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NO885489L - ARALIFATYLAMINOALKANDIFOSFONSYRER. - Google Patents

ARALIFATYLAMINOALKANDIFOSFONSYRER.

Info

Publication number
NO885489L
NO885489L NO88885489A NO885489A NO885489L NO 885489 L NO885489 L NO 885489L NO 88885489 A NO88885489 A NO 88885489A NO 885489 A NO885489 A NO 885489A NO 885489 L NO885489 L NO 885489L
Authority
NO
Norway
Prior art keywords
denotes
aliphatic radical
formula
image
radical
Prior art date
Application number
NO88885489A
Other languages
Norwegian (no)
Other versions
NO885489D0 (en
NO176663B (en
NO176663C (en
Inventor
Knut A Jaeggi
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO885489D0 publication Critical patent/NO885489D0/en
Publication of NO885489L publication Critical patent/NO885489L/en
Publication of NO176663B publication Critical patent/NO176663B/en
Publication of NO176663C publication Critical patent/NO176663C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

Araliphatylaminoalkanediphosphonic acids of the formula <IMAGE> in which R1 represents an aromatically substituted aliphatic radical, R2 represents hydrogen or a monovalent aliphatic radical and alk denotes a divalent aliphatic radical, and their salts have a marked regulating action on calcium metabolism and can be used as medicaments for the treatment of diseases which can be traced back to disorders thereof. They are prepared, for example, by reacting a compound of the formula <IMAGE> in which X3 denotes carboxyl and R0 denotes a radical R2, with phosphorous acid and phosphorus trichloride and hydrolysing the primary product.
NO885489A 1987-12-11 1988-12-09 Analogous Process for Preparing Therapeutically Usable Aromatically-Substituted Alkylamino Alkandiphosphonic Acids NO176663C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH484787 1987-12-11

Publications (4)

Publication Number Publication Date
NO885489D0 NO885489D0 (en) 1988-12-09
NO885489L true NO885489L (en) 1989-06-12
NO176663B NO176663B (en) 1995-01-30
NO176663C NO176663C (en) 1995-05-10

Family

ID=4283590

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885489A NO176663C (en) 1987-12-11 1988-12-09 Analogous Process for Preparing Therapeutically Usable Aromatically-Substituted Alkylamino Alkandiphosphonic Acids

Country Status (21)

Country Link
EP (1) EP0320455B1 (en)
JP (1) JPH01197495A (en)
KR (1) KR890009956A (en)
AT (1) ATE90353T1 (en)
AU (1) AU609549B2 (en)
CA (1) CA1329609C (en)
DD (1) DD283631A5 (en)
DE (1) DE3881659D1 (en)
DK (1) DK688488A (en)
ES (1) ES2054868T3 (en)
FI (1) FI92704C (en)
HU (1) HU202880B (en)
IE (1) IE62738B1 (en)
IL (1) IL88620A (en)
MX (1) MX14109A (en)
NO (1) NO176663C (en)
NZ (1) NZ227273A (en)
PH (1) PH26416A (en)
PT (1) PT89193B (en)
YU (1) YU221388A (en)
ZA (1) ZA889157B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW198039B (en) * 1988-11-28 1993-01-11 Ciba Geigy Ag
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
CA2136825C (en) * 1992-05-29 1997-10-28 Frank H. Ebetino Quaternary nitrogen-containing phosphonate compounds, for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
HUT69731A (en) * 1992-05-29 1995-09-28 Procter & Gamble Pharma Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
CZ296794A3 (en) * 1992-05-29 1995-04-12 Procter & Gamble Pharma Phosphonate sulfur-containing compounds and their use in the preparation of a pharmaceutical for treating abnormal metabolism of calcium and phosphate
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
SK160994A3 (en) * 1992-06-30 1996-01-10 Procter & Gamble Pharma Compositions for the treatment of arthritis containing phosphonates and nsaid
JP2017504060A (en) * 2013-12-19 2017-02-02 スリーエム イノベイティブ プロパティズ カンパニー Article comprising self-assembled layer comprising nanoparticles having phosphorus surface treating agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3623397A1 (en) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
CA1329609C (en) 1994-05-17
DE3881659D1 (en) 1993-07-15
JPH01197495A (en) 1989-08-09
DD283631A5 (en) 1990-10-17
FI885710A7 (en) 1989-06-12
IE883680L (en) 1989-06-11
IE62738B1 (en) 1995-02-22
ES2054868T3 (en) 1994-08-16
PT89193A (en) 1989-12-29
ZA889157B (en) 1989-07-26
NO885489D0 (en) 1988-12-09
FI92704B (en) 1994-09-15
AU609549B2 (en) 1991-05-02
NO176663B (en) 1995-01-30
DK688488D0 (en) 1988-12-09
ATE90353T1 (en) 1993-06-15
HUT48899A (en) 1989-07-28
IL88620A (en) 1994-11-28
EP0320455B1 (en) 1993-06-09
FI92704C (en) 1994-12-27
EP0320455A1 (en) 1989-06-14
KR890009956A (en) 1989-08-05
NO176663C (en) 1995-05-10
DK688488A (en) 1989-06-12
NZ227273A (en) 1991-06-25
FI885710A0 (en) 1988-12-09
MX14109A (en) 1994-02-28
PT89193B (en) 1993-06-30
IL88620A0 (en) 1989-07-31
PH26416A (en) 1992-07-15
YU221388A (en) 1990-06-30
AU2673888A (en) 1989-06-15
HU202880B (en) 1991-04-29

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