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NO20075370L - Alfa-ketoamidforbindelser som cysteinproteaseinhibitorer - Google Patents

Alfa-ketoamidforbindelser som cysteinproteaseinhibitorer

Info

Publication number
NO20075370L
NO20075370L NO20075370A NO20075370A NO20075370L NO 20075370 L NO20075370 L NO 20075370L NO 20075370 A NO20075370 A NO 20075370A NO 20075370 A NO20075370 A NO 20075370A NO 20075370 L NO20075370 L NO 20075370L
Authority
NO
Norway
Prior art keywords
alpha
protease inhibitors
cysteine protease
compounds
ketoamide compounds
Prior art date
Application number
NO20075370A
Other languages
English (en)
Other versions
NO340619B1 (no
Inventor
John O Link
Michael Graupe
Michael G Roepel
Original Assignee
Virobay Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virobay Inc filed Critical Virobay Inc
Publication of NO20075370L publication Critical patent/NO20075370L/no
Publication of NO340619B1 publication Critical patent/NO340619B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
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  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Urology & Nephrology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser som er inhibitorer av cystein proteaser, særlig katepsinene B, K, L, F og S, og er derfor anvendelige ved behandling av sykdommer mediert av disse proteaser. Foreliggende oppfinnelse angår farmasøytiske sammensetninger som innbefatter disse forbindelsene og fremgangsmåter for fremstilling av dem.
NO20075370A 2005-03-21 2007-10-19 Alfa-ketoamid forbindelser som cystein protease inhibitorer og farmasøytiske sammensetninger inneholdende slike. NO340619B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66397005P 2005-03-21 2005-03-21
US68462305P 2005-05-24 2005-05-24
PCT/US2006/010063 WO2006102243A2 (en) 2005-03-21 2006-03-17 Alpha ketoamide compounds as cysteine protease inhibitors

Publications (2)

Publication Number Publication Date
NO20075370L true NO20075370L (no) 2007-12-19
NO340619B1 NO340619B1 (no) 2017-05-15

Family

ID=37024483

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20075370A NO340619B1 (no) 2005-03-21 2007-10-19 Alfa-ketoamid forbindelser som cystein protease inhibitorer og farmasøytiske sammensetninger inneholdende slike.
NO20170371A NO20170371A1 (no) 2005-03-21 2017-03-13 Alfa-ketoamid forbindelser som cystein protease inhibitorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20170371A NO20170371A1 (no) 2005-03-21 2017-03-13 Alfa-ketoamid forbindelser som cystein protease inhibitorer

Country Status (22)

Country Link
US (4) US7488848B2 (no)
EP (2) EP1865940B1 (no)
JP (2) JP5209466B2 (no)
KR (1) KR101447897B1 (no)
AU (1) AU2006227254B2 (no)
BR (1) BRPI0609695A2 (no)
CA (1) CA2602175C (no)
CY (1) CY1114075T1 (no)
DK (1) DK1865940T3 (no)
EA (2) EA017874B1 (no)
ES (1) ES2400582T3 (no)
HR (1) HRP20130419T1 (no)
IL (2) IL186102A (no)
LV (1) LV13669B (no)
MX (1) MX2007011617A (no)
NO (2) NO340619B1 (no)
NZ (1) NZ561681A (no)
PL (1) PL1865940T3 (no)
PT (1) PT1865940E (no)
RS (1) RS52762B (no)
TW (1) TWI384982B (no)
WO (1) WO2006102243A2 (no)

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EA200702030A1 (ru) 2008-02-28
IL186102A (en) 2012-09-24
IL186102A0 (en) 2008-01-20
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AU2006227254B2 (en) 2011-09-01
RS52762B (sr) 2013-08-30
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US20070021353A1 (en) 2007-01-25
PT1865940E (pt) 2013-04-08
TWI384982B (zh) 2013-02-11
HK1111981A1 (en) 2008-08-22
NO340619B1 (no) 2017-05-15
BRPI0609695A2 (pt) 2011-10-18
CY1114075T1 (el) 2016-07-27
JP2008538212A (ja) 2008-10-16
EP2511257B1 (en) 2015-06-17
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