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NO20073058L - NOVEL DIAZABICYCLONONES DERIVATIVE - Google Patents

NOVEL DIAZABICYCLONONES DERIVATIVE

Info

Publication number
NO20073058L
NO20073058L NO20073058A NO20073058A NO20073058L NO 20073058 L NO20073058 L NO 20073058L NO 20073058 A NO20073058 A NO 20073058A NO 20073058 A NO20073058 A NO 20073058A NO 20073058 L NO20073058 L NO 20073058L
Authority
NO
Norway
Prior art keywords
derivative
novel
diazabicyclonones
preparation
pharmaceutical compositions
Prior art date
Application number
NO20073058A
Other languages
Norwegian (no)
Inventor
Hans-Peter Weber
Thomas Weller
Sylvia Richard-Bildstein
Walter Fischli
Thierry Sifferlen
Daniel Bur
Lubos Remen
Olivier Bezencon
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36332872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20073058(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NO20073058L publication Critical patent/NO20073058L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Oppfinnelsen angår et hittil ukjent 3,9-diazabisyklo[3.3.1]nonenderivat og enantiomerene derav og anvendelsen derav som aktive ingredienser i fremstillingen av farmasøytiske preparater. Oppfinnelsen angår også relaterte aspekter, herunder fremgangsmåter til fremstillingen av forbindelsene, farmasøytiske preparater som inneholder minst én forbindelse ifølge formel (I) eller dens (1R,5S)-enantiomer og spesielt deres anvendelse som renininhibitorer.The invention relates to a novel 3,9-diazabicyclo [3.3.1] nonenergy derivative and its enantiomers and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also relates to related aspects, including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I) or its (1R, 5S) enantiomer and in particular their use as renin inhibitors.

NO20073058A 2004-12-08 2007-06-15 NOVEL DIAZABICYCLONONES DERIVATIVE NO20073058L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004013949 2004-12-08
PCT/IB2005/054113 WO2006061791A2 (en) 2004-12-08 2005-12-08 Novel diazabicyclononene derivative

Publications (1)

Publication Number Publication Date
NO20073058L true NO20073058L (en) 2007-07-04

Family

ID=36332872

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073058A NO20073058L (en) 2004-12-08 2007-06-15 NOVEL DIAZABICYCLONONES DERIVATIVE

Country Status (15)

Country Link
EP (1) EP1824851A2 (en)
JP (1) JP2008522967A (en)
KR (1) KR20070086977A (en)
CN (1) CN101072776A (en)
AR (1) AR052263A1 (en)
AU (1) AU2005313002A1 (en)
BR (1) BRPI0518610A2 (en)
CA (1) CA2589966A1 (en)
IL (1) IL183754A0 (en)
MX (1) MX2007006745A (en)
NO (1) NO20073058L (en)
RU (1) RU2007125724A (en)
TW (1) TW200634014A (en)
WO (1) WO2006061791A2 (en)
ZA (1) ZA200705557B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510755A (en) 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド Bicyclononene derivatives
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
EP2162436A4 (en) 2007-05-24 2010-08-04 Merck Frosst Canada Ltd NEW RHININE INHIBITORS
CA2696689A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
CN102015682B (en) 2008-05-05 2014-07-16 埃科特莱茵药品有限公司 3,4-Substituted piperidine derivatives as renin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL372141A1 (en) * 2002-04-29 2005-07-11 Actelion Pharmaceuticals Ltd. 7-aryl-3,9-diazabicyclo[3.3.1]non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

Also Published As

Publication number Publication date
ZA200705557B (en) 2008-09-25
TW200634014A (en) 2006-10-01
WO2006061791A3 (en) 2006-08-10
BRPI0518610A2 (en) 2008-11-25
RU2007125724A (en) 2009-01-20
EP1824851A2 (en) 2007-08-29
CN101072776A (en) 2007-11-14
IL183754A0 (en) 2007-09-20
CA2589966A1 (en) 2006-06-15
AU2005313002A1 (en) 2006-06-15
MX2007006745A (en) 2007-07-09
KR20070086977A (en) 2007-08-27
AR052263A1 (en) 2007-03-07
JP2008522967A (en) 2008-07-03
WO2006061791A2 (en) 2006-06-15

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application