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NO20076003L - TGF-beta 1 spesifikke antistoffer - Google Patents

TGF-beta 1 spesifikke antistoffer

Info

Publication number
NO20076003L
NO20076003L NO20076003A NO20076003A NO20076003L NO 20076003 L NO20076003 L NO 20076003L NO 20076003 A NO20076003 A NO 20076003A NO 20076003 A NO20076003 A NO 20076003A NO 20076003 L NO20076003 L NO 20076003L
Authority
NO
Norway
Prior art keywords
tgf
beta
specific antibodies
compositions
methods
Prior art date
Application number
NO20076003A
Other languages
English (en)
Norwegian (no)
Inventor
David Matthew Marquis
Jeffry Dean Watkins
Ying Tang
Lihua Huang
Julian Davies
Craig Duane Dickinson
Bryan Edward Jones
Scott William Rowlinson
Peter Edward Vaillancourt
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20076003L publication Critical patent/NO20076003L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
NO20076003A 2005-04-22 2007-11-21 TGF-beta 1 spesifikke antistoffer NO20076003L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67408205P 2005-04-22 2005-04-22
PCT/US2006/014943 WO2006116002A2 (fr) 2005-04-22 2006-04-20 Compositions de liaison; reactifs connexes

Publications (1)

Publication Number Publication Date
NO20076003L true NO20076003L (no) 2008-01-22

Family

ID=37192643

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076003A NO20076003L (no) 2005-04-22 2007-11-21 TGF-beta 1 spesifikke antistoffer

Country Status (23)

Country Link
US (2) US7619069B2 (fr)
EP (1) EP1874818B1 (fr)
JP (1) JP5070200B2 (fr)
KR (1) KR100978684B1 (fr)
CN (1) CN101163719A (fr)
AT (1) ATE505489T1 (fr)
AU (1) AU2006240056B2 (fr)
BR (1) BRPI0608376A8 (fr)
CA (1) CA2607448C (fr)
CY (1) CY1111518T1 (fr)
DE (1) DE602006021292D1 (fr)
DK (1) DK1874818T3 (fr)
EA (1) EA016038B1 (fr)
ES (1) ES2361269T3 (fr)
HR (1) HRP20110334T1 (fr)
IL (1) IL186775A (fr)
NO (1) NO20076003L (fr)
PL (1) PL1874818T3 (fr)
PT (1) PT1874818E (fr)
RS (1) RS51845B (fr)
SI (1) SI1874818T1 (fr)
UA (1) UA93201C2 (fr)
WO (1) WO2006116002A2 (fr)

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US8685932B2 (en) * 2008-12-16 2014-04-01 Option Pharmaceuticals, Llc Targeted transforming growth factor-beta-bound IgG for Treatment of Diseases
CA3150199C (fr) 2009-01-09 2025-07-22 Seagen Inc Regimes posologiques hebdomadaires pour des conjugues anticorps anti-cd30 vc-pab-mmae - medicament
WO2012129330A1 (fr) 2011-03-23 2012-09-27 Option Pharmaceutical, Llc Cytokine ciblée pour le traitement de maladies musculosquelettiques
AU2012261933B2 (en) * 2011-06-03 2017-06-15 Xoma Technology Ltd. Antibodies specific for TGF-beta
SG11201401360XA (en) 2011-10-25 2014-05-29 Onclave Therapeutics Ltd Antibody formulations and methods
DK2822592T3 (en) 2012-03-08 2018-10-15 Ludwig Institute For Cancer Res Limited TGF-1-SPECIFIC ANTIBODIES AND PROCEDURES AND APPLICATIONS THEREOF
US10259626B2 (en) 2012-03-08 2019-04-16 Selig Sealing Products, Inc. Container sealing member with protected security component and removal tab
PL3489261T3 (pl) 2012-08-24 2021-08-16 The Regents Of The University Of California Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
CA2911514A1 (fr) 2013-05-06 2014-11-13 Scholar Rock, Inc. Compositions et procedes de modulation du facteur de croissance
PT3107573T (pt) * 2014-02-19 2019-01-10 Merck Patent Gmbh Imunoterapia com il-12 visada ao cancro
WO2016115345A1 (fr) 2015-01-14 2016-07-21 The Brigham And Women's Hospital, Traitement du cancer avec des anticorps monoclonaux anti-lap
TWI726870B (zh) * 2015-03-04 2021-05-11 美商健臻公司 具有高親和性、結合性及專一性之結合轉形生長因子-β1的scFv-Fc二聚體
TWI733661B (zh) 2015-03-04 2021-07-21 美商健臻公司 以高親合性、結合性及特異性結合轉化生長因子-β1的經修飾IgG抗體
SG11201805941WA (en) 2016-02-17 2018-09-27 Novartis Ag Tgfbeta 2 antibodies
AU2017222928A1 (en) * 2016-02-26 2018-09-20 Eli Lilly And Company Anti-CD11d antibodies and uses thereof
EP4169942A1 (fr) * 2016-03-11 2023-04-26 Scholar Rock, Inc. Immunoglobulines se liant à tgfbeta1 et leur utilisation
CA3024465A1 (fr) 2016-05-17 2017-11-23 Genentech, Inc. Signatures genetiques stromales destinees au diagnostic et a l'utilisation en immunotherapie
AU2017268469C1 (en) * 2016-05-20 2025-01-02 President And Fellows Of Harvard College Gene therapy methods for age-related diseases and conditions
CA3029003A1 (fr) 2016-06-27 2018-01-04 The Regents Of The University Of California Associations medicamenteuses pour le traitement du cancer
WO2018043734A1 (fr) * 2016-09-05 2018-03-08 Chugai Seiyaku Kabushiki Kaisha Anticorps anti-tgf-beta 1 et leurs procédés d'utilisation
CN109071656B (zh) 2017-01-05 2021-05-18 璟尚生物制药公司 检查点调节物拮抗剂
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
SG11201909955XA (en) 2017-05-02 2019-11-28 Merck Sharp & Dohme Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
WO2019045086A1 (fr) * 2017-08-29 2019-03-07 林化成株式会社 UTILISATION D'UN ANTICORPS SPÉCIFIQUE POUR TGF-β1 ACTIF OU LATENT
EP3694552A1 (fr) 2017-10-10 2020-08-19 Tilos Therapeutics, Inc. Anticorps anti-lap et leurs utilisations
AU2018359967A1 (en) 2017-11-06 2020-04-23 Genentech, Inc. Diagnostic and therapeutic methods for cancer
WO2020006516A1 (fr) 2018-06-29 2020-01-02 Gensun Biopharma, Inc. Antagonistes des régulateurs de points de contrôle immunitaires antitumoraux
WO2020076969A2 (fr) 2018-10-10 2020-04-16 Tilos Therapeutics, Inc. Variants d'anticorps anti-lap et leurs utilisations
EP3876990A4 (fr) 2018-11-07 2023-09-06 Merck Sharp & Dohme LLC Co-formulations d'anticorps anti-lag3 et d'anticorps anti-pd-1
EA202192130A1 (ru) 2019-01-30 2021-12-28 Сколар Рок, Инк. Специфичные к ltbp-комплексу ингибиторы tgf и их применение
WO2020263312A1 (fr) 2019-06-28 2020-12-30 Gensun Biopharma, Inc. ANTAGONISTE ANTITUMORAL COMPOSÉ D'UN DOMAINE EXTRACELLULAIRE TGFβ1 - RII MUTÉ ET D'UN ÉCHAFAUDAGE D'IMMUNOGLOBULINE
JP2023511255A (ja) 2020-01-11 2023-03-17 スカラー ロック インコーポレイテッド TGF-β阻害剤及びその使用
CN115190812A (zh) 2020-01-11 2022-10-14 供石公司 TGFβ抑制剂及其用途
WO2022204581A2 (fr) 2021-03-26 2022-09-29 Scholar Rock, Inc. Inhibiteurs de tgf-bêta et leur utilisation
WO2022256723A2 (fr) 2021-06-03 2022-12-08 Scholar Rock, Inc. Inhibiteurs de tgf-bêta et leur utilisation thérapeutique
WO2022266510A1 (fr) * 2021-06-18 2022-12-22 Genzyme Corporation Formulations d'anticorps anti-tgf-bêta et leur utilisation
EP4370148A1 (fr) 2021-07-14 2024-05-22 Scholar Rock, Inc. Inhibiteurs spécifiques du complexe ltbp de tgf bêta1 et leurs utilisations
WO2023080900A1 (fr) 2021-11-05 2023-05-11 Genentech, Inc. Procédés et compositions pour classer et traiter le cancer rénal
EP4599089A1 (fr) 2022-10-05 2025-08-13 Genentech, Inc. Méthodes et compositions de classification et de traitement du cancer de la vessie
EP4599088A1 (fr) 2022-10-05 2025-08-13 Genentech, Inc. Procédés et compositions pour la classification et le traitement du cancer du poumon
WO2024187051A1 (fr) 2023-03-07 2024-09-12 Scholar Rock, Inc. Inhibiteurs de tgf-bêta destinés à être utilisés pour traiter un cancer résistant ou réfractaire chez des patients
WO2025240343A1 (fr) 2024-05-13 2025-11-20 Scholar Rock, Inc. Inhibiteurs de tgf-bêta pour le traitement du cancer

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AU2005251764A1 (en) 2004-06-04 2005-12-22 Genentech, Inc. Method for treating lupus

Also Published As

Publication number Publication date
IL186775A0 (en) 2008-02-09
RS51845B (sr) 2012-02-29
ATE505489T1 (de) 2011-04-15
HRP20110334T1 (hr) 2011-06-30
WO2006116002A2 (fr) 2006-11-02
WO2006116002A3 (fr) 2007-02-01
PT1874818E (pt) 2011-05-05
US20100040633A1 (en) 2010-02-18
JP2008538564A (ja) 2008-10-30
BRPI0608376A2 (pt) 2010-11-16
CA2607448A1 (fr) 2006-11-02
CN101163719A (zh) 2008-04-16
ES2361269T3 (es) 2011-06-15
EA016038B1 (ru) 2012-01-30
BRPI0608376A8 (pt) 2018-10-16
CA2607448C (fr) 2014-11-18
EA200702278A1 (ru) 2008-08-29
DK1874818T3 (da) 2011-06-14
UA93201C2 (ru) 2011-01-25
AU2006240056B2 (en) 2012-02-16
KR100978684B1 (ko) 2010-08-31
EP1874818A2 (fr) 2008-01-09
KR20070114220A (ko) 2007-11-29
AU2006240056A1 (en) 2006-11-02
IL186775A (en) 2013-03-24
US8128927B2 (en) 2012-03-06
US20080050375A1 (en) 2008-02-28
EP1874818B1 (fr) 2011-04-13
WO2006116002A9 (fr) 2007-07-19
CY1111518T1 (el) 2015-08-05
JP5070200B2 (ja) 2012-11-07
PL1874818T3 (pl) 2011-09-30
DE602006021292D1 (de) 2011-05-26
US7619069B2 (en) 2009-11-17
SI1874818T1 (sl) 2011-08-31

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