NO20090424L - Humane antistoffer mot ErbB2 - Google Patents
Humane antistoffer mot ErbB2Info
- Publication number
- NO20090424L NO20090424L NO20090424A NO20090424A NO20090424L NO 20090424 L NO20090424 L NO 20090424L NO 20090424 A NO20090424 A NO 20090424A NO 20090424 A NO20090424 A NO 20090424A NO 20090424 L NO20090424 L NO 20090424L
- Authority
- NO
- Norway
- Prior art keywords
- antibodies
- erbb2
- relates
- nucleic acid
- acid molecules
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83551406P | 2006-08-04 | 2006-08-04 | |
| PCT/US2007/075078 WO2008019290A2 (en) | 2006-08-04 | 2007-08-02 | Human antibodies to erbb 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20090424L true NO20090424L (no) | 2009-03-03 |
Family
ID=38925686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20090424A NO20090424L (no) | 2006-08-04 | 2009-01-28 | Humane antistoffer mot ErbB2 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8350011B2 (pt) |
| EP (2) | EP2054444B1 (pt) |
| JP (1) | JP5638804B2 (pt) |
| KR (1) | KR20090058512A (pt) |
| CN (1) | CN101522717A (pt) |
| AU (1) | AU2007281774A1 (pt) |
| BR (1) | BRPI0714728A2 (pt) |
| CA (1) | CA2659631A1 (pt) |
| CY (1) | CY1120065T1 (pt) |
| DK (1) | DK2511301T3 (pt) |
| ES (2) | ES2613957T3 (pt) |
| HU (1) | HUE038454T2 (pt) |
| IL (1) | IL196701A0 (pt) |
| LT (1) | LT2511301T (pt) |
| MX (1) | MX2009001291A (pt) |
| NO (1) | NO20090424L (pt) |
| PL (1) | PL2511301T3 (pt) |
| PT (1) | PT2511301T (pt) |
| RU (1) | RU2009107494A (pt) |
| SI (1) | SI2511301T1 (pt) |
| WO (1) | WO2008019290A2 (pt) |
| ZA (1) | ZA200900753B (pt) |
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| JP2533206Y2 (ja) | 1991-09-04 | 1997-04-23 | 光洋精工株式会社 | 圧延機用円筒ころ軸受装置 |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| WO2009088805A2 (en) | 2008-01-03 | 2009-07-16 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| AU2009213141A1 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind EGFR |
| AR071874A1 (es) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| GB0812277D0 (en) * | 2008-07-04 | 2008-08-13 | Fusion Antibodies Ltd | Antibody and uses thereof |
| CA2779436A1 (en) | 2008-10-31 | 2010-05-06 | Biogen Idec Ma Inc. | Light targeting molecules and uses thereof |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| CN101633695B (zh) * | 2009-04-15 | 2012-12-12 | 北京天广实生物技术股份有限公司 | 基于erbB2蛋白胞外区C-端功能表位特征设计抗erbB2功能抗体 |
| CN101591396B (zh) * | 2009-04-15 | 2013-01-09 | 北京天广实生物技术股份有限公司 | 一种抗erbB2人源抗体MIL-5及其应用 |
| CN102167742B (zh) * | 2010-02-25 | 2014-05-14 | 上海百迈博制药有限公司 | 一种全人源抗her2单克隆抗体、其制备方法及用途 |
| EP2558501B1 (en) | 2010-04-15 | 2016-09-07 | Alper Biotech, Llc | Monoclonal antibodies against her2 antigens, and uses therefor |
| JP6023703B2 (ja) | 2010-05-26 | 2016-11-09 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 改善された安定性を有するフィブロネクチンをベースとする足場タンパク質 |
| CN103153339B (zh) | 2010-05-27 | 2021-05-04 | 根马布股份公司 | 针对her2表位的单克隆抗体 |
| NZ604003A (en) | 2010-05-27 | 2015-04-24 | Genmab As | Monoclonal antibodies against her2 |
| AU2016201799B2 (en) * | 2010-05-27 | 2017-09-07 | Genmab A/S | Monoclonal antibodies aganst HER2 epitope |
| CN101928345B (zh) * | 2010-06-21 | 2012-08-29 | 中国科学技术大学 | 一种人源化抗体及其人源化改造方法 |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| MY162825A (en) | 2010-08-20 | 2017-07-31 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
| EP2683413A1 (en) * | 2011-03-07 | 2014-01-15 | F.Hoffmann-La Roche Ag | In vivo selection of therapeutically active antibodies |
| AU2012245116A1 (en) | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| ES2704038T3 (es) | 2011-05-24 | 2019-03-13 | Zyngenia Inc | Complejos multiespecíficos multivalentes y monovalentes y sus usos |
| CN102492039B (zh) * | 2011-11-21 | 2015-03-11 | 无锡天演生物技术有限公司 | 全人源抗人her2单抗 |
| EA036225B1 (ru) | 2012-03-14 | 2020-10-15 | Ридженерон Фармасьютикалз, Инк. | Мультиспецифические антигенсвязывающие молекулы и их применения |
| KR101505157B1 (ko) | 2012-05-08 | 2015-03-24 | 주식회사 종근당 | 항―ErbB2 항체 변이체 |
| KR20160003634A (ko) * | 2013-02-13 | 2016-01-11 | 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 | 고도로 갈락토실화된 항-her2 항체 및 이의 용도 |
| US10150800B2 (en) | 2013-03-15 | 2018-12-11 | Zyngenia, Inc. | EGFR-binding modular recognition domains |
| KR101453462B1 (ko) * | 2013-05-16 | 2014-10-23 | 앱클론(주) | Her2에 특이적으로 결합하는 항체 |
| US9738726B2 (en) | 2013-06-11 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HER2-specific monoclonal antibodies and conjugates thereof |
| US10519247B2 (en) * | 2013-11-01 | 2019-12-31 | Board Of Regents,The University Of Texas System | Targeting HER2 and HER3 with bispecific antibodies in cancerous cells |
| BR112016022910A2 (pt) * | 2014-04-11 | 2017-10-17 | Medimmune Llc | anticorpos contra her2 biespecíficos |
| TWI695011B (zh) * | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
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| RU2640259C2 (ru) * | 2015-12-09 | 2017-12-27 | Федеральное государственное бюджетное учреждение науки Институт теоретической и экспериментальной биофизики Российской академии наук (ИТЭБ РАН) | Антитело МАТ40, которое связывается с доменом I экстраклеточной части рецептора эпидермального фактора роста HER2/CD340, и его применение для лечения рака |
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| US11459394B2 (en) | 2017-02-24 | 2022-10-04 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
| SG11202005557TA (en) | 2017-12-12 | 2020-07-29 | Macrogenics Inc | Bispecific cd 16-binding molecules and their use in the treatment of disease |
| CN111787949A (zh) | 2018-02-15 | 2020-10-16 | 宏观基因有限公司 | 变体cd3-结合结构域及其在用于治疗疾病的组合疗法中的用途 |
| KR102871690B1 (ko) | 2018-04-30 | 2025-10-16 | 리제너론 파마슈티칼스 인코포레이티드 | Her2 및/또는 aplp2에 결합하는 항체 및 이중특이적 항원-결합 분자 및 접합체 그리고 이들의 용도 |
| JP7745556B2 (ja) | 2020-02-21 | 2025-09-29 | マクロジェニクス,インコーポレーテッド | Cd137結合分子及びその使用 |
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2007
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- 2007-08-02 SI SI200732014T patent/SI2511301T1/en unknown
- 2007-08-02 BR BRPI0714728-7A patent/BRPI0714728A2/pt not_active Application Discontinuation
- 2007-08-02 ES ES12154574.3T patent/ES2661952T3/es active Active
- 2007-08-02 US US12/376,196 patent/US8350011B2/en not_active Expired - Fee Related
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- 2007-08-02 KR KR1020097004290A patent/KR20090058512A/ko not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2661952T3 (es) | 2018-04-04 |
| JP2009545325A (ja) | 2009-12-24 |
| LT2511301T (lt) | 2018-04-10 |
| CA2659631A1 (en) | 2008-02-14 |
| CY1120065T1 (el) | 2018-12-12 |
| RU2009107494A (ru) | 2010-09-10 |
| EP2511301A2 (en) | 2012-10-17 |
| JP5638804B2 (ja) | 2014-12-10 |
| EP2054444A2 (en) | 2009-05-06 |
| PL2511301T3 (pl) | 2018-05-30 |
| IL196701A0 (en) | 2011-08-01 |
| AU2007281774A1 (en) | 2008-02-14 |
| ZA200900753B (en) | 2010-09-29 |
| PT2511301T (pt) | 2018-03-08 |
| ES2613957T3 (es) | 2017-05-29 |
| KR20090058512A (ko) | 2009-06-09 |
| WO2008019290A2 (en) | 2008-02-14 |
| WO2008019290A3 (en) | 2008-04-03 |
| MX2009001291A (es) | 2009-03-10 |
| US20100158926A1 (en) | 2010-06-24 |
| EP2054444B1 (en) | 2016-11-02 |
| DK2511301T3 (en) | 2018-03-12 |
| US20130089544A1 (en) | 2013-04-11 |
| BRPI0714728A2 (pt) | 2013-05-14 |
| SI2511301T1 (en) | 2018-05-31 |
| HUE038454T2 (hu) | 2018-10-29 |
| EP2511301A3 (en) | 2013-05-01 |
| CN101522717A (zh) | 2009-09-02 |
| EP2511301B1 (en) | 2017-12-06 |
| US8350011B2 (en) | 2013-01-08 |
| US8858942B2 (en) | 2014-10-14 |
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