NO20081026L - Kinolinderivater som antibakterielle midler - Google Patents
Kinolinderivater som antibakterielle midlerInfo
- Publication number
- NO20081026L NO20081026L NO20081026A NO20081026A NO20081026L NO 20081026 L NO20081026 L NO 20081026L NO 20081026 A NO20081026 A NO 20081026A NO 20081026 A NO20081026 A NO 20081026A NO 20081026 L NO20081026 L NO 20081026L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- het
- hydrogen
- alkylthio
- hydroxy
- Prior art date
Links
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000002431 hydrogen Chemical class 0.000 abstract 6
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- -1 cyano, hydroxy Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Anvendelse av en forbindelse for fremstilling av et medikament for behandling av en bakteriell infeksjon forutsatt at den bakterielle infeksjon er noe annet enn en mykobakteriell infeksjon, idet nevnte forbindelse er en forbindelse med formel (I) (I) et farmasøytisk akseptabelt syre- eller baseaddisjonssalt, et kvaternært amin, en stereokjemisk isomer form, en tautomer form eller en N-oksidform derav, hvori R1 er hydrogen, halogen, halogenalkyl, cyano, hydroksy, Ar, Het, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; p er 1 til 3; s er 0 til 4; R2 er hydrogen; halogen; alkyl; hydroksy; merkapto; valgfritt substituert alkyloksy; alkyloksyalkyloksy; alkyltio; mono eller di(alkyl)amino, hvori alkyl kan valgfritt være substituert; Ar; Het eller et radikal med formel ; R3 er alkyl, Ar, Ar-alkyl, Het eller Het-alkyl; q er 0 til 4; R4 og R5 hver uavhengig er hydrogen, alkyl eller benzyl eller R4 og R5 kan være tatt sammen iberegnet N-atomet som de er bundet til; R6 er hydrogen, halogen, halogenalkyl, hydroksy, Ar, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl, eller to nærliggende R6-radikaler kan være tatt sammen og danner sammen med fenylringen som de er bundet til, et naftyl; r er 1 til 5; R7 er hydrogen, alkyl, Ar eller Het; R8 er hydrogen, alkyl, hydroksyl, aminokarbonyl, mono-eller di(alkyl)aminokarbonyl, Ar, Het, alkyl substituert med ett eller to Het, alkyl substituert med ett eller to Ar, Het-C(=O)- eller Ar-C(=O)-; forutsatt at når det R3-bærende radikal er plassert i stilling 3 i kinolingruppen; R7 er plassert i stilling 4, og R2 er plassert i stilling 2 og representerer hydrogen, hydroksy, merkapto, alkyloksy, alkyloksyalkyloksy, alkyltio, mono eller di(alkyl)amino eller et radikal med formel , da er s 1 til 4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107164 | 2005-08-03 | ||
| PCT/EP2006/064858 WO2007014941A2 (en) | 2005-08-03 | 2006-07-31 | Quinoline derivatives as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20081026L true NO20081026L (no) | 2008-02-27 |
| NO341242B1 NO341242B1 (no) | 2017-09-25 |
Family
ID=35744723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081026A NO341242B1 (no) | 2005-08-03 | 2008-02-27 | Kinolinderivater som antibakterielle midler |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8802671B2 (no) |
| EP (1) | EP1912648B1 (no) |
| JP (1) | JP5302680B2 (no) |
| KR (1) | KR101413997B1 (no) |
| CN (2) | CN101277696A (no) |
| AP (1) | AP2654A (no) |
| AR (1) | AR054890A1 (no) |
| AU (1) | AU2006274880B2 (no) |
| BR (1) | BRPI0614493B8 (no) |
| CA (1) | CA2615903C (no) |
| CY (1) | CY1114318T1 (no) |
| DK (1) | DK1912648T3 (no) |
| EA (1) | EA014833B1 (no) |
| ES (1) | ES2414956T3 (no) |
| HR (1) | HRP20130540T1 (no) |
| IL (1) | IL189142A0 (no) |
| JO (1) | JO2855B1 (no) |
| ME (1) | ME01616B (no) |
| MX (1) | MX2008001603A (no) |
| MY (1) | MY159560A (no) |
| NO (1) | NO341242B1 (no) |
| NZ (1) | NZ565947A (no) |
| PL (1) | PL1912648T3 (no) |
| PT (1) | PT1912648E (no) |
| RS (1) | RS52808B (no) |
| SI (1) | SI1912648T1 (no) |
| TW (1) | TWI422374B (no) |
| UA (1) | UA95915C2 (no) |
| WO (1) | WO2007014941A2 (no) |
| ZA (1) | ZA200801110B (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004186452A (ja) | 2002-12-04 | 2004-07-02 | Renesas Technology Corp | 不揮発性半導体記憶装置およびその製造方法 |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| CN104254527B (zh) | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| AU2013254670B2 (en) | 2012-04-27 | 2017-03-30 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| KR20150070348A (ko) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제 |
