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NO20075726L - Fremgangsmate for syntese av 6-alkylaminokinolinderivater - Google Patents

Fremgangsmate for syntese av 6-alkylaminokinolinderivater

Info

Publication number
NO20075726L
NO20075726L NO20075726A NO20075726A NO20075726L NO 20075726 L NO20075726 L NO 20075726L NO 20075726 A NO20075726 A NO 20075726A NO 20075726 A NO20075726 A NO 20075726A NO 20075726 L NO20075726 L NO 20075726L
Authority
NO
Norway
Prior art keywords
present
alkylaminoquinoline
synthesis
derivatives
formula
Prior art date
Application number
NO20075726A
Other languages
English (en)
Inventor
Allan Wissner
Mary Carolyn Discafani-Marro
Warren Chew
Sridhar Krishna Rabindran
John Patrick Ii Mcginnis
Youchu Wang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20075726L publication Critical patent/NO20075726L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

, , Foreliggende oppfinnelse angår en metode for syntetisering av forbindelser med formel (I) hvor X, Z, V, R1, R3, R4, G2, n, x, y og z er definert her. Foreliggende oppfinnelse omfatter også en metode for fremstilling av syre-forbindelser med formel (VII): hvor R er H og R4, x, y og z er som definert her og PG er en beskyttelsesgruppe. Foreliggende oppfinnelse angår også (E) N-{4-[ 3-klor-4-(2-pyridinylmetoksy)anilino]-3-cyano-7-etoksy-6-kinolinyl}-4-(metylamino)-2-butenamid, preparater inneholdende den og metoder for anvendelse av den for å behandle kreft.
NO20075726A 2005-05-25 2007-11-09 Fremgangsmate for syntese av 6-alkylaminokinolinderivater NO20075726L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68504005P 2005-05-25 2005-05-25
PCT/US2006/015931 WO2006127203A2 (en) 2005-05-25 2006-04-26 Methods of synthesizing 6-alkylaminoquinoline derivatives

Publications (1)

Publication Number Publication Date
NO20075726L true NO20075726L (no) 2008-02-04

Family

ID=36794434

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075726A NO20075726L (no) 2005-05-25 2007-11-09 Fremgangsmate for syntese av 6-alkylaminokinolinderivater

Country Status (20)

Country Link
US (1) US20060270670A1 (no)
EP (1) EP1883630A2 (no)
JP (1) JP2008542266A (no)
KR (1) KR20080016604A (no)
CN (1) CN101180273A (no)
AR (1) AR054192A1 (no)
AU (1) AU2006249596A1 (no)
BR (1) BRPI0610142A2 (no)
CA (1) CA2608589A1 (no)
CR (1) CR9545A (no)
GT (1) GT200600215A (no)
IL (1) IL187301A0 (no)
MX (1) MX2007014774A (no)
NO (1) NO20075726L (no)
PA (1) PA8676301A1 (no)
PE (1) PE20070007A1 (no)
RU (1) RU2007140957A (no)
TW (1) TW200716556A (no)
WO (1) WO2006127203A2 (no)
ZA (1) ZA200710143B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007008942A2 (en) * 2005-07-11 2007-01-18 Aerie Pharmaceuticals, Inc. Phenylamino-acetic acid [1-(pyridin-4-yl)-methylidene]-hydrazide derivatives and related compounds as modulators of g protein-coupled receptor kinases for the treatment of eye diseases
US7470787B2 (en) * 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
JP5235887B2 (ja) 2006-09-20 2013-07-10 アエリー ファーマシューティカルズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) * 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
WO2010126626A2 (en) 2009-05-01 2010-11-04 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
WO2010131921A2 (ko) * 2009-05-14 2010-11-18 코오롱생명과학 주식회사 알킬아민 유도체의 제조방법
BR112013006030B1 (pt) 2010-09-29 2020-03-17 Intervet International B.V. Composto e sais ou n-óxidos farmaceuticamente aceitáveis, e, uso do composto
HUE034347T2 (en) 2010-09-29 2018-02-28 Intervet Int Bv N-heteroaryl compounds with a cyclic bridge unit for the treatment of parasitic diseases
CN102649778A (zh) * 2011-02-23 2012-08-29 苏州波锐生物医药科技有限公司 喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途
CN104203242B (zh) * 2012-04-04 2017-03-15 杭州德润玉成生物科技有限公司 取代的喹啉类作为布鲁顿酪氨酸激酶抑制剂
PT3811943T (pt) 2013-03-15 2023-03-15 Aerie Pharmaceuticals Inc Composto para uso no tratamento de distúrbios oculares
TWI609012B (zh) 2013-04-28 2017-12-21 廣東東陽光藥業有限公司 氨基喹唑啉類衍生物及其鹽和使用方法
WO2017086941A1 (en) 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
BR112018071617A2 (pt) * 2016-04-28 2019-02-19 Jiangsu Hengrui Medicine Co., Ltd. método para preparar inibidor de tirosina quinase e derivado do mesmo
US11389441B2 (en) 2016-08-31 2022-07-19 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
CA3057872A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
KR102713340B1 (ko) * 2022-11-08 2024-10-02 경희대학교 산학협력단 고리화첨가 반응과 고리축소 반응의 연속 반응을 이용한 피롤로[1,2-a]퀴놀린의 제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
US6297258B1 (en) * 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
AU4545201A (en) * 2000-03-13 2001-09-24 American Cyanamid Co Method of treating or inhibiting colonic polyps
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CN1330627C (zh) * 2002-02-05 2007-08-08 惠氏公司 N－酰基－2－氨基－4－烷氧基－5－硝基苯甲酸类化合物的合成方法
CL2004000016A1 (es) * 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
MXPA06001590A (es) * 2003-08-19 2006-05-19 Wyeth Corp Proceso para la preparacion de 4-amino-3-quinolincarbonitrilos.
CN1930128A (zh) * 2004-01-16 2007-03-14 惠氏公司 受体酪氨酸激酶抑制剂的喹啉中间体及其合成

Also Published As

Publication number Publication date
MX2007014774A (es) 2008-02-19
AR054192A1 (es) 2007-06-06
RU2007140957A (ru) 2009-06-27
TW200716556A (en) 2007-05-01
AU2006249596A1 (en) 2006-11-30
CR9545A (es) 2008-01-10
EP1883630A2 (en) 2008-02-06
CN101180273A (zh) 2008-05-14
ZA200710143B (en) 2008-11-26
PA8676301A1 (es) 2009-03-31
BRPI0610142A2 (pt) 2011-01-04
CA2608589A1 (en) 2006-11-30
PE20070007A1 (es) 2007-02-12
KR20080016604A (ko) 2008-02-21
US20060270670A1 (en) 2006-11-30
WO2006127203A3 (en) 2007-05-03
IL187301A0 (en) 2008-04-13
JP2008542266A (ja) 2008-11-27
GT200600215A (es) 2006-12-26
WO2006127203A2 (en) 2006-11-30

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