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NO20084302L - 2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorer - Google Patents

2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorer

Info

Publication number
NO20084302L
NO20084302L NO20084302A NO20084302A NO20084302L NO 20084302 L NO20084302 L NO 20084302L NO 20084302 A NO20084302 A NO 20084302A NO 20084302 A NO20084302 A NO 20084302A NO 20084302 L NO20084302 L NO 20084302L
Authority
NO
Norway
Prior art keywords
hydrogen
cyclic amino
pyrimidone derivatives
integer
tpk1
Prior art date
Application number
NO20084302A
Other languages
English (en)
Inventor
Satoshi Yokoshima
Fumiaki Uehara
Kazutoshi Watanabe
Kenji Fukunaga
Toshiyuki Kohara
Yoshihiro Usul
Daiki Sakai
Shi-Ichi Kusaka
Kazuki Nakayama
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of NO20084302L publication Critical patent/NO20084302L/no

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
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  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Forbindelse representert ved formel en optisk aktiv isomer derav, eller et farmasøytisk akseptabelt salt derav, hvor R2 er hydrogen eller lignende; R3 er metyl eller lignende; R20 er halogen eller lignende; q er et helt tall fra 0 til 3; Z er nitrogen, CH eller lignende; R4 er hydrogen eller lignende; R5 er hydrogen eller lignende; R6 er substituert alkyloksy eller lignende; p er et helt tall fra 0 til 3; X representerer en binding, CH2, oksygenatom, NH eller lignende; hvilke som helst av R5 og R6, R5 og R4, R6 og R4, X og R5, X og R4, X og R6 og R6 og R6 kan være kombinert med hverandre og danne en ring. Forbindelsen anvendes til forebyggende og/eller terapeutisk behandling av en sykdom forårsaket av t-proteinkinase 1-hyperaktivitet, så som neurodegenerative sykdommer (f.eks. Alzheimers sykdom).
NO20084302A 2006-03-15 2008-10-14 2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorer NO20084302L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006110242 2006-03-15
PCT/JP2007/055787 WO2007119463A1 (en) 2006-03-15 2007-03-14 2-(cyclic amino)-pyrimidone derivatives as tpk1 inhibitors

Publications (1)

Publication Number Publication Date
NO20084302L true NO20084302L (no) 2008-12-03

Family

ID=38110618

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084302A NO20084302L (no) 2006-03-15 2008-10-14 2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorer

Country Status (16)

Country Link
US (1) US8569294B2 (no)
EP (2) EP2001863A1 (no)
JP (2) JP2009530229A (no)
KR (1) KR20080102430A (no)
CN (1) CN101400668A (no)
AR (1) AR059899A1 (no)
AU (1) AU2007239962A1 (no)
BR (1) BRPI0708914A2 (no)
CA (1) CA2644979A1 (no)
EA (1) EA200870358A1 (no)
MX (1) MX2008011780A (no)
NO (1) NO20084302L (no)
NZ (1) NZ571709A (no)
TW (1) TW200813015A (no)
WO (1) WO2007119463A1 (no)
ZA (1) ZA200808364B (no)

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WO2007119463A1 (en) 2007-10-25
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EP2423207A2 (en) 2012-02-29
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JP2015078216A (ja) 2015-04-23
US8569294B2 (en) 2013-10-29
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