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NO980878L - Microporation of human skin for drug delivery and monitoring applications - Google Patents

Microporation of human skin for drug delivery and monitoring applications

Info

Publication number
NO980878L
NO980878L NO980878A NO980878A NO980878L NO 980878 L NO980878 L NO 980878L NO 980878 A NO980878 A NO 980878A NO 980878 A NO980878 A NO 980878A NO 980878 L NO980878 L NO 980878L
Authority
NO
Norway
Prior art keywords
microporation
drug delivery
human skin
monitoring applications
monitoring
Prior art date
Application number
NO980878A
Other languages
Norwegian (no)
Other versions
NO980878D0 (en
NO334437B1 (en
Inventor
Jonathan A Eppstein
Michael R Hatch
Difei Yang
Original Assignee
Spectrx Inc
Altea Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc, Altea Tech Inc filed Critical Spectrx Inc
Publication of NO980878D0 publication Critical patent/NO980878D0/en
Publication of NO980878L publication Critical patent/NO980878L/en
Publication of NO334437B1 publication Critical patent/NO334437B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Laser Surgery Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO19980878A 1995-08-29 1998-02-27 Microporation of human skin for drug delivery and monitoring applications NO334437B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52054795A 1995-08-29 1995-08-29
US804395P 1995-10-30 1995-10-30
PCT/US1996/013865 WO1997007734A1 (en) 1995-08-29 1996-08-29 Microporation of human skin for drug delivery and monitoring applications

Publications (3)

Publication Number Publication Date
NO980878D0 NO980878D0 (en) 1998-02-27
NO980878L true NO980878L (en) 1998-04-27
NO334437B1 NO334437B1 (en) 2014-03-03

Family

ID=26677684

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19980878A NO334437B1 (en) 1995-08-29 1998-02-27 Microporation of human skin for drug delivery and monitoring applications

Country Status (14)

