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NO943687L - 4-(4'-piperidinyl eller 3'-pirrolidinyl) substituerte imidazoler som H3-reseptorantagonister og terapeutiske anvendelser derav - Google Patents

4-(4'-piperidinyl eller 3'-pirrolidinyl) substituerte imidazoler som H3-reseptorantagonister og terapeutiske anvendelser derav

Info

Publication number
NO943687L
NO943687L NO943687A NO943687A NO943687L NO 943687 L NO943687 L NO 943687L NO 943687 A NO943687 A NO 943687A NO 943687 A NO943687 A NO 943687A NO 943687 L NO943687 L NO 943687L
Authority
NO
Norway
Prior art keywords
pyrrolidinyl
piperidinyl
receptor antagonists
therapeutic uses
group
Prior art date
Application number
NO943687A
Other languages
English (en)
Other versions
NO943687D0 (no
Inventor
Graham J Durant
Amin M Khan
Original Assignee
Univ Toledo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Toledo filed Critical Univ Toledo
Publication of NO943687D0 publication Critical patent/NO943687D0/no
Publication of NO943687L publication Critical patent/NO943687L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Nye forbindelser som har aktivitet som hlstamln-H3- reseptorantagonlster. Ifølge et foretrukket aspekt viser foreliggende forbindelser lett penetrasjon av blod-hjernebarrieren og redusert tokslsltet. De nye forbindelsene Innbefatter forbindelser av formelen: <°>x<CH2>nR2 (D hvor D er CH2 eller CH2-CH2. Z er S eller O, fortrinns- vis O, x er O eller l, n er et helt tall fra O til 6, R! representerer fortrinnsvis hydrogen eller en hydrolyserbar gruppe, men kan være en lavere alkyl- eller arylgruppe, og R2 representerer en lineær, forgrenet eller karbocykllsk gruppe eller arylgruppe med opp til ca 20 karbonatomer og salter derav. Dersom R2 er tert-butyl, cykloheksyl eller dicykloheksylmetyl så må x eller n ikke være 0. Dersom R2 er adamantan må summen av x og n være større enn 1. De forskjellige alkyl- eller arylgruppene kan ha funksjonelle grupper som substltuenter. Illustrerende for foreliggende forbindelser er molekylet 4-(l-cykloheksylvaleroyl-4- piperidyl )-lH-imldazol.
NO943687A 1992-04-01 1994-10-03 4-(4'-piperidinyl eller 3'-pirrolidinyl) substituerte imidazoler som H3-reseptorantagonister og terapeutiske anvendelser derav NO943687L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86265792A 1992-04-01 1992-04-01
PCT/US1993/003104 WO1993020061A1 (en) 1992-04-01 1993-03-31 4-[4'-piperidinyl or 3'-pirrolidinyl] substituted imidazoles as h3-receptor antagonists and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
NO943687D0 NO943687D0 (no) 1994-10-03
NO943687L true NO943687L (no) 1994-11-21

Family

ID=25338976

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943687A NO943687L (no) 1992-04-01 1994-10-03 4-(4'-piperidinyl eller 3'-pirrolidinyl) substituerte imidazoler som H3-reseptorantagonister og terapeutiske anvendelser derav

Country Status (13)

