NO20111241A1 - Pyrrolo[2, 3-B] pyridinderivater for inhibering av raf kinaser - Google Patents

Pyrrolo[2, 3-B] pyridinderivater for inhibering av raf kinaser Download PDF

Info

Publication number: NO20111241A1
Authority: NO; Norway
Prior art keywords: difluoro; pyrrolo; cancer; pyridine; raf
Prior art date: 2009-03-11

Application number

NO20111241A

Other languages

English (en)

Norwegian (no)

Inventor

Wayne Spevak

Hanna Cho

Prabha N Ibrahim

Hongyao Zhu

Original Assignee

Plexxikon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-11

Filing date

2011-09-13

Publication date

2011-09-28

2011-09-13 Application filed by Plexxikon Inc filed Critical Plexxikon Inc

2011-09-28 Publication of NO20111241A1 publication Critical patent/NO20111241A1/no

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

NO20111241A 2009-03-11 2011-09-13 Pyrrolo[2, 3-B] pyridinderivater for inhibering av raf kinaser NO20111241A1 (no)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US15939009P	2009-03-11	2009-03-11
US15940009P	2009-03-11	2009-03-11
US15940209P	2009-03-11	2009-03-11
US15939509P	2009-03-11	2009-03-11
US15939209P	2009-03-11	2009-03-11
US15940609P	2009-03-11	2009-03-11
US15939609P	2009-03-11	2009-03-11
PCT/US2010/026816 WO2010104945A1 (en)	2009-03-11	2010-03-10	Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases

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NO20111241A1 true NO20111241A1 (no)	2011-09-28

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NO20111241A NO20111241A1 (no)	2009-03-11	2011-09-13	Pyrrolo[2, 3-B] pyridinderivater for inhibering av raf kinaser

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US (1)	US8901301B2 (es)
EP (1)	EP2406259A1 (es)
JP (1)	JP2012520307A (es)
KR (1)	KR101663339B1 (es)
CN (1)	CN102421776A (es)
AR (1)	AR075812A1 (es)
AU (1)	AU2010224245B2 (es)
BR (1)	BRPI1011515A2 (es)
CA (1)	CA2755045A1 (es)
CO (1)	CO6620074A2 (es)
CR (1)	CR20110476A (es)
EC (1)	ECSP11011313A (es)
MA (1)	MA33181B1 (es)
MX (1)	MX2011009489A (es)
MY (1)	MY161861A (es)
NI (1)	NI201100168A (es)
NO (1)	NO20111241A1 (es)
PE (1)	PE20120184A1 (es)
RU (1)	RU2011141123A (es)
SG (2)	SG10201402977WA (es)
TW (1)	TW201036973A (es)
WO (1)	WO2010104945A1 (es)
ZA (1)	ZA201106599B (es)

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Publication number	Publication date
EP2406259A1 (en)	2012-01-18
AU2010224245B2 (en)	2016-07-21
TW201036973A (en)	2010-10-16
SG10201402977WA (en)	2014-09-26
MX2011009489A (es)	2011-10-11
CO6620074A2 (es)	2013-02-15
MA33181B1 (fr)	2012-04-02
CR20110476A (es)	2012-01-04
MY161861A (en)	2017-05-15
CA2755045A1 (en)	2010-09-16
NI201100168A (es)	2012-01-11
AU2010224245A1 (en)	2011-09-29
AR075812A1 (es)	2011-04-27
RU2011141123A (ru)	2013-04-20
PE20120184A1 (es)	2012-03-28
JP2012520307A (ja)	2012-09-06
US20100286178A1 (en)	2010-11-11
US8901301B2 (en)	2014-12-02
ZA201106599B (en)	2014-02-26
WO2010104945A1 (en)	2010-09-16
SG174257A1 (en)	2011-10-28
BRPI1011515A2 (pt)	2016-03-29
CN102421776A (zh)	2012-04-18
KR20110125670A (ko)	2011-11-21
ECSP11011313A (es)	2011-10-31
KR101663339B1 (ko)	2016-10-06

Publication	Publication Date	Title
US8901301B2 (en)	2014-12-02	Pyrrolo[2,3-]pyridine kinase inhibitors
US10426760B2 (en)	2019-10-01	Compounds and methods for kinase modulation, and indications therefor
US8198273B2 (en)	2012-06-12	Compounds and methods for kinase modulation, and indications therefor
JP6194389B2 (ja)	2017-09-06	キナーゼ調節のための化合物および方法、ならびにその適応
US8129404B2 (en)	2012-03-06	Compounds and uses thereof
TW201132639A (en)	2011-10-01	Compounds and methods for kinase modulation, and indications therefor
HK1176238A (en)	2013-07-26	N-[2-fluoro-3-(4-amino-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4 benzenesulfonamid e derivatives as raf protein kinase modulators for the treatment of cancer
HK1176238B (en)	2018-04-20	N-[2-fluoro-3-(4-amino-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4 benzenesulfonamid e derivatives as raf protein kinase modulators for the treatment of cancer

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2013-10-28	FC2A	Withdrawal, rejection or dismissal of laid open patent application