[go: up one dir, main page]

NO20091976L - Nye forbindelser - Google Patents

Nye forbindelser

Info

Publication number
NO20091976L
NO20091976L NO20091976A NO20091976A NO20091976L NO 20091976 L NO20091976 L NO 20091976L NO 20091976 A NO20091976 A NO 20091976A NO 20091976 A NO20091976 A NO 20091976A NO 20091976 L NO20091976 L NO 20091976L
Authority
NO
Norway
Prior art keywords
new connections
connections
new
applications
methods
Prior art date
Application number
NO20091976A
Other languages
English (en)
Inventor
Beat Schmitz
Gottfried Sedelmeier
Olivier Loiseleur
Daniel Kaufmann
Stephan Abel
Hans Michael Buerger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20091976L publication Critical patent/NO20091976L/no
Application filed by Novartis Ag filed Critical Novartis Ag

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører nye forbindelser, fremgangsmåterog anvendelser.
NO20091976A 2002-02-07 2009-05-20 Nye forbindelser NO20091976L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0202873.6A GB0202873D0 (en) 2002-02-07 2002-02-07 Organic compounds
PCT/EP2003/001188 WO2003066613A1 (en) 2002-02-07 2003-02-06 N-phenyl-2-pyrimidine-amine derivatives

Publications (1)

Publication Number Publication Date
NO20091976L true NO20091976L (no) 2004-11-05

Family

ID=9930607

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20043685A NO327366B1 (no) 2002-02-07 2004-09-03 Amider og fremgangsmåter for fremstilling derav
NO20091976A NO20091976L (no) 2002-02-07 2009-05-20 Nye forbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20043685A NO327366B1 (no) 2002-02-07 2004-09-03 Amider og fremgangsmåter for fremstilling derav

Country Status (25)

Country Link
US (8) US7456283B2 (no)
EP (2) EP1474408B1 (no)
JP (2) JP4653954B2 (no)
KR (1) KR101027044B1 (no)
CN (2) CN101016262A (no)
AU (1) AU2003244444B2 (no)
BR (2) BR0307529A (no)
CA (2) CA2474738C (no)
CO (1) CO5601018A2 (no)
CY (2) CY1112938T1 (no)
DK (2) DK2248807T3 (no)
EC (2) ECSP045220A (no)
ES (2) ES2384872T3 (no)
GB (1) GB0202873D0 (no)
IL (3) IL163158A (no)
MX (1) MXPA04007642A (no)
NO (2) NO327366B1 (no)
NZ (3) NZ554430A (no)
PL (1) PL209475B1 (no)
PT (2) PT2248807E (no)
RU (2) RU2370493C2 (no)
SG (1) SG160195A1 (no)
SI (2) SI1474408T1 (no)
WO (1) WO2003066613A1 (no)
ZA (1) ZA200405970B (no)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
AU2003242988A1 (en) * 2003-06-06 2005-01-04 Adibhatla Kali Sathya Bhujanga Rao Process for the preparation of the anti-cancer drug imatinib and its analogues
CN1805748B (zh) * 2003-06-13 2010-05-26 诺瓦提斯公司 作为raf激酶抑制剂的2-氨基嘧啶衍生物
AR047530A1 (es) 2004-02-04 2006-01-25 Novartis Ag Formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n-(4-metil-3-(4-piridin-3-il)pirimidin-2-ilamino)fenil)-benzamida
US7507821B2 (en) 2004-12-30 2009-03-24 Chemagis Ltd. Process for preparing Imatinib
KR101346902B1 (ko) 2005-07-09 2014-01-02 아스트라제네카 아베 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US20060223816A1 (en) * 2006-05-08 2006-10-05 Chemagis Ltd. Imatinib mesylate alpha form and production process therefor
US20090324718A1 (en) * 2006-09-01 2009-12-31 Ilan Zalit Imatinib compositions
AU2007299764B2 (en) 2006-09-22 2011-10-13 Novartis Ag Method of optimizing the treatment of Philadelphia-positive leukemia with Abl tyrosine kinase inhibitors
WO2008057291A2 (en) * 2006-10-26 2008-05-15 Sicor Inc. Crystalline and amorphous imatinib base, imatinib mesylate- and processes for preparation thereof
EP2009008A1 (en) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
WO2008059551A2 (en) * 2006-11-16 2008-05-22 F.I.S. Fabbrica Italiana Sintetici S.P.A. Process for the preparation of imatinib and intermediates thereof
CN100451015C (zh) * 2007-02-14 2009-01-14 杭州盛美医药科技开发有限公司 一种伊马替尼的制备方法
US7550591B2 (en) 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
TWI433677B (zh) 2007-06-04 2014-04-11 Avila Therapeutics Inc 雜環化合物及其用途
EP2081556A1 (en) * 2007-09-25 2009-07-29 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
WO2009080366A1 (en) * 2007-12-22 2009-07-02 Synthon B.V. A process of making imatinib
CN101497601B (zh) * 2008-01-29 2012-11-07 福建南方制药股份有限公司 伊马替尼的合成方法
PL215042B1 (pl) * 2008-08-01 2013-10-31 Temapharm Spolka Z Ograniczona Odpowiedzialnoscia Sposób wytwarzania imatinibu
KR20100021321A (ko) * 2008-08-14 2010-02-24 일양약품주식회사 Ν-페닐-2-피리미딘-아민 유도체의 제조방법
JP2012510470A (ja) 2008-12-01 2012-05-10 ノバルティス アーゲー メシル酸イマチニブを用いたフィラデルフィア陽性白血病の処置を最適化する方法
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CN101654416B (zh) * 2009-09-16 2013-06-05 成都神黄医药科技开发有限公司 N-[3-硝基-4-甲基-苯基]-4-醛基-苯甲酰胺及其制备方法以及其衍生物的制备方法
US20110306763A1 (en) 2009-12-10 2011-12-15 Shanghai Parling Pharmatech Co., Ltd. Process for the preparation of imatinib and salts thereof
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
US8609842B2 (en) 2010-04-23 2013-12-17 Fujian South Pharmaceutical Co., Ltd. Method for synthesizing Imatinib
WO2011157450A1 (en) 2010-06-18 2011-12-22 Krka, D. D., Novo Mesto New polymorphic form of imatinib base and preparation of salts thereof
TR201007005A2 (tr) 2010-08-23 2011-09-21 Mustafa Nevzat İlaç Sanayi̇i̇ A.Ş. İmatinib baz üretim yöntemi
WO2013035102A1 (en) 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
JP2014532647A (ja) 2011-10-28 2014-12-08 ノバルティス アーゲー 消化管間質腫瘍を治療する方法
WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
WO2013120852A1 (en) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
KR20150036014A (ko) 2012-07-11 2015-04-07 노파르티스 아게 위장 기질 종양을 치료하는 방법
CN102827144A (zh) * 2012-09-05 2012-12-19 湖南欧亚生物有限公司 一种伊马替尼的制备方法
RU2537398C1 (ru) * 2013-08-20 2015-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный технологический университет" (СибГТУ) Гексазамещенные пара-аминофенолы с ариламидными группами в 2,6-положениях по отношению к гидроксилу
CN103588754B (zh) * 2013-11-04 2015-05-27 遵义医学院 伊马替尼的制备方法
JP6691971B2 (ja) 2016-10-17 2020-05-13 Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 慢性骨髄性白血病を治療又は寛解するための医薬組成物
PL3539138T3 (pl) 2016-11-11 2021-12-13 Curium Us Llc Sposoby generowania germanu-68 ze zmniejszoną ilością części lotnych
EP3333162A1 (en) 2016-12-12 2018-06-13 Silesian Catalysts sp. z o.o. Metod for preparing n-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
JP7065951B2 (ja) 2017-09-22 2022-05-12 ジュビラント エピパッド エルエルシー Ｐａｄ阻害剤としての複素環式化合物
WO2019077631A1 (en) 2017-10-18 2019-04-25 Jubilant Biosys Limited IMIDAZO-PYRIDINE COMPOUNDS FOR USE AS PAD INHIBITORS
EP3707135A1 (en) 2017-11-06 2020-09-16 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
IL274762B2 (en) 2017-11-24 2023-10-01 Jubilant Episcribe Llc Novel heterocyclic compounds as prmt5 inhibitors
CN108164505B (zh) * 2018-01-16 2020-11-03 扬州大学 一种伊马替尼的合成方法
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE
WO2019175897A1 (en) 2018-03-13 2019-09-19 Jubilant Biosys Limited Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE531480C (de) * 1929-07-03 1931-08-10 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Aryliden einer unsymmetrischen o-Xylenolcarbonsaeure
US2808433A (en) * 1953-08-21 1957-10-01 Du Pont Benzene dicarboxylic acid derivatives
GB862127A (en) * 1958-07-04 1961-03-01 Ici Ltd Derivatives of 2-hydroxy-3-naphthanilide
US3505433A (en) * 1965-03-08 1970-04-07 Hooker Chemical Corp 2-haloperfluoro-1-cycloalken-1-ylphosphoryl compounds
US3505389A (en) * 1966-08-18 1970-04-07 Hooker Chemical Corp 4-amino-2,3,5,6-tetrachlorobenzoic acid and derivatives thereof
US3505398A (en) 1966-09-22 1970-04-07 Standard Oil Co Terephthalic acid crystallization
US3763234A (en) * 1970-12-03 1973-10-02 Halcon International Inc Preparation of amides
JPS4987761U (no) 1972-11-17 1974-07-30
JPS563375B2 (no) * 1972-12-25 1981-01-24
JPS5720923B2 (no) * 1974-04-02 1982-05-04
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
JPS5665804A (en) * 1979-11-01 1981-06-03 Ishihara Sangyo Kaisha Ltd Control agent against injurious organism
DE3305755A1 (de) * 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
NZ219974A (en) * 1986-04-22 1989-08-29 Goedecke Ag N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
JP2894804B2 (ja) * 1989-07-19 1999-05-24 武田薬品工業株式会社 ２―アミノ―５―メチルベンゾフェノン類及びその製造法
JPH03130252U (no) 1990-04-11 1991-12-27
FR2664895B1 (fr) * 1990-07-20 1992-10-30 Theramex Laboratoire Nouveaux derives de la 6-methyl 19-nor progesterone, substitues en 3 et leur procede d'obtention.
DE4110483A1 (de) * 1991-03-30 1992-10-01 Bayer Ag Substituierte salicylamide, mittel gegen pflanzenkrankheiten
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (no) * 1992-04-03 1994-06-21 Ciba Geigy Ag
FR2689925B1 (fr) 1992-04-08 1994-05-27 Valeo Securite Habitacle Dispositif de verrouillage d'une serrure dans son support.
US5543520A (en) 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
DE4428380A1 (de) * 1994-08-11 1996-02-15 Bayer Ag 4-Trifluormethylbenzamide
IL117440A0 (en) * 1995-03-31 1996-07-23 Pfizer Pyrrolidinyl hydroxamic acid compounds and their production process
JPH0987761A (ja) 1995-09-22 1997-03-31 Nikko Kinzoku Kk 銅転炉スラグからの銅の回収方法
JP3130252B2 (ja) 1996-07-12 2001-01-31 小糸工業株式会社 座席のヘッドレスト装置
JP2002511090A (ja) * 1997-06-30 2002-04-09 アール・ジェイ・レイノルズ・タバコ・カンパニー Ｃｎｓ疾患の予防と治療用３−ピリジル−１−アザ−ビシクロ−アルカン誘導体
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
PL195600B1 (pl) * 1998-05-15 2007-10-31 Astrazeneca Ab Pochodne benzamidowe, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku do leczenia stanów medycznych powstających za pośrednictwem cytokin
AU761361B2 (en) 1998-09-25 2003-06-05 Astrazeneca Ab Benzamide derivatives and their use as cytokine inhibitors
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
US7338957B2 (en) * 2003-08-28 2008-03-04 Irm Llc Compounds and compositions as protein kinase inhibitors