Country Link
US (1) US5633382A (no)
EP (1) EP0633882A1 (no)
JP (1) JPH07509219A (no)
KR (1) KR950700902A (no)
AU (1) AU3944593A (no)
BR (1) BR9306190A (no)
CA (1) CA2133461A1 (no)
FI (1) FI944605A7 (no)
HU (1) HUT71353A (no)
NO (1) NO943687L (no)
RU (1) RU94044337A (no)
SK (1) SK118794A3 (no)
WO (1) WO1993020061A1 (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE141269T1 (de) * 1991-12-18 1996-08-15 Schering Corp Imidazolyl oder imidazolylalkyl substituiert mit einem 4- oder 5-gliedrigen stickstoff enthaltenden heterozyklischen ring
US6407132B1 (en) 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
WO1999021555A2 (en) * 1997-10-27 1999-05-06 Takeda Chemical Industries, Ltd. Adenosine a3 receptor antagonists
EP1147092A1 (en) 1999-01-18 2001-10-24 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
AU3957600A (en) * 1999-04-26 2000-11-10 Boehringer Ingelheim International Gmbh Piperidyl-imidazole derivatives, their preparations and therapeutic uses
DE19940130A1 (de) 1999-08-24 2001-03-01 Probiodrug Ges Fuer Arzneim Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
US6610721B2 (en) 2000-03-17 2003-08-26 Novo Nordisk A/S Imidazo heterocyclic compounds
DK1313721T3 (da) 2000-08-08 2006-06-26 Ortho Mcneil Pharm Inc Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander
AU2001281119A1 (en) * 2000-08-08 2002-02-18 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic compounds as h3 receptor ligands
HUP0302893A3 (en) 2000-08-08 2006-04-28 Ortho Mcneil Pharm Inc Non-imidazole aryloxypiperidines and pharmaceutical compositions containing them and their use
FR2818978B1 (fr) * 2000-12-28 2003-02-28 Sod Conseils Rech Applic Modulateurs de canaux sodiques derives de 2-piperidylimidazoles
US20030130199A1 (en) 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
CA2473468C (en) * 2002-02-01 2011-06-21 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
CN101837127A (zh) 2003-05-05 2010-09-22 前体生物药物股份公司 谷氨酰胺酰基和谷氨酸环化酶效应物的应用
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
BRPI0410078A (pt) * 2003-05-05 2006-05-16 Probiodrug Ag uso de efetuadores de ciclases de glutaminila e glutamato
CN102302781A (zh) 2003-10-15 2012-01-04 前体生物药物股份公司 谷氨酰胺酰基环化酶效应物和谷氨酸环化酶效应物的应用
US7304086B2 (en) 2004-02-05 2007-12-04 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP1816912A4 (en) * 2004-11-23 2008-09-10 Merck & Co Inc TREATMENT OF APOPLEXY WITH INVERSE HISTAMINE H3 AGONISTS OR HISTAMINE H3 ANTAGONISTS
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
JP2017100949A (ja) * 2014-04-01 2017-06-08 大日本住友製薬株式会社 ５員環ヘテロアリール誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
FR2586562B1 (fr) * 1985-09-02 1989-03-10 Inst Nat Sante Rech Med Composition pharmaceutique contenant de l'a-methylhistamine
FR2630328B1 (fr) * 1988-04-22 1990-08-24 Inst Nat Sante Rech Med Derive de l'histamine, sa preparation et son application en therapeutique
FR2661909B1 (fr) * 1990-05-09 1997-08-14 Inst Nat Sante Rech Med Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation.
FR2671083B1 (fr) * 1990-12-31 1994-12-23 Inst Nat Sante Rech Med Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.
US5070101A (en) * 1991-02-14 1991-12-03 Mount Sinai School Of Medicine Of The City University Of New York Method and pharmaceutical composition for the treatment of schizophrenia

Also Published As

Publication number Publication date
NO943687D0 (no) 1994-10-03
WO1993020061A1 (en) 1993-10-14
BR9306190A (pt) 1998-06-23
EP0633882A1 (en) 1995-01-18
SK118794A3 (en) 1995-06-07
HU9402827D0 (en) 1994-12-28
US5633382A (en) 1997-05-27
RU94044337A (ru) 1996-08-10
JPH07509219A (ja) 1995-10-12
FI944605A0 (fi) 1994-10-03
CA2133461A1 (en) 1993-10-14
AU3944593A (en) 1993-11-08
HUT71353A (en) 1995-11-28
KR950700902A (ko) 1995-02-20
FI944605A7 (fi) 1994-11-30

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