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NO970892D0 - Oxazolderivater - Google Patents

Oxazolderivater

Info

Publication number
NO970892D0
NO970892D0 NO970892A NO970892A NO970892D0 NO 970892 D0 NO970892 D0 NO 970892D0 NO 970892 A NO970892 A NO 970892A NO 970892 A NO970892 A NO 970892A NO 970892 D0 NO970892 D0 NO 970892D0
Authority
NO
Norway
Prior art keywords
group
ring
integer
alkylthio
amino
Prior art date
Application number
NO970892A
Other languages
English (en)
Other versions
NO308741B1 (no
NO970892L (no
Inventor
Koichi Kojima
Junichi Sakai
Yuichi Aizawa
Naozumi Samata
Masao Kozuka
Kenji Yoshimi
Isao Kaneko
Kazuro Koyama
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO970892D0 publication Critical patent/NO970892D0/no
Publication of NO970892L publication Critical patent/NO970892L/no
Publication of NO308741B1 publication Critical patent/NO308741B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO970892A 1994-08-30 1997-02-27 Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene NO308741B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20536394 1994-08-30
JP15057195 1995-06-16
PCT/JP1995/001714 WO1996006837A1 (en) 1994-08-30 1995-08-29 Isoxazoles

Publications (3)

Publication Number Publication Date
NO970892D0 true NO970892D0 (no) 1997-02-27
NO970892L NO970892L (no) 1997-04-29
NO308741B1 NO308741B1 (no) 2000-10-23

Family

ID=26480122

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970892A NO308741B1 (no) 1994-08-30 1997-02-27 Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene

Country Status (19)

Country Link
US (2) US5965591A (no)
EP (1) EP0779281B1 (no)
KR (1) KR970705549A (no)
CN (1) CN1098843C (no)
AT (1) ATE253057T1 (no)
AU (1) AU688102B2 (no)
CA (1) CA2198457A1 (no)
CZ (1) CZ290961B6 (no)
DE (1) DE69532039T2 (no)
DK (1) DK0779281T3 (no)
ES (1) ES2208690T3 (no)
FI (1) FI970864A7 (no)
HU (1) HU221138B1 (no)
MX (1) MX9701630A (no)
NO (1) NO308741B1 (no)
NZ (1) NZ291508A (no)
PT (1) PT779281E (no)
RU (1) RU2140414C1 (no)
WO (1) WO1996006837A1 (no)