| PE20150778A1 (es) | 2012-10-16 | 2015-05-23 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo unidos a metileno de ror-gamma-t |
| PE20151203A1 (es) | 2012-10-16 | 2015-08-31 | Janssen Pharmaceutica Nv | MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t |
| US9346782B2 (en) | 2013-10-15 | 2016-05-24 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US9624225B2 (en) | 2013-10-15 | 2017-04-18 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| CN109111397B (zh) * | 2018-08-28 | 2021-12-10 | 广东工业大学 | 一种喹啉芳香乙烯类衍生物及其制备方法和应用 |
| CN109111396B (zh) * | 2018-08-28 | 2021-09-03 | 广东工业大学 | 一种喹啉芳香乙烯衍生物及其制备方法和应用 |
| CN112079825B (zh) * | 2020-10-09 | 2021-12-21 | 中央民族大学 | 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用 |
| CN112110907B (zh) * | 2020-10-09 | 2021-12-21 | 中央民族大学 | 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB807750A (en) * | 1956-06-15 | 1959-01-21 | Rhone Poulenc Sa | Improvements in or relating to piperazine derivatives |
| GB9317491D0 (en) * | 1993-08-23 | 1993-10-06 | Fujisawa Pharmaceutical Co | New compound and a process for preparation thereof |
| WO1998018326A1 (en) * | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| DK2301544T3 (da) * | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
| PL360102A3 (en) | 2003-05-13 | 2004-11-15 | "ENERGOMAR-NORD" Sp.z o.o. | Method for manufacturing highly reactive calcium sorbing agents and facility designed for manufacturing highly reactive calcium sorbing agents |
| WO2005070430A1 (en) | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Quinoline derivatives and use thereof as mycobacterial inhibitors |
| WO2005070924A1 (en) | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Substituted quinolines and their use as mycobacterial inhibitors |
| ES2306098T3 (es) * | 2004-01-29 | 2008-11-01 | Janssen Pharmaceutica Nv | Derivados de quinolina para uso como inhibidores de micobacterias. |
| EE05697B1 (et) | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
| US20070018948A1 (en) | 2005-07-22 | 2007-01-25 | Elaine Chen | Apparatus for stabilizing an electronic device during data input and device control |
-
2006
- 2006-07-18 JO JO2006232A patent/JO2855B1/en active
- 2006-07-31 NZ NZ565947A patent/NZ565947A/en not_active IP Right Cessation
- 2006-07-31 WO PCT/EP2006/064858 patent/WO2007014941A2/en not_active Ceased
- 2006-07-31 EP EP06778083.3A patent/EP1912648B1/en active Active
- 2006-07-31 SI SI200631602T patent/SI1912648T1/sl unknown
- 2006-07-31 US US11/997,173 patent/US8802671B2/en active Active
- 2006-07-31 KR KR1020087005071A patent/KR101413997B1/ko not_active Expired - Fee Related
- 2006-07-31 HR HRP20130540TT patent/HRP20130540T1/hr unknown
- 2006-07-31 EA EA200800508A patent/EA014833B1/ru unknown
- 2006-07-31 MX MX2008001603A patent/MX2008001603A/es active IP Right Grant
- 2006-07-31 CN CNA2006800367512A patent/CN101277696A/zh active Granted
- 2006-07-31 JP JP2008524509A patent/JP5302680B2/ja not_active Expired - Fee Related
- 2006-07-31 PL PL06778083T patent/PL1912648T3/pl unknown
- 2006-07-31 DK DK06778083.3T patent/DK1912648T3/da active
- 2006-07-31 ES ES06778083T patent/ES2414956T3/es active Active
- 2006-07-31 CN CN200680036751.2D patent/CN101277696B8/zh not_active Expired - Fee Related
- 2006-07-31 RS RS20130254A patent/RS52808B/sr unknown
- 2006-07-31 CA CA2615903A patent/CA2615903C/en active Active
- 2006-07-31 BR BRPI0614493A patent/BRPI0614493B8/pt not_active IP Right Cessation
- 2006-07-31 PT PT67780833T patent/PT1912648E/pt unknown
- 2006-07-31 UA UAA200801432A patent/UA95915C2/ru unknown
- 2006-07-31 ME MEP-2013-65A patent/ME01616B/me unknown
- 2006-07-31 AP AP2008004316A patent/AP2654A/xx active
- 2006-07-31 AU AU2006274880A patent/AU2006274880B2/en not_active Ceased
- 2006-08-01 MY MYPI20063727A patent/MY159560A/en unknown
- 2006-08-02 AR ARP060103372A patent/AR054890A1/es unknown
- 2006-08-02 TW TW095128224A patent/TWI422374B/zh not_active IP Right Cessation
-
2008
- 2008-01-31 IL IL189142A patent/IL189142A0/en active IP Right Grant
- 2008-02-01 ZA ZA2008/01110A patent/ZA200801110B/en unknown
- 2008-02-27 NO NO20081026A patent/NO341242B1/no not_active IP Right Cessation
-
2013
- 2013-07-09 CY CY20131100578T patent/CY1114318T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |