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NO942952L - 11-benzaldoxyn-17 aters, a process for their preparation and a medicament containing such - Google Patents

11-benzaldoxyn-17 aters, a process for their preparation and a medicament containing such

Info

Publication number
NO942952L
NO942952L NO942952A NO942952A NO942952L NO 942952 L NO942952 L NO 942952L NO 942952 A NO942952 A NO 942952A NO 942952 A NO942952 A NO 942952A NO 942952 L NO942952 L NO 942952L
Authority
NO
Norway
Prior art keywords
preparation
benzaldoxyn
aters
medicament containing
oestradiene
Prior art date
Application number
NO942952A
Other languages
Norwegian (no)
Other versions
NO304988B1 (en
NO942952D0 (en
Inventor
Gerd Schubert
Gunther Kaufmann
Lothar Sobeck
Michael Oettel
Walter Elger
Anatoli Kurischko
Original Assignee
Jenapharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm Gmbh filed Critical Jenapharm Gmbh
Publication of NO942952D0 publication Critical patent/NO942952D0/en
Publication of NO942952L publication Critical patent/NO942952L/en
Publication of NO304988B1 publication Critical patent/NO304988B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

11-Benzaldoxime-oestradiene derivatives of the general formula I <IMAGE> and their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them are described. The described compounds display potent antigestagenic effects with lower glucocorticoid activity.
NO942952A 1993-09-20 1994-08-09 11-benzaldoxime-17 <beta> -methoxy-17 <alpha> -methoxymethyl- ° stradiene derivatives and pharmaceutical preparations containing such NO304988B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4332284A DE4332284C2 (en) 1993-09-20 1993-09-20 11-Benzaldoxime-17beta-methoxy-17alpha-methoxymethyl-estradiene derivatives, process for their preparation and medicaments containing these compounds

Publications (3)

Publication Number Publication Date
NO942952D0 NO942952D0 (en) 1994-08-09
NO942952L true NO942952L (en) 1995-03-21
NO304988B1 NO304988B1 (en) 1999-03-15

Family

ID=6498354

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942952A NO304988B1 (en) 1993-09-20 1994-08-09 11-benzaldoxime-17 <beta> -methoxy-17 <alpha> -methoxymethyl- ° stradiene derivatives and pharmaceutical preparations containing such

Country Status (19)

Country Link
EP (1) EP0648779B1 (en)
JP (1) JP2696672B2 (en)
KR (1) KR100190775B1 (en)
AT (1) ATE149513T1 (en)
AU (1) AU682373B2 (en)
CA (1) CA2130515C (en)
CZ (1) CZ289801B6 (en)
DE (2) DE4332284C2 (en)
DK (1) DK0648779T3 (en)
ES (1) ES2102144T3 (en)
FI (1) FI112948B (en)
GR (1) GR3023644T3 (en)
HU (1) HU219399B (en)
NO (1) NO304988B1 (en)
NZ (1) NZ264228A (en)
PL (1) PL179460B1 (en)
RU (1) RU2130944C1 (en)
SK (1) SK280315B6 (en)
UA (1) UA39101C2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332283A1 (en) * 1993-09-20 1995-04-13 Jenapharm Gmbh Novel 11-benzaldoximestradiene derivatives, processes for their preparation and medicaments containing these compounds
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
DE19745085A1 (en) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11β-Benzaldoxim-9alpha, 10alpha-epoxy-estr-4-ene derivatives, processes for their preparation and pharmaceutical preparations containing these compounds
DE19809845A1 (en) * 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituted 11beta-benzaldoxime-estra-4,9-diene-carbonic acid thiol esters, processes for their preparation and pharmaceutical preparations containing these compounds
DE19906152B4 (en) 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Active substance-containing laminates for transdermal systems
PE20010581A1 (en) * 1999-08-31 2001-06-04 Schering Ag MESOPROGESTINES (MODULAR PROGESTERONE RECEPTORS) AS COMPONENTS OF COMPOSITIONS USED FOR HORMONE SUBSTITUTION THERAPY (HRT)
MXPA02002186A (en) 1999-08-31 2002-09-02 Jenapharm Gmbh Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives.
US7629334B1 (en) * 1999-08-31 2009-12-08 Bayer Schering Pharma Aktiengesellschaft Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
HUP0202429A3 (en) 1999-08-31 2004-04-28 Schering Ag Use of mesoprogestins (progesterone receptor modulators) for the preparation of pharmaceutical compositions for the treatment and prevention of benign hormone dependent gynecological disorders
DE19961219A1 (en) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-phenyltratriene derivatives with fluoroalkyl groups in the aromatic side chain, their preparation and pharmaceutical compositions containing these compounds
DE10056677A1 (en) 2000-11-10 2002-05-16 Jenapharm Gmbh Preparation of estradienyl-benzaldoxime urethane or carbonate derivative, for use e.g. in treating endometriosis, involves reacting corresponding oxime with trichloromethyl chloroformate then alcohol, thiol or amine
DE10056676A1 (en) * 2000-11-10 2002-05-16 Jenapharm Gmbh Preparation of estradienyl-benzaldoxime derivative preparation in high yield, for use e.g. in treating endometriosis, from epoxy-estrenone by multi-stage process including selective Grignard reaction
EP1285927A3 (en) * 2001-08-16 2005-06-29 Schering Aktiengesellschaft Use of glucocorticoid antagonists for the prevention and treatment of diseases of the male reproductive system
DE10221034A1 (en) 2002-05-03 2003-11-20 Schering Ag New 17-alpha-fluoroalkyl-11-beta-benzaldoxime-estradiene derivatives, useful as antigestagens in post-menopausal hormone replacement therapy or for treating e.g. gynecological disorders
DK1525215T3 (en) * 2002-08-02 2007-01-15 Schering Ag Modulators for the progesterone receptor with elevated anti-gonadotropic activity for women's fertility control and hormone replacement therapy
DE10236405A1 (en) 2002-08-02 2004-02-19 Schering Ag New 4-(3-oxo-estra-4,9-dien-11 beta-yl)-benzaldehyde oximes, are progesterone receptor modulators useful in female contraception, hormone replacement therapy and treatment of gynecological disorders
DE102005059222B4 (en) * 2005-12-08 2007-10-11 Bayer Schering Pharma Ag 11β-Benzaldoxime derivatives of D-homoestra-4,9-dien-3-ones
HUE051484T2 (en) 2006-10-24 2021-03-01 Allergan Pharmaceuticals Int Ltd Compositions and methods for suppressing endometrial proliferations
TWI539953B (en) 2008-04-28 2016-07-01 瑞波若斯治療學公司 Compositions and methods for treating breast cancer
WO2011119194A1 (en) 2010-03-22 2011-09-29 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins
KR102856539B1 (en) 2023-11-01 2025-09-08 김종구 The TLC coagulation now hole, wedge, and the crush operation method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3504421A1 (en) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen 11 beta -Phenylgonanes, the preparation thereof and pharmaceutical products containing these
NZ214998A (en) * 1985-02-07 1989-06-28 Schering Ag 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions
DK0411733T3 (en) * 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-ones
DE4332283A1 (en) * 1993-09-20 1995-04-13 Jenapharm Gmbh Novel 11-benzaldoximestradiene derivatives, processes for their preparation and medicaments containing these compounds

Also Published As

Publication number Publication date
SK95894A3 (en) 1995-04-12
CZ289801B6 (en) 2002-04-17
SK280315B6 (en) 1999-11-08
PL305091A1 (en) 1995-04-03
JPH07149790A (en) 1995-06-13
CZ196994A3 (en) 1995-04-12
PL179460B1 (en) 2000-09-29
FI943688A0 (en) 1994-08-09
CA2130515A1 (en) 1995-03-21
CA2130515C (en) 2001-07-17
DE59401919D1 (en) 1997-04-10
EP0648779A2 (en) 1995-04-19
DK0648779T3 (en) 1997-09-15
NO304988B1 (en) 1999-03-15
NZ264228A (en) 1995-04-27
KR950008531A (en) 1995-04-19
ATE149513T1 (en) 1997-03-15
DE4332284A1 (en) 1995-03-23
HUT68315A (en) 1995-06-28
RU94029667A (en) 1996-06-27
NO942952D0 (en) 1994-08-09
AU7035194A (en) 1995-03-30
RU2130944C1 (en) 1999-05-27
HU219399B (en) 2001-04-28
EP0648779B1 (en) 1997-03-05
AU682373B2 (en) 1997-10-02
FI112948B (en) 2004-02-13
ES2102144T3 (en) 1997-07-16
FI943688L (en) 1995-03-21
DE4332284C2 (en) 1997-05-28
GR3023644T3 (en) 1997-08-29
HU9402695D0 (en) 1994-11-28
EP0648779A3 (en) 1995-08-09
JP2696672B2 (en) 1998-01-14
UA39101C2 (en) 2001-06-15
KR100190775B1 (en) 1999-06-01

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