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WO1996006837A1 (en) * 1994-08-30 1996-03-07 Sankyo Company, Limited Isoxazoles
CZ272598A3 (cs) * 1996-02-27 1999-01-13 Sankyo Company, Limited Isoxazolové deriváty
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO2000027199A1 (en) * 1998-11-12 2000-05-18 Eli Lilly And Company Aminobenzisoxazole compounds and libraries thereof
US6497928B1 (en) 1999-05-14 2002-12-24 Canon Kabushiki Kaisha Liquid crystal device, mesomorphic functional material and liquid crystal apparatus
DE10000577A1 (de) 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US8933236B2 (en) 2012-05-22 2015-01-13 Xenon Pharmaceuticals Inc. N-substituted benzamides and methods of use thereof
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US6660736B2 (en) * 2002-03-27 2003-12-09 Hoffmann-La Roche Inc. Phthalimido derivatives and a process for their preparation
PE20050077A1 (es) * 2002-09-20 2005-03-01 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil-eter
AU2004312530A1 (en) * 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
WO2005066143A2 (en) * 2003-12-29 2005-07-21 Sepracor Inc. Benzo[d]isoxazol-3-ol daao inhibitors
EP1746991A2 (en) * 2004-03-16 2007-01-31 Janssen Pharmaceutica N.V. Daao inhibiting benzisoxazoles for treating mental disorders
AU2005268894B2 (en) * 2004-08-02 2010-12-16 F. Hoffmann-La Roche Ag Benzyloxy derivatives as MAOB inhibitors
DE102005018389A1 (de) * 2005-04-20 2006-10-26 Sanofi-Aventis Deutschland Gmbh Azolderivate als Inhibitoren von Lipasen und Phospholipasen
CN101553217A (zh) 2005-07-06 2009-10-07 塞普拉科公司 艾司佐匹克隆与反式4－(3,4－二氯苯基)－1,2,3,4－四氢－n－甲基－1－萘胺或反式4－(3,4－二氯苯基)－1,2,3,4－四氢－1－萘胺的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
CA2616337A1 (en) * 2005-07-28 2007-02-08 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
US8053603B2 (en) * 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
CA2636324C (en) * 2006-01-06 2012-03-20 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
RU2434002C2 (ru) * 2006-02-21 2011-11-20 Тояма Кемикал Ко., Лтд. Способ получения сложного эфира 3-[5-[4-(циклопентилокси)-2-гидроксибензоил]-2-[(3-оксо-2-замещенный-2, 3-дигидро-1, 2-бензизоксазол-6-ил)метокси]фенил]пропионовой кислоты и промежуточного продукта для данного способа
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
ES2627221T3 (es) 2006-12-28 2017-07-27 Rigel Pharmaceuticals, Inc. Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
KR20090111322A (ko) * 2007-01-18 2009-10-26 세프라코 아이엔시. 디 아미노산 옥시다제의 억제제
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP5420534B2 (ja) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
CA2716080C (en) 2008-02-20 2016-12-13 Targia Pharmaceuticals Cns pharmaceutical compositions and methods of use
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
AU2011215645A1 (en) 2010-02-11 2012-09-20 Vanderbilt University Benzisoxazoles and azabenzisoxazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2013064984A1 (en) 2011-10-31 2013-05-10 Xenon Pharmaceuticals Inc. Biaryl ether sulfonamides and their use as therapeutic agents
JP6014154B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用
BR112015000187A2 (pt) 2012-07-06 2017-06-27 Genentech Inc benzamidas substituídas com n e métodos de uso das mesmas
KR20150131233A (ko) 2013-03-14 2015-11-24 제넨테크, 인크. 치환된 트리아졸로피리딘 및 이의 사용 방법
CN105492430B (zh) * 2013-03-15 2017-10-10 基因泰克公司 取代的苯并噁唑及其使用方法
US9493429B2 (en) 2013-03-15 2016-11-15 Genentech, Inc. Substituted benzoxazoles and methods of use thereof
CR20160296A (es) 2013-11-27 2016-09-20 Genentech Inc Benzamidas sustituidas y métodos para usarlas
WO2016007534A1 (en) 2014-07-07 2016-01-14 Genentech, Inc. Therapeutic compounds and methods of use thereof
EP3297989A1 (en) 2015-05-22 2018-03-28 Genentech, Inc. Substituted benzamides and methods of use thereof
CN108137477A (zh) 2015-08-27 2018-06-08 基因泰克公司 治疗化合物及其使用方法
EP3380466A1 (en) 2015-11-25 2018-10-03 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
US10766858B2 (en) 2016-03-30 2020-09-08 Genentech, Inc. Substituted benzamides and methods of use thereof
CN105801510A (zh) * 2016-04-08 2016-07-27 李勇 一种治疗抑郁症的药物组合物
MX388175B (es) 2016-10-17 2025-03-19 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos
EP3601273B1 (en) 2017-03-24 2021-12-01 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
CN112041313A (zh) 2018-02-26 2020-12-04 基因泰克公司 吡啶-磺酰胺化合物及其针对疼痛和相关疾患的用途
JP2021519788A (ja) 2018-03-30 2021-08-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
CN114349690B (zh) * 2022-02-15 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体合成方法

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SU539522A3 (ru) * 1970-02-05 1976-12-15 Мерк Энд Ко. Инк. (Фирма) Способ получени гидразин- -фенилпропионовой кислоты
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US5321037A (en) * 1986-12-26 1994-06-14 Sankyo Company, Limited Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
IE62276B1 (en) * 1988-03-30 1995-01-25 Sankyo Co "New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants"
US5116839A (en) * 1989-06-26 1992-05-26 Sankyo Company, Limited Use of isoxazolin-3-one derivatives as antidepressants
US5352688A (en) * 1991-02-14 1994-10-04 The Mount Sinai School Of Medicine Of The City University Of New York Methods for the treatment of bradyphrenia in parkinson's disease
US5750542A (en) * 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
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Also Published As

Publication number Publication date
CA2198457A1 (en) 1996-03-07
HU221138B1 (en) 2002-08-28
US6096771A (en) 2000-08-01
ATE253057T1 (de) 2003-11-15
FI970864A7 (fi) 1997-04-24
CN1162957A (zh) 1997-10-22
AU3266095A (en) 1996-03-22
EP0779281A1 (en) 1997-06-18
NZ291508A (en) 1999-07-29
RU2140414C1 (ru) 1999-10-27
AU688102B2 (en) 1998-03-05
EP0779281A4 (en) 2000-07-26
DK0779281T3 (da) 2004-03-08
NO308741B1 (no) 2000-10-23
MX9701630A (es) 1997-06-28
HK1018878A1 (en) 2000-01-07
DE69532039D1 (de) 2003-12-04
EP0779281B1 (en) 2003-10-29
KR970705549A (ko) 1997-10-09
HUT77225A (hu) 1998-03-02
CN1098843C (zh) 2003-01-15
PT779281E (pt) 2004-02-27
US5965591A (en) 1999-10-12
CZ290961B6 (cs) 2002-11-13
CZ59897A3 (en) 1997-07-16
FI970864A0 (fi) 1997-02-28
WO1996006837A1 (en) 1996-03-07
NO970892L (no) 1997-04-29
ES2208690T3 (es) 2004-06-16
DE69532039T2 (de) 2004-07-08

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