NO974595L - Imidazo £ 1,2-a | pyridin-derivatives - Google Patents
Imidazo £ 1,2-a | pyridin-derivativesInfo
- Publication number
- NO974595L NO974595L NO974595A NO974595A NO974595L NO 974595 L NO974595 L NO 974595L NO 974595 A NO974595 A NO 974595A NO 974595 A NO974595 A NO 974595A NO 974595 L NO974595 L NO 974595L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- derivatives
- imidazo
- pyridin
- compounds
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Denne oppfinnelse tilveiebringer forbindelsene med formel (I) og farmasøytisk akseptable derivater derav hvori: R° representerer halogen; R1 og RJ uavhengig er valgt fra H, halogen, C^alkyl. CMalkyl substituert med ett eller flere fluoratomer. CMalkoksy. C^hydroksyalkyl. SCMalkyl. C(0)H eller C(0)C,.4alkyl; og R5 representerer C,.4alkyl. Forbindelser med formel (I) er potente og selektive inhibitorer av COX-2 og kan anvendes ved behandling av smerte, feber og betennelse ved flere forskjellige tilstander og sykdommer.This invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R R represents halogen; R1 and RJ are independently selected from H, halogen, C1-4 alkyl. C1-4 alkyl substituted with one or more fluorine atoms. Alkoxy. C ^ hydroxyalkyl. SCMalkyl. C (O) H or C (O) C 1-4 alkyl; and R 5 represents C 1-4 alkyl. Compounds of formula (I) are potent and selective inhibitors of COX-2 and can be used in the treatment of pain, fever and inflammation in a variety of conditions and diseases.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9506965.4A GB9506965D0 (en) | 1995-04-04 | 1995-04-04 | Chemical compounds |
| GBGB9512099.4A GB9512099D0 (en) | 1995-06-14 | 1995-06-14 | Chemical compounds |
| GBGB9516117.0A GB9516117D0 (en) | 1995-08-05 | 1995-08-05 | Chemical compounds |
| PCT/EP1996/001438 WO1996031509A1 (en) | 1995-04-04 | 1996-04-02 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO974595D0 NO974595D0 (en) | 1997-10-03 |
| NO974595L true NO974595L (en) | 1997-12-03 |
Family
ID=27267657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO974595A NO974595L (en) | 1995-04-04 | 1997-10-03 | Imidazo £ 1,2-a | pyridin-derivatives |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0819127A1 (en) |
| JP (1) | JPH11501049A (en) |
| KR (1) | KR19980703559A (en) |
| CN (1) | CN1186492A (en) |
| AU (1) | AU5276696A (en) |
| BG (1) | BG101934A (en) |
| CA (1) | CA2216809A1 (en) |
| CZ (1) | CZ313397A3 (en) |
| EA (1) | EA199700209A1 (en) |
| HU (1) | HUP9801602A3 (en) |
| IS (1) | IS4570A (en) |
| NO (1) | NO974595L (en) |
| NZ (1) | NZ304886A (en) |
| PL (1) | PL322623A1 (en) |
| SK (1) | SK133297A3 (en) |
| TR (1) | TR199701105T1 (en) |
| WO (1) | WO1996031509A1 (en) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2764292B1 (en) * | 1997-06-10 | 2000-12-29 | Innothera Lab Sa | USE OF DICETONIC TETRACYCLE DERIVATIVES, NOVEL COMPOUNDS OBTAINED AND THEIR APPLICATION IN THERAPEUTICS |
| US6307047B1 (en) | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| US6525053B1 (en) | 1997-08-22 | 2003-02-25 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| HRP20000122B1 (en) * | 1997-09-05 | 2003-06-30 | Glaxo Group Ltd | 2,3-diaryl-pyrazolo/1,5-b/pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (cox-2) |
| FR2770131A1 (en) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Analgesic combinations of a cyclooxygenase-2 inhibitor and acetaminophen or an opiate having synergistic activity |
