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NO20085004L - Radioaktivt merkede dihydrotetrabenazinderivater og deres anvendelse som avbildningsmidler - Google Patents

Radioaktivt merkede dihydrotetrabenazinderivater og deres anvendelse som avbildningsmidler

Info

Publication number
NO20085004L
NO20085004L NO20085004A NO20085004A NO20085004L NO 20085004 L NO20085004 L NO 20085004L NO 20085004 A NO20085004 A NO 20085004A NO 20085004 A NO20085004 A NO 20085004A NO 20085004 L NO20085004 L NO 20085004L
Authority
NO
Norway
Prior art keywords
imaging agents
radioactively labeled
dihydrotetrabenazine
derivatives
dihydrotetrabenazine derivatives
Prior art date
Application number
NO20085004A
Other languages
English (en)
Other versions
NO341065B1 (no
Inventor
Hank F Kung
Mei-Ping Kung
Michael Kilbourn
Daniel M Skovronsky
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of NO20085004L publication Critical patent/NO20085004L/no
Publication of NO341065B1 publication Critical patent/NO341065B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Denne oppfinnelsen vedrører en fremgangsmåte for avbilding av vesikulære monoamintransportører, og merkede forbindelser og farmasøytiske preparater derav, og fremgangsmåter for fremstilling av merkede forbindelser som kan anvendes ved avbilding av vesikulære monoamintransportører. Denne oppfinnelsen vedrører også forbindelser og fremgangsmåter for overvåkning av utvikling av en sykdom relatert til vesikulære monoamintransportører. (Fig 1)
NO20085004A 2006-05-02 2008-12-01 Radioaktivt merkede dihydrotetrabenazinderivater, en fremgangsmåte for deres fremstilling og deres anvendelse som avbildningsmidler for vesikulære monoamintransportører. NO341065B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79651806P 2006-05-02 2006-05-02
US90811607P 2007-03-26 2007-03-26
PCT/US2007/010478 WO2007130365A2 (en) 2006-05-02 2007-05-01 Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents

Publications (2)

Publication Number Publication Date
NO20085004L true NO20085004L (no) 2009-02-02
NO341065B1 NO341065B1 (no) 2017-08-14

Family

ID=38668238

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20085004A NO341065B1 (no) 2006-05-02 2008-12-01 Radioaktivt merkede dihydrotetrabenazinderivater, en fremgangsmåte for deres fremstilling og deres anvendelse som avbildningsmidler for vesikulære monoamintransportører.

Country Status (19)

Country Link
US (1) US8562949B2 (no)
EP (2) EP2604290A3 (no)
JP (1) JP5392622B2 (no)
KR (1) KR101429302B1 (no)
CN (1) CN101484190B (no)
AU (1) AU2007248764B2 (no)
BR (1) BRPI0711481A8 (no)
CA (1) CA2650904C (no)
DK (1) DK2012833T3 (no)
ES (1) ES2525932T3 (no)
IL (1) IL195044A (no)
MX (1) MX2008014064A (no)
NO (1) NO341065B1 (no)
PL (1) PL2012833T3 (no)
PT (1) PT2012833E (no)
SI (1) SI2012833T1 (no)
TW (1) TWI432214B (no)
WO (1) WO2007130365A2 (no)
ZA (1) ZA200810200B (no)

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US7897769B2 (en) 2007-10-25 2011-03-01 General Electric Company Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes
US7897770B2 (en) 2007-10-25 2011-03-01 General Electric Company Fluorinated dihydrotetrabenazine ether imaging agents and probes
JP2011502966A (ja) * 2007-10-31 2011-01-27 アルセレス ファーマシューティカルズ， インコーポレイテッド ドーパミントランスポーターレベルを評価することによるレビー小体型認知症の診断およびレビー小体型認知症の処置のモニタリングのための方法
US8053578B2 (en) * 2007-11-29 2011-11-08 General Electric Company Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes
US7910738B2 (en) 2007-11-29 2011-03-22 General Electric Company Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US7902364B2 (en) 2007-11-29 2011-03-08 General Electric Company Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US8013161B1 (en) 2007-12-07 2011-09-06 General Electric Company Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes
US7919622B2 (en) 2007-12-07 2011-04-05 Kande Kankanamalage Dayarathna Amarasinghe Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
EP3345905B1 (en) 2008-09-18 2021-09-01 Auspex Pharmaceuticals, Inc. Deuterated benzoquinolizine derivatives as inhibitors of vesicular monoamine transporter 2
JP5273571B2 (ja) * 2009-03-19 2013-08-28 国立大学法人京都大学 膵島イメージング用分子プローブ前駆体及びその使用
CN102120742B (zh) * 2010-01-08 2013-03-13 中国药科大学 一种丁苯那嗪的制备方法
EP2394668A1 (en) * 2010-06-01 2011-12-14 Julius-Maximilians-Universität Würzburg PET radiopharmaceuticals for differential diagnosis between bilateral and unilateral conditions of primary hyperaldosteronism
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CN101985446B (zh) * 2010-06-10 2012-05-30 江苏省原子医学研究所 一种(±)-9-O-去甲基-α-二氢丁苯那嗪合成方法
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CN102936246A (zh) * 2012-11-08 2013-02-20 江苏暨明医药科技有限公司 丁苯那嗪的合成方法
EP2951178A4 (en) 2013-01-31 2016-07-06 Auspex Pharmaceuticals Inc VMAT2 INHIBITORS OF BENZOQUINOLONE TYPE
WO2015048370A1 (en) * 2013-09-27 2015-04-02 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
CA2930167A1 (en) * 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Methods of treating abnormal muscular activity
WO2015077521A1 (en) * 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
CA2930744A1 (en) 2013-12-03 2015-06-11 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds
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EA201691582A1 (ru) 2014-02-07 2017-01-30 Оспекс Фармасьютикалз, Инк. Новые фармацевтические препараты
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CN111320620A (zh) * 2020-03-17 2020-06-23 四川大学华西医院 一种异喹啉并哒嗪酮类化合物及其合成方法和应用
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Also Published As

Publication number Publication date
EP2012833A4 (en) 2011-06-29
IL195044A0 (en) 2011-08-01
CA2650904A1 (en) 2007-11-15
CN101484190A (zh) 2009-07-15
KR101429302B1 (ko) 2014-08-11
SI2012833T1 (sl) 2015-03-31
CA2650904C (en) 2015-07-07
DK2012833T3 (en) 2015-01-19
IL195044A (en) 2013-08-29
EP2012833B1 (en) 2014-10-29
KR20090007781A (ko) 2009-01-20
TWI432214B (zh) 2014-04-01
PT2012833E (pt) 2014-12-23
US8562949B2 (en) 2013-10-22
EP2604290A3 (en) 2013-07-10
JP5392622B2 (ja) 2014-01-22
EP2604290A2 (en) 2013-06-19
PL2012833T3 (pl) 2015-05-29
NO341065B1 (no) 2017-08-14
WO2007130365A3 (en) 2008-11-27
AU2007248764B2 (en) 2013-08-01
MX2008014064A (es) 2009-06-12
JP2009535403A (ja) 2009-10-01
TW200810783A (en) 2008-03-01
AU2007248764A1 (en) 2007-11-15
CN101484190B (zh) 2011-07-20
EP2012833A2 (en) 2009-01-14
WO2007130365A2 (en) 2007-11-15
BRPI0711481A2 (pt) 2011-11-16
ZA200810200B (en) 2012-02-29
ES2525932T3 (es) 2015-01-02
US20080050312A1 (en) 2008-02-28
BRPI0711481A8 (pt) 2017-11-28

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