Country Link
EP (1) EP0858285A4 (en)
JP (2) JP3899427B2 (en)
CN (1) CN1174713C (en)
AU (1) AU707065B2 (en)
BR (1) BR9610012A (en)
CA (1) CA2199002C (en)
ES (1) ES2536459T3 (en)
GB (1) GB2307414B (en)
HK (1) HK1009321A1 (en)
IL (1) IL123379A (en)
NO (1) NO334437B1 (en)
PT (1) PT1563788E (en)
TR (1) TR199800347T1 (en)
WO (1) WO1997007734A1 (en)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251100B1 (en) 1993-09-24 2001-06-26 Transmedica International, Inc. Laser assisted topical anesthetic permeation
ATE234129T1 (en) 1996-06-18 2003-03-15 Alza Corp DEVICE FOR IMPROVING TRANSDERMAL ADMINISTRATION OF MEDICATIONS OR EXTRACTION OF BODY FLUID
ATE241405T1 (en) * 1996-07-03 2003-06-15 Altea Therapeutics Corp MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOUS MEASURES
ATE231015T1 (en) * 1996-09-17 2003-02-15 Deka Products Lp SYSTEM FOR DELIVERY OF MEDICATION THROUGH TRANSPORT
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
ATE365026T1 (en) * 1996-12-31 2007-07-15 Altea Therapeutics Corp MICROPORATION OF TISSUE FOR ADMINISTRATION OF BIOACTIVE SUBSTANCES
US6027496A (en) * 1997-03-25 2000-02-22 Abbott Laboratories Removal of stratum corneum by means of light
JP4338307B2 (en) 1997-10-21 2009-10-07 アボット・ラボラトリーズ Apparatus and method for collecting interstitial fluid
US6155992A (en) * 1997-12-02 2000-12-05 Abbott Laboratories Method and apparatus for obtaining interstitial fluid for diagnostic tests
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1037686B1 (en) * 1997-12-11 2005-08-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029364A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
DE69839969D1 (en) 1997-12-11 2008-10-16 Alza Corp DEVICE FOR IMPROVING THE TRANSDERMAL RIVER OF MEDICAMENTS
ATE375752T1 (en) * 1998-03-06 2007-11-15 Spectrx Inc INTEGRATED TISSUE PORATION, FLUID COLLECTION AND ANALYSIS DEVICE
US6530915B1 (en) 1998-03-06 2003-03-11 Spectrx, Inc. Photothermal structure for biomedical applications, and method therefor
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6569157B1 (en) * 1998-05-18 2003-05-27 Abbott Laboratories Removal of stratum corneum by means of light
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6077660A (en) * 1998-06-10 2000-06-20 Abbott Laboratories Diagnostic assay requiring a small sample of biological fluid
DK1124607T3 (en) 1998-07-14 2009-01-26 Altea Therapeutics Corp Controlled biological membrane removal using pyrotechnic charge for transmembrane transport
MXPA01000698A (en) * 1998-07-21 2002-04-08 Spectrx Inc System and method for continuous analyte monitoring.
US7384396B2 (en) 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring
DE69906992T2 (en) * 1998-09-04 2004-02-05 Powderject Research Ltd. SECOND MEDICAL INDICATION OF A PARTICLE ADMINISTRATION METHOD
US6468229B1 (en) 1998-10-20 2002-10-22 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
CN100402105C (en) * 1999-06-08 2008-07-16 奥尔蒂治疗学公司 Apparatus and method for making micropores in biological membrane using thin film tissue interface device
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6355054B1 (en) * 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
DE19963034A1 (en) 1999-12-24 2001-06-28 Roche Diagnostics Gmbh Glucose level detection system based on measurement of interstitial fluid, uses heating device or ultrasound to reduce time offset between concentration in interstitial fluid and blood
IL136008A0 (en) 2000-05-07 2001-05-20 Elecsys Ltd Electrically-mediated transdermal drug injection
US6706032B2 (en) 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
US7597692B2 (en) 2000-06-08 2009-10-06 Massachusetts Institute Of Technology Microscission processes and procedures
AUPR044000A0 (en) * 2000-09-28 2000-10-26 Norwood Abbey Ltd Diagnostic device
US6537243B1 (en) 2000-10-12 2003-03-25 Abbott Laboratories Device and method for obtaining interstitial fluid from a patient for diagnostic tests
US6882884B1 (en) 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US6733493B2 (en) * 2000-11-16 2004-05-11 Innotech Usa, Inc. Laser skin perforator
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
JP2005504002A (en) 2001-02-13 2005-02-10 ガバメント オブ ザ ユナイテッド ステイツ、 アズ リプリゼンティッド バイ ザ セクレタリィ オブ ジ アーミイ Vaccine for transcutaneous immunization
JP4704583B2 (en) * 2001-02-28 2011-06-15 有限会社開発顧問室 Patch test sheet
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US8361037B2 (en) 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
EP1471953B1 (en) 2001-09-21 2011-02-16 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
EP2319577B1 (en) 2001-11-07 2017-03-15 Syneron Medical Ltd. Integrated transdermal drug delivery system
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
AU2003225735A1 (en) 2002-03-11 2003-09-29 Altea Therapeutics Corporation Transdermal drug delivery patch system, method of making same and method of using same
AU2003226605A1 (en) 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152573A (en) 2002-10-31 2009-11-18 Transpharma Medical Ltd Transdermal delivery system for anti-emetic medication
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd Transdermal delivery system for dried particulate or lyophilized medications
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152575A (en) 2002-10-31 2008-12-29 Transpharma Medical Ltd Transdermal delivery system for water insoluble drugs
US7258673B2 (en) 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US20050089554A1 (en) * 2003-10-24 2005-04-28 Cormier Michel J. Apparatus and method for enhancing transdermal drug delivery
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
AU2004285484A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
US7896819B2 (en) 2004-10-21 2011-03-01 Rebec Mihailo V Method of determining the concentration of an analyte in a body fluid and system in therefor
JP2006326147A (en) * 2005-05-30 2006-12-07 Shingo Wakamatsu Laser therapy equipment
TWI419717B (en) * 2005-06-17 2013-12-21 Altea Therapeutics Corp Osmotic delivery system and method of use thereof
JP5011936B2 (en) * 2006-10-11 2012-08-29 パナソニック株式会社 Blood test equipment
JP5011935B2 (en) * 2006-10-11 2012-08-29 パナソニック株式会社 Blood test equipment
KR101214764B1 (en) * 2006-11-14 2012-12-21 가고시마 유니버시티 Drug injecting device
RU2328739C1 (en) * 2007-02-26 2008-07-10 Айрат Анварович Халиков Analysis of cadaver biological tissue cell membrane integrity
BRPI0810969A2 (en) 2007-04-27 2015-01-27 Echo Therapeutics Inc SKIN PERMEATION DEVICE FOR ANALYTIC DETECTION OR TRANSDERMAL PHARMACEUTICAL RELEASE
WO2016141136A1 (en) * 2015-03-03 2016-09-09 Guided Therapy Systems, Llc Methods and systems for ultrasound assisted delivery of a medicant to tissue
WO2009047774A2 (en) 2007-10-09 2009-04-16 Transpharma Ltd. Magnetic patch coupling
US8281675B2 (en) 2007-10-17 2012-10-09 Syneron Medical Ltd Dissolution rate verification
JP5407868B2 (en) * 2007-11-06 2014-02-05 コニカミノルタ株式会社 Micro-aperture forming apparatus and body fluid collecting system using the same
KR101464058B1 (en) 2007-12-05 2014-11-20 시네론 메디컬 리미티드 A disposable electromagnetic energy applicator and method of using it
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US20100256466A1 (en) * 2009-04-02 2010-10-07 Avraham Shekalim Metabolite Management System
US9402678B2 (en) 2009-07-27 2016-08-02 Novoxel Ltd. Methods and devices for tissue ablation
PT105635B (en) 2011-04-19 2014-04-11 Univ De Coimbra DEVICE FOR THE EFFICIENT ADMINISTRATION OF COMPOUNDS IN THE SKIN OR BIOLOGICAL BARRIERS, OR THROUGH THEM, USING FINE ABSORBENT LIGHT FILMS
PL3082634T3 (en) 2013-12-18 2021-10-18 Novoxel Ltd. Devices for tissue vaporization
WO2016042546A2 (en) 2014-09-15 2016-03-24 Novoxel Ltd. Methods and devices for thermal tissue vaporization and compression
EP3193758A1 (en) * 2014-09-15 2017-07-26 Novoxel Ltd. Methods and devices for thermal surgical vaporization and incision of tissue
WO2017102867A1 (en) * 2015-12-15 2017-06-22 Koninklijke Philips N.V. Surface treatment device and method
EP3403092A4 (en) * 2016-01-15 2019-08-28 University of Cincinnati ADVANCED ELECTROPORATION DEVICES AND METHODS FOR ANALYTE ACCESS IN BIOFLUIDS
CN109640858B (en) * 2016-06-20 2022-02-01 北德克萨斯大学 Laser Assisted Machining (LAM) of non-monolithic composite bone materials
FI127811B (en) * 2016-11-21 2019-03-15 Helsingin Yliopisto Device for sampling one or more analytes
EP3361402B1 (en) * 2017-02-14 2024-12-04 Roche Diabetes Care GmbH A computer-implemented method and a portable device for analyzing glucose monitoring data indicative of a glucose level in a bodily fluid, and a non-transitory computer readable medium
US11441994B2 (en) * 2017-07-27 2022-09-13 Tata Consultancy Services Limited Method and system for in-silico design of skin electroporation
US20210129136A1 (en) * 2017-08-03 2021-05-06 Fibrotx Oü Lateral flow assay and device for skin care application
CN109157280A (en) * 2018-08-10 2019-01-08 重庆大学 Irreversible electroporated tissue ablation effect dynamic realtime assessment equipment
DK3804648T3 (en) * 2018-08-23 2022-04-11 Novocure Gmbh USE OF ELECTRIC AC FIELDS TO INCREASE THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER
EP3990063A4 (en) * 2019-06-28 2023-07-05 PassPort Technologies, Inc. Methods and systems for controlling energy delivery to filament devices
CN119097308A (en) * 2019-08-02 2024-12-10 华广生技股份有限公司 Physiological signal sensor device
CN110613893A (en) * 2019-10-31 2019-12-27 南京工业职业技术学院 Novel excitation coil
CN111693434B (en) * 2020-06-19 2024-01-19 中建路桥集团有限公司 Experimental device for test concrete impervious performance
CN114504373A (en) * 2020-11-16 2022-05-17 澳美力科技(成都)有限公司 Novel radio frequency conversion beauty instrument
CN112957124B (en) * 2021-01-30 2023-08-22 南京理工大学 In-vitro laser biological tissue welding and sewing method for energy targeting regulation and control
CN113397698B (en) * 2021-05-20 2023-04-18 东莞市飞越激光设备有限公司 Laser tangent device capable of ensuring high precision and high speed
CN114343839B (en) * 2021-12-30 2024-07-23 德州环球之光医疗科技股份有限公司 Treatment pattern conversion method based on adjustable spiral linear laser spots
CN116999687B (en) * 2023-07-19 2024-11-12 河南翔宇医疗设备股份有限公司 Ultrasonic permeameter and ultrasonic permeameter output parameter setting device and medium

