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NO20073602L - Fremgangsmate for fremstilling av hoyrent meloksikam og meloksikamkaliumsalt - Google Patents

Fremgangsmate for fremstilling av hoyrent meloksikam og meloksikamkaliumsalt

Info

Publication number
NO20073602L
NO20073602L NO20073602A NO20073602A NO20073602L NO 20073602 L NO20073602 L NO 20073602L NO 20073602 A NO20073602 A NO 20073602A NO 20073602 A NO20073602 A NO 20073602A NO 20073602 L NO20073602 L NO 20073602L
Authority
NO
Norway
Prior art keywords
meloxicam
preparation
potassium salt
high pure
high purity
Prior art date
Application number
NO20073602A
Other languages
English (en)
Inventor
Tibor Mezei
Gyula Simig
Marta Porcs-Makkay
Balazs Volk
Gyula Lukacs
Enik Molnar
Valeria Hofmanne Fekete
Kalman Nagy
Norbert Mesterhazy
Gyorgy Krasznai
Gyorgyi Vereczkeyne Donath
Gyulane Kortvelyessy
Eva Pecsi
Original Assignee
Egis Gyogyszergyar Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyrt filed Critical Egis Gyogyszergyar Nyrt
Publication of NO20073602L publication Critical patent/NO20073602L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)

Abstract

Oppfinnelsen tilveiebringer en fremgangsmåte for fremstilling av høyrent meloksikam med formel (II). Meloksikam råproduktet reageres med løsningen av kaliumhydroksid eller kaliumkarbonat, hvorved høyrent meloksikam kaliumsaltmonohydrat fremstilles. Det nevnte saltet behandles deretter med mineralsyre eller organisk syre for å gi høyrent meloksikam.
NO20073602A 2004-12-18 2007-07-12 Fremgangsmate for fremstilling av hoyrent meloksikam og meloksikamkaliumsalt NO20073602L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0402634A HU227359B1 (en) 2004-12-18 2004-12-18 Process for producing meloxicam and meloxicam potassium salt of high purity
PCT/HU2005/000136 WO2006064298A1 (en) 2004-12-18 2005-12-16 Process for preparation of high-purity meloxicam and meloxicam potassium salt

Publications (1)

Publication Number Publication Date
NO20073602L true NO20073602L (no) 2007-09-14

Family

ID=89985699

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073602A NO20073602L (no) 2004-12-18 2007-07-12 Fremgangsmate for fremstilling av hoyrent meloksikam og meloksikamkaliumsalt

Country Status (22)

Country Link
US (2) US8097616B2 (no)
EP (1) EP1828178B1 (no)
JP (1) JP5329812B2 (no)
CN (1) CN101090900B (no)
AT (1) ATE486867T1 (no)
BG (1) BG66118B1 (no)
CY (1) CY1112714T1 (no)
CZ (1) CZ2007465A3 (no)
DE (1) DE602005024612D1 (no)
DK (1) DK1828178T3 (no)
EA (1) EA013791B1 (no)
ES (1) ES2356840T3 (no)
HU (1) HU227359B1 (no)
IL (1) IL183739A (no)
NO (1) NO20073602L (no)
PL (2) PL1828178T3 (no)
PT (1) PT1828178E (no)
RU (1) RU2394032C2 (no)
SI (1) SI1828178T1 (no)
SK (1) SK50932007A3 (no)
UA (1) UA89657C2 (no)
WO (1) WO2006064298A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2443891B (en) * 2006-11-20 2009-04-08 Norbrook Lab Ltd Process for the purification of meloxicam
CA2770338A1 (en) * 2009-08-27 2011-03-03 Merck Sharp & Dohme Corp. Processes for preparing protease inhibitors of hepatitis c virus
RU2465892C1 (ru) * 2011-09-21 2012-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет (НГУ)" Способ получения высокодисперсного мелоксикама
CN103772378B (zh) * 2014-01-26 2016-02-24 悦康药业集团有限公司 一种美洛昔康化合物及其片剂
CN106896162B (zh) * 2015-12-17 2019-10-18 瑞普（天津）生物药业有限公司 一种检测美洛昔康片中杂质的hplc方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
EP0945134A1 (de) * 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Neue galenische Zubereitungsformen von Meloxicam zur oralen Applikation
ES2223209B1 (es) * 2001-12-11 2005-10-01 Esteve Quimica, S.A. Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion.
US8992980B2 (en) * 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
ITMI20041918A1 (it) * 2004-10-11 2005-01-11 A M S A Anonima Materie Sintetiche Affini Spa Processo di purificazione di meloxicam

Also Published As

Publication number Publication date
RU2007126723A (ru) 2009-01-27
IL183739A (en) 2011-12-29
JP2008524197A (ja) 2008-07-10
CN101090900A (zh) 2007-12-19
HK1114848A1 (en) 2008-11-14
ES2356840T3 (es) 2011-04-13
PL1828178T3 (pl) 2011-07-29
HU227359B1 (en) 2011-04-28
CZ2007465A3 (cs) 2007-12-05
CY1112714T1 (el) 2016-02-10
CN101090900B (zh) 2013-11-20
PL382907A1 (pl) 2008-02-04
BG109916A (bg) 2008-02-29
EA013791B1 (ru) 2010-06-30
ATE486867T1 (de) 2010-11-15
HU0402634D0 (en) 2005-02-28
EP1828178A1 (en) 2007-09-05
PT1828178E (pt) 2011-02-07
WO2006064298A1 (en) 2006-06-22
UA89657C2 (ru) 2010-02-25
BG66118B1 (bg) 2011-05-31
JP5329812B2 (ja) 2013-10-30
EA200701256A1 (ru) 2007-12-28
HUP0402634A3 (en) 2008-10-28
EP1828178B1 (en) 2010-11-03
DE602005024612D1 (de) 2010-12-16
RU2394032C2 (ru) 2010-07-10
SK50932007A3 (sk) 2008-03-05
HUP0402634A2 (en) 2006-11-28
IL183739A0 (en) 2007-09-20
US20090215757A1 (en) 2009-08-27
US20120035162A1 (en) 2012-02-09
SI1828178T1 (sl) 2011-03-31
DK1828178T3 (da) 2011-02-14
US8097616B2 (en) 2012-01-17

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