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NO20083822L - Farmasoytisk antikreftpreparat - Google Patents

Farmasoytisk antikreftpreparat

Info

Publication number
NO20083822L
NO20083822L NO20083822A NO20083822A NO20083822L NO 20083822 L NO20083822 L NO 20083822L NO 20083822 A NO20083822 A NO 20083822A NO 20083822 A NO20083822 A NO 20083822A NO 20083822 L NO20083822 L NO 20083822L
Authority
NO
Norway
Prior art keywords
group
substituted
inhibitor
membered
salt
Prior art date
Application number
NO20083822A
Other languages
English (en)
Inventor
Kosaku Fujiwara
Naomi Shimazaki
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of NO20083822L publication Critical patent/NO20083822L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Det er beskrevet et farmasøytisk antikreftpreparat for anvendelse ved forebyggelse eller behandling av et karsinom, et sarkom eller hematopoesekreft. Preparatet omfatter en forbindelse representert ved den generelle formel (I) eller et salt derav som en aktiv bestanddel, hvor R er en fenylgruppe substituert med 1-5 substituenter valgt blant et halogenatom, en hydroksygruppe, en Cl-C6-alkylgruppe, en halogen-C1-C6-alkylgruppe, en C1-C6--alkoksygruppe, en Cl-C6-alkyltiogruppe, en amingruppe som kan være substituert, en C3-C10-sykloalkylgruppe som kan være substituert, en alifatisk Cl-C7-acyloksygruppe, en nitrogenert 4-7leddet, mettet, heterosyklisk gruppe, en nitrogenert 5-6-leddet, aromatisk, heterosyklisk gruppe, en nitrogruppe og en cyangruppe; og X er et oksygen- eller svovelatom. Også beskrevet er et farmasøytisk antikreftpreparat som omfatter en inhibitor av epidermal vekstfaktorreseptor (EGFR), en inhibitor av vaskulær endotelvekstfaktorreseptor (VEGFR) eller en Raf-kinaseinhibitor, og en forbindelse representert ved den generelle formel (I) ovenfor, eller et salt derav, som aktive bestanddeler.
NO20083822A 2006-02-09 2008-09-08 Farmasoytisk antikreftpreparat NO20083822L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006031791 2006-02-09
PCT/JP2007/052178 WO2007091622A1 (ja) 2006-02-09 2007-02-08 抗癌医薬組成物

Publications (1)

Publication Number Publication Date
NO20083822L true NO20083822L (no) 2008-11-05

Family

ID=38345216

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083822A NO20083822L (no) 2006-02-09 2008-09-08 Farmasoytisk antikreftpreparat

Country Status (15)

Country Link
US (4) US8263631B2 (no)
EP (1) EP1982718A4 (no)
JP (2) JP5133071B2 (no)
KR (1) KR20080101888A (no)
CN (1) CN101415422B (no)
AU (1) AU2007213028C1 (no)
BR (1) BRPI0707671A2 (no)
CA (1) CA2642665C (no)
IL (1) IL193243A0 (no)
NO (1) NO20083822L (no)
NZ (1) NZ570381A (no)
RU (1) RU2419430C2 (no)
TW (1) TW200800181A (no)
WO (1) WO2007091622A1 (no)
ZA (1) ZA200807721B (no)

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Also Published As

Publication number Publication date
EP1982718A4 (en) 2010-05-12
US20120258991A1 (en) 2012-10-11
BRPI0707671A2 (pt) 2011-05-10
AU2007213028B2 (en) 2010-10-28
AU2007213028A1 (en) 2007-08-16
RU2008136188A (ru) 2010-03-20
CN101415422B (zh) 2012-11-07
CA2642665C (en) 2013-01-08
EP1982718A1 (en) 2008-10-22
ZA200807721B (en) 2010-02-24
CN101415422A (zh) 2009-04-22
US20120263716A1 (en) 2012-10-18
IL193243A0 (en) 2009-02-11
AU2007213028C1 (en) 2011-05-19
JP2012255042A (ja) 2012-12-27
US20090028868A1 (en) 2009-01-29
JP5133071B2 (ja) 2013-01-30
TW200800181A (en) 2008-01-01
CA2642665A1 (en) 2007-08-16
WO2007091622A1 (ja) 2007-08-16
KR20080101888A (ko) 2008-11-21
NZ570381A (en) 2011-02-25
JPWO2007091622A1 (ja) 2009-07-02
RU2419430C2 (ru) 2011-05-27
US20130183297A1 (en) 2013-07-18
US8263631B2 (en) 2012-09-11

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