| FR2771005B1 (en) * | 1997-11-18 | 2002-06-07 | Union Pharma Scient Appl | NEW PHARMACEUTICAL ASSOCIATION WITH ANALGESIC ACTIVITY |
| GB9810920D0 (en) * | 1998-05-21 | 1998-07-22 | Merck Sharp & Dohme | Therapeutic use |
| ES2140354B1 (en) * | 1998-08-03 | 2000-11-01 | S A L V A T Lab Sa | IMIDAZO (1,2A) AZINAS SUBSTITUTED AS SELECTIVE INHIBITORS OF COX-2. |
| TW587079B (en) | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
| BR9915011A (en) | 1998-11-03 | 2001-08-07 | Glaxo Group Ltd | Compounds, method for preparing them, pharmaceutical composition, methods of treating a human or animal individual suffering from a condition that is mediated by selective inhibition of cox-2 and suffering from an inflammatory disorder, and, use of a compound |
| JP2002538157A (en) | 1999-02-27 | 2002-11-12 | グラクソ グループ リミテッド | Pyrazolopyridine |
| CO5261556A1 (en) | 1999-12-08 | 2003-03-31 | Pharmacia Corp | CYCLLOXYGENASE-2 INHIBITING COMPOSITIONS THAT HAVE FAST THERAPEUTIC EFFECT ACCESS |
| GB9930358D0 (en) * | 1999-12-22 | 2000-02-09 | Glaxo Group Ltd | Process for the preparation of chemical compounds |
| CA2393724A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| GB0002312D0 (en) * | 2000-02-01 | 2000-03-22 | Glaxo Group Ltd | Medicaments |
| PE20011333A1 (en) | 2000-03-16 | 2002-01-16 | Almirall Prodesfarma Ag | DERIVATIVES OF 2-FENYLPYRAN-4-ONA AS INHIBITORS OF CYCLOOXYGENASE 2 |
| PE20020146A1 (en) * | 2000-07-13 | 2002-03-31 | Upjohn Co | OPHTHALMIC FORMULATION INCLUDING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR |
| DK1303265T3 (en) | 2000-07-20 | 2007-11-12 | Lauras As | Use of COX-2 inhibitors as immunostimulants in the treatment of HIV or AIDS |
| PE20020506A1 (en) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | PIRAZOLE DERIVATIVES FUSED AS PROTEIN KINASE INHIBITORS |
| GB0025449D0 (en) * | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| US7163940B2 (en) | 2000-12-15 | 2007-01-16 | Smithkline Beecham Corporation | Pyrazolopyridinyl pyrimidine therapeutic compounds |
| ES2245380T3 (en) | 2000-12-15 | 2006-01-01 | Glaxo Group Limited | PIRAZOLOPIRIDINAS. |
| DE60201074T2 (en) | 2001-03-08 | 2005-09-15 | Smithkline Beecham Corp. | pyrazolopyridine derivatives |
| US7034030B2 (en) | 2001-03-30 | 2006-04-25 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapeutic compounds |
| PE20021017A1 (en) | 2001-04-03 | 2002-11-24 | Pharmacia Corp | RECONSTITUABLE PARENTERAL COMPOSITION |
| US7141569B2 (en) | 2001-04-10 | 2006-11-28 | Smithkline Beecham Corporation | Antiviral pyrazolopyridine compounds |
| US6756498B2 (en) | 2001-04-27 | 2004-06-29 | Smithkline Beecham Corporation | Process for the preparation of chemical compounds |
| ES2242028T3 (en) | 2001-04-27 | 2005-11-01 | Smithkline Beecham Corporation | DERIVATIVES OF PIRAZOLO (1,5-A) PIRIDINA. |
| PL366827A1 (en) | 2001-06-21 | 2005-02-07 | Smithkline Beecham Corporation | Imidazo[1,2-a]pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
| AR038957A1 (en) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | COMBINATION THERAPY FOR CANCER TREATMENT |
| US7244740B2 (en) | 2001-10-05 | 2007-07-17 | Smithkline Beecham Corporation | Imidazo-pyridine derivatives for use in the treatment of herpes viral infection |
| GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124938D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| ES2292839T3 (en) | 2001-12-11 | 2008-03-16 | Smithkline Beecham Corporation | DERIVATIVES OF PIRAZOLO-PIRIDINA AS AGENTS AGAINST HERPES. |