Also Published As

Publication number Publication date
SG160195A1 (en) 2010-04-29
JP2005528340A (ja) 2005-09-22
ECSP045220A (es) 2004-09-28
ES2425980T3 (es) 2013-10-18
HK1070893A1 (en) 2005-06-30
NZ534315A (en) 2007-06-29
CO5601018A2 (es) 2006-01-31
AU2003244444A1 (en) 2003-09-02
CY1114351T1 (el) 2016-08-31
IL189658A (en) 2011-05-31
CN101016262A (zh) 2007-08-15
NO20043685L (no) 2004-11-05
AU2003244444B9 (en) 2003-09-02
NO327366B1 (no) 2009-06-15
CY1112938T1 (el) 2016-04-13
CN1630648A (zh) 2005-06-22
NZ569731A (en) 2009-11-27
EP2248807A1 (en) 2010-11-10
BR0307529A (pt) 2004-12-21
US20060142580A1 (en) 2006-06-29
WO2003066613A1 (en) 2003-08-14
RU2370493C2 (ru) 2009-10-20
CA2474738C (en) 2011-10-04
US7825247B2 (en) 2010-11-02
JP4653954B2 (ja) 2011-03-16
IL189658A0 (en) 2008-06-05
US7816359B2 (en) 2010-10-19
IL189657A0 (en) 2008-06-05
DK2248807T3 (da) 2013-08-26
KR20040081154A (ko) 2004-09-20
ES2384872T3 (es) 2012-07-13
AU2003244444B2 (en) 2007-08-09
US20070293504A1 (en) 2007-12-20
US20090137805A1 (en) 2009-05-28
US7456283B2 (en) 2008-11-25
JP2010138194A (ja) 2010-06-24
RU2007148217A (ru) 2009-07-10
EP2248807B1 (en) 2013-07-03
HK1145322A1 (en) 2011-04-15
CN100347162C (zh) 2007-11-07
CA2474738A1 (en) 2003-08-14
PL209475B1 (pl) 2011-09-30
US20150018552A1 (en) 2015-01-15
US7579467B2 (en) 2009-08-25
ECSP095220A (es) 2009-08-28
SI2248807T1 (sl) 2013-10-30
RU2004126941A (ru) 2005-10-10
CA2737565A1 (en) 2003-08-14
PT1474408E (pt) 2012-07-25
US20070293672A1 (en) 2007-12-20
GB0202873D0 (en) 2002-03-27
US20070293673A1 (en) 2007-12-20
BRPI0307529B1 (pt) 2018-01-30
PT2248807E (pt) 2013-09-02
NZ554430A (en) 2008-08-29
IL189657A (en) 2010-12-30
DK1474408T3 (da) 2012-06-25
EP1474408A1 (en) 2004-11-10
KR101027044B1 (ko) 2011-04-11
CA2737565C (en) 2013-04-09
PL371197A1 (en) 2005-06-13
SI1474408T1 (sl) 2012-07-31
MXPA04007642A (es) 2004-11-10
US20120226039A1 (en) 2012-09-06
US20070293683A1 (en) 2007-12-20
US9573928B2 (en) 2017-02-21
IL163158A (en) 2010-11-30
ZA200405970B (en) 2006-05-31
EP1474408B1 (en) 2012-05-23

Similar Documents

Publication Publication Date Title
NO20091976L (no) Nye forbindelser
BRPI0414599A (pt) pirrol-indóis substituìdos
ATE541857T1 (de) Optimierte fc-varianten und herstellungsverfahren dafür
ATE525377T1 (de) Imidazoä1,5-aüpyrazine als inhibitoren von tyrosinkinase
NO20041493L (no) Kjemiske forbindelser.
BRPI0411897A (pt) pirroldihidroisoquinolinas como inibidores de pde10
DK1644348T3 (da) Epoxy-afsluttede polythioethere, Epoxy-afsluttede polythioethere
BR0313330A (pt) Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
DK1668001T3 (da) Substituerede heteroarylbenzofuransyrer
UY3450Q (es) Botella
ATE445386T1 (de) Polymerische parfümpartikel
EA200701918A1 (ru) Белок липокалин
SE0301653D0 (sv) Novel compounds
NO20062649L (no) Biarylsulfonamider og metoder for anvendelse av disse
DK1519944T3 (da) Fremgangsmåder til fremstilling af fibrinogen
NO20044448L (no) Nye forbindelser
NO20044898L (no) Nye etonogestrel estere
HRP20080057T3 (en) 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof
DE60316984D1 (de) Benzoylsulfonamide als antitumor-mittel
PL380950A1 (pl) Pewne związki amionoalkiloglukozaminidofosforanowe i ich zastosowanie
DK1628989T3 (da) Hidtil ukendte, 14- og 15-leddet ring-forbindelser
DE602004028493D1 (de) Isochinolinon-kaliumkanalinhibitoren
EA200600404A1 (ru) Пероральные препаративные формы кладрибина
DE50310579D1 (de) Furancarboxamide
ATE483714T1 (de) Podophyllotoxine als antiproliferative mittel

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application