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
JP2798459B2 (en) * 1988-01-21 1998-09-17 マサチユセツツ・インスチチユート・オブ・テクノロジー Diagnostic device using electroporation and device for moving molecules into tissue
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
GB9014307D0 (en) * 1990-06-27 1990-08-15 Scient Generics Ltd Method of treatment and compositions therefor
JP3189337B2 (en) * 1991-11-08 2001-07-16 日本電気株式会社 Skin stratum corneum removal device and method
US5344418A (en) * 1991-12-12 1994-09-06 Shahriar Ghaffari Optical system for treatment of vascular lesions
US5165418B1 (en) 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
US5267985A (en) * 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
US5582184A (en) * 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5445611A (en) 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
DE69624668T2 (en) * 1995-07-25 2003-08-28 Massachusetts Institute Of Technology, Cambridge IMPROVED TRANSDERMAL TRANSPORTATION USING ULTRASOUND

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AU6863196A (en) 1997-03-19
EP0858285A1 (en) 1998-08-19
ES2536459T3 (en) 2015-05-25
GB9702766D0 (en) 1997-04-02
JP2006192285A (en) 2006-07-27
IL123379A0 (en) 1998-09-24
GB2307414B (en) 1998-03-11
AU707065B2 (en) 1999-07-01
PT1563788E (en) 2015-06-02
BR9610012A (en) 1999-12-21
CA2199002A1 (en) 1997-03-01
JPH11511360A (en) 1999-10-05
NO980878D0 (en) 1998-02-27
TR199800347T1 (en) 1998-05-21
JP3899427B2 (en) 2007-03-28
CN1195276A (en) 1998-10-07
EP0858285A4 (en) 2000-05-17
CN1174713C (en) 2004-11-10
IL123379A (en) 2002-04-21
NO334437B1 (en) 2014-03-03
HK1009321A1 (en) 1999-05-28
CA2199002C (en) 1999-02-23
GB2307414A (en) 1997-05-28

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