	1989-04-18	PROCEDURE FOR THE PREPARATION OF PHOSPHONOAL COOLPURIN DERIVATIVES.
NO980471D0 (en)	1998-02-03	Benzenesulfonamide derivatives, their preparation and therapeutic uses thereof
NO981537L (en)	1998-04-03	Process for the preparation of antimalarial drugs
FI973230L (en)	1997-08-05	New pharmaceutical formulation
NO891574D0 (en)	1989-04-18	PROCEDURE FOR THE PREPARATION OF PHARMACEUTICAL USES.
NO306993B1 (en)	2000-01-24	Piperidinylmethyloxyzolidin-2-one derivatives, pharmaceutical preparations containing such, and use of the compounds in the manufacture of medicinal products
NO982755D0 (en)	1998-06-15	Covalent lipid phosphonocarboxylic acid derivatives and their use as antiviral drugs
FI940551A0 (en)	1994-02-07	Process for the preparation of phenylbenzamide derivatives
NO961429D0 (en)	1996-04-11	Process for the preparation of quinolone-containing oral preparations
DK568289A (en)	1990-05-15	1-AMINOALKYL-3-OXY-SUBSTITUTED-4-ARYL-1,3,4,5-TETRAHYDRO-2H-1,3-BENZODIAZEPIN-2-ONER, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
NO894707L (en)	1990-05-28	PROCEDURE FOR THE PREPARATION OF BENZOKSAZINE DERIVATIVES.
NO964519D0 (en)	1996-10-24	Process for the preparation of chitosanalkyl derivatives
BR9603673A (en)	1998-05-19	Pharmaceutical combination preparation comprising ketoprofen

Legal Events

Date	Code	Title	Description
2005-09-12	FC2A	Withdrawal, rejection or dismissal of laid open patent application