NO20063298L - Benzensulfonylamino-pyridin-2-yl-derivater og beslektede forbindelser som inhibitorer for 11-beta-hydroksy steroid dehydrogenase type 1(11-beta-hsd-1) for behandling av diabetes og fedme - Google Patents
Benzensulfonylamino-pyridin-2-yl-derivater og beslektede forbindelser som inhibitorer for 11-beta-hydroksy steroid dehydrogenase type 1(11-beta-hsd-1) for behandling av diabetes og fedmeInfo
- Publication number
- NO20063298L NO20063298L NO20063298A NO20063298A NO20063298L NO 20063298 L NO20063298 L NO 20063298L NO 20063298 A NO20063298 A NO 20063298A NO 20063298 A NO20063298 A NO 20063298A NO 20063298 L NO20063298 L NO 20063298L
- Authority
- NO
- Norway
- Prior art keywords
- beta
- hsd
- obesity
- diabetes
- inhibitors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 102000008645 11-beta-Hydroxysteroid Dehydrogenase Type 1 Human genes 0.000 title 1
- 108010088011 11-beta-Hydroxysteroid Dehydrogenase Type 1 Proteins 0.000 title 1
- -1 Benzenesulfonylamino-pyridin-2-yl Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 101100451537 Caenorhabditis elegans hsd-1 gene Proteins 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53118603P | 2003-12-19 | 2003-12-19 | |
| US55692104P | 2004-03-26 | 2004-03-26 | |
| PCT/IB2004/004056 WO2005060963A1 (en) | 2003-12-19 | 2004-12-06 | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-hsd-1) for the treatment of diabetes and obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20063298L true NO20063298L (no) | 2006-09-14 |
Family
ID=34713786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20063298A NO20063298L (no) | 2003-12-19 | 2006-07-17 | Benzensulfonylamino-pyridin-2-yl-derivater og beslektede forbindelser som inhibitorer for 11-beta-hydroksy steroid dehydrogenase type 1(11-beta-hsd-1) for behandling av diabetes og fedme |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20050148631A1 (xx) |
| EP (1) | EP1696915A1 (xx) |
| JP (1) | JP2007514731A (xx) |
| KR (1) | KR20060101772A (xx) |
| AP (1) | AP2006003633A0 (xx) |
| AR (1) | AR046767A1 (xx) |
| AU (1) | AU2004305321A1 (xx) |
| BR (1) | BRPI0417687A (xx) |
| CA (1) | CA2549651A1 (xx) |
| DO (1) | DOP2004001052A (xx) |
| EA (1) | EA200600990A1 (xx) |
| EC (1) | ECSP066653A (xx) |
| IL (1) | IL175949A0 (xx) |
| IS (1) | IS8473A (xx) |
| MA (1) | MA28271A1 (xx) |
| MX (1) | MXPA06007077A (xx) |
| NL (1) | NL1027811C2 (xx) |
| NO (1) | NO20063298L (xx) |
| OA (1) | OA13344A (xx) |
| PA (1) | PA8620301A1 (xx) |
| PE (1) | PE20050864A1 (xx) |
| TW (1) | TW200530185A (xx) |
| UY (1) | UY28674A1 (xx) |
| WO (1) | WO2005060963A1 (xx) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| EA200700117A1 (ru) | 2004-06-24 | 2007-06-29 | Инсайт Корпорейшн | N-замещенные пиперидины и их применение в качестве фармацевтических препаратов |
| HRP20090151T3 (en) | 2004-09-29 | 2009-04-30 | F. Hoffmann - La Roche Ag | Indozolone derivatives as 11b-hsd1 inhibitors |
| NZ554014A (en) * | 2004-10-04 | 2010-06-25 | Hoffmann La Roche | Alkil-pyridines as 11-beta inhibitors for diabetes |
| EP1659113A1 (en) * | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| KR101302627B1 (ko) | 2005-01-05 | 2013-09-10 | 아비에 인코포레이티드 | 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제 |
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| WO2006095822A1 (ja) * | 2005-03-11 | 2006-09-14 | Ono Pharmaceutical Co., Ltd. | スルホンアミド化合物およびその医薬 |
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| WO2006113261A2 (en) * | 2005-04-14 | 2006-10-26 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type i |
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| ES2383090T3 (es) | 2005-10-12 | 2012-06-18 | Vertex Pharmaceuticals, Inc. | Derivados de bifenilo como moduladores de los canales iónicos dependientes de voltaje |
| BRPI0619446A2 (pt) | 2005-12-05 | 2011-10-04 | Incyte Corp | compostos de lactama, suas composições e método de modulação da atividade de 11bhsd1 |
| US20090018118A1 (en) * | 2005-12-29 | 2009-01-15 | Uros Urleb | Heterocyclic compounds |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| AU2007207055B2 (en) | 2006-01-18 | 2011-06-02 | F. Hoffmann-La Roche Ag | Thiazoles as 11 beta-HSD1 inhibitors |
| TW200804341A (en) * | 2006-01-31 | 2008-01-16 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| WO2007114763A1 (en) * | 2006-03-31 | 2007-10-11 | Astrazeneca Ab | Sulphonamide derivates as modulators of the glucocorticoid receptor |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP2018378A2 (en) | 2006-05-17 | 2009-01-28 | Incyte Corporation | Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same |
| TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| WO2008061795A2 (en) * | 2006-11-24 | 2008-05-29 | Ac Immune Sa | N- (methyl) -1h- pyrazol- 3 -amine, n- (methyl) -pyridin-2-amine and n- (methyl) -thiaz0l-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| SA109300309B1 (ar) | 2008-05-20 | 2013-01-22 | باير شيرنج فارما ايه جي | مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال |
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| DE102010033690A1 (de) * | 2010-08-06 | 2012-02-09 | Saltigo Gmbh | Verfahren zur Herstellung vom Aminoarylalkylverbindungen |
| UA112418C2 (uk) | 2010-09-07 | 2016-09-12 | Астеллас Фарма Інк. | Терапевтичний болезаспокійливий засіб |
| US9233946B2 (en) | 2010-09-17 | 2016-01-12 | Kancera Ab | Sulfonamide compounds |
| WO2012124744A1 (ja) * | 2011-03-14 | 2012-09-20 | 大正製薬株式会社 | 含窒素縮合複素環化合物 |
| EP2794009B1 (en) * | 2011-12-22 | 2017-08-30 | Kancera AB | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| US10000449B2 (en) | 2011-12-22 | 2018-06-19 | Kancera Ab | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| US20160168132A1 (en) * | 2013-07-31 | 2016-06-16 | Minoryx Therapeutics S.L. | Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof |
| EP2940022B1 (en) * | 2014-04-30 | 2020-09-02 | Masarykova Univerzita | Furopyridines as inhibitors of protein kinases |
| EP3262028B1 (en) | 2014-12-17 | 2021-10-27 | Pimco 2664 Limited | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(-4hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| CN111801314B (zh) | 2018-01-02 | 2023-10-31 | 西尔洛克治疗公司 | Ask1抑制剂化合物及其用途 |
| IL283069B2 (en) | 2018-11-20 | 2025-09-01 | Sparrow Pharmaceuticals Inc | Methods of administering corticosteroids |
| CN114845709B (zh) | 2019-11-05 | 2024-10-01 | 德米拉公司 | 用于治疗炎性病症的mrgprx2拮抗剂 |
| EP4054570A1 (en) * | 2019-11-05 | 2022-09-14 | Dermira, Inc | Mrgprx2 antagonists and uses thereof |
| JP2025517334A (ja) | 2022-05-16 | 2025-06-05 | スパロー ファーマシューティカルズ,インコーポレーテッド | グルココルチコイド過剰を治療するための方法及び組成物 |
| WO2025117672A1 (en) * | 2023-12-01 | 2025-06-05 | Hotspot Therapeutics, Inc. | Indazolyl-piperidine sulfonamides and related compounds and their use in therapy |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE167473T1 (de) * | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
| DE4041780A1 (de) * | 1990-12-24 | 1992-06-25 | Boehringer Mannheim Gmbh | Neue amine, verfahren zu ihrer herstellung, sowie diese verbindungen enthaltende arzneimittel |
| SE9103397D0 (sv) * | 1991-11-18 | 1991-11-18 | Kabi Pharmacia Ab | Nya substituerade salicylsyror |
| GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| GB9409618D0 (en) * | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
| AU5772296A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| US5939451A (en) * | 1996-06-28 | 1999-08-17 | Hoffmann-La Roche Inc. | Use of sulfonamides |
| GB9805520D0 (en) * | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Chemical compounds |
| JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
| US6552225B1 (en) * | 1999-09-04 | 2003-04-22 | Astrazeneca Ab | Chemical compounds |
| US6506754B1 (en) * | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Non-covalent thrombin inhibitors |
| SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| CN1564816A (zh) * | 2001-11-22 | 2005-01-12 | 比奥维特罗姆股份公司 | 11-β-羟基类固醇脱氢酶1型抑制剂 |
| US7094792B2 (en) * | 2001-11-22 | 2006-08-22 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| WO2003099773A1 (en) * | 2002-05-24 | 2003-12-04 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| CA2525945A1 (en) * | 2003-05-21 | 2004-12-02 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i |
-
2004
- 2004-12-06 EP EP04801352A patent/EP1696915A1/en not_active Withdrawn
- 2004-12-06 EA EA200600990A patent/EA200600990A1/ru unknown
- 2004-12-06 KR KR1020067012036A patent/KR20060101772A/ko not_active Ceased
- 2004-12-06 JP JP2006544581A patent/JP2007514731A/ja active Pending
- 2004-12-06 BR BRPI0417687-1A patent/BRPI0417687A/pt not_active IP Right Cessation
- 2004-12-06 MX MXPA06007077A patent/MXPA06007077A/es not_active Application Discontinuation
- 2004-12-06 WO PCT/IB2004/004056 patent/WO2005060963A1/en not_active Ceased
- 2004-12-06 AU AU2004305321A patent/AU2004305321A1/en not_active Abandoned
- 2004-12-06 OA OA1200600201A patent/OA13344A/en unknown
- 2004-12-06 CA CA002549651A patent/CA2549651A1/en not_active Abandoned
- 2004-12-06 AP AP2006003633A patent/AP2006003633A0/xx unknown
- 2004-12-10 PE PE2004001240A patent/PE20050864A1/es not_active Application Discontinuation
- 2004-12-15 AR ARP040104669A patent/AR046767A1/es unknown
- 2004-12-16 DO DO2004001052A patent/DOP2004001052A/es unknown
- 2004-12-16 UY UY28674A patent/UY28674A1/es not_active Application Discontinuation
- 2004-12-17 TW TW093139461A patent/TW200530185A/zh unknown
- 2004-12-17 US US11/016,152 patent/US20050148631A1/en not_active Abandoned
- 2004-12-17 PA PA20048620301A patent/PA8620301A1/es unknown
- 2004-12-17 NL NL1027811A patent/NL1027811C2/nl not_active IP Right Cessation
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2006
- 2006-05-18 IS IS8473A patent/IS8473A/is unknown
- 2006-05-25 IL IL175949A patent/IL175949A0/en unknown
- 2006-06-16 EC EC2006006653A patent/ECSP066653A/es unknown
- 2006-06-19 MA MA29114A patent/MA28271A1/fr unknown
- 2006-07-17 NO NO20063298A patent/NO20063298L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2004001052A (es) | 2005-06-30 |
| AP2006003633A0 (en) | 2006-06-30 |
| JP2007514731A (ja) | 2007-06-07 |
| BRPI0417687A (pt) | 2007-04-03 |
| WO2005060963A8 (en) | 2005-12-01 |
| AU2004305321A1 (en) | 2005-07-07 |
| PA8620301A1 (es) | 2005-08-04 |
| UY28674A1 (es) | 2005-07-29 |
| OA13344A (en) | 2007-04-13 |
| ECSP066653A (es) | 2006-10-25 |
| EA200600990A1 (ru) | 2006-10-27 |
| EP1696915A1 (en) | 2006-09-06 |
| WO2005060963A1 (en) | 2005-07-07 |
| TW200530185A (en) | 2005-09-16 |
| KR20060101772A (ko) | 2006-09-26 |
| PE20050864A1 (es) | 2005-10-31 |
| MA28271A1 (fr) | 2006-11-01 |
| US20050148631A1 (en) | 2005-07-07 |
| CA2549651A1 (en) | 2005-07-07 |
| AR046767A1 (es) | 2005-12-21 |
| IL175949A0 (en) | 2006-10-05 |
| NL1027811C2 (nl) | 2006-03-06 |
| IS8473A (is) | 2006-05-18 |
| MXPA06007077A (es) | 2006-08-23 |
| NL1027811A1 (nl) | 2005-06-21 |
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