NO20082566L - Kombinasjon av AZ2171 og permetrexed - Google Patents
Kombinasjon av AZ2171 og permetrexedInfo
- Publication number
- NO20082566L NO20082566L NO20082566A NO20082566A NO20082566L NO 20082566 L NO20082566 L NO 20082566L NO 20082566 A NO20082566 A NO 20082566A NO 20082566 A NO20082566 A NO 20082566A NO 20082566 L NO20082566 L NO 20082566L
- Authority
- NO
- Norway
- Prior art keywords
- azd2171
- pemetrexed
- human
- combination
- antiangiogenic
- Prior art date
Links
- XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 abstract 5
- 229960002412 cediranib Drugs 0.000 abstract 5
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 abstract 5
- 229960005079 pemetrexed Drugs 0.000 abstract 5
- 241001465754 Metazoa Species 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000005855 radiation Effects 0.000 abstract 2
- 230000001603 reducing effect Effects 0.000 abstract 2
- 230000008728 vascular permeability Effects 0.000 abstract 2
- 239000013066 combination product Substances 0.000 abstract 1
- 229940127555 combination product Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Ink Jet (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår en fremgangsmåte for frembringelse av en anti-angiogen og/eller vaskulær permeabilitetsreduserende effekt hos et varmblodig dyr slik som et menneske som eventuelt behandles med ioniserende stråling, særlig en fremgangsmåte for behandling av kreft, særlig kreft som involverer en fast tumor, som innbefatter administrering av AZD2171 i kombinasjon med pemetrexed; en farmasøytisk sammensetning som innbefatter AZD2171 og pemetrexed; et kombinasjonsprodukt som omfatter AZD2171 og pemetrexed for anvendelse i en fremgangsmåte for behandling av menneske- eller dyrekroppen ved behandling; et kit som innbefatter AZD2171 og pemetrexed; anvendelse av AZD2171 og pemetrexed for fremstilling av et medikament for anvendelse ved frembringelse av en anti-angiogen og/eller vaskulær permeabilitetsreduserende effekt hos et varmblodig dyr slik som et menneske som eventuelt behandles med ioniserende stråling. 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0526132A GB0526132D0 (en) | 2005-12-22 | 2005-12-22 | Combination Therapy |
| GB0610708A GB0610708D0 (en) | 2006-05-31 | 2006-05-31 | Combination therapy |
| PCT/GB2006/004768 WO2007071970A2 (en) | 2005-12-22 | 2006-12-19 | Combination of azd2171 and pemetrexed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082566L true NO20082566L (no) | 2008-07-31 |
Family
ID=37964934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082566A NO20082566L (no) | 2005-12-22 | 2008-06-02 | Kombinasjon av AZ2171 og permetrexed |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20080306094A1 (no) |
| EP (1) | EP1965801B1 (no) |
| JP (1) | JP2009520787A (no) |
| KR (1) | KR20080077678A (no) |
| AT (1) | ATE502641T1 (no) |
| AU (1) | AU2006328201B2 (no) |
| BR (1) | BRPI0620118A2 (no) |
| CA (1) | CA2631676A1 (no) |
| CY (1) | CY1111482T1 (no) |
| DE (1) | DE602006020919D1 (no) |
| DK (1) | DK1965801T3 (no) |
| HR (1) | HRP20110365T1 (no) |
| IL (1) | IL191797A0 (no) |
| NO (1) | NO20082566L (no) |
| NZ (1) | NZ568812A (no) |
| PL (1) | PL1965801T3 (no) |
| PT (1) | PT1965801E (no) |
| SI (1) | SI1965801T1 (no) |
| WO (1) | WO2007071970A2 (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| GB0406445D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| KR20060130764A (ko) * | 2004-03-23 | 2006-12-19 | 아스트라제네카 아베 | 병용 요법 |
| GB0406446D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| JP2009500384A (ja) * | 2005-07-06 | 2009-01-08 | アストラゼネカ アクチボラグ | 併用療法 |
| SI1971338T1 (sl) * | 2005-12-22 | 2011-06-30 | Astrazeneca Ab | Kombinacija ZD6474 in pemetrekseda |
| US20090221615A1 (en) * | 2008-02-29 | 2009-09-03 | Guru Reddy | Combination anti-cancer agents |
| CA2789895C (en) | 2010-03-08 | 2019-04-09 | Spectrum Pharmaceuticals, Inc. | Thioxanthone-based autophagy inhibitor therapies to treat cancer |
| CA2994167A1 (en) * | 2015-07-30 | 2017-02-02 | Expression Pathology, Inc. | Quantifying fr-a and gart proteins for optimal cancer therapy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1087785A2 (en) * | 1998-06-15 | 2001-04-04 | Arch Development Corporation | Combination of radiotherapy and anti-angiogenic factors |
| BRPI0017548B8 (pt) * | 1999-02-10 | 2023-05-02 | Astrazeneca Ab | Composto |
| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
| GB0316127D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| GB0316123D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| GB0330002D0 (en) * | 2003-12-24 | 2004-01-28 | Astrazeneca Ab | Quinazoline derivatives |
| KR20060130764A (ko) * | 2004-03-23 | 2006-12-19 | 아스트라제네카 아베 | 병용 요법 |
| GB0406446D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| GB0406445D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
| WO2005117980A1 (en) * | 2004-06-04 | 2005-12-15 | Pfizer Products Inc. | Method for treating abnormal cell growth |
| JP2008514576A (ja) * | 2004-09-27 | 2008-05-08 | アストラゼネカ アクチボラグ | Azd2171およびイマチニブを含む癌組合せ療法 |
| JP2009500384A (ja) * | 2005-07-06 | 2009-01-08 | アストラゼネカ アクチボラグ | 併用療法 |
| JP5179373B2 (ja) * | 2005-12-15 | 2013-04-10 | アストラゼネカ アクチボラグ | 癌を治療するためのアンジオポエチン−2アンタゴニストとVEGF−A、KDR、及び/又はFlt1アンタゴニストの組合せ |
| SI1971338T1 (sl) * | 2005-12-22 | 2011-06-30 | Astrazeneca Ab | Kombinacija ZD6474 in pemetrekseda |
-
2006
- 2006-12-19 KR KR1020087016943A patent/KR20080077678A/ko not_active Withdrawn
- 2006-12-19 CA CA002631676A patent/CA2631676A1/en not_active Abandoned
- 2006-12-19 DE DE602006020919T patent/DE602006020919D1/de active Active
- 2006-12-19 SI SI200631009T patent/SI1965801T1/sl unknown
- 2006-12-19 WO PCT/GB2006/004768 patent/WO2007071970A2/en not_active Ceased
- 2006-12-19 HR HR20110365T patent/HRP20110365T1/hr unknown
- 2006-12-19 US US12/158,266 patent/US20080306094A1/en not_active Abandoned
- 2006-12-19 BR BRPI0620118-0A patent/BRPI0620118A2/pt not_active Application Discontinuation
- 2006-12-19 DK DK06820574.9T patent/DK1965801T3/da active
- 2006-12-19 NZ NZ568812A patent/NZ568812A/en unknown
- 2006-12-19 PT PT06820574T patent/PT1965801E/pt unknown
- 2006-12-19 AU AU2006328201A patent/AU2006328201B2/en not_active Ceased
- 2006-12-19 EP EP06820574A patent/EP1965801B1/en active Active
- 2006-12-19 JP JP2008546594A patent/JP2009520787A/ja active Pending
- 2006-12-19 AT AT06820574T patent/ATE502641T1/de active
- 2006-12-19 PL PL06820574T patent/PL1965801T3/pl unknown
-
2008
- 2008-05-28 IL IL191797A patent/IL191797A0/en unknown
- 2008-06-02 NO NO20082566A patent/NO20082566L/no not_active Application Discontinuation
-
2011
- 2011-05-20 CY CY20111100490T patent/CY1111482T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009520787A (ja) | 2009-05-28 |
| PL1965801T3 (pl) | 2011-07-29 |
| NZ568812A (en) | 2011-09-30 |
| HK1123976A1 (en) | 2009-07-03 |
| ATE502641T1 (de) | 2011-04-15 |
| CA2631676A1 (en) | 2007-06-28 |
| AU2006328201A1 (en) | 2007-06-28 |
| DE602006020919D1 (de) | 2011-05-05 |
| EP1965801A2 (en) | 2008-09-10 |
| BRPI0620118A2 (pt) | 2011-11-01 |
| CY1111482T1 (el) | 2015-08-05 |
| SI1965801T1 (sl) | 2011-06-30 |
| AU2006328201B2 (en) | 2010-08-19 |
| EP1965801B1 (en) | 2011-03-23 |
| DK1965801T3 (da) | 2011-06-14 |
| PT1965801E (pt) | 2011-05-25 |
| KR20080077678A (ko) | 2008-08-25 |
| IL191797A0 (en) | 2008-12-29 |
| HRP20110365T1 (hr) | 2011-06-30 |
| WO2007071970A2 (en) | 2007-06-28 |
| WO2007071970A3 (en) | 2007-08-09 |
| US20080306094A1 (en) | 2008-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |