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NO971811L - Bicyclic tetrahydropyrazolopyridines and their use as drugs - Google Patents

Bicyclic tetrahydropyrazolopyridines and their use as drugs

Info

Publication number
NO971811L
NO971811L NO971811A NO971811A NO971811L NO 971811 L NO971811 L NO 971811L NO 971811 A NO971811 A NO 971811A NO 971811 A NO971811 A NO 971811A NO 971811 L NO971811 L NO 971811L
Authority
NO
Norway
Prior art keywords
tnf
compounds
formula
tetrahydropyrazolopyridines
bicyclic
Prior art date
Application number
NO971811A
Other languages
Norwegian (no)
Other versions
NO971811D0 (en
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO971811D0 publication Critical patent/NO971811D0/en
Publication of NO971811L publication Critical patent/NO971811L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formelen. hvor R, R, R.og X er som definert. Forbindelsene med formel I og farmasøytisk godtagbare salter derav er nyttig for å hemme fosfodiesterase (PDE) type IV og produksjon av tumor-nekrose-faktor(TNF) og for behandling av astma, artritt, bronkitt, kronisk obstruktiv luftveissykdom, psoriasis, allergisk rhinitt, dermatitt og andre inflammatoriske sykdommer, AIDS, septisk sjokk og andre sykdommer som involverer produksjon av TNF.Compounds of the formula. where R, R, R 1 and X are as defined. The compounds of formula I and pharmaceutically acceptable salts thereof are useful for inhibiting phosphodiesterase (PDE) type IV and production of tumor necrosis factor (TNF) and for the treatment of asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases, AIDS, septic shock and other diseases involving the production of TNF.

NO971811A 1994-10-20 1997-04-18 Bicyclic tetrahydropyrazolopyridines and their use as drugs NO971811L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32643494A 1994-10-20 1994-10-20
PCT/IB1995/000847 WO1996012720A1 (en) 1994-10-20 1995-10-06 Bicyclic tetrahydro pyrazolopyridines and their use as medicaments

Publications (2)

Publication Number Publication Date
NO971811D0 NO971811D0 (en) 1997-04-18
NO971811L true NO971811L (en) 1997-06-18

Family

ID=23272184

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971811A NO971811L (en) 1994-10-20 1997-04-18 Bicyclic tetrahydropyrazolopyridines and their use as drugs

Country Status (16)

Country Link
EP (1) EP0787132A1 (en)
JP (1) JPH09511758A (en)
KR (1) KR970707124A (en)
CN (1) CN1050129C (en)
AU (1) AU702105B2 (en)
BR (1) BR9504491A (en)
CZ (1) CZ120097A3 (en)
FI (1) FI954991L (en)
HU (1) HUT77517A (en)
IL (1) IL115667A0 (en)
MX (1) MX9504422A (en)
NO (1) NO971811L (en)
NZ (1) NZ292991A (en)
PL (1) PL319758A1 (en)
WO (1) WO1996012720A1 (en)
ZA (1) ZA958839B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2001002304A0 (en) * 1996-05-03 2001-12-31 Pfizer Substituted indazole derivatives and related compounds
CA2258728C (en) 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
PT912558E (en) * 1996-06-25 2003-11-28 Pfizer SUBSTITUTED INDAZOLE DERIVATIVES AND THEIR USE AS TYPE IV PHOSPHODIESTERASE (PDE) INHIBITORS AND TUMOR NECROSIS (TNF) FACTOR INHIBITORS
PT983249E (en) 1997-05-08 2002-08-30 Pfizer Prod Inc PROCESSES AND INTERMEDIARIES FOR THE PREPARATION OF SUBSTITUTED INDAZOLE DERIVATIVES
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
SI1140941T1 (en) 1998-12-23 2005-04-30 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
TR200909479T2 (en) 1999-08-21 2012-02-21 Nycomed Gmbh Synergistic combination.
MXPA03001169A (en) * 2000-08-10 2003-06-30 Pharmacia Italia Spa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them.
US6998408B2 (en) 2001-03-23 2006-02-14 Bristol-Myers Squibb Pharma Company 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
US6750225B2 (en) 2001-04-18 2004-06-15 Bristol-Myers Squibb Pharms Company 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors
EP1379244A4 (en) 2001-04-18 2006-03-15 Bristol Myers Squibb Co 1,4,5,6-tetrahydropyrazolo- 3,4-c]-pyridin-7-ones as factor xa inhibitors
WO2002088122A1 (en) * 2001-04-26 2002-11-07 Ajinomoto Co., Inc. Heterocyclic compounds
GEP20074098B (en) 2001-09-21 2007-05-10 Bristol Myers Squibb Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
US20060100233A1 (en) * 2002-07-25 2006-05-11 Manuela Villa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
MXPA05010373A (en) 2003-04-01 2005-12-05 Applied Research Systems Inhibitors of phosphodiesterases in infertility.
FR2857363B1 (en) * 2003-07-10 2007-09-07 Aventis Pharma Sa SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO [3,4-C] PYRIDINES COMPOSITIONS CONTAINING SAME AND USE THEREOF
AR045037A1 (en) * 2003-07-10 2005-10-12 Aventis Pharma Sa TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE.
US7732609B2 (en) * 2005-12-01 2010-06-08 Elan Pharmaceuticals, Inc. 5-(arylsulfonyl)-pyrazolopiperidines
EP2276769A4 (en) * 2008-04-30 2011-08-17 Almqvist Fredrik New peptidomimetic compounds
US7741350B1 (en) 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
JP6062633B2 (en) 2009-01-28 2017-01-18 カラ セラピューティクス インコーポレイテッド Bicyclic pyrazoloheterocycles
US10144732B2 (en) 2014-06-06 2018-12-04 Biogen Ma Inc. ATX modulating agents
CN115043768A (en) * 2022-06-20 2022-09-13 新乡市润宇新材料科技有限公司 Method for synthesizing N-aryl pyrrolidine-2-ketone by acid-promoted ring opening of cyclopropyl

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
FR1463883A (en) * 1964-09-08 1966-07-22 Ciba Geigy Process for the preparation of bicyclic triaza-compounds
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
EP0707585A1 (en) * 1993-07-06 1996-04-24 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines

Also Published As

Publication number Publication date
NZ292991A (en) 1999-02-25
KR970707124A (en) 1997-12-01
EP0787132A1 (en) 1997-08-06
NO971811D0 (en) 1997-04-18
AU3531795A (en) 1996-05-15
JPH09511758A (en) 1997-11-25
WO1996012720A1 (en) 1996-05-02
FI954991A0 (en) 1995-10-19
MX9504422A (en) 1997-04-30
CN1161040A (en) 1997-10-01
CZ120097A3 (en) 1998-01-14
HUT77517A (en) 1998-05-28
AU702105B2 (en) 1999-02-11
FI954991A7 (en) 1996-04-21
FI954991L (en) 1996-04-21
ZA958839B (en) 1997-04-21
CN1050129C (en) 2000-03-08
PL319758A1 (en) 1997-08-18
IL115667A0 (en) 1996-01-19
BR9504491A (en) 1997-05-20

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