NO20081454L - Met-kinaseinhibitorer - Google Patents
Met-kinaseinhibitorerInfo
- Publication number
- NO20081454L NO20081454L NO20081454A NO20081454A NO20081454L NO 20081454 L NO20081454 L NO 20081454L NO 20081454 A NO20081454 A NO 20081454A NO 20081454 A NO20081454 A NO 20081454A NO 20081454 L NO20081454 L NO 20081454L
- Authority
- NO
- Norway
- Prior art keywords
- kinase inhibitors
- met kinase
- met
- cancer
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72208905P | 2005-09-30 | 2005-09-30 | |
| US11/529,875 US7547782B2 (en) | 2005-09-30 | 2006-09-28 | Met kinase inhibitors |
| PCT/US2006/038216 WO2007041379A1 (fr) | 2005-09-30 | 2006-09-29 | Inhibiteurs de met kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081454L true NO20081454L (no) | 2008-04-22 |
Family
ID=37547515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081454A NO20081454L (no) | 2005-09-30 | 2008-03-25 | Met-kinaseinhibitorer |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7547782B2 (fr) |
| EP (1) | EP1937682B1 (fr) |
| JP (1) | JP2009510113A (fr) |
| NO (1) | NO20081454L (fr) |
| WO (1) | WO2007041379A1 (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1934174T1 (sl) * | 2005-10-07 | 2011-08-31 | Exelixis Inc | Inhibitorji MEK in postopki za njihovo uporabo |
| JP2009529047A (ja) * | 2006-03-07 | 2009-08-13 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環系ピラゾール化合物およびその使用 |
| US20110053931A1 (en) * | 2006-06-08 | 2011-03-03 | John Gaudino | Quinoline compounds and methods of use |
| WO2008079294A1 (fr) * | 2006-12-20 | 2008-07-03 | Amgen Inc. | Hétérocycles substitués et procédés d'utilisation |
| EP2125781A2 (fr) | 2006-12-20 | 2009-12-02 | Amgen Inc. | Hétérocycles substitués et leurs méthodes d'utilisation |
| AU2008210455A1 (en) * | 2007-01-31 | 2008-08-07 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as kinase inhibitors |
| EP2125819B1 (fr) * | 2007-03-21 | 2014-10-22 | Bristol-Myers Squibb Company | Composés hétérocycliques fusionnés utiles pour le traitement de maladies prolifératives, allergiques, auto-immunes ou inflammatoires |
| EP2137177B1 (fr) * | 2007-04-05 | 2014-05-07 | Amgen, Inc | Modulateurs de la kinase aurora et méthode d'utilisation |
| WO2008141130A1 (fr) * | 2007-05-11 | 2008-11-20 | Kosan Biosciences, Inc. | Procédé pour la préparation d'épothilones |
| US8030503B2 (en) | 2007-05-11 | 2011-10-04 | Kosan Biosciences Incorporated | Process for the preparation of epothilones |
| AU2008282156B2 (en) * | 2007-07-31 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1H-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
| US20110130406A1 (en) * | 2007-09-06 | 2011-06-02 | Array Biopharma Inc. | Pyrazolo-pyridines as tyrosine kinase inhibitors |
| WO2009073300A1 (fr) | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | Dérivés de [1h-pyrazolo[3,4-b]pyridin-4-yl]-phényle ou -pyridin-2-yle en tant qu'inhibiteurs de la protéine kinase c-thêta |
| JP5693239B2 (ja) | 2008-01-23 | 2015-04-01 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ４−ピリジノン化合物および癌についてのその使用 |
| EP2328896B1 (fr) | 2008-07-23 | 2013-10-23 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de pyrazolopyridine kinase tricylique |
| KR20110039563A (ko) | 2008-07-23 | 2011-04-19 | 버텍스 파마슈티칼스 인코포레이티드 | 피라졸로피리딘 키나제 억제제 |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| JP2011529073A (ja) * | 2008-07-24 | 2011-12-01 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ調節因子として有用な縮合ヘテロ環化合物 |
| AU2009279611A1 (en) * | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
| TWI491610B (zh) | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
| JP5627675B2 (ja) | 2009-05-06 | 2014-11-19 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ピラゾロピリジン |
| RU2615130C2 (ru) * | 2009-10-06 | 2017-04-04 | Милленниум Фармасьютикалз, Инк | Гетероциклические соединения, используемые в качестве ингибиторов pdk1 |
| CN102858769A (zh) | 2010-01-27 | 2013-01-02 | 沃泰克斯药物股份有限公司 | 吡唑并吡啶激酶抑制剂 |
| WO2011094290A1 (fr) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Inhibiteurs des kinases à base de pyrazolopyrimidine |
| CA2787079A1 (fr) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la pyrazolopyrazine kinase |
| EP2571361A4 (fr) | 2010-05-19 | 2013-11-13 | Univ North Carolina | Composés de pyrazolopyrimidine pour le traitement du cancer |
| KR102063098B1 (ko) | 2011-10-03 | 2020-01-08 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 암 치료를 위한 피롤로피리미딘 화합물 |
| CN104302627A (zh) * | 2012-05-22 | 2015-01-21 | 北卡罗来纳大学教堂山分校 | 用于治疗癌症的嘧啶化合物 |
| BR112015008113B1 (pt) | 2012-10-12 | 2022-05-24 | Exelixis, Inc. | Novo processo para preparar compostos para uso no tratamento de câncer |
| WO2014062774A1 (fr) | 2012-10-17 | 2014-04-24 | The University Of North Carolina At Chapel Hill | Composés pyrazolopyrimidines pour le traitement du cancer |
| EP2925752A4 (fr) * | 2012-11-27 | 2016-06-01 | Univ North Carolina | Composés à base de pyrimidine utilisables à des fins de traitement du cancer |
| DK3087070T3 (en) * | 2013-12-26 | 2017-12-04 | Ignyta Inc | PYRAZOLO [1,5-A] PYRIDINE DERIVATIVES AND PROCEDURES FOR THEIR USE |
| WO2015157123A1 (fr) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Composés de pyrrolopyrimidine spécifiques de mertk |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| CN110218205B (zh) * | 2019-07-05 | 2022-04-05 | 辽宁大学 | 含吡啶结构的2,4-二芳氨基嘧啶类衍生物及其应用 |
| CA3213079A1 (fr) | 2021-04-13 | 2022-10-20 | Kristin Lynne ANDREWS | Heterocycles amino-substitues pour le traitement de cancers avec des mutations egfr |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3464368D1 (de) | 1983-03-09 | 1987-07-30 | Beecham Group Plc | Anti-inflammatory pyrazolo pyridines |
| EP0151962A3 (fr) | 1984-01-25 | 1985-10-02 | Beecham Group Plc | Dérivés de pyrazolopyridine |
| GB8404584D0 (en) | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| IE904346A1 (en) | 1989-12-04 | 1991-06-05 | Searle & Co | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY |
| GB9312891D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| DE69717627T2 (de) | 1996-06-27 | 2003-09-18 | Janssen Pharmaceutica N.V., Beerse | N-4-(heteroarylmethyl)phenyl-heteroarylaminderivate |
| ES2196806T3 (es) | 1998-05-08 | 2003-12-16 | Smithkline Beecham Plc | Derivados de fenilurea y de feniltiourea. |
| JP2000212141A (ja) * | 1999-01-13 | 2000-08-02 | Warner Lambert Co | ジアリ―ルアミン |
| JP2002534446A (ja) | 1999-01-13 | 2002-10-15 | ワーナー−ランバート・カンパニー | ４′ヘテロアリールジアリールアミン |
| KR100666514B1 (ko) | 1999-05-21 | 2007-02-28 | 브리스톨-마이어즈 스퀴브 컴페니 | 키나제의 피롤로트리아진 저해제 |
| WO2001057040A1 (fr) | 2000-02-03 | 2001-08-09 | Abbott Laboratories | Composes de 4-aminopyrido[2,3-d]pyrimidine a disubstitution en position 6,7 |
| WO2001094353A1 (fr) | 2000-06-06 | 2001-12-13 | Pfizer Products Inc. | Derives de thiophene utilises comme agents anticancereux |
| NZ525334A (en) | 2000-11-17 | 2005-07-29 | Bristol Myers Squibb Co | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| US20020147198A1 (en) | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
| JP2004526756A (ja) * | 2001-04-06 | 2004-09-02 | スミスクライン ビーチャム コーポレーション | ｈＹＡＫ１及びｈＹＡＫ３キナーゼのキノリン阻害剤 |
| WO2003000194A2 (fr) | 2001-06-21 | 2003-01-03 | Pfizer Inc. | Derives bicycliques de pyridine et de pyrimidine utiles en tant qu'agents anticancereux |
| GB0126902D0 (en) | 2001-11-08 | 2002-01-02 | Novartis Ag | Organic compounds |
| TW200300350A (en) | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
| US6900208B2 (en) | 2002-03-28 | 2005-05-31 | Bristol Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
| ES2318122T3 (es) | 2002-04-23 | 2009-05-01 | Bristol-Myers Squibb Company | Compuestos de aril cetona pirrolo-triazina utiles como inhibidores de quinasa. |
| US6989451B2 (en) * | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
| TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
| CL2003002287A1 (es) | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
| TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| MXPA06002296A (es) | 2003-08-29 | 2006-05-22 | Pfizer | Tienopiridina-fenilacetamidas y sus derivados utiles como nuevos agentes antiangiogenicos. |
| WO2005044793A2 (fr) | 2003-10-31 | 2005-05-19 | Takeda Pharmaceutical Company Limited | Composes heterocycliques accoles contenant de l'azote |
-
2006
- 2006-09-28 US US11/529,875 patent/US7547782B2/en active Active
- 2006-09-29 EP EP06804275.3A patent/EP1937682B1/fr active Active
- 2006-09-29 JP JP2008533713A patent/JP2009510113A/ja active Pending
- 2006-09-29 WO PCT/US2006/038216 patent/WO2007041379A1/fr not_active Ceased
-
2008
- 2008-03-25 NO NO20081454A patent/NO20081454L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007041379A1 (fr) | 2007-04-12 |
| US7547782B2 (en) | 2009-06-16 |
| EP1937682B1 (fr) | 2015-08-12 |
| JP2009510113A (ja) | 2009-03-12 |
| US20070078140A1 (en) | 2007-04-05 |
| EP1937682A1 (fr) | 2008-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |