NO985480L - Use of Inhibitors of a Cellular Na + / H + Exchanger (NHE) for the Preparation of a Drug for Normalization of Serum Lipids - Google Patents

Use of Inhibitors of a Cellular Na + / H + Exchanger (NHE) for the Preparation of a Drug for Normalization of Serum Lipids

Info

Publication number: NO985480L
Authority: NO; Norway
Prior art keywords: nhe; normalization; inhibitors; exchanger; cellular
Prior art date: 1996-06-03

Application number

NO985480A

Other languages

Norwegian (no)

Other versions

NO985480D0 (en

Inventor

Hans Jochen Lang

Hans-Willi Jansen

Jan-Robert Schwark

Heinz-Werner Kleemann

Oliver Jung

Hans-Ludwig Schofer

Wolfgang Linz

Werner Kramer

Lkens Bernward Sch

Eugen Falk

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-03

Filing date

1998-11-24

Publication date

1999-01-28

1997-03-26 Priority claimed from DE19712636A external-priority patent/DE19712636A1/en

1998-11-24 Application filed by Hoechst Ag filed Critical Hoechst Ag

1998-11-24 Publication of NO985480D0 publication Critical patent/NO985480D0/en

1999-01-28 Publication of NO985480L publication Critical patent/NO985480L/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

NO985480A 1996-06-03 1998-11-24 Use of Inhibitors of a Cellular Na + / H + Exchanger (NHE) for the Preparation of a Drug for Normalization of Serum Lipids NO985480L (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19622222A DE19622222A1 (en)	1996-06-03	1996-06-03	Use of sodium=proton exchange inhibitor
DE19712636A DE19712636A1 (en)	1997-03-26	1997-03-26	Use of inhibitor of sodium/proton exchange to treat hyperlipidaemia
PCT/EP1997/002548 WO1997046226A2 (en)	1996-06-03	1997-05-20	USE OF INHIBITORS OF THE CELLULAR Na+/H+ EXCHANGER (NHE) FOR PREPARING A MEDICAMENT FOR NORMALIZING SERUM LIPIDS

Publications (2)

Publication Number	Publication Date
NO985480D0 NO985480D0 (en)	1998-11-24
NO985480L true NO985480L (en)	1999-01-28

Family

ID=26026256

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO985480A NO985480L (en)	1996-06-03	1998-11-24	Use of Inhibitors of a Cellular Na + / H + Exchanger (NHE) for the Preparation of a Drug for Normalization of Serum Lipids

Country Status (23)

Country	Link
EP (1)	EP0918515B1 (en)
JP (1)	JP4527811B2 (en)
KR (1)	KR100511711B1 (en)
CN (1)	CN1221339A (en)
AR (1)	AR007353A1 (en)
AT (1)	ATE293965T1 (en)
AU (1)	AU722166B2 (en)
BR (1)	BR9709516A (en)
CA (1)	CA2257299A1 (en)
DE (2)	DE19622222A1 (en)
DK (1)	DK0918515T3 (en)
ES (1)	ES2241049T3 (en)
IL (1)	IL126935A0 (en)
NO (1)	NO985480L (en)
NZ (1)	NZ333095A (en)
PL (1)	PL189950B1 (en)
PT (1)	PT918515E (en)
RU (1)	RU2211032C2 (en)
SI (1)	SI0918515T1 (en)
SK (1)	SK165898A3 (en)
TR (1)	TR199802505T2 (en)
WO (1)	WO1997046226A2 (en)
ZA (1)	ZA974828B (en)

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US6160134A (en) *	1997-12-24	2000-12-12	Bristol-Myers Squibb Co.	Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
US6011059A (en) *	1997-12-24	2000-01-04	Bristol-Myers Squibb Company	Acyl guanidine sodium/proton exchange inhibitors and method
DE19859727A1 (en) *	1998-12-23	2000-06-29	Aventis Pharma Gmbh	The use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the prevention of age-related organ dysfunctions, age-related illnesses for the prolongation of life
JP2002542291A (en)	1999-04-23	2002-12-10	ブリストル−マイヤーズスクイブカンパニー	Dicyclic acylguanidine sodium / proton exchange inhibitors and methods
DE19945302A1 (en) *	1999-09-22	2001-03-29	Merck Patent Gmbh	Biphenyl derivatives as NHE-3 inhibitors
US6423705B1 (en)	2001-01-25	2002-07-23	Pfizer Inc.	Combination therapy
US6984645B2 (en)	2001-11-16	2006-01-10	Bristol-Myers Squibb Company	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
FR2856062B1 (en) *	2003-06-12	2005-11-11	Aventis Pharma Sa	3-GUANIDINOCARBONYL-HETEROCYCLE DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
US7230007B2 (en)	2003-06-12	2007-06-12	Sanofi-Aventis Deutschland Gmbh	Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom
JP5030587B2 (en) *	2003-06-26	2012-09-19	バイオトロン・リミテッド	Antiviral acylguanidine compounds and methods
US7371759B2 (en)	2003-09-25	2008-05-13	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
US7420059B2 (en)	2003-11-20	2008-09-02	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
US7517991B2 (en)	2004-10-12	2009-04-14	Bristol-Myers Squibb Company	N-sulfonylpiperidine cannabinoid receptor 1 antagonists
WO2006076568A2 (en)	2005-01-12	2006-07-20	Bristol-Myers Squibb Company	Thiazolopyridines as cannabinoid receptor modulators
WO2006076598A2 (en)	2005-01-12	2006-07-20	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
US20060160850A1 (en)	2005-01-18	2006-07-20	Chongqing Sun	Bicyclic heterocycles as cannabinoid receptor modulators
EP1846410B1 (en)	2005-02-10	2009-01-21	Bristol-Myers Squibb Company	Dihydroquinazolinones as 5ht modulators
US7629342B2 (en)	2005-06-17	2009-12-08	Bristol-Myers Squibb Company	Azabicyclic heterocycles as cannabinoid receptor modulators
US7452892B2 (en)	2005-06-17	2008-11-18	Bristol-Myers Squibb Company	Triazolopyrimidine cannabinoid receptor 1 antagonists
US7632837B2 (en)	2005-06-17	2009-12-15	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid-1 receptor modulators
TW200726765A (en)	2005-06-17	2007-07-16	Bristol Myers Squibb Co	Triazolopyridine cannabinoid receptor 1 antagonists
US7317012B2 (en)	2005-06-17	2008-01-08	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoind-1 receptor modulators
US7795436B2 (en)	2005-08-24	2010-09-14	Bristol-Myers Squibb Company	Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
US8618115B2 (en)	2005-10-26	2013-12-31	Bristol-Myers Squibb Company	Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
US7553836B2 (en)	2006-02-06	2009-06-30	Bristol-Myers Squibb Company	Melanin concentrating hormone receptor-1 antagonists
US20090011994A1 (en)	2007-07-06	2009-01-08	Bristol-Myers Squibb Company	Non-basic melanin concentrating hormone receptor-1 antagonists and methods
PE20091928A1 (en)	2008-05-29	2009-12-31	Bristol Myers Squibb Co	HAVE HYDROXYSUSTITUTED PYRIMIDINES AS NON-BASIC MELANIN-CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
US10517839B2 (en)	2008-06-09	2019-12-31	Cornell University	Mast cell inhibition in diseases of the retina and vitreous
WO2010111665A1 (en)	2009-03-27	2010-09-30	Bristol-Myers Squibb Company	Methods for preventing major adverse cardiovascular events with dpp-iv inhibitors
SG182662A1 (en)	2010-01-28	2012-08-30	Harvard College	Compositions and methods for enhancing proteasome activity
PT2707101T (en)	2011-05-12	2019-05-30	Proteostasis Therapeutics Inc	Proteostasis regulators
US9499482B2 (en)	2012-09-05	2016-11-22	Bristol-Myers Squibb Company	Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
EP2892896B1 (en)	2012-09-05	2016-06-29	Bristol-Myers Squibb Company	Pyrrolone or pyrrolidinone melanin concentrating hormore receptor-1 antagonists
US9849135B2 (en)	2013-01-25	2017-12-26	President And Fellows Of Harvard College	USP14 inhibitors for treating or preventing viral infections
WO2015073528A1 (en)	2013-11-12	2015-05-21	Proteostasis Therapeutics, Inc.	Proteasome activity enhancing compounds
EA202190226A1 (en)	2018-07-19	2021-06-16	Астразенека Аб	METHODS FOR TREATMENT OF HFpEF USING DAPAGLIFLOSIN AND COMPOSITIONS CONTAINING IT

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US5110817A (en) *	1988-10-21	1992-05-05	Beyer Jr Karl H	Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
US4920123A (en) *	1988-10-21	1990-04-24	Beyer Jr Karl H	Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
AU7316591A (en) *	1990-02-28	1991-09-18	Upjohn Company, The	Use of 3-guanidinopropionic acid in the treatment and prevention of metabolic disorders
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ATE157351T1 (en) *	1993-02-20	1997-09-15	Hoechst Ag	SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION, AS INHIBITORS OF CELLULAR NA+/H+ EXCHANGE OR AS A DIAGNOSTIC, AND MEDICINE CONTAINING THEM
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1996
- 1996-06-03 DE DE19622222A patent/DE19622222A1/en not_active Withdrawn
1997
- 1997-05-20 SI SI9730705T patent/SI0918515T1/en unknown
- 1997-05-20 WO PCT/EP1997/002548 patent/WO1997046226A2/en not_active Ceased
- 1997-05-20 TR TR1998/02505T patent/TR199802505T2/en unknown
- 1997-05-20 JP JP50014498A patent/JP4527811B2/en not_active Expired - Fee Related
- 1997-05-20 CN CN97195194A patent/CN1221339A/en active Pending
- 1997-05-20 DE DE59712287T patent/DE59712287D1/en not_active Expired - Lifetime
- 1997-05-20 BR BR9709516A patent/BR9709516A/en not_active Application Discontinuation
- 1997-05-20 SK SK1658-98A patent/SK165898A3/en unknown
- 1997-05-20 CA CA002257299A patent/CA2257299A1/en not_active Abandoned
- 1997-05-20 ES ES97923937T patent/ES2241049T3/en not_active Expired - Lifetime
- 1997-05-20 EP EP97923937A patent/EP0918515B1/en not_active Expired - Lifetime
- 1997-05-20 PT PT97923937T patent/PT918515E/en unknown
- 1997-05-20 AT AT97923937T patent/ATE293965T1/en not_active IP Right Cessation
- 1997-05-20 DK DK97923937T patent/DK0918515T3/en active
- 1997-05-20 NZ NZ333095A patent/NZ333095A/en unknown
- 1997-05-20 IL IL12693597A patent/IL126935A0/en not_active IP Right Cessation
- 1997-05-20 RU RU99100084/14A patent/RU2211032C2/en not_active IP Right Cessation
- 1997-05-20 KR KR10-1998-0709811A patent/KR100511711B1/en not_active Expired - Fee Related
- 1997-05-20 AU AU29576/97A patent/AU722166B2/en not_active Ceased
- 1997-05-20 PL PL97330412A patent/PL189950B1/en not_active IP Right Cessation
- 1997-05-30 AR ARP970102344A patent/AR007353A1/en unknown
- 1997-06-02 ZA ZA9704828A patent/ZA974828B/en unknown
1998
- 1998-11-24 NO NO985480A patent/NO985480L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0918515B1 (en)	2005-04-27
PT918515E (en)	2005-06-30
PL330412A1 (en)	1999-05-10
CN1221339A (en)	1999-06-30
WO1997046226A2 (en)	1997-12-11
ATE293965T1 (en)	2005-05-15
DE59712287D1 (en)	2005-06-02
DK0918515T3 (en)	2005-08-15
SK165898A3 (en)	1999-05-07
AR007353A1 (en)	1999-10-27
AU2957697A (en)	1998-01-05
WO1997046226A3 (en)	1998-03-05
TR199802505T2 (en)	1999-04-21
NO985480D0 (en)	1998-11-24
JP4527811B2 (en)	2010-08-18
PL189950B1 (en)	2005-10-31
IL126935A0 (en)	1999-09-22
AU722166B2 (en)	2000-07-20
CA2257299A1 (en)	1997-12-11
RU2211032C2 (en)	2003-08-27
DE19622222A1 (en)	1997-12-04
EP0918515A2 (en)	1999-06-02
ZA974828B (en)	1997-12-03
NZ333095A (en)	2000-08-25
KR20000016240A (en)	2000-03-25
JP2000506906A (en)	2000-06-06
BR9709516A (en)	1999-08-10
KR100511711B1 (en)	2005-12-26
SI0918515T1 (en)	2005-12-31
ES2241049T3 (en)	2005-10-16

