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NO20080129L - Process for the preparation of dihydroquinazolines - Google Patents

Process for the preparation of dihydroquinazolines

Info

Publication number
NO20080129L
NO20080129L NO20080129A NO20080129A NO20080129L NO 20080129 L NO20080129 L NO 20080129L NO 20080129 A NO20080129 A NO 20080129A NO 20080129 A NO20080129 A NO 20080129A NO 20080129 L NO20080129 L NO 20080129L
Authority
NO
Norway
Prior art keywords
dihydroquinazolines
preparation
dihydroquinalzolines
useful
formula
Prior art date
Application number
NO20080129A
Other languages
Norwegian (no)
Other versions
NO340521B1 (en
Inventor
Hans-Christian Militzer
Kathe Goossen
Oliver Kuhn
Mathias Berwe
Joachim Kruger
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of NO20080129L publication Critical patent/NO20080129L/en
Publication of NO340521B1 publication Critical patent/NO340521B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Dihydroquinazolines of the formula: The dihydroquinalzolines are useful as antiviral agents in particular against cytomegaloviruses.
NO20080129A 2005-06-15 2008-01-08 Process for the preparation of dihydroquinazolines NO340521B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005027517A DE102005027517A1 (en) 2005-06-15 2005-06-15 Process for the preparation of dihydroquinazolines
PCT/EP2006/005298 WO2006133822A1 (en) 2005-06-15 2006-06-02 Method for producing dihydroquinazolines

Publications (2)

Publication Number Publication Date
NO20080129L true NO20080129L (en) 2008-01-08
NO340521B1 NO340521B1 (en) 2017-05-02

Family

ID=36764739

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080129A NO340521B1 (en) 2005-06-15 2008-01-08 Process for the preparation of dihydroquinazolines

Country Status (23)

Country Link
US (3) US8084604B2 (en)
EP (1) EP1893587B1 (en)
JP (1) JP5114391B2 (en)
KR (1) KR101355229B1 (en)
CN (2) CN101863843B (en)
AT (1) ATE542803T1 (en)
AU (1) AU2006257415B2 (en)
BR (1) BRPI0613277B1 (en)
CA (1) CA2611927C (en)
DE (1) DE102005027517A1 (en)
DK (1) DK1893587T3 (en)
ES (1) ES2383989T3 (en)
HR (1) HRP20120319T1 (en)
IL (1) IL187586A (en)
MX (1) MX2007016040A (en)
NO (1) NO340521B1 (en)
NZ (1) NZ564325A (en)
PL (1) PL1893587T3 (en)
PT (1) PT1893587E (en)
RU (1) RU2419617C2 (en)
SI (1) SI1893587T1 (en)
WO (1) WO2006133822A1 (en)
ZA (1) ZA200710481B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (en) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituted dihydroquinazolines
DE10305785A1 (en) * 2003-02-12 2004-08-26 Bayer Healthcare Ag New 2-(2-phenylpiperanyl-3-phenyl-dihydroquinazolinyl)-acetic acid derivatives, useful as antiviral agents, especially effective against human cytomegalovirus infections
DE10320780A1 (en) * 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituted dihydroquinazolines
DE10352499A1 (en) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituted dihydroquinazolines II
DE102004022672A1 (en) * 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituted azachinazolines
DE102005027517A1 (en) 2005-06-15 2006-12-21 Bayer Healthcare Ag Process for the preparation of dihydroquinazolines
DE102012101673A1 (en) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salts of a dihydroquinazoline derivative
DE102012101680A1 (en) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative
DE102012101659A1 (en) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salts of a dihydroquinazoline derivative
CN103232400B (en) * 2013-04-26 2015-01-21 苏州大学 Method for preparing quinazoline-2-thioketone
LT3010891T (en) * 2013-06-19 2019-08-26 Aicuris Anti-Infective Cures Gmbh AMORPHIC LETERMOVIR AND ITS SOLID PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2016109360A1 (en) * 2014-12-29 2016-07-07 Auspex Pharmaceuticals, Inc. Dihydroquinazoline inhibitors of viral terminase
WO2017091453A1 (en) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
CN111024861A (en) * 2019-12-31 2020-04-17 山东省药学科学院 Detection method of Latemovir and related substances in Latemovir-containing preparation
UY39097A (en) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg POTASSIUM SALT OF ACID 2 - [(4S) -8-FLUORO-2- [4- (3- METOXIFENIL) PIPERAZIN-1-IL] -3- [2-METOXI-5- (TRIFLUOROMETIL) FENIL] -4H- QUINAZOLIN-4-IL] ACETIC
UY39098A (en) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg 2 - [(4S) -8-FLUORO-2- [4- (3-METOXIFENIL) PIPERAZIN-1-IL] -3- [2-METOXI-5- (TRIFLUOROMETIL) FENIL] -4H-QUINAZOLIN-4-IL ] SODIUM ACETATE MONOHYDRATE, ITS PREPARATION AND USE
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
IT202000017617A1 (en) 2020-07-21 2022-01-21 Olon Spa PROCEDURE FOR THE PREPARATION OF AN INTERMEDIATE USED IN THE SYNTHESIS OF LETERMOVIR
US20230312485A1 (en) 2020-08-17 2023-10-05 Lupin Limited A precipitation process for amorphous letermovir
CN115403528B (en) * 2021-05-27 2025-01-07 南京正大天晴制药有限公司 Preparation method of amorphous 3,4-dihydroquinazoline derivatives
CN118974026A (en) * 2022-04-01 2024-11-15 上海迪赛诺化学制药有限公司 Letermovir intermediate and preparation method thereof
CN115322157B (en) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 Letermopevir intermediate compound, preparation method and application thereof
WO2024037485A1 (en) * 2022-08-15 2024-02-22 上海迪赛诺化学制药有限公司 Preparation method for letermovir amorphous form
CN115677539B (en) * 2022-11-01 2023-10-24 南京工业大学 A cobalt-catalyzed method for highly selective monoalkenylation of urea-directed aromatics under mild conditions
CN115974793B (en) * 2022-12-23 2025-01-28 浙江车头制药股份有限公司 A racemization recovery method for the by-product of the resolution of a letermovir intermediate
CN115947694A (en) * 2023-01-10 2023-04-11 云南大学 A kind of preparation method of dihydroquinazoline compound
CN116874436B (en) * 2023-07-11 2025-08-08 济宁学院 Leitemivir Process for the preparation of intermediates
CN117486808A (en) * 2023-11-06 2024-02-02 北京康立生医药技术开发有限公司 A new preparation method for key intermediates of letermovir
CN117658928A (en) * 2023-11-07 2024-03-08 北京康立生医药技术开发有限公司 A new preparation method of drug intermediates for preventing CMV infection
WO2025133248A1 (en) 2023-12-21 2025-06-26 Aic246 Ag & Co. Kg Diastereomeric aminoalcohol and aminoether salts of 2-[(4r,s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl]acetic acid and their use for enantiomeric separation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
KR20010041015A (en) 1998-02-17 2001-05-15 윌리엄 제이. 리플린 Anti-viral pyrimidine derivatives
US6730682B2 (en) * 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
EP1325008B1 (en) * 2000-07-31 2005-10-05 F. Hoffmann-La Roche Ag Piperazine derivatives
EP1201765A3 (en) 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
DE10251914A1 (en) 2002-11-08 2004-05-19 Bayer Ag New 2,3-diphenyl-quinazoline-4-acetic acid derivatives, useful as antiviral agents, especially effective against human cytomegalovirus infections
DE10319612A1 (en) * 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituted dihydroquinazolines
DE10305785A1 (en) * 2003-02-12 2004-08-26 Bayer Healthcare Ag New 2-(2-phenylpiperanyl-3-phenyl-dihydroquinazolinyl)-acetic acid derivatives, useful as antiviral agents, especially effective against human cytomegalovirus infections
DE10320780A1 (en) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituted dihydroquinazolines
DE10352499A1 (en) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituted dihydroquinazolines II
KR100610731B1 (en) * 2004-02-24 2006-08-09 한국과학기술연구원 3,4-dihydroquinazolin derivatives useful as T-type calcium channel blockers and methods for their preparation
DE102004022672A1 (en) * 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituted azachinazolines
US7615554B2 (en) * 2005-01-25 2009-11-10 Prolexys Pharmaceuticals, Inc. Erastin and erastin binding proteins, and uses thereof
DE102005027517A1 (en) 2005-06-15 2006-12-21 Bayer Healthcare Ag Process for the preparation of dihydroquinazolines
EP1910359B1 (en) * 2005-07-21 2009-11-18 F. Hoffmann-Roche AG PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS

Also Published As

Publication number Publication date
AU2006257415B2 (en) 2011-11-24
US8816075B2 (en) 2014-08-26
IL187586A0 (en) 2008-03-20
HK1116185A1 (en) 2008-12-19
AU2006257415A1 (en) 2006-12-21
IL187586A (en) 2013-07-31
BRPI0613277A2 (en) 2010-12-28
DE102005027517A1 (en) 2006-12-21
ES2383989T3 (en) 2012-06-28
CA2611927C (en) 2013-10-22
US8084604B2 (en) 2011-12-27
US20120130072A1 (en) 2012-05-24
US20130066073A1 (en) 2013-03-14
CN101213180B (en) 2011-09-07
CA2611927A1 (en) 2006-12-21
US20090221822A1 (en) 2009-09-03
SI1893587T1 (en) 2012-10-30
PT1893587E (en) 2012-05-07
NO340521B1 (en) 2017-05-02
ATE542803T1 (en) 2012-02-15
EP1893587A1 (en) 2008-03-05
DK1893587T3 (en) 2012-05-07
RU2007147955A (en) 2009-07-20
MX2007016040A (en) 2008-03-10
WO2006133822A1 (en) 2006-12-21
NZ564325A (en) 2010-11-26
BRPI0613277B1 (en) 2022-01-25
CN101213180A (en) 2008-07-02
KR101355229B1 (en) 2014-01-27
EP1893587B1 (en) 2012-01-25
JP5114391B2 (en) 2013-01-09
US8372972B2 (en) 2013-02-12
CN101863843B (en) 2013-03-27
HRP20120319T1 (en) 2012-05-31
CN101863843A (en) 2010-10-20
JP2008543797A (en) 2008-12-04
PL1893587T3 (en) 2012-06-29
RU2419617C2 (en) 2011-05-27
KR20080031278A (en) 2008-04-08
ZA200710481B (en) 2009-08-26

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: AICURIS ANTI-INFECTIVE CURES GMBH, DE

CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: AIC246 AG & CO. KG, DE