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NO20070686L - 17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv - Google Patents

17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv

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Publication number
NO20070686L
NO20070686L NO20070686A NO20070686A NO20070686L NO 20070686 L NO20070686 L NO 20070686L NO 20070686 A NO20070686 A NO 20070686A NO 20070686 A NO20070686 A NO 20070686A NO 20070686 L NO20070686 L NO 20070686L
Authority
NO
Norway
Prior art keywords
compounds
analogs
diseases
processes
desmethylrapamucine
Prior art date
Application number
NO20070686A
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English (en)
Inventor
Matthew Alan Gregory
Christine Janet Martin
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Biotica Tech Ltd
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Filing date
Publication date
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Publication of NO20070686L publication Critical patent/NO20070686L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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  • Health & Medical Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Produksjon av polyketoner og andre naturlige produkter og til bibliotek av forbindelser og individuelle nye forbindelser. I ett aspekt framskaffer derfor den foreliggende oppfinnelsen 17-desmetylrapamycin og analoger av det, framgangsmåter for framstilling av disse, inkludert rekombinante stammer, og isolasjon og bruk av forbindelsene i samsvar med oppfinnelsen. I et ytterligere aspekt framskaffer foreliggende oppfinnelse bruk av 17-desmetylrapamycin og analoger av det i innføringen av vedlikehold av immunosuppresjon, stimulering av neuronal regenerering eller behandling av kreft, B-celle malignansier, sopp-infeksjoner, transplantat-avvisning, transpantat-versus-verts sykdommer, autoimmune sykdommer, sykdommer av inflammasjon vaskulær sykdom og fibrotiske sykdommer og i reguleringen av sår-heling.
NO20070686A 2004-08-11 2007-02-06 17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv NO20070686L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417852.1A GB0417852D0 (en) 2004-08-11 2004-08-11 Production of polyketides and other natural products
PCT/GB2005/003158 WO2006016167A2 (en) 2004-08-11 2005-08-11 17-desmethylrapamycin and analogues thereof, methods for their roduction and their use as immunosupressants, anticancer agents, antifungal agents, etc.

Publications (1)

Publication Number Publication Date
NO20070686L true NO20070686L (no) 2007-04-25

Family

ID=33017292

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Application Number Title Priority Date Filing Date
NO20070686A NO20070686L (no) 2004-08-11 2007-02-06 17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv

Country Status (19)

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US (1) US7803808B2 (no)
EP (2) EP2471797B1 (no)
JP (1) JP2008509895A (no)
KR (1) KR20070052784A (no)
CN (2) CN101056880A (no)
AU (1) AU2005270989B2 (no)
BR (1) BRPI0514236A (no)
CA (1) CA2575582A1 (no)
CR (1) CR8990A (no)
EC (1) ECSP077303A (no)
GB (1) GB0417852D0 (no)
IL (1) IL181171A0 (no)
MX (1) MX2007001809A (no)
NO (1) NO20070686L (no)
NZ (1) NZ553074A (no)
RU (2) RU2430922C2 (no)
UA (1) UA95895C2 (no)
WO (1) WO2006016167A2 (no)
ZA (1) ZA200701622B (no)

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MX2007001809A (es) 2007-10-08
WO2006016167A2 (en) 2006-02-16
EP2471797A3 (en) 2012-10-17
CA2575582A1 (en) 2006-02-16
AU2005270989B2 (en) 2012-04-05
BRPI0514236A (pt) 2008-06-03
AU2005270989A1 (en) 2006-02-16
EP2471797A2 (en) 2012-07-04
US20090253732A1 (en) 2009-10-08
GB0417852D0 (en) 2004-09-15
IL181171A0 (en) 2007-07-04
EP2029611A2 (en) 2009-03-04
CN101056880A (zh) 2007-10-17
NZ553074A (en) 2011-01-28
US7803808B2 (en) 2010-09-28
EP2471797B1 (en) 2016-02-03
ECSP077303A (es) 2007-04-26
WO2006016167A3 (en) 2006-04-13
CR8990A (es) 2009-01-14
UA95895C2 (ru) 2011-09-26
CN101805748A (zh) 2010-08-18
RU2007108772A (ru) 2008-09-20
JP2008509895A (ja) 2008-04-03
ZA200701622B (en) 2008-06-25
KR20070052784A (ko) 2007-05-22
RU2430922C2 (ru) 2011-10-10

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