NO20083710L - Dihydrotienopyrimidin for behandling av betennelsesforstyrrelser - Google Patents
Dihydrotienopyrimidin for behandling av betennelsesforstyrrelserInfo
- Publication number
- NO20083710L NO20083710L NO20083710A NO20083710A NO20083710L NO 20083710 L NO20083710 L NO 20083710L NO 20083710 A NO20083710 A NO 20083710A NO 20083710 A NO20083710 A NO 20083710A NO 20083710 L NO20083710 L NO 20083710L
- Authority
- NO
- Norway
- Prior art keywords
- dihydrotienopyrimidine
- treatment
- inflammatory disorders
- diseases
- well
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- -1 diastereomers Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001508 eye Anatomy 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 210000001503 joint Anatomy 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06112779A EP1847543A1 (fr) | 2006-04-19 | 2006-04-19 | Dihydrothienopyrimidines pour le traitement de maladies inflammatoires |
| PCT/EP2007/053255 WO2007118793A1 (fr) | 2006-04-19 | 2007-04-03 | Dihydrothiénopyrimidines destinées au traitement de maladies inflammatoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083710L true NO20083710L (no) | 2008-11-18 |
Family
ID=36847643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083710A NO20083710L (no) | 2006-04-19 | 2008-08-28 | Dihydrotienopyrimidin for behandling av betennelsesforstyrrelser |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8114878B2 (fr) |
| EP (2) | EP1847543A1 (fr) |
| JP (1) | JP5214588B2 (fr) |
| KR (1) | KR20090009885A (fr) |
| CN (1) | CN101426505A (fr) |
| AR (1) | AR060516A1 (fr) |
| AU (1) | AU2007239573A1 (fr) |
| BR (1) | BRPI0710459A2 (fr) |
| CA (1) | CA2647243A1 (fr) |
| CO (1) | CO6140032A2 (fr) |
| EA (1) | EA200802051A1 (fr) |
| EC (1) | ECSP088738A (fr) |
| IL (1) | IL194739A0 (fr) |
| MX (1) | MX2008012915A (fr) |
| NO (1) | NO20083710L (fr) |
| PE (1) | PE20080319A1 (fr) |
| TW (1) | TW200808811A (fr) |
| UY (1) | UY30287A1 (fr) |
| WO (1) | WO2007118793A1 (fr) |
| ZA (1) | ZA200807015B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1847543A1 (fr) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidines pour le traitement de maladies inflammatoires |
| PL2205608T3 (pl) * | 2007-10-18 | 2013-09-30 | Boehringer Ingelheim Int | Sposób otrzymywania dihydrotieno[3,2-d]pirymidyn i związków pośrednich stosowanych w tym sposobie |
| KR20100075930A (ko) | 2007-10-19 | 2010-07-05 | 베링거 인겔하임 인터내셔날 게엠베하 | 헤테로사이클-치환된 피페라지노-디하이드로티에노피리미딘 |
| WO2009053268A1 (fr) * | 2007-10-19 | 2009-04-30 | Boehringer Ingelheim International Gmbh | Nouvelles pipérazino-dihydrothiénopyrimidines phényl-substituées |
| RS52271B (sr) * | 2007-10-19 | 2012-10-31 | Boehringer Ingelheim International Gmbh | Substituisani piperidino-dihidrotienopirimidin |
| US8486948B2 (en) | 2007-10-19 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Piperazinodihydrothienopyrimidine derivatives |
| WO2010097332A1 (fr) * | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Combinaisons de médicaments contenant des inhibiteurs de pde4 et des ains |
| US20130059866A1 (en) * | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| WO2014124860A1 (fr) | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Inhibiteurs spécifiques de pde4b pour le traitement du diabète sucré |
| CN105037369B (zh) * | 2015-06-23 | 2017-07-07 | 河南师范大学 | 一种吡唑并[5,1‑a]异吲哚‑3‑甲酰胺类化合物的合成方法 |
| EP3675861A4 (fr) * | 2017-09-01 | 2021-01-06 | Kadmon Corporation, LLC | Inhibiteurs de protéine kinase à superenroulement d'hélices alpha (« coiled-coil ») associée à rho |
| CN111108109A (zh) | 2017-09-20 | 2020-05-05 | 利奥制药有限公司 | 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途 |
| FI3700529T3 (fi) | 2017-10-23 | 2025-09-18 | Boehringer Ingelheim Int | Uusi aktiivisten aineiden yhdistelmä etenevien fibrotisoivien interstitiaalisten keuhkosairauksien (pf-ild) hoitoon |
| EP3724196B9 (fr) | 2017-12-15 | 2023-03-22 | UNION therapeutics A/S | Azétidine dihydrothiénopyridines substituées et leur utilisation en tant qu'inhibiteurs de phosphodiestérase |
| WO2019115775A1 (fr) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Dihydrothiénopyrimidines de tétrahydropyrane substituées, et leur utilisation en tant qu'inhibiteurs de la phosphodiestérase |
| JP7198820B2 (ja) | 2017-12-15 | 2023-01-04 | ユニオン・セラピューティクス・アクティエセルスカブ | 置換アゼチジンジヒドロチエノピリミジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用 |
| AU2022404695B2 (en) | 2021-12-09 | 2025-08-28 | Boehringer Ingelheim International Gmbh | New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases |
| DK4426307T3 (da) | 2021-12-09 | 2025-09-15 | Boehringer Ingelheim Int | Ny oral farmaceutisk sammensætning og doseringsplan til behandling af progressive fibroserende interstitielle lungesygdomme |
| US20250263426A1 (en) * | 2022-08-09 | 2025-08-21 | Xizang Haisco Pharmaceutical Co., Ltd. | Pde4b inhibitor and use thereof |
| EP4593838A1 (fr) | 2022-09-28 | 2025-08-06 | Boehringer Ingelheim International GmbH | Utilisation de biomarqueurs dans le traitement d'états fibrotiques avec inhibiteur de la pde4b |
| CN119698422A (zh) | 2022-09-29 | 2025-03-25 | 苏州爱科百发生物医药技术有限公司 | 氮杂稠环类化合物、其制备方法及其在医药上的应用 |
| WO2025067168A1 (fr) * | 2023-09-25 | 2025-04-03 | 苏州爱科百发生物医药技术有限公司 | Composé cyclique fusionné d'aza, son procédé de préparation et son utilisation |
| WO2025092985A1 (fr) * | 2023-11-03 | 2025-05-08 | 合肥医工医药股份有限公司 | Inhibiteur de phosphodiestérase 4b, son procédé de préparation et son utilisation |
| WO2025162431A1 (fr) * | 2024-02-04 | 2025-08-07 | 西藏海思科制药有限公司 | Composition pharmaceutique orale de composé inhibiteur de pde4b et son procédé de préparation |
| WO2025162289A2 (fr) * | 2024-02-04 | 2025-08-07 | 西藏海思科制药有限公司 | Forme cristalline d'un inhibiteur de pde4b et son utilisation pharmaceutique |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470336A1 (de) | 1962-07-04 | 1969-03-20 | Thomae Gmbh Dr K | Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung |
| NL122810C (fr) | 1963-06-17 | |||
| DE1470356A1 (de) | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| BE663693A (fr) | 1965-03-31 | |||
| DE2032687A1 (en) | 1970-07-02 | 1972-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Cardiovascular 2-aminoalkylamino-thienopyrimidines - and 4-morpholino derivatives from 4-diethanolamino-compounds by intramolecular cyclisa |
| DE1940572A1 (de) | 1969-08-08 | 1971-02-11 | Thomae Gmbh Dr K | Neue 2-Aminoalkylamino-thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| BE754606A (fr) | 1969-08-08 | 1971-02-08 | Thomae Gmbh Dr K | Nouvelles 2-aminoalcoylamino-thieno(3,2-d)pyrimidines et leurs procedesde fabrication |
| US3763156A (en) | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
| FR2082496A5 (fr) | 1970-03-18 | 1971-12-10 | Westinghouse Freins & Signaux | |
| DE2121950A1 (en) | 1971-05-04 | 1972-11-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Thieno(3,2-d)pyrimidine derivs - with thrombocyte aggregation inhibiting activity |
| DE2750288A1 (de) | 1977-11-10 | 1979-05-17 | Thomae Gmbh Dr K | Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4256737A (en) | 1979-06-11 | 1981-03-17 | Syntex (U.S.A.) Inc. | Long acting depot injectable formulations for LH-RH analogues |
| US5187168A (en) | 1991-10-24 | 1993-02-16 | American Home Products Corporation | Substituted quinazolines as angiotensin II antagonists |
| JPH07330777A (ja) | 1994-06-08 | 1995-12-19 | Taisho Pharmaceut Co Ltd | チエノ［３，２−ｄ］ピリミジン−４−オン誘導体 |
| JPH09301958A (ja) | 1996-05-09 | 1997-11-25 | Nippon Shoji Kk | 新規ピリミジン化合物及び抗ロタウイルス剤 |
| US6339089B2 (en) | 1997-08-13 | 2002-01-15 | Fujirebio Inc. | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same |
| CZ301841B6 (cs) | 2000-10-12 | 2010-07-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Krystalický monohydrát tiotropiumbromidu, zpusob jeho výroby a jeho použití pro výrobu léciva |
| DE10064994A1 (de) | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
| IL159238A0 (en) | 2001-06-22 | 2004-06-01 | Boehringer Ingelheim Pharma | Crystalline anticholinergic, method for its production, and use thereof in the production of a drug |
| US6587548B2 (en) | 2001-07-17 | 2003-07-01 | Hewlett-Packard Development Co., L.P. | Method and system of using a single telephone number for multiple services |
| WO2003055890A1 (fr) | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Composes derives de thienopyrimidine utilises comme inhibiteurs de la prolylpeptidase, inducteurs d'apoptose et agents de traitement anticancereux |
| CA2472619A1 (fr) | 2002-01-10 | 2003-07-24 | Bayer Corporation | Derives de pyrimidine fusionnes en tant qu'inhibiteurs de la rho-kinase |
| ATE438401T1 (de) | 2002-06-12 | 2009-08-15 | Chemocentryx Inc | 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen |
| OA13050A (en) | 2003-04-29 | 2006-11-10 | Pfizer Ltd | 5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension. |
| AU2004280575B8 (en) | 2003-10-02 | 2010-05-13 | Dsm Ip Assets B.V. | Production of high levels of DHA in microalgae using modified amounts of chloride and potassium |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| WO2005082865A1 (fr) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | Dérivé de pyrimidine bicyclique fondu |
| DE102005019201A1 (de) * | 2006-04-19 | 2006-11-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen zur Behandlung von entzündlichen Erkrankungen |
| EP1847543A1 (fr) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidines pour le traitement de maladies inflammatoires |
| MY149347A (en) | 2007-04-20 | 2013-08-30 | Glaxo Group Ltd | Tricyclic nitrogen containing compounds as antibacterial agents |
| PL2205608T3 (pl) | 2007-10-18 | 2013-09-30 | Boehringer Ingelheim Int | Sposób otrzymywania dihydrotieno[3,2-d]pirymidyn i związków pośrednich stosowanych w tym sposobie |
| US8486948B2 (en) | 2007-10-19 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Piperazinodihydrothienopyrimidine derivatives |
| FR2922550B1 (fr) | 2007-10-19 | 2009-11-27 | Sanofi Aventis | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
| TW200934771A (en) | 2007-10-19 | 2009-08-16 | Astrazeneca Ab | New compounds |
| RS52271B (sr) | 2007-10-19 | 2012-10-31 | Boehringer Ingelheim International Gmbh | Substituisani piperidino-dihidrotienopirimidin |
