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NO975710D0 - New dolastatin derivatives, their preparation and use - Google Patents

New dolastatin derivatives, their preparation and use

Info

Publication number
NO975710D0
NO975710D0 NO975710A NO975710A NO975710D0 NO 975710 D0 NO975710 D0 NO 975710D0 NO 975710 A NO975710 A NO 975710A NO 975710 A NO975710 A NO 975710A NO 975710 D0 NO975710 D0 NO 975710D0
Authority
NO
Norway
Prior art keywords
preparation
dolastatin derivatives
new dolastatin
new
derivatives
Prior art date
Application number
NO975710A
Other languages
Norwegian (no)
Other versions
NO975710L (en
NO318384B1 (en
Inventor
Andreas Haupt
Franz Emling
Cynthia Romerdahl
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO975710D0 publication Critical patent/NO975710D0/en
Publication of NO975710L publication Critical patent/NO975710L/en
Publication of NO318384B1 publication Critical patent/NO318384B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO19975710A 1995-06-07 1997-12-05 New dolastatin derivatives, their preparation and use, as well as pharmaceutical compositions containing them. NO318384B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/472,453 US5831002A (en) 1992-05-20 1995-06-07 Antitumor peptides
PCT/EP1996/002393 WO1996040752A1 (en) 1995-06-07 1996-06-03 Novel dolastatin derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
NO975710D0 true NO975710D0 (en) 1997-12-05
NO975710L NO975710L (en) 1998-02-02
NO318384B1 NO318384B1 (en) 2005-03-14

Family

ID=23875567

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19975711A NO317670B1 (en) 1995-06-07 1997-12-05 New dolastatin derivatives, their preparation and use
NO19975710A NO318384B1 (en) 1995-06-07 1997-12-05 New dolastatin derivatives, their preparation and use, as well as pharmaceutical compositions containing them.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19975711A NO317670B1 (en) 1995-06-07 1997-12-05 New dolastatin derivatives, their preparation and use

Country Status (33)

Country Link
US (1) US5831002A (en)
EP (2) EP0871656B1 (en)
JP (2) JP3957751B2 (en)
KR (2) KR100437986B1 (en)
CN (2) CN1182154C (en)
AR (2) AR003427A1 (en)
AT (2) ATE223431T1 (en)
AU (2) AU725170B2 (en)
BG (2) BG102125A (en)
BR (2) BR9609424A (en)
CA (2) CA2219819C (en)
CO (2) CO4700526A1 (en)
CZ (2) CZ293682B6 (en)
DE (2) DE69623992T2 (en)
DK (2) DK0832104T3 (en)
ES (2) ES2188759T3 (en)
HR (2) HRP960277A2 (en)
HU (2) HU228071B1 (en)
IL (2) IL122215A (en)
MX (2) MX9709146A (en)
MY (2) MY119042A (en)
NO (2) NO317670B1 (en)
NZ (2) NZ310443A (en)
PL (2) PL185763B1 (en)
PT (2) PT871656E (en)
RO (2) RO118953B1 (en)
SI (2) SI0832104T1 (en)
SK (1) SK282466B6 (en)
TR (2) TR199701545T1 (en)
TW (2) TW508357B (en)
UA (2) UA46776C2 (en)
WO (2) WO1996040752A1 (en)
ZA (2) ZA964710B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP1381668A1 (en) 2001-04-27 2004-01-21 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
AU2002359792A1 (en) * 2001-12-18 2003-06-30 Proteologics, Inc. Methods and compositions for the inhibition of viral release
EP1531846A4 (en) * 2002-02-27 2006-04-19 Us Gov Health & Human Serv LIGAND CONJUGATES, ADAPTER AND CYTOTOXIC AGENT, RELATED COMPOSITIONS AND RELATED METHODS OF USE
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
JP2009504751A (en) * 2005-08-19 2009-02-05 アメリカ合衆国 Topical preparation of histone deacetylase inhibitor and method of use thereof
EP1973928A2 (en) * 2005-10-11 2008-10-01 Ramot at Tel-Aviv University Ltd. Self-assembled fmoc-ff hydrogels
MY159563A (en) 2006-05-16 2017-01-13 Pharmascience Inc Iap bir domain binding compounds
JP5452223B2 (en) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション IAP inhibitor
US7985879B2 (en) * 2007-04-12 2011-07-26 Scinopharm Taiwan Ltd. Process for making galantamine
UY32099A (en) 2008-09-11 2010-04-30 Enanta Pharm Inc HEPATITIS C SERINA PROTEASAS MACROCYCLIC INHIBITORS
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
EP2658858A4 (en) 2010-12-30 2014-06-25 Enanta Pharm Inc Phenanthridine macrocyclic hepatitis c serine protease inhibitors
MX2013007677A (en) 2010-12-30 2013-07-30 Abbvie Inc Macrocyclic hepatitis c serine protease inhibitors.
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US9796754B2 (en) 2011-05-27 2017-10-24 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
WO2023033129A1 (en) 2021-09-03 2023-03-09 東レ株式会社 Pharmaceutical composition for treating and/or preventing cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
EP0598129B1 (en) * 1991-08-09 2000-03-22 Teikoku Hormone Mfg. Co., Ltd. Novel tetrapeptide derivative
JP3523253B2 (en) * 1992-05-20 2004-04-26 アボット ゲーエムベーハー ウント カンパニー カーゲー Dolastatin derivatives
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters

Also Published As

Publication number Publication date
UA46775C2 (en) 2002-06-17
UA46776C2 (en) 2002-06-17
IL122216A0 (en) 1998-04-05
IL122215A0 (en) 1998-04-05
EP0871656A1 (en) 1998-10-21
IL122215A (en) 2001-08-26
JP4221062B2 (en) 2009-02-12
DE69623992D1 (en) 2002-10-31
CN1182153C (en) 2004-12-29
CA2219818C (en) 2008-05-20
RO118953B1 (en) 2004-01-30
PL323726A1 (en) 1998-04-14
HUP9801910A2 (en) 1999-01-28
TW424096B (en) 2001-03-01
AR003427A1 (en) 1998-08-05
HRP960277A2 (en) 1997-10-31
HUP9801817A3 (en) 1999-06-28
TW508357B (en) 2002-11-01
NO317670B1 (en) 2004-11-29
BR9609424A (en) 2000-03-28
EP0832104A1 (en) 1998-04-01
PT871656E (en) 2002-12-31
PT832104E (en) 2002-12-31
SI0832104T1 (en) 2003-08-31
KR100437986B1 (en) 2004-09-18
BG102125A (en) 1998-09-30
SI0871656T1 (en) 2003-08-31
SK282466B6 (en) 2002-02-05
PL323723A1 (en) 1998-04-14
HUP9801910A3 (en) 1999-06-28
HUP9801817A2 (en) 1998-11-30
DK0832104T3 (en) 2003-01-06
SK165397A3 (en) 1998-10-07
AU6124296A (en) 1996-12-30
AR003136A1 (en) 1998-07-08
NO975711D0 (en) 1997-12-05
CA2219819A1 (en) 1996-12-19
NO975710L (en) 1998-02-02
WO1996040751A1 (en) 1996-12-19
BG102152A (en) 1998-09-30
MY119042A (en) 2005-03-31
KR100437985B1 (en) 2004-09-18
NO975711L (en) 1998-01-30
MX9709146A (en) 1998-03-31
PL185762B1 (en) 2003-07-31
DE69623472T2 (en) 2003-08-21
TR199701545T1 (en) 1998-04-21
JPH11504653A (en) 1999-04-27
ATE224910T1 (en) 2002-10-15
BR9609423A (en) 1999-06-29
CZ376597A3 (en) 1998-06-17
DK0871656T3 (en) 2003-01-27
NZ310444A (en) 1999-11-29
TR199701544T1 (en) 1998-03-21
ES2188759T3 (en) 2003-07-01
CN1182154C (en) 2004-12-29
AU725164B2 (en) 2000-10-05
CA2219819C (en) 2008-05-20
HU228073B1 (en) 2012-09-28
AU6124196A (en) 1996-12-30
ES2186783T3 (en) 2003-05-16
KR19990022583A (en) 1999-03-25
CO4700527A1 (en) 1998-12-29
AU725170B2 (en) 2000-10-05
JP3957751B2 (en) 2007-08-15
JPH11504652A (en) 1999-04-27
CN1187198A (en) 1998-07-08
NO318384B1 (en) 2005-03-14
EP0832104B1 (en) 2002-09-04
US5831002A (en) 1998-11-03
CZ293682B6 (en) 2004-07-14
CZ293683B6 (en) 2004-07-14
MX9709147A (en) 1998-03-31
DE69623472D1 (en) 2002-10-10
DE69623992T2 (en) 2003-05-22
ZA964711B (en) 1997-12-08
MY124487A (en) 2006-06-30
WO1996040752A1 (en) 1996-12-19
EP0871656B1 (en) 2002-09-25
CA2219818A1 (en) 1996-12-19
HU228071B1 (en) 2012-09-28
IL122216A (en) 2002-02-10
CZ376397A3 (en) 1998-06-17
ATE223431T1 (en) 2002-09-15
PL185763B1 (en) 2003-07-31
RO119783B1 (en) 2005-03-30
CN1187199A (en) 1998-07-08
NZ310443A (en) 1999-10-28
HRP960257A2 (en) 1998-02-28
CO4700526A1 (en) 1998-12-29
KR19990022582A (en) 1999-03-25
ZA964710B (en) 1997-12-08

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: ABBVIE DEUTSCHLAND GMBH & CO AG, DE

MM1K Lapsed by not paying the annual fees