NO20071093L - Nye anti-IGF-IR-antistoffer og anvendelse derav - Google Patents
Nye anti-IGF-IR-antistoffer og anvendelse deravInfo
- Publication number
- NO20071093L NO20071093L NO20071093A NO20071093A NO20071093L NO 20071093 L NO20071093 L NO 20071093L NO 20071093 A NO20071093 A NO 20071093A NO 20071093 A NO20071093 A NO 20071093A NO 20071093 L NO20071093 L NO 20071093L
- Authority
- NO
- Norway
- Prior art keywords
- antibodies
- igf
- overexpression
- receptor
- well
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000002018 overexpression Effects 0.000 abstract 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 abstract 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 241001529936 Murinae Species 0.000 abstract 1
- 206010061309 Neoplasm progression Diseases 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 230000005751 tumor progression Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SAMMENDRAG Den foreliggende oppfinnelse angår nye antistoffer som er i stand til å bindes spesifikt til den humane insulinliknende vekstfaktor 1-reseptor IGF-IR og/eller i stand til spesifikt å inhibere tyrosinkinaseaktiviteten til nevnte IGF-IR, særlig monoklonale antistoffer av murin, kimerisk og human opprinnelse, så vel som aminosyre- og nukleinsyresekvenser som koder for disse antistoffer. Oppfinnelsene omfatter likeledes anvendelse av disse antistoffene som et medikament for profylaktisk og/eller terapeutisk behandling av kreft som overuttrykker IGF-IR eller enhver patologi forbundet med overuttrykk av nevnte reseptor så vel som i fremgangsmåter eller sett for diagnose av sykdommer forbundet med overekspresjon av IGF-IR. Oppfinnelsen omfatter avslutningsvis produkter og/eller sammensetninger som omfatter slike antistoffer i kombinasjon med anti-EGFR-antistoffer og/eller anti-VEGF-antistoffer og/eller antistoffer rettet mot andre vekstfaktorer involvert i tumorprogresjon eller metastase, og/eller forbindelser og/eller antikreftmidler eller midler konjugert med toksiner, og deres anvendelse til å forhindre og/eller å behandle visse kreftformer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59193204P | 2004-07-29 | 2004-07-29 | |
| FR0408379A FR2873699B1 (fr) | 2004-07-29 | 2004-07-29 | Nouveaux anticorps anti igf ir rt leurs utilisations |
| PCT/IB2005/002619 WO2006013472A2 (en) | 2004-07-29 | 2005-07-27 | Novel anti-igf-ir antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20071093L true NO20071093L (no) | 2007-02-27 |
Family
ID=34950307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20071093A NO20071093L (no) | 2004-07-29 | 2007-02-27 | Nye anti-IGF-IR-antistoffer og anvendelse derav |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7854930B2 (no) |
| EP (4) | EP2365005A3 (no) |
| JP (3) | JP5016487B2 (no) |
| KR (1) | KR101220635B1 (no) |
| CN (2) | CN101014625B (no) |
| AR (1) | AR050036A1 (no) |
| AU (1) | AU2005268505B2 (no) |
| BR (1) | BRPI0513890A (no) |
| CA (1) | CA2575348A1 (no) |
| CO (1) | CO5700152A1 (no) |
| FR (1) | FR2873699B1 (no) |
| GT (1) | GT200500205A (no) |
| IL (2) | IL181025A (no) |
| MX (1) | MX2007001109A (no) |
| NO (1) | NO20071093L (no) |
| NZ (2) | NZ569718A (no) |
| PA (1) | PA8640601A1 (no) |
| RU (2) | RU2406729C2 (no) |
| SV (1) | SV2006002182A (no) |
| TW (1) | TWI432451B (no) |
| WO (1) | WO2006013472A2 (no) |
| ZA (1) | ZA200700593B (no) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7553485B2 (en) * | 2002-01-18 | 2009-06-30 | Pierre Fabre Medicament | Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof |
| US7241444B2 (en) * | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| CN1938428A (zh) | 2003-11-12 | 2007-03-28 | 先灵公司 | 多基因表达的质粒系统 |
| FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| ES2356830T3 (es) | 2004-12-03 | 2011-04-13 | Schering Corporation | Biomarcadores para preselección de pacientes para terapia de anti-igf-1r. |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| PT2100614E (pt) | 2005-06-17 | 2013-12-16 | Imclone Llc | Antagonistas de receptor para tratamento de cancro ósseo metastático |
| FR2888850B1 (fr) * | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| WO2007092453A2 (en) | 2006-02-03 | 2007-08-16 | Imclone Systems Incorporated | Igf-ir antagonists as adjuvants for treatment of prostate cancer |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
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| CA2709029A1 (en) | 2007-12-21 | 2009-07-02 | Bianca Eser | Stability testing of antibodies |
| EP2236139A1 (en) | 2009-03-31 | 2010-10-06 | F. Hoffmann-La Roche AG | Combination therapy of erlotinib with an anti-IGF-1R antibody, which does not inhibit binding of insulin to the insulin receptor |
| WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
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| US8444982B2 (en) * | 2009-12-04 | 2013-05-21 | The University Of Hong Kong | Anti-IGF-IR antibodies and uses thereof |
| US20110200595A1 (en) | 2010-02-18 | 2011-08-18 | Roche Glycart | TREATMENT WITH A HUMANIZED IgG CLASS ANTI EGFR ANTIBODY AND AN ANTIBODY AGAINST INSULIN LIKE GROWTH FACTOR 1 RECEPTOR |
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