| MX2010004312A (es) | 2007-10-19 | 2010-07-05 | Schering Corp | Derivados de 1,3,4-tiadiazol espiro-condensados para inhibir la actividad de quinesina de la proteina de quinesina del huso. |
| KR20100075930A (ko) | 2007-10-19 | 2010-07-05 | 베링거 인겔하임 인터내셔날 게엠베하 | 헤테로사이클-치환된 피페라지노-디하이드로티에노피리미딘 |
| WO2009053268A1 (fr) | 2007-10-19 | 2009-04-30 | Boehringer Ingelheim International Gmbh | Nouvelles pipérazino-dihydrothiénopyrimidines phényl-substituées |
| EP2400962B1 (fr) | 2009-02-27 | 2017-11-08 | Boehringer Ingelheim International GmbH | Combinaisons de médicaments contenant des inhibiteurs PDE4 et NSAID |
| WO2010097332A1 (fr) | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Combinaisons de médicaments contenant des inhibiteurs de pde4 et des ains |
-
2006
- 2006-04-19 EP EP06112779A patent/EP1847543A1/fr not_active Withdrawn
-
2007
- 2007-04-03 WO PCT/EP2007/053255 patent/WO2007118793A1/fr not_active Ceased
- 2007-04-03 JP JP2009505831A patent/JP5214588B2/ja active Active
- 2007-04-03 EP EP07727726A patent/EP2010185B1/fr active Active
- 2007-04-03 KR KR1020087028318A patent/KR20090009885A/ko not_active Withdrawn
- 2007-04-03 AU AU2007239573A patent/AU2007239573A1/en not_active Abandoned
- 2007-04-03 CA CA002647243A patent/CA2647243A1/fr not_active Abandoned
- 2007-04-03 MX MX2008012915A patent/MX2008012915A/es not_active Application Discontinuation
- 2007-04-03 BR BRPI0710459-6A patent/BRPI0710459A2/pt not_active IP Right Cessation
- 2007-04-03 EA EA200802051A patent/EA200802051A1/ru unknown
- 2007-04-03 CN CNA2007800140081A patent/CN101426505A/zh active Pending
- 2007-04-16 UY UY30287A patent/UY30287A1/es not_active Application Discontinuation
- 2007-04-17 PE PE2007000470A patent/PE20080319A1/es not_active Application Discontinuation
- 2007-04-18 TW TW096113678A patent/TW200808811A/zh unknown
- 2007-04-18 AR ARP070101646A patent/AR060516A1/es unknown
- 2007-04-18 US US11/736,703 patent/US8114878B2/en active Active
-
2008
- 2008-08-14 ZA ZA200807015A patent/ZA200807015B/xx unknown
- 2008-08-28 NO NO20083710A patent/NO20083710L/no not_active Application Discontinuation
- 2008-09-15 EC EC2008008738A patent/ECSP088738A/es unknown
- 2008-10-17 CO CO08111120A patent/CO6140032A2/es unknown
- 2008-10-22 IL IL194739A patent/IL194739A0/en unknown
-
2012
- 2012-01-04 US US13/343,391 patent/US8604039B2/en active Active
-
2013
- 2013-09-05 US US14/019,019 patent/US8822474B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200807015B (en) | 2010-01-27 |
| JP5214588B2 (ja) | 2013-06-19 |
| WO2007118793A1 (fr) | 2007-10-25 |
| JP2010523467A (ja) | 2010-07-15 |
| US8114878B2 (en) | 2012-02-14 |
| TW200808811A (en) | 2008-02-16 |
| US20120108534A1 (en) | 2012-05-03 |
| EA200802051A1 (ru) | 2009-04-28 |
| ECSP088738A (es) | 2008-10-31 |
| US20080096882A1 (en) | 2008-04-24 |
| EP2010185B1 (fr) | 2012-06-13 |
| EP2010185A1 (fr) | 2009-01-07 |
| AU2007239573A1 (en) | 2007-10-25 |
| EP1847543A1 (fr) | 2007-10-24 |
| CA2647243A1 (fr) | 2007-10-25 |
| AR060516A1 (es) | 2008-06-25 |
| US20140005154A1 (en) | 2014-01-02 |
| CN101426505A (zh) | 2009-05-06 |
| UY30287A1 (es) | 2007-11-30 |
| KR20090009885A (ko) | 2009-01-23 |
| US8822474B2 (en) | 2014-09-02 |
| US8604039B2 (en) | 2013-12-10 |
| CO6140032A2 (es) | 2010-03-19 |
| BRPI0710459A2 (pt) | 2011-08-16 |
| IL194739A0 (en) | 2009-08-03 |
| PE20080319A1 (es) | 2008-05-13 |
| MX2008012915A (es) | 2008-10-15 |
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