| ATE485275T1 (en) | 2002-02-12 | 2010-11-15 | Glaxosmithkline Llc | NICOTINAMIDES AND THEIR USE AS P38 INHIBITORS |
| CA2492066A1 (en) | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| US7153863B2 (en) | 2002-10-03 | 2006-12-26 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridline derivatives |
| KR20040072004A (en) | 2003-02-07 | 2004-08-16 | 삼성에스디아이 주식회사 | Emitting compound for electroluminescence device and device using thereof |
| GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| DE602004002832T2 (en) | 2003-05-07 | 2007-06-06 | Osteologix A/S | TREATMENT OF CARTILAGE / BONE DISEASES WITH WATER-SOLUBLE STRONTIUM SALTS |
| GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| WO2006041855A2 (en) | 2004-10-04 | 2006-04-20 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
| US20090018091A1 (en) | 2005-08-02 | 2009-01-15 | Nitromed, Inc. | Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use |
| WO2007126609A1 (en) | 2006-03-29 | 2007-11-08 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
| MX2009004700A (en) | 2006-11-06 | 2009-05-15 | Supergen Inc | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors. |
| EP3409278B8 (en) | 2011-07-21 | 2020-11-04 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| EP3292213A1 (en) | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Biomarkers for the detection of aspirin insensitivity |
| CA3127502A1 (en) | 2019-02-12 | 2020-08-20 | Sumitomo Dainippon Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
| WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455924A (en) * | 1967-02-08 | 1969-07-15 | Upjohn Co | Dianisylimidazoles |
-
1996
- 1996-04-02 EA EA199700209A patent/EA199700209A1/en unknown
- 1996-04-02 CA CA002216809A patent/CA2216809A1/en not_active Abandoned
- 1996-04-02 EP EP96909164A patent/EP0819127A1/en not_active Withdrawn
- 1996-04-02 CN CN96194403A patent/CN1186492A/en active Pending
- 1996-04-02 WO PCT/EP1996/001438 patent/WO1996031509A1/en not_active Ceased
- 1996-04-02 HU HU9801602A patent/HUP9801602A3/en unknown
- 1996-04-02 CZ CZ973133A patent/CZ313397A3/en unknown
- 1996-04-02 TR TR97/01105T patent/TR199701105T1/en unknown
- 1996-04-02 NZ NZ304886A patent/NZ304886A/en unknown
- 1996-04-02 KR KR1019970706963A patent/KR19980703559A/en not_active Ceased
- 1996-04-02 SK SK1332-97A patent/SK133297A3/en unknown
- 1996-04-02 AU AU52766/96A patent/AU5276696A/en not_active Abandoned
- 1996-04-02 PL PL96322623A patent/PL322623A1/en unknown
- 1996-04-02 JP JP8529971A patent/JPH11501049A/en active Pending
-
1997
- 1997-09-25 IS IS4570A patent/IS4570A/en unknown
- 1997-09-30 BG BG101934A patent/BG101934A/en unknown
- 1997-10-03 NO NO974595A patent/NO974595L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IS4570A (en) | 1997-09-25 |
| WO1996031509A1 (en) | 1996-10-10 |
| HUP9801602A2 (en) | 1998-11-30 |
| MX9707379A (en) | 1997-11-29 |
| EA199700209A1 (en) | 1998-04-30 |
| AU5276696A (en) | 1996-10-23 |
| CA2216809A1 (en) | 1996-10-10 |
| CZ313397A3 (en) | 1998-03-18 |
| NZ304886A (en) | 1998-11-25 |
| CN1186492A (en) | 1998-07-01 |
| NO974595D0 (en) | 1997-10-03 |
| TR199701105T1 (en) | 1998-02-21 |
| SK133297A3 (en) | 1998-07-08 |
| BG101934A (en) | 1999-04-30 |
| EP0819127A1 (en) | 1998-01-21 |
| KR19980703559A (en) | 1998-11-05 |
| PL322623A1 (en) | 1998-02-02 |
| HUP9801602A3 (en) | 1999-01-28 |
| JPH11501049A (en) | 1999-01-26 |
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