Publication	Publication Date	Title
NO985480L (en)	1999-01-28	Use of Inhibitors of a Cellular Na + / H + Exchanger (NHE) for the Preparation of a Drug for Normalization of Serum Lipids
MX173362B (en)	1994-02-23	PIPERAZINIL HETERO-CYCLIC COMPOUNDS AND PROCEDURE FOR THE PREPARATION
FI972555L (en)	1997-06-16	Preparation of coated tablets
FI970995L (en)	1997-04-25	Pharmaceutical compounds
FI971018L (en)	1997-04-18	Pharmaceutical compounds
EE9700313A (en)	1998-06-15	Stable reagents for the preparation of radiopharmaceuticals
FI972631L (en)	1997-06-18	Preparation of divisible tablets
NO971422D0 (en)	1997-03-25	drugs
FI951962A7 (en)	1995-10-26	Hydroxamic acid derivatives
FI954243A7 (en)	1996-03-13	Pharmaceutical compounds
NO972937D0 (en)	1997-06-23	Pharmaceutical piperazine compounds
EP0907644A4 (en)	2003-02-05	PHARMACEUTICAL PREPARATION
KR970707115A (en)	1997-12-01	A NEW PHYSICALLY STABLE SOLID FORM OF A FLUOROQUINOLONE
FI970574L (en)	1997-04-08	Disc aligner
MX14533A (en)	1993-10-01	PROCEDURE FOR THE PREPARATION OF PHARMACEUTICAL COMPOUNDS
BR8802893A (en)	1990-01-23	DISCHARGE SYSTEM FOR HERMETIC COMPRESSOR
FI951155A7 (en)	1995-09-15	Pharmaceutical preparation
ES552840A0 (en)	1988-01-16	PROCEDURE FOR PREPARING HETERO-CYCLIC DISULPHES
DK37589A (en)	1989-07-30	PHARMACEUTICAL PREPARATION FOR 4-AROYLIMIDAZOLE-2-ONER
HUP0001879A3 (en)	2001-03-28	Use of inhibitors of the cellular na+/h+ exchanger (nhe) for preparing a medicament for normalizing serum lipids
BR9506663A (en)	1997-09-16	Hydroxamic acid derivatives
BR8805020A (en)	1990-05-15	DISCHARGE FOR ROTARY COMPRESSOR
NO962816D0 (en)	1996-07-03	Pharmaceutical compounds
BR6901548U (en)	1991-07-02	ANTI-VIBRATION SUPPORT FOR CARDAN
ES288057Y (en)	1986-06-16	STRUCTURE FOR THE INTERNAL COMPARTMENTALATION OF A ROOM

Legal Events

Date	Code	Title	Description
2006-09-11	FC2A	Withdrawal, rejection or dismissal of laid open patent application