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NO20083955L - Nye kromen-2-on-derivater og deres anvendelse som monoaminneurotransmittergjenopptaksinhibitorer - Google Patents

Nye kromen-2-on-derivater og deres anvendelse som monoaminneurotransmittergjenopptaksinhibitorer

Info

Publication number
NO20083955L
NO20083955L NO20083955A NO20083955A NO20083955L NO 20083955 L NO20083955 L NO 20083955L NO 20083955 A NO20083955 A NO 20083955A NO 20083955 A NO20083955 A NO 20083955A NO 20083955 L NO20083955 L NO 20083955L
Authority
NO
Norway
Prior art keywords
alkyl
group
reuptake inhibitors
derivatives
monoamine neurotransmitter
Prior art date
Application number
NO20083955A
Other languages
English (en)
Inventor
Dan Peters
Elsebet Ostergaard Nielsen
John Paul Redrobe
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO20083955L publication Critical patent/NO20083955L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/34—Tobacco-abuse
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)

Abstract

Som kan anvendes som monoaminnevrotransmitter gjenopptaksinhibitorer. I andre aspekter vedrører oppfinnelsen anvendelse av disse forbindelsene i en fremgangsmåte for terapi, og farmasøytiske preparater som omfatter forbindelsene ifølge oppfinnelsen. Formel (I) hvor Q er en kromen-2-on-gruppe; hvor kromen-2-on-gruppen eventuelt er substituert med én eller flere substituenter uavhengig av hverandre valgt fra gruppen bestående av: halo, trifluormetyl, trifluormetoksy, cyano, hydroksy, amino, nitro, alkoksy, syklo-alkoksy, alkyl, sykloalkyl, sykloalkylalkyl, alkenyl og alkynyl; R1 er hydrogen eller alkyl; hvor alkyl er eventuelt substituert med én eller flere substituenter uavhengig av hverandre valgt fra gruppen bestående av: halo, trifluormetyl, trifluormetoksy, cyano, hydroksy, amino, nitro, alkoksy, syklo-alkoksy, alkyl, sykloalkyl, sykloalkylalkyl, alkenyl og alkynyl; og R2 og R3 danner til sammen -(CH2)-(CH2)- eller -(CH)=(CH>.
NO20083955A 2006-02-17 2008-09-16 Nye kromen-2-on-derivater og deres anvendelse som monoaminneurotransmittergjenopptaksinhibitorer NO20083955L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200600233 2006-02-17
US77466906P 2006-02-21 2006-02-21
PCT/EP2007/051401 WO2007093604A1 (en) 2006-02-17 2007-02-13 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Publications (1)

Publication Number Publication Date
NO20083955L true NO20083955L (no) 2008-09-16

Family

ID=39272807

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083955A NO20083955L (no) 2006-02-17 2008-09-16 Nye kromen-2-on-derivater og deres anvendelse som monoaminneurotransmittergjenopptaksinhibitorer

Country Status (15)

Country Link
US (1) US8153797B2 (no)
EP (2) EP2311835A1 (no)
JP (1) JP2009526816A (no)
KR (1) KR20080096833A (no)
CN (1) CN101405287B (no)
AR (1) AR059546A1 (no)
AU (1) AU2007216535A1 (no)
BR (1) BRPI0707853A2 (no)
CA (1) CA2641916A1 (no)
IL (1) IL192485A0 (no)
NO (1) NO20083955L (no)
RU (1) RU2008129865A (no)
TW (1) TW200800980A (no)
WO (1) WO2007093604A1 (no)
ZA (1) ZA200805908B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20110190T1 (hr) * 2004-09-30 2011-04-30 Neurosearch A/S Novi derivati kromen-2-ona i njihova upotreba kao inhibitora povratnog unosa monoamina neurotransmitora
PL2121677T3 (pl) * 2006-12-20 2011-04-29 Neurosearch As Nowe pochodne chromen-2-onu i ich zastosowanie jako inhibitorów wychwytu zwrotnego neurotransmiteru monoaminowego
US20090312364A1 (en) * 2006-12-20 2009-12-17 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CN102428083A (zh) * 2009-05-15 2012-04-25 神经研究公司 色原烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途
US20130040985A1 (en) 2010-01-29 2013-02-14 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en) 2010-03-25 2011-09-29 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en) 2010-07-02 2012-01-05 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8923209D0 (en) * 1989-10-14 1989-11-29 Wyeth John & Brother Ltd Heterocyclic compounds
CZ285571B6 (cs) 1995-11-02 1999-09-15 Neurosearch A/S Kondenzované tropanové deriváty, způsob jejich výroby, farmaceutické prostředky, které je obsahují a jejich použití k léčení
SK281813B6 (sk) 1996-02-22 2001-08-06 Neurosearch A/S Tropánové deriváty, spôsob ich prípravy, použitie a farmaceutická kompozícia s ich obsahom
US5916914A (en) * 1997-08-08 1999-06-29 Warner-Lambert Company Compounds and method of treating psychosis and schizophrenia
WO2002102801A1 (en) * 2001-05-23 2002-12-27 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MXPA04012440A (es) 2002-06-12 2005-04-28 Abbott Lab Antagonistas de receptor de hormona concentradora de melanina.
US7538233B2 (en) 2003-09-05 2009-05-26 Aventis Pharmaceuticals Inc. Coumarins as iNOS inhibitors
JP5001156B2 (ja) * 2004-09-30 2012-08-15 ノイロサーチ アクティーゼルスカブ 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのその使用
KR20070089170A (ko) 2004-12-17 2007-08-30 뉴로서치 에이/에스 3-헤테로아릴-8ｈ-8-아자비사이클로(3.2.1)옥트-2-엔의에난티오머 및 모노아민 신경전달물질 재흡수 억제제로서의이의 용도
PL2121677T3 (pl) 2006-12-20 2011-04-29 Neurosearch As Nowe pochodne chromen-2-onu i ich zastosowanie jako inhibitorów wychwytu zwrotnego neurotransmiteru monoaminowego
US20090312364A1 (en) 2006-12-20 2009-12-17 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Also Published As

Publication number Publication date
CN101405287B (zh) 2011-05-18
AU2007216535A1 (en) 2007-08-23
JP2009526816A (ja) 2009-07-23
CN101405287A (zh) 2009-04-08
RU2008129865A (ru) 2010-03-27
IL192485A0 (en) 2009-02-11
BRPI0707853A2 (pt) 2011-05-10
ZA200805908B (en) 2009-10-28
EP2311835A1 (en) 2011-04-20
US8153797B2 (en) 2012-04-10
EP1989202A1 (en) 2008-11-12
CA2641916A1 (en) 2007-08-23
KR20080096833A (ko) 2008-11-03
AR059546A1 (es) 2008-04-09
EP1989202B1 (en) 2012-07-25
US20100227883A1 (en) 2010-09-09
TW200800980A (en) 2008-01-01
WO2007093604A1 (en) 2